EE05402B1 - Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks - Google Patents

Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks

Info

Publication number: EE05402B1
Authority: EE; Estonia
Prior art keywords: benzimidazole; preparation; sulfones; removal; products
Prior art date: 2001-07-16

Application number

EEP200400052A

Other languages

English (en)

Estonian (et)

Inventor

Laurent Maria Broeckx Rudy

De Smaele Dirk

Marcel Herman Leurs Stefan

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-16

Filing date

2002-07-09

Publication date

2011-04-15

2002-07-09 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2004-04-15 Publication of EE200400052A publication Critical patent/EE200400052A/xx

2011-04-15 Publication of EE05402B1 publication Critical patent/EE05402B1/xx

Links

239000006227 byproduct Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
150000003457 sulfones Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 1
IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 abstract 1
UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
239000012670 alkaline solution Substances 0.000 abstract 1
229960004770 esomeprazole Drugs 0.000 abstract 1
SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
229960003174 lansoprazole Drugs 0.000 abstract 1
MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 abstract 1
229960000381 omeprazole Drugs 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
229960005019 pantoprazole Drugs 0.000 abstract 1
229940126409 proton pump inhibitor Drugs 0.000 abstract 1
239000000612 proton pump inhibitor Substances 0.000 abstract 1
229960004157 rabeprazole Drugs 0.000 abstract 1
YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preventing Corrosion Or Incrustation Of Metals (AREA)
Extraction Or Liquid Replacement (AREA)

EEP200400052A 2001-07-16 2002-07-09 Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks EE05402B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01202696		2001-07-16
PCT/EP2002/007693 WO2003008406A1 (en)	2001-07-16	2002-07-09	Improved process for preparing benzimidazole-type compounds

Publications (2)

Publication Number	Publication Date
EE200400052A EE200400052A (et)	2004-04-15
EE05402B1 true EE05402B1 (et)	2011-04-15

Family

ID=8180641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200400052A EE05402B1 (et)	2001-07-16	2002-07-09	Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks

Country Status (22)

Country	Link
US (1)	US6919459B2 (cs)
EP (1)	EP1409478B1 (cs)
JP (1)	JP4320250B2 (cs)
KR (1)	KR100914175B1 (cs)
CN (1)	CN1235899C (cs)
AT (1)	ATE321758T1 (cs)
AU (1)	AU2002321204B2 (cs)
BR (1)	BRPI0211101B8 (cs)
CA (1)	CA2450433C (cs)
CZ (1)	CZ304526B6 (cs)
DE (1)	DE60210292T2 (cs)
EA (1)	EA005773B1 (cs)
EE (1)	EE05402B1 (cs)
ES (1)	ES2261703T3 (cs)
HU (1)	HU230155B1 (cs)
IL (2)	IL159854A0 (cs)
MX (1)	MXPA04000433A (cs)
NO (1)	NO324257B1 (cs)
NZ (1)	NZ530168A (cs)
PL (1)	PL208291B1 (cs)
SK (1)	SK287245B6 (cs)
WO (1)	WO2003008406A1 (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0315574A (pt) *	2002-10-22	2005-09-20	Ranbaxy Lab Ltd	Forma amorfa de esomeprazol, composição farmacêutica contendo o mesmo e processo para sua preparação
CA2528993A1 (en) *	2003-06-10	2004-12-23	Teva Pharmaceutical Industries Ltd.	Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
JP4987477B2 (ja) *	2004-08-20	2012-07-25	エーザイ・アール・アンド・ディー・マネジメント株式会社	ベンズイミダゾール誘導体の製造方法
WO2006049486A1 (en) *	2004-11-08	2006-05-11	Dishman Pharmaceuticals And Chemicals Ltd.	A PREPARATION METHOD FOR SUBSTITUTED 2-(2-PYRIDYLMETHOYLSULPHINYL)-l-H-BENZIMID AZOLES
EP1681056A1 (en)	2005-01-14	2006-07-19	Krka Tovarna Zdravil, D.D., Novo Mesto	Process for preparing lansoprazole
GB0525710D0 (en) *	2005-12-17	2006-01-25	Pliva Hrvatska D O O	An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds
EP1801110A1 (en)	2005-12-22	2007-06-27	KRKA, tovarna zdravil, d.d., Novo mesto	Esomeprazole arginine salt
EP1818331A1 (en)	2006-02-14	2007-08-15	EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S.	Process for the preparation of 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole substantially free of sulfone impurity
WO2007129328A2 (en) *	2006-05-09	2007-11-15	Cadila Healthcare Limited	Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles
WO2007138468A2 (en) *	2006-06-01	2007-12-06	Wockhardt Ltd	Processes for the preparation of lansoprazole
WO2008017020A2 (en) *	2006-08-03	2008-02-07	Dr. Reddy's Laboratories Limited	Process for preparing proton pump inhibitors
EP2069329A4 (en) *	2006-10-06	2010-04-07	Reddys Lab Ltd Dr	PROCESS FOR THE PREPARATION OF BENZIMIDAZOLE DERIVATIVES AND THEIR SALTS
EP1947099A1 (en)	2007-01-18	2008-07-23	LEK Pharmaceuticals D.D.	Process for solvent removal from omeprazole salts
EA016297B1 (ru) *	2007-06-15	2012-03-30	Эмкьюр Фармасьютикалз Лимитед	Способ сульфоксидирования биологически активных соединений
US8247568B2 (en) *	2007-06-21	2012-08-21	Matrix Laboratories Ltd	Process for the preparation of pure rabeprazole
EP2022789A1 (en) *	2007-08-06	2009-02-11	Farmaprojects, S.A.	Process for the preparation of a gastric acid secretion inhibitor
WO2009066317A2 (en) *	2007-08-20	2009-05-28	Macleods Pharmaceuticals Limited	Process for the preparation of pantoprazole sodium
EP2030973A1 (en) *	2007-08-31	2009-03-04	KRKA, tovarna zdravil, d.d., Novo mesto	Process for preparing 2-sulfinyl-1H-benzimidazoles
US8071781B2 (en)	2008-11-11	2011-12-06	Syn-Tech Chem. & Pharm. Co., Ltd.	Process for preparing rabeprazole sodium
JP5797210B2 (ja) *	2010-03-02	2015-10-21	シアトルジェネティックス，インコーポレイテッド	抗体をスクリーニングするための方法
CN104418837A (zh) *	2013-08-19	2015-03-18	长沙市如虹医药科技有限公司	一种氧化硫醚成亚砜的方法
CN104402867A (zh) *	2014-11-07	2015-03-11	烟台万润精细化工股份有限公司	一种制备埃索美拉唑杂质h和b的方法
CN104402866A (zh) *	2014-11-07	2015-03-11	烟台万润精细化工股份有限公司	一种制备埃索美拉唑杂质j和k的方法
CN104530006B (zh) *	2015-01-06	2018-05-11	江苏奥赛康药业股份有限公司	兰索拉唑的制备方法
CN104744440B (zh) *	2015-03-12	2016-09-07	常州康丽制药有限公司	雷贝拉唑硫醚的回收方法
CN110487918B (zh) *	2018-05-14	2022-02-08	中国医学科学院药物研究所	泮托拉唑钠及其起始原料中基因毒性杂质的分析方法
CN109354587B (zh) *	2018-10-18	2020-09-18	成都天台山制药有限公司	泮托拉唑钠的制备方法和泮托拉唑钠

