EE9800248A - Külmkuivatatud, vesiikuleid sisaldav ultraheli kontrastaine, selle valmistamismeetod ning ladustamise ja transpordi meetod, ultraheli kontrastaine keskkond ja selle valmistamismeetod ning külmkuivatuse stabilisaatorite kasutamine - Google Patents

Külmkuivatatud, vesiikuleid sisaldav ultraheli kontrastaine, selle valmistamismeetod ning ladustamise ja transpordi meetod, ultraheli kontrastaine keskkond ja selle valmistamismeetod ning külmkuivatuse stabilisaatorite kasutamine

Info

Publication number
EE9800248A
EE9800248A EE9800248A EE9800248A EE9800248A EE 9800248 A EE9800248 A EE 9800248A EE 9800248 A EE9800248 A EE 9800248A EE 9800248 A EE9800248 A EE 9800248A EE 9800248 A EE9800248 A EE 9800248A
Authority
EE
Estonia
Prior art keywords
freeze
preparation
ultrasound contrast
contrast medium
dried
Prior art date
Application number
EE9800248A
Other languages
English (en)
Inventor
Helge Gulliksen Per
Undheim Br�nden Jorunn
Kjersti Fahlvik Anne
Swaerd-Nordmo Marit
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9624919.8A external-priority patent/GB9624919D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of EE9800248A publication Critical patent/EE9800248A/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Light Receiving Elements (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
EE9800248A 1996-02-19 1997-02-19 Külmkuivatatud, vesiikuleid sisaldav ultraheli kontrastaine, selle valmistamismeetod ning ladustamise ja transpordi meetod, ultraheli kontrastaine keskkond ja selle valmistamismeetod ning külmkuivatuse stabilisaatorite kasutamine EE9800248A (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9624919.8A GB9624919D0 (en) 1996-11-29 1996-11-29 Product
PCT/GB1997/000458 WO1997029782A1 (en) 1996-02-19 1997-02-19 Thermally stabilized contrast agent

Publications (1)

Publication Number Publication Date
EE9800248A true EE9800248A (et) 1999-02-15

Family

ID=27268136

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800248A EE9800248A (et) 1996-02-19 1997-02-19 Külmkuivatatud, vesiikuleid sisaldav ultraheli kontrastaine, selle valmistamismeetod ning ladustamise ja transpordi meetod, ultraheli kontrastaine keskkond ja selle valmistamismeetod ning külmkuivatuse stabilisaatorite kasutamine

Country Status (18)

