EE200300455A - Imidasopürimidiini derivaadid, nende valmistamisprotsess ja kasutamine ning farmatseutiline kompositsioon - Google Patents

Imidasopürimidiini derivaadid, nende valmistamisprotsess ja kasutamine ning farmatseutiline kompositsioon

Info

Publication number: EE200300455A
Authority: EE; Estonia
Prior art keywords: preparation; pharmaceutical composition; phenyl ring; substituted; imidazopyrimidine derivatives
Prior art date: 2001-03-21

Application number

EEP200300455A

Other languages

English (en)

Estonian (et)

Inventor

William Moore Kevin

Joseph Street Leslie

Stuart Chambers Mark

Charles Goodacre Simon

James Hallett David

Jennings Andrew

Jones Philip

Thomas Lewis Richard

Jane Szekeres Helen

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-21

Filing date

2002-03-19

Publication date

2003-12-15

2001-03-21 Priority claimed from GB0107134A external-priority patent/GB0107134D0/en

2001-11-21 Priority claimed from GB0127938A external-priority patent/GB0127938D0/en

2002-03-19 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

2003-12-15 Publication of EE200300455A publication Critical patent/EE200300455A/xx

Links

150000005237 imidazopyrimidines Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
XKTONDZDILVOOL-UHFFFAOYSA-N 3-phenylimidazo[1,2-a]pyrimidine Chemical class C=1N=C2N=CC=CN2C=1C1=CC=CC=C1 XKTONDZDILVOOL-UHFFFAOYSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
102000027484 GABAA receptors Human genes 0.000 abstract 1
108091008681 GABAA receptors Proteins 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
230000036461 convulsion Effects 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EEP200300455A 2001-03-21 2002-03-19 Imidasopürimidiini derivaadid, nende valmistamisprotsess ja kasutamine ning farmatseutiline kompositsioon EE200300455A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0107134A GB0107134D0 (en)	2001-03-21	2001-03-21	Therapeutic agents
GB0127938A GB0127938D0 (en)	2001-11-21	2001-11-21	Therapeutic agents
PCT/GB2002/001351 WO2002074772A1 (en)	2001-03-21	2002-03-19	Imidazo-pyrimidine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
EE200300455A true EE200300455A (et)	2003-12-15

Family

ID=26245875

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300455A EE200300455A (et)	2001-03-21	2002-03-19	Imidasopürimidiini derivaadid, nende valmistamisprotsess ja kasutamine ning farmatseutiline kompositsioon

Country Status (24)

