EE04053B1 - (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod - Google Patents

(S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod

Info

Publication number
EE04053B1
EE04053B1 EE9700320A EE9700320A EE04053B1 EE 04053 B1 EE04053 B1 EE 04053B1 EE 9700320 A EE9700320 A EE 9700320A EE 9700320 A EE9700320 A EE 9700320A EE 04053 B1 EE04053 B1 EE 04053B1
Authority
EE
Estonia
Prior art keywords
aminomethyl
methylhexanoic acid
alkali
earth metal
alkaline earth
Prior art date
Application number
EE9700320A
Other languages
English (en)
Estonian (et)
Other versions
EE9700320A (et
Inventor
Michel Grote Todd
Keith Huckabee Brian
Martin Sobieray Denis
Daniel Titus Robert
Mulhern Thomas
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700320A publication Critical patent/EE9700320A/xx
Publication of EE04053B1 publication Critical patent/EE04053B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EE9700320A 1995-06-07 1996-05-13 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod EE04053B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (fr) 1995-06-07 1996-05-13 Procede de preparation d'acide (s)-3-(aminomethyl)-5-methylhexanoique

Publications (2)

Publication Number Publication Date
EE9700320A EE9700320A (et) 1998-06-15
EE04053B1 true EE04053B1 (et) 2003-06-16

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700320A EE04053B1 (et) 1995-06-07 1996-05-13 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod

Country Status (18)

Country Link
US (4) US5637767A (fr)
EP (1) EP0830338B1 (fr)
JP (1) JP3874306B2 (fr)
AT (1) ATE210628T1 (fr)
CA (1) CA2219150C (fr)
CZ (2) CZ291147B6 (fr)
DE (1) DE69617948T2 (fr)
DK (1) DK0830338T3 (fr)
EE (1) EE04053B1 (fr)
ES (1) ES2170231T3 (fr)
GE (1) GEP19991870B (fr)
HU (2) HU229957B1 (fr)
NZ (2) NZ308319A (fr)
PL (3) PL185557B1 (fr)
PT (1) PT830338E (fr)
SI (1) SI0830338T1 (fr)
SK (2) SK283507B6 (fr)
WO (1) WO1996040617A1 (fr)