Country Link
EP (1) EP0885016B1 (et)
JP (1) JP4250747B2 (et)
KR (1) KR100501863B1 (et)
CN (1) CN1092988C (et)
AT (1) ATE237362T1 (et)
AU (1) AU722735B2 (et)
CA (1) CA2246778A1 (et)
CZ (1) CZ262698A3 (et)
DE (1) DE69720979T2 (et)
EA (1) EA000900B1 (et)
EE (1) EE9800248A (et)
ES (1) ES2197331T3 (et)
HU (1) HUP9900812A3 (et)
IL (1) IL125800A0 (et)
NO (1) NO313815B1 (et)
NZ (1) NZ331372A (et)
PL (1) PL328309A1 (et)
WO (1) WO1997029782A1 (et)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ334365A (en) * 1996-08-02 1999-10-28 Nycomed Imaging As Use of a contrast agent comprising microbubbles of biocompatible gas stabilised by opsonisable amphiphilic material for ultrasound imaging of the liver
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
AU2001271037A1 (en) 2000-07-13 2002-01-30 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical compositions containing dds compounds
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
ES2243350T3 (es) * 2001-01-31 2005-12-01 Bracco International B.V. Agente de contraste liofizable que comprende microburbujas de gas.
US7931595B2 (en) 2002-11-29 2011-04-26 Ge Healthcare As Ultrasound triggering method to reduce cardiac arrhythmia
DE602004029010D1 (de) * 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
WO2006076826A1 (fr) * 2005-01-18 2006-07-27 Institute Of Pharmacology Toxicology, Academy Of Military Medical Sciences Composition de contraste pour ultrasons utilisant un phospholipide filmogene et procede de preparation de celle-ci
DE602007006968D1 (de) 2006-09-05 2010-07-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden
EP2117603A2 (en) 2006-12-19 2009-11-18 Bracco International B.V. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
WO2009033660A2 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of octreotide as a therapeutic agent
KR20100056508A (ko) 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 폐렴 연쇄상 구균 감염의 치료를 위한 ｂｆｇｆ １－２４ 및 임의의 （ａｒｇ ８）바소프레신의 용도
JP2010539002A (ja) 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト ウロジラチンの治療剤としての使用
WO2009033690A1 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Bfgf (119-126) for therapeutic applications
JP2010538979A (ja) 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト Ｓ．Ｐｎｅｕｍｏｎｉａｅの感染等を処置するための治療剤としての、ＲＧＤＳＰＡＳＳＫＰ、および随意的なアンギオテンシンＩＩの使用
WO2009040051A2 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of the peptide rfmwmk alone or in combination with the peptide ymdgtmsqv as a therapeutic agent
EP2187929A2 (en) 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Use of a peptide as a therapeutic agent
WO2009039982A2 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
KR20100061481A (ko) 2007-09-11 2010-06-07 몬도바이오테크 래보래토리즈 아게 치료제로서의 미니가스트린
WO2009033739A2 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US20100204145A1 (en) 2007-09-11 2010-08-12 Dorian Bevec Use of a peptide as a therapeutic agent
EP2190533A2 (en) 2007-09-11 2010-06-02 Mondobiotech Laboratories AG Use of a peptide as a therapeutic agent
EP2090322A1 (en) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of fsh receptor ligands for diagnosis and therapy of cancer
CN102202694B (zh) 2008-10-07 2014-03-12 博莱科瑞士股份有限公司 包含抗-聚合物抗体的靶向构建体和结合它们的脂质体或微泡
CN101649293B (zh) * 2009-09-02 2012-07-18 中国农业大学 一种微生物冷冻干燥保护剂及其应用
WO2012020030A1 (en) 2010-08-09 2012-02-16 Bracco Suisse Sa Targeted gas-filled microvesicles
EP2426202A1 (en) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinases as targets for anti-diabetic therapy
EP2654788B1 (en) 2010-12-24 2018-03-14 Bracco Suisse SA Gas-filled microvesicles for use as vaccine
CN103917637B (zh) 2011-08-24 2016-08-17 加州理工学院 靶向微泡
SI2768484T1 (sl) * 2011-10-21 2019-12-31 Jazz Pharmaceuticals Research Llc Liofilizirani liposomi
EP2589383A1 (en) 2011-11-06 2013-05-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin FKBP subtype-specific rapamycin analogue for use in treatment of diseases
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
GB201411423D0 (en) * 2014-06-26 2014-08-13 Ge Healthcare As Lipid sterilisation method
EP3020813A1 (en) 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
EP3236999B1 (en) 2014-12-22 2019-03-20 Bracco Suisse SA Gas-filled microvesicles for use as vaccine
WO2017184672A1 (en) * 2016-04-19 2017-10-26 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
JP7539316B2 (ja) 2018-03-07 2024-08-23 ブラッコ・スイス・ソシエテ・アノニム サイズが制御された微小胞の調製
EP3990032B1 (en) 2019-06-25 2023-12-06 Bracco Suisse SA Freeze-dried composition for preparing calibrated gas-filled microvesicles
JP7712877B2 (ja) * 2019-06-25 2025-07-24 ブラッコ・スイス・ソシエテ・アノニム 校正されたガス充填微小胞を調製するための凍結乾燥組成物
US10953023B1 (en) * 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN112891565A (zh) * 2021-04-09 2021-06-04 上海师范大学 锌-二甲基吡啶胺在制备诊断血栓性疾病药物中的应用
EP4105328A1 (en) 2021-06-15 2022-12-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Antisense-oligonucleotides for prevention of kidney dysfunction promoted by endothelial dysfunction by ephrin-b2 suppression
CN117797279B (zh) * 2023-11-07 2025-08-26 浙江普利药业有限公司 一种荧光-磁共振双模态造影剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
JPH06211645A (ja) * 1993-01-14 1994-08-02 Mitsubishi Kasei Corp リポソーム凍結乾燥製剤

Also Published As

Publication number Publication date
NO983584L (no) 1998-10-16
PL328309A1 (en) 1999-01-18
EP0885016A1 (en) 1998-12-23
NO313815B1 (no) 2002-12-09
ATE237362T1 (de) 2003-05-15
CN1213971A (zh) 1999-04-14
ES2197331T3 (es) 2004-01-01
HUP9900812A3 (en) 1999-11-29
CN1092988C (zh) 2002-10-23
EA000900B1 (ru) 2000-06-26
DE69720979D1 (de) 2003-05-22
EA199800739A1 (ru) 1999-02-25
CZ262698A3 (cs) 1999-03-17
EP0885016B1 (en) 2003-04-16
AU722735B2 (en) 2000-08-10
WO1997029782A1 (en) 1997-08-21
CA2246778A1 (en) 1997-08-21
NZ331372A (en) 2000-01-28
JP4250747B2 (ja) 2009-04-08
KR19990082670A (ko) 1999-11-25
NO983584D0 (no) 1998-08-05
HUP9900812A2 (hu) 1999-07-28
AU1805197A (en) 1997-09-02
JP2000506122A (ja) 2000-05-23
IL125800A0 (en) 1999-04-11
KR100501863B1 (ko) 2005-09-27
DE69720979T2 (de) 2004-02-26

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