Country	Link
EP (1)	EP1381606B1 (de)
JP (1)	JP4409174B2 (de)
KR (1)	KR20030083001A (de)
CN (1)	CN1294133C (de)
AT (1)	ATE299882T1 (de)
AU (1)	AU2002241138B2 (de)
BG (1)	BG108166A (de)
BR (1)	BR0207994A (de)
CA (1)	CA2461426C (de)
CZ (1)	CZ20032539A3 (de)
DE (1)	DE60205101T2 (de)
EA (1)	EA006234B1 (de)
EE (1)	EE200300455A (de)
ES (1)	ES2244752T3 (de)
HU (1)	HUP0303630A3 (de)
IL (1)	IL157641A0 (de)
MX (1)	MXPA03008572A (de)
NO (1)	NO20034170L (de)
NZ (1)	NZ527901A (de)
PE (1)	PE20020970A1 (de)
PL (1)	PL363804A1 (de)
SK (1)	SK11672003A3 (de)
TW (1)	TWI248936B (de)
WO (2)	WO2002074772A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0117277D0 (en)	2001-07-16	2001-09-05	Merck Sharp & Dohme	Therapeutic agents
GB0128499D0 (en) *	2001-11-28	2002-01-23	Merck Sharp & Dohme	Therapeutic agents
GB0226462D0 (en) *	2002-11-13	2002-12-18	Merck Sharp & Dohme	Therapeutic agents
ES2278345T3 (es) *	2003-07-25	2007-08-01	Neurogen Corporation	Imidazo-pirimidinas y triazolo-pirimidinas: ligandos de receptores de benzodiazepinas.
EP2114941B1 (de)	2006-12-22	2015-03-25	Astex Therapeutics Limited	Bicyclische heterocyclische verbindungen als fgfr-inhibitoren
JP5442449B2 (ja)	2006-12-22	2014-03-12	アステックス、セラピューティックス、リミテッド	新規化合物
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
CN105646370A (zh) *	2009-10-16	2016-06-08	梅琳塔治疗公司	抗微生物化合物和其制备和使用方法
BR112012008759A2 (pt)	2009-10-16	2020-08-25	Rib-X Pharmaceuticals, Inc.	compostos antimicrobianos e métodos de fabricação e uso dos mesmos
WO2011047323A2 (en)	2009-10-16	2011-04-21	Rib-X Pharmaceuticals, Inc.	Antimicrobial compounds and methods of making and using the same
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
CN102898315B (zh) *	2012-11-05	2015-01-28	上海毕得医药科技有限公司	3-乙炔基-4-氟苯胺的制备方法
EP3039025A4 (de)	2013-09-09	2017-05-31	Melinta Therapeutics, Inc.	Antimikrobielle verbindungen und verfahren zur herstellung und verwendung davon
MX2016003046A (es)	2013-09-09	2016-09-08	Melinta Therapeutics Inc	Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
CN107922418A (zh)	2015-03-11	2018-04-17	梅琳塔治疗公司	抗微生物化合物及制备和使用所述化合物的方法
EP3386983A1 (de) *	2015-12-10	2018-10-17	Pfizer Limited	4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazin-derivate der formel (i) als gaba-rezeptormodulatoren zur verwendung bei der behandlung von epilepsie und schmerzen
BR112018015386A2 (pt)	2016-01-27	2019-03-19	Universität Zürich	uso de moduladores de receptor gabaa para tratamento de prurido
JP2019515041A (ja)	2016-05-06	2019-06-06	メリンタセラピューティクス、インコーポレイテッドＭｅｌｉｎｔａＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	抗菌剤ならびにそれを作製および使用する方法
BR112020021104A2 (pt) *	2018-04-18	2021-02-23	Neurocycle Therapeutics, Inc	compostos moduladores alostéricos positivos gabaa, métodos de produção e usos dos mesmos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5185446A (en) *	1990-09-04	1993-02-09	Neurogen Corporation	Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
CN1089762C (zh) *	1995-04-21	2002-08-28	纽罗研究公司	苯并咪唑化合物及其用作gabaa受体复合物调节器的用途
PA8535601A1 (es) *	2000-12-21	2002-11-28	Pfizer	Derivados benzimidazol y piridilimidazol como ligandos para gabaa

