EE03876B1 - Aminohappe estrit sisaldavad asool-antimükootikumid, nende valmistamine ja kasutamine ning neid sisaldavad farmatseutilised kompositsioonid - Google Patents

Aminohappe estrit sisaldavad asool-antimükootikumid, nende valmistamine ja kasutamine ning neid sisaldavad farmatseutilised kompositsioonid

Info

Publication number: EE03876B1
Authority: EE; Estonia
Prior art keywords: preparation; amino acids; pharmaceutical compositions; compositions containing; antimycotic agents
Prior art date: 1997-02-11

Application number

EEP199900100A

Other languages

English (en)

Estonian (et)

Inventor

Meerpoel Lieven

Heeres Jan

Jozef Maria Hendrickx Robert

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-11

Filing date

1998-02-03

Publication date

2002-10-15

1998-02-03 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1999-10-15 Publication of EE9900100A publication Critical patent/EE9900100A/xx

2002-10-15 Publication of EE03876B1 publication Critical patent/EE03876B1/xx

Links

KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title abstract 4
150000001413 amino acids Chemical class 0.000 title abstract 2
239000003429 antifungal agent Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical class C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
125000000815 N-oxide group Chemical group 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

EEP199900100A 1997-02-11 1998-02-03 Aminohappe estrit sisaldavad asool-antimükootikumid, nende valmistamine ja kasutamine ning neid sisaldavad farmatseutilised kompositsioonid EE03876B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP97200374		1997-02-11
EP97203228		1997-10-15
PCT/EP1998/000646 WO1998034934A1 (en)	1997-02-11	1998-02-03	Amino acid ester containing azole antifungals

Publications (2)

Publication Number	Publication Date
EE9900100A EE9900100A (et)	1999-10-15
EE03876B1 true EE03876B1 (et)	2002-10-15

Family

ID=26146124

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900100A EE03876B1 (et)	1997-02-11	1998-02-03	Aminohappe estrit sisaldavad asool-antimükootikumid, nende valmistamine ja kasutamine ning neid sisaldavad farmatseutilised kompositsioonid

Country Status (31)

Country	Link
US (3)	US6262052B1 (pl)
EP (1)	EP0958289B1 (pl)
JP (1)	JP4347911B2 (pl)
KR (1)	KR100509171B1 (pl)
CN (1)	CN1238353C (pl)
AT (1)	ATE270290T1 (pl)
AU (1)	AU725302C (pl)
BG (1)	BG63872B1 (pl)
BR (1)	BR9809744A (pl)
CA (1)	CA2262791C (pl)
CZ (1)	CZ297197B6 (pl)
DE (1)	DE69824834T2 (pl)
DK (1)	DK0958289T3 (pl)
EE (1)	EE03876B1 (pl)
ES (1)	ES2224364T3 (pl)
HU (1)	HU227744B1 (pl)
ID (1)	ID21755A (pl)
IL (2)	IL128513A (pl)
MY (1)	MY129537A (pl)
NO (1)	NO316668B1 (pl)
NZ (1)	NZ334477A (pl)
PL (1)	PL191152B1 (pl)
PT (1)	PT958289E (pl)
RU (1)	RU2197489C2 (pl)
SI (1)	SI0958289T1 (pl)
SK (1)	SK284910B6 (pl)
TR (1)	TR199900584T2 (pl)
TW (1)	TW495508B (pl)
UA (1)	UA61919C2 (pl)
WO (1)	WO1998034934A1 (pl)
ZA (1)	ZA981079B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0957101A1 (en)	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Water soluble azoles as broad-spectrum antifungals
AU1915500A (en)	1998-11-20	2000-06-13	Bristol-Myers Squibb Company	Water soluble prodrugs of azole compounds
ES2194723T3 (es)	1999-05-04	2003-12-01	Janssen Pharmaceutica Nv	Eteres antifungicos.
WO2003052117A2 (en) *	2001-09-19	2003-06-26	Massachusetts Institute Of Technology	Methods and products related to non-viral transfection
ITMI20032020A1 (it)	2003-10-17	2005-04-18	Italfarmaco Spa	Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
EP2571871B1 (en) *	2010-05-19	2017-06-21	Sandoz AG	Process for the preparation of chiral triazolones
US20170290333A1 (en)	2014-12-30	2017-10-12	Dow Agrosciences Llc	Picolinamide compounds with fungicidal activity
BR102019004480B1 (pt) *	2018-03-08	2023-03-28	Dow Agrosciences Llc	Picolinamidas como fungicidas
CN111138421A (zh) *	2019-12-26	2020-05-12	上海英诺富成生物科技有限公司	抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267179A (en)	1978-06-23	1981-05-12	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4791111A (en) *	1985-12-23	1988-12-13	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
US4916134A (en)	1987-03-25	1990-04-10	Janssen Pharmacuetica N.V.	4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
CA1331757C (en)	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
NZ233502A (en) *	1989-06-09	1991-11-26	Janssen Pharmaceutica Nv	4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
HU221189B1 (en)	1992-03-18	2002-08-28	Janssen Pharmaceutica Nv	Itraconazole and saperconazole stereoisomers, their cyclodextrin complexes and pharmaceutical compositions containing them and process for producing them
PL181193B1 (pl)	1993-12-21	2001-06-29	Schering Corp	Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków
NZ278882A (en) *	1994-01-24	1997-06-24	Janssen Pharmaceutica Nv	Piperazine-containing azole antifungal compounds
SK27097A3 (en) *	1995-06-02	1997-09-10	Schering Corp	Tetrahydrofuran antifungals
CA2224707A1 (en) *	1995-06-19	1997-01-03	Schering Corporation	Tetrahydrofuran antifungals