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9002043D0 (sv) *	1990-06-07	1990-06-07	Astra Ab	Improved method for synthesis
WO1993006097A1 (en) *	1991-09-20	1993-04-01	Merck & Co., Inc.	Novel process for the preparation of anti-ulcer agents
KR960002912B1 (ko) *	1993-02-19	1996-02-28	영진약품공업주식회사	신규한 벤즈이미다졸 유도체
ES2094694B1 (es)	1995-02-01	1997-12-16	Esteve Quimica Sa	Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
CN1053444C (zh) *	1996-03-20	2000-06-14	常州市第四制药厂	奥美拉唑的一种精制方法
SK283805B6 (sk) *	1996-09-09	2004-02-03	Slovakofarma, A. S.	Spôsob prípravy omeprazolu
SI20019A (sl) *	1998-07-13	2000-02-29	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola

2002
- 2002-07-09 EA EA200400185A patent/EA005773B1/ru not_active IP Right Cessation
- 2002-07-09 DE DE60210292T patent/DE60210292T2/de not_active Expired - Lifetime
- 2002-07-09 US US10/483,587 patent/US6919459B2/en not_active Expired - Lifetime
- 2002-07-09 EP EP02754865A patent/EP1409478B1/en not_active Expired - Lifetime
- 2002-07-09 IL IL15985402A patent/IL159854A0/xx unknown
- 2002-07-09 CZ CZ2004-208A patent/CZ304526B6/cs not_active IP Right Cessation
- 2002-07-09 AU AU2002321204A patent/AU2002321204B2/en not_active Expired
- 2002-07-09 CN CNB028139615A patent/CN1235899C/zh not_active Expired - Lifetime
- 2002-07-09 BR BRPI0211101A patent/BRPI0211101B8/pt not_active IP Right Cessation
- 2002-07-09 AT AT02754865T patent/ATE321758T1/de not_active IP Right Cessation
- 2002-07-09 KR KR1020037015941A patent/KR100914175B1/ko not_active Expired - Lifetime
- 2002-07-09 PL PL367006A patent/PL208291B1/pl unknown
- 2002-07-09 HU HU0400610A patent/HU230155B1/hu unknown
- 2002-07-09 NZ NZ530168A patent/NZ530168A/en not_active IP Right Cessation
- 2002-07-09 SK SK92-2004A patent/SK287245B6/sk not_active IP Right Cessation
- 2002-07-09 JP JP2003513965A patent/JP4320250B2/ja not_active Expired - Lifetime
- 2002-07-09 ES ES02754865T patent/ES2261703T3/es not_active Expired - Lifetime
- 2002-07-09 WO PCT/EP2002/007693 patent/WO2003008406A1/en not_active Ceased
- 2002-07-09 CA CA2450433A patent/CA2450433C/en not_active Expired - Lifetime
- 2002-07-09 MX MXPA04000433A patent/MXPA04000433A/es active IP Right Grant
- 2002-07-09 EE EEP200400052A patent/EE05402B1/xx unknown
2004
- 2004-01-08 NO NO20040074A patent/NO324257B1/no not_active IP Right Cessation
- 2004-01-14 IL IL159854A patent/IL159854A/en active IP Right Grant