2002
- 2002-03-12 TW TW091104588A patent/TWI248936B/zh active
- 2002-03-19 EP EP02706976A patent/EP1381606B1/de not_active Expired - Lifetime
- 2002-03-19 IL IL15764102A patent/IL157641A0/xx unknown
- 2002-03-19 AU AU2002241138A patent/AU2002241138B2/en not_active Ceased
- 2002-03-19 CZ CZ20032539A patent/CZ20032539A3/cs unknown
- 2002-03-19 CN CNB028070577A patent/CN1294133C/zh not_active Expired - Fee Related
- 2002-03-19 PE PE2002000211A patent/PE20020970A1/es not_active Application Discontinuation
- 2002-03-19 HU HU0303630A patent/HUP0303630A3/hu unknown
- 2002-03-19 MX MXPA03008572A patent/MXPA03008572A/es unknown
- 2002-03-19 EA EA200301037A patent/EA006234B1/ru not_active IP Right Cessation
- 2002-03-19 EE EEP200300455A patent/EE200300455A/xx unknown
- 2002-03-19 WO PCT/GB2002/001351 patent/WO2002074772A1/en not_active Ceased
- 2002-03-19 NZ NZ527901A patent/NZ527901A/en unknown
- 2002-03-19 SK SK1167-2003A patent/SK11672003A3/sk not_active Application Discontinuation
- 2002-03-19 AT AT02706976T patent/ATE299882T1/de not_active IP Right Cessation
- 2002-03-19 PL PL02363804A patent/PL363804A1/xx not_active Application Discontinuation
- 2002-03-19 WO PCT/GB2002/001352 patent/WO2002074773A1/en not_active Ceased
- 2002-03-19 BR BR0207994-1A patent/BR0207994A/pt not_active IP Right Cessation
- 2002-03-19 KR KR10-2003-7012252A patent/KR20030083001A/ko not_active Withdrawn
- 2002-03-19 JP JP2002573781A patent/JP4409174B2/ja not_active Expired - Fee Related
- 2002-03-19 CA CA2461426A patent/CA2461426C/en not_active Expired - Fee Related
- 2002-03-19 ES ES02706976T patent/ES2244752T3/es not_active Expired - Lifetime
- 2002-03-19 DE DE60205101T patent/DE60205101T2/de not_active Expired - Lifetime
2003
- 2003-09-09 BG BG108166A patent/BG108166A/xx unknown
- 2003-09-19 NO NO20034170A patent/NO20034170L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20034170D0 (no)	2003-09-19
WO2002074773A1 (en)	2002-09-26
EP1381606A1 (de)	2004-01-21
HUP0303630A3 (en)	2005-06-28
SK11672003A3 (sk)	2004-05-04
CN1498218A (zh)	2004-05-19
DE60205101D1 (de)	2005-08-25
EP1381606B1 (de)	2005-07-20
WO2002074772A1 (en)	2002-09-26
KR20030083001A (ko)	2003-10-23
EA006234B1 (ru)	2005-10-27
ATE299882T1 (de)	2005-08-15
BR0207994A (pt)	2004-03-02
AU2002241138B2 (en)	2007-09-20
PE20020970A1 (es)	2002-11-01
CA2461426C (en)	2010-08-03
PL363804A1 (en)	2004-11-29
NZ527901A (en)	2005-09-30
JP4409174B2 (ja)	2010-02-03
DE60205101T2 (de)	2006-05-24
EA200301037A1 (ru)	2004-04-29
MXPA03008572A (es)	2003-12-08
CN1294133C (zh)	2007-01-10
TWI248936B (en)	2006-02-11
HUP0303630A2 (hu)	2004-03-01
JP2004523584A (ja)	2004-08-05
NO20034170L (no)	2003-11-19
ES2244752T3 (es)	2005-12-16
IL157641A0 (en)	2004-03-28
CA2461426A1 (en)	2002-09-26
BG108166A (en)	2004-09-30
CZ20032539A3 (en)	2004-03-17

Publication	Publication Date	Title
IL157641A0 (en)	2004-03-28	Imidazo-pyrimidine derivatives as ligands for gaba receptors
WO2001038326A3 (en)	2002-05-10	Imidazo-pyridine derivatives as ligands for gaba receptors
AU1253002A (en)	2002-05-21	Imidazo-triazine derivatives as ligands for gaba receptors
GB0212048D0 (en)	2002-07-03	Therapeutic agents
GB0117277D0 (en)	2001-09-05	Therapeutic agents
ATE371659T1 (de)	2007-09-15	Pyrazolotriazinderivate als gaba-rezeptorliganden
MXPA06000716A (es)	2006-03-30	Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1.
DE60214532D1 (de)	2006-10-19	Imidazopyrimidin-derivate als liganden für gaba-rezeptoren
ATE428694T1 (de)	2009-05-15	N-ä1h-indol-5-ylünaphthalin-1-sulphonamid- derivate und verwandte verbindungen als serotonin 5-ht6 rezeptor antagonisten zur behandlung von erkrankungen des zentralen nervensystems
IL157179A0 (en)	2004-02-08	Fused heterocyclic compounds
ATE253066T1 (de)	2003-11-15	Imidazotriazinderivate als gaba rezeptor-liganden
LV12539A (en)	2000-10-20	Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
TW200630371A (en)	2006-09-01	Halogen substituted benzodiazepine derivatives
MX2007007115A (es)	2007-07-11	Imidazo-benzodiazepinas tetraciclicas como moduladoras del receptor del acido gamma-aminobutirico (gaba).
ATE269329T1 (de)	2004-07-15	Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung
JO2312B1 (en)	2005-09-12	Imidazo-pyrimidine derivatives as associative groups of JABA receptors
MXPA04008880A (es)	2007-07-18	Nuevos compuestos de benzoindolina, un proceso para su preparacion y las composiciones farmaceuticals que los contienen.
DK0773947T3 (da)	2000-10-16	5H-thiazolo[3,2-a]pyrimidin-5-on-derivater
AR035876A1 (es)	2004-07-21	Compuestos derivados de imidazo-triazina como ligandos para receptores gaba, composiciones farmaceuticas y uso de los compuestos en la fabricacion de medicamentos