1998
- 1998-02-03 AU AU66207/98A patent/AU725302C/en not_active Expired
- 1998-02-03 SK SK1059-99A patent/SK284910B6/sk not_active IP Right Cessation
- 1998-02-03 NZ NZ334477A patent/NZ334477A/en not_active IP Right Cessation
- 1998-02-03 DK DK98908064T patent/DK0958289T3/da active
- 1998-02-03 DE DE69824834T patent/DE69824834T2/de not_active Expired - Lifetime
- 1998-02-03 JP JP53376398A patent/JP4347911B2/ja not_active Expired - Lifetime
- 1998-02-03 PT PT98908064T patent/PT958289E/pt unknown
- 1998-02-03 CN CNB988011352A patent/CN1238353C/zh not_active Expired - Lifetime
- 1998-02-03 EP EP98908064A patent/EP0958289B1/en not_active Expired - Lifetime
- 1998-02-03 SI SI9830687T patent/SI0958289T1/xx unknown
- 1998-02-03 HU HU0001050A patent/HU227744B1/hu unknown
- 1998-02-03 US US09/355,369 patent/US6262052B1/en not_active Expired - Lifetime
- 1998-02-03 ES ES98908064T patent/ES2224364T3/es not_active Expired - Lifetime
- 1998-02-03 BR BR9809744-0A patent/BR9809744A/pt not_active Application Discontinuation
- 1998-02-03 ID IDW990505A patent/ID21755A/id unknown
- 1998-02-03 WO PCT/EP1998/000646 patent/WO1998034934A1/en not_active Ceased
- 1998-02-03 IL IL12851398A patent/IL128513A/en not_active IP Right Cessation
- 1998-02-03 RU RU99106585/04A patent/RU2197489C2/ru active
- 1998-02-03 PL PL332008A patent/PL191152B1/pl unknown
- 1998-02-03 KR KR10-1999-7001983A patent/KR100509171B1/ko not_active Expired - Lifetime
- 1998-02-03 TR TR1999/00584T patent/TR199900584T2/xx unknown
- 1998-02-03 CZ CZ0283599A patent/CZ297197B6/cs not_active IP Right Cessation
- 1998-02-03 CA CA002262791A patent/CA2262791C/en not_active Expired - Lifetime
- 1998-02-03 EE EEP199900100A patent/EE03876B1/xx unknown
- 1998-02-03 AT AT98908064T patent/ATE270290T1/de active
- 1998-02-09 MY MYPI98000513A patent/MY129537A/en unknown
- 1998-02-09 TW TW087101662A patent/TW495508B/zh not_active IP Right Cessation
- 1998-02-10 ZA ZA9801079A patent/ZA981079B/xx unknown
- 1998-03-02 UA UA99020835A patent/UA61919C2/uk unknown
1999
- 1999-02-02 NO NO19990484A patent/NO316668B1/no not_active IP Right Cessation
- 1999-02-11 BG BG103171A patent/BG63872B1/bg unknown
2001
- 2001-05-04 US US09/848,989 patent/US6512116B2/en not_active Expired - Lifetime
2002
- 2002-04-23 IL IL149285A patent/IL149285A/en not_active IP Right Cessation
- 2002-11-15 US US10/298,038 patent/US6703506B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20030158210A1 (en)	2003-08-21
PL191152B1 (pl)	2006-03-31
AU725302B2 (en)	2000-10-12
IL149285A0 (en)	2002-11-10
BG103171A (en)	1999-09-30
PL332008A1 (en)	1999-08-16
IL149285A (en)	2007-08-19
US6703506B2 (en)	2004-03-09
ES2224364T3 (es)	2005-03-01
CA2262791A1 (en)	1998-08-13
BR9809744A (pt)	2000-06-20
US20010039281A1 (en)	2001-11-08
UA61919C2 (uk)	2003-12-15
JP4347911B2 (ja)	2009-10-21
SK105999A3 (en)	2000-06-12
HUP0001050A2 (hu)	2001-04-28
CN1236366A (zh)	1999-11-24
RU2197489C2 (ru)	2003-01-27
DK0958289T3 (da)	2004-11-01
EP0958289A1 (en)	1999-11-24
TW495508B (en)	2002-07-21
ID21755A (id)	1999-07-22
CZ283599A3 (cs)	2000-02-16
SK284910B6 (sk)	2006-02-02
DE69824834D1 (de)	2004-08-05
US6262052B1 (en)	2001-07-17
NO316668B1 (no)	2004-03-29
ZA981079B (en)	1999-08-10
DE69824834T2 (de)	2005-07-21
NZ334477A (en)	2001-05-25
AU6620798A (en)	1998-08-26
CN1238353C (zh)	2006-01-25
NO990484L (no)	1999-10-11
BG63872B1 (bg)	2003-04-30
IL128513A0 (en)	2000-01-31
KR20000068526A (ko)	2000-11-25
CA2262791C (en)	2008-10-28
HU227744B1 (en)	2012-02-28
CZ297197B6 (cs)	2006-09-13
JP2001508080A (ja)	2001-06-19
NO990484D0 (no)	1999-02-02
MY129537A (en)	2007-04-30
PT958289E (pt)	2004-11-30
EP0958289B1 (en)	2004-06-30
IL128513A (en)	2002-11-10
EE9900100A (et)	1999-10-15
SI0958289T1 (en)	2004-12-31
TR199900584T2 (xx)	1999-10-21
WO1998034934A1 (en)	1998-08-13
HUP0001050A3 (en)	2001-07-30
AU725302C (en)	2001-08-23
US6512116B2 (en)	2003-01-28
ATE270290T1 (de)	2004-07-15
KR100509171B1 (ko)	2005-08-22