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PL189872B1 (pl) 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
US6194459B1 (en) 1997-08-19 2001-02-27 Warner-Lambert Company Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants
RS50352B (sr) * 1999-06-10 2009-11-10 Warner-Lambert Company Llc., Monosupstituisane 3-propil gama-aminobuterne kiseline
BRPI0107863B8 (pt) * 2000-01-27 2017-04-25 Warner-Lambert Company método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina
GB2368579A (en) * 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
US7169812B2 (en) * 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
EP1543831A1 (fr) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Composition de pregabaline
ES2292107T3 (es) * 2004-03-12 2008-03-01 Warner-Lambert Company Llc Ligandos de bifosfina simetricos en c1 y su uso en la sintesis asimetrica de pregabalina.
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
HRP20100054T1 (hr) * 2004-06-21 2010-05-31 Warner-Lambert Company Llc Dobivanje pregabalina i njemu sličnih spojeva
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
EP1768950A2 (fr) * 2005-04-11 2007-04-04 Teva Pharmaceutical Industries Ltd. Procede de fabrication de (s)-pregabaline
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
DE602006017995D1 (de) * 2005-05-10 2010-12-16 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
US20070043241A1 (en) * 2005-05-10 2007-02-22 Lilach Hedvati Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid
WO2006122255A1 (fr) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabaline exempte d'acide isobutylglutarique et son procede de preparation
WO2006121557A1 (fr) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabaline exempte de lactame et son procede de preparation
ES2398579T3 (es) * 2005-09-19 2013-03-20 Teva Pharmaceutical Industries Ltd Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
EP1904486A2 (fr) * 2006-04-24 2008-04-02 Teva Pharmaceutical Industries Ltd Procede de synthese d'acide 3-isobutylglutarique
WO2007139933A2 (fr) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Procédés pour la préparation d'acide r-(+)-3-(carbamoyl méthyl)-5-méthylhexanoïque et de sels de celui-ci
EP1912931A2 (fr) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Préparation de (s)-prégabaline nitrile
US20080026433A1 (en) * 2006-05-31 2008-01-31 Lilach Hedvati Use of enzymatic resolution for the preparation of intermediates of pregabalin
US20090286880A1 (en) * 2006-07-12 2009-11-19 Generics [Uk] Limited Novel process
WO2008062460A2 (fr) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Formes cristallines de la prégabaline
KR101036536B1 (ko) * 2007-03-22 2011-05-24 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성
WO2008138874A1 (fr) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Procédé de préparation de la (s)-prégabaline par résolution optique de prégabaline racémique
EP1992609A1 (fr) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. Processus de préparation d'acide (S)(+)-3-(aminomethyl)-5-methylhexanoique
WO2009001372A2 (fr) 2007-06-25 2008-12-31 Manne Satyanarayana Reddy Nouveau procédé pour la préparation de la prégabaline
WO2009044409A2 (fr) * 2007-10-01 2009-04-09 Natco Pharma Limited Nouveau procédé de résolution pour la prégabaline
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
ITMI20072262A1 (it) 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
EP2225199A2 (fr) * 2007-12-18 2010-09-08 Watson Pharma Private Limited Procédé perfectionné pour la préparation de (s)-prégabaline
CN101965328A (zh) * 2007-12-26 2011-02-02 基因里克斯(英国)有限公司 普瑞巴林的制备方法
CN101910124B (zh) * 2007-12-27 2013-07-03 东丽精细化工株式会社 光学活性3-氨基吡咯烷盐、其制造方法以及3-氨基吡咯烷的光学拆分方法
WO2009082861A1 (fr) * 2008-01-02 2009-07-09 Zhejiang Jiuzhou Pharmaceutical Co., Ltd. Nouveau procédé de dédoublement de l'acide (s)-3-aminométhyl-5-méthylhexanoïque
WO2009125427A2 (fr) * 2008-02-18 2009-10-15 Matrix Laboratories Limited Procédé de fabrication d'acide (s)-3-(aminométhyl)-5-méthylhexanoïque
JP2011516459A (ja) * 2008-04-04 2011-05-26 ジェネリクス・（ユーケー）・リミテッド 新規な方法
EP2110372A1 (fr) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermédiaires pour la préparation de prégabaline et leur procédé de préparation
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
EP2294207B1 (fr) * 2008-05-21 2012-09-26 Sandoz AG Procédé pour l'hydrolyse enzymatique stéréosélective d'un ester d'acide 5-méthyl-3-nitrométhyl-hexanoïque
US20110190393A1 (en) * 2008-06-03 2011-08-04 Generics (Uk) Limited Novel and efficient method for the synthesis of an amino acid
EP2297090A1 (fr) * 2008-06-23 2011-03-23 Teva Pharmaceutical Industries Ltd. Synthèse enzymatique stéréosélective de l ester (s) ou (r)-isobutylglutarique
WO2010061403A2 (fr) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Procédé pour préparer de la (s)-prégabaline très pure
WO2010070593A2 (fr) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Esters de malonate
IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
HUP1000186A2 (en) 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
WO2011141923A2 (fr) 2010-05-14 2011-11-17 Lupin Limited Synthèse améliorée d'un ester alkylique optiquement pur de l'acide (s) - 3-cyano-5-méthyl-hexanoïque, intermédiaire de la (s)-prégabaline
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (fr) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Procédé de préparation de dérivés d'acide (s)-3-cyano-5-méthylhexanoïque et de prégabaline
US8895769B2 (en) 2011-04-20 2014-11-25 Kemphys Ltd. Silicon-containing carboxylic acid derivative
EP2527319A1 (fr) 2011-05-24 2012-11-28 Laboratorios Del. Dr. Esteve, S.A. Formes cristallines de prégabaline et co-formateurs pour le traitement de la douleur
CN104781264A (zh) 2012-10-18 2015-07-15 有限会社肯菲思 含有硅的羧酸衍生物
WO2014072785A2 (fr) 2012-11-07 2014-05-15 Hikal Limited Procédé de préparation de prégabaline
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
CN106488906B (zh) 2014-06-12 2018-10-26 斯福瑞有限公司 β-取代的γ-氨基羧酸的制备方法
CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
WO2016075082A1 (fr) 2014-11-10 2016-05-19 Sandoz Ag Amination réductrice stéréosélective d'aldéhydes alpha-chiraux au moyen d'ω-transaminases pour la synthèse de précurseurs de la prégabaline et du brivaracétam
CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
HK1253735A1 (zh) 2015-05-26 2019-06-28 艾萨‧欧蒂迪 控制延缓释放普瑞巴林
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
US20240000727A1 (en) 2020-12-04 2024-01-04 Laboratorios Silanes S.A. De C.V. Stable coated solid pharmaceutical composition of an opioid analgesic and an anti-epileptic for pain
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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Also Published As

Publication number Publication date
GEP19991870B (en) 1999-12-06
CZ384697A3 (cs) 1998-03-18
PL185425B1 (pl) 2003-05-30
CZ291147B6 (cs) 2002-12-11
CA2219150C (fr) 2008-11-18
SK283507B6 (sk) 2003-08-05
ATE210628T1 (de) 2001-12-15
MX9708652A (es) 1998-06-30
JP3874306B2 (ja) 2007-01-31
DK0830338T3 (da) 2002-04-02
DE69617948T2 (de) 2002-06-13
DE69617948D1 (de) 2002-01-24
HUP9802504A2 (hu) 1999-02-01
CA2219150A1 (fr) 1996-12-19
SK164597A3 (en) 1998-05-06
US5637767A (en) 1997-06-10
JPH11506726A (ja) 1999-06-15
HU228194B1 (en) 2013-01-28
US5840956A (en) 1998-11-24
PL185557B1 (pl) 2003-06-30
EP0830338B1 (fr) 2001-12-12
SK282865B6 (sk) 2003-01-09
CZ296895B6 (cs) 2006-07-12
AU700091B2 (en) 1998-12-24
SI0830338T1 (en) 2002-04-30
US20010016665A1 (en) 2001-08-23
PT830338E (pt) 2002-04-29
US6046353A (en) 2000-04-04
HU229957B1 (hu) 2015-03-30
WO1996040617A1 (fr) 1996-12-19
ES2170231T3 (es) 2002-08-01
PL185560B1 (pl) 2003-06-30
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
EE9700320A (et) 1998-06-15
HUP9802504A3 (en) 2000-06-28
HU0500934D0 (en) 2005-12-28
AU5792196A (en) 1996-12-30
EP0830338A1 (fr) 1998-03-25
NZ501628A (en) 2001-09-28

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Effective date: 20031231

KB4A Valid patent at the end of a year

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KB4A Valid patent at the end of a year

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KB4A Valid patent at the end of a year

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KB4A Valid patent at the end of a year

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Effective date: 20101231

HC1A Change of owner name