Also Published As

Publication number	Publication date
PL208291B1 (pl)	2011-04-29
SK922004A3 (en)	2004-08-03
CN1525970A (zh)	2004-09-01
ATE321758T1 (de)	2006-04-15
CZ2004208A3 (cs)	2005-03-16
HU230155B1 (hu)	2015-09-28
KR20040016877A (ko)	2004-02-25
WO2003008406A1 (en)	2003-01-30
EA005773B1 (ru)	2005-06-30
NZ530168A (en)	2004-08-27
EE200400052A (et)	2004-04-15
PL367006A1 (en)	2005-02-07
EP1409478B1 (en)	2006-03-29
BR0211101A (pt)	2004-06-22
HUP0400610A2 (hu)	2004-08-30
CN1235899C (zh)	2006-01-11
IL159854A0 (en)	2004-06-20
CZ304526B6 (cs)	2014-06-18
DE60210292T2 (de)	2006-12-07
JP2005500333A (ja)	2005-01-06
JP4320250B2 (ja)	2009-08-26
NO324257B1 (no)	2007-09-17
ES2261703T3 (es)	2006-11-16
EA200400185A1 (ru)	2004-06-24
CA2450433C (en)	2010-05-25
AU2002321204B2 (en)	2008-05-08
US20040209918A1 (en)	2004-10-21
CA2450433A1 (en)	2003-01-30
KR100914175B1 (ko)	2009-08-27
US6919459B2 (en)	2005-07-19
IL159854A (en)	2008-11-03
HK1069168A1 (en)	2005-05-13
BRPI0211101B8 (pt)	2021-05-25
SK287245B6 (sk)	2010-04-07
BR0211101B1 (pt)	2013-12-17
NO20040074L (no)	2004-01-08
DE60210292D1 (de)	2006-05-18
HUP0400610A3 (en)	2012-09-28
MXPA04000433A (es)	2004-03-18
EP1409478A1 (en)	2004-04-21

Publication	Publication Date	Title
EE05402B1 (et)	2011-04-15	Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks
TR200201072T2 (tr)	2002-07-22	4-Triflorometilsulfinilpirazol türevi hazırlama süreci
BG97146A (bg)	1993-12-24	Усъвършенствуван метод за синтез
NO20016087D0 (no)	2001-12-13	Benzimidazolforbindelsekrystall
DE60111362D1 (de)	2005-07-14	Stabilisierte ascorbinsäure-lösungen
FI20010705L (fi)	2002-10-05	Menetelmä peretikkahapon valmistamiseksi
NO20052474L (no)	2005-05-23	Amort form av esomeprazolsalter
SE0104295D0 (sv)	2001-12-18	New process
MXPA03006904A (es)	2004-12-06	Procesos para la produccion de 2-(2-piridilmetil) sulfinil - 1h - bencimidazoles sustituidos.
ATE338027T1 (de)	2006-09-15	Herstellung von iminodiessigsäure-derivaten aus monoethanolamin-substraten
MXPA02010039A (es)	2004-08-19	Procedimiento para la obtencion de derivados de 1[[piridil sustituido)metil]tio]bencimidazol.
NO20040604L (no)	2004-02-10	Trisykliske imidazolpyridiner
DE60211758D1 (de)	2006-06-29	Verfahren zur herstellung von sulfinylderivaten mittels oxidation der entsprechenden sulfide
DK1140788T3 (da)	2004-06-07	Fremgangsmåde til fremstilling af arylethere
WO2001068594A1 (es)	2001-09-20	Procedimiento de oxidacion de un grupo tioeter a sulfoxido
ATE419242T1 (de)	2009-01-15	Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
DK1335913T3 (da)	2005-01-10	Fremgangsmåde til fremstilling af pantoprazol og intermediære deraf
JP2019194219A (ja)	2019-11-07	光学活性のプロトンポンプ阻害化合物の製造方法
SE0302382D0 (sv)	2003-09-04	New salts II
RU2003137221A (ru)	2005-06-10	Комплекс включения s-омепразола (эсомепразола) с циклодекстрином
EA200501125A1 (ru)	2005-12-29	Способ получения метил-2-дифенилметилсульфинилацетата
SE0400410D0 (sv)	2004-02-20	New compounds
CY1105987T1 (el)	2011-04-06	Παραγωγα πυριδινο-2-υλο-μεθυλαμινης για την θepαπεια της εξαρτησης απο τα οπιοειδη
WO2008087665A3 (en)	2011-01-27	Process for preparation of lansoprazole
UY26420A1 (es)	2000-12-29	Procedimiento mejorado para la preparación de derivados bencimidazol adecuados como fármacos antiulcerosos, particularmente omeprazol o pantoprazol