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231

Publication	Publication Date	Title
ATE61050T1 (de)	1991-03-15	Pyridazinamine wirksam gegen viren.
IL100015A0 (en)	1992-08-18	Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
BG60102B2 (bg)	1993-10-29	Метод за получаване на 5-флуор-2(((4-циклопропил- метокси-2-пиридинил)метил)тионил)-1н-бензимидазол
FR2743562B1 (fr)	1998-04-03	Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant
NO920035D0 (no)	1992-01-02	Trifluormetylketon-derivater, og deres fremstilling og anvendelse
DK529888D0 (da)	1988-09-23	Substituerede n-(1-alkyl-3-hydroxy-4-piperidinyl) benzamider
DK581889D0 (da)	1989-11-20	Antiatherosclerotiske diarylforbindelser
EE9900100A (et)	1999-10-15	Aminohappe estrit sisaldavad asool-antimükootikumid
EP1019047A4 (en)	2001-06-13	ANTITHROMBOTIC AGENTS
BR9807330A (pt)	2000-04-18	Agentes inibidores do progresso de pterìgio e recorrência pós-operatória do mesmo
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
NO950177D0 (no)	1995-01-17	Farmakologisk aktive erivater
ATE248163T1 (de)	2003-09-15	Neuartige, pharmazeutisch aktive verbindung
ATE268768T1 (de)	2004-06-15	Antithrombosemittel
RU95116239A (ru)	1998-01-10	Применение 5-тиа-1,4-диазабицикло[4.2.0]октан-3,8-диоксопроизводных в противоопухолевой терапии