EG16107A - A process for the preparation of substituted pyrimidines - Google Patents

A process for the preparation of substituted pyrimidines

Info

Publication number
EG16107A
EG16107A EG653/81A EG65381A EG16107A EG 16107 A EG16107 A EG 16107A EG 653/81 A EG653/81 A EG 653/81A EG 65381 A EG65381 A EG 65381A EG 16107 A EG16107 A EG 16107A
Authority
EG
Egypt
Prior art keywords
preparation
substituted pyrimidines
pyrimidines
substituted
Prior art date
Application number
EG653/81A
Other languages
English (en)
Inventor
Mary Dalluge Susan
Marcel Skonezny Paul
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of EG16107A publication Critical patent/EG16107A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EG653/81A 1980-11-11 1981-11-10 A process for the preparation of substituted pyrimidines EG16107A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8036135 1980-11-11

Publications (1)

Publication Number Publication Date
EG16107A true EG16107A (en) 1987-10-30

Family

ID=10517217

Family Applications (1)

Application Number Title Priority Date Filing Date
EG653/81A EG16107A (en) 1980-11-11 1981-11-10 A process for the preparation of substituted pyrimidines

Country Status (35)

Country Link
US (4) US4438267A (cs)
EP (1) EP0051879B1 (cs)
JP (1) JPS57114581A (cs)
KR (1) KR880001736B1 (cs)
AR (1) AR245447A1 (cs)
AU (1) AU549449B2 (cs)
CA (1) CA1186310A (cs)
CS (1) CS273153B2 (cs)
CY (1) CY1419A (cs)
DD (1) DD201896A5 (cs)
DE (1) DE3173752D1 (cs)
DK (1) DK172884B1 (cs)
EG (1) EG16107A (cs)
ES (5) ES8307759A1 (cs)
FI (1) FI76333C (cs)
GB (1) GB2087881B (cs)
GR (1) GR81317B (cs)
HK (1) HK23388A (cs)
HU (1) HU188762B (cs)
IE (1) IE52128B1 (cs)
IL (1) IL64256A (cs)
IT (1) IT1210589B (cs)
MC (1) MC1418A1 (cs)
MY (1) MY8600678A (cs)
NO (2) NO160137C (cs)
NZ (1) NZ198932A (cs)
PH (2) PH25053A (cs)
PL (4) PL139523B1 (cs)
PT (1) PT73960B (cs)
RU (1) RU1819264C (cs)
SG (1) SG62686G (cs)
SU (4) SU1424732A3 (cs)
YU (5) YU42444B (cs)
ZA (1) ZA817780B (cs)
ZM (1) ZM9481A1 (cs)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
US4590271A (en) * 1982-05-01 1986-05-20 Burroughs Wellcome Co. 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
ZA833067B (en) * 1982-05-01 1984-12-24 Wellcome Found Antibacterial compounds
US4587341A (en) * 1982-05-07 1986-05-06 Burroughs Wellcome Co. 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
GB8603962D0 (en) * 1986-02-18 1986-03-26 Wellcome Found Chemical compositions
GB8603964D0 (en) * 1986-02-18 1986-03-26 Cooper Animal Health Ltd Compositions
LU86703A1 (fr) * 1986-12-08 1988-07-14 Oreal Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
GB8903978D0 (en) * 1989-02-22 1989-04-05 Coopers Animal Health Chemical compositions
GB9000241D0 (en) * 1990-01-05 1990-03-07 Coopers Animal Health Pharmaceutical use
RU95113597A (ru) * 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
KR100224135B1 (ko) * 1993-01-28 1999-10-15 다께다 구니오 퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
US5707996A (en) * 1995-11-06 1998-01-13 Macleod Pharmaceuticals, Inc. Pharmaceutical solution and methods for preparation thereof
CA2238521C (en) * 1995-12-04 2005-08-16 F. Hoffmann-La Roche Ag Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
RU2141322C1 (ru) * 1997-08-12 1999-11-20 Голощапов Николай Михайлович Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
WO2003003006A2 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
PT1401416E (pt) 2001-06-29 2007-02-28 Ab Science Utilização de inibidores de c-kit para tratar doenças inflamatórias intestinais (dii)
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
ES2274993T3 (es) * 2001-06-29 2007-06-01 Ab Science Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas.
DE60225590T2 (de) * 2001-09-20 2008-09-25 Ab Science C-kithemmer zur behandlung von bakteriellen infektionen
CA2460845A1 (en) * 2001-09-20 2003-03-27 Ab Science Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
EP1461032B1 (en) * 2001-09-20 2008-07-16 AB Science Use of c-kit inhibitors for promoting hair growth
CN100443482C (zh) 2003-07-11 2008-12-17 阿皮德公开股份有限公司 苯并呋喃衍生物及其在制备治疗由细菌引起的感染的药物中的用途
CN101115746A (zh) * 2005-02-18 2008-01-30 阿皮德公开股份有限公司 用于制备苯并呋喃的新方法
AU2006286576B2 (en) * 2005-09-01 2012-06-14 F. Hoffmann-La Roche Ag Diaminopyrimidines as P2X3 and P3X2/3 modulators
WO2010003084A2 (en) * 2008-07-02 2010-01-07 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
EP2440533B1 (en) * 2009-06-12 2015-09-23 Socpra-Sciences Et Génie S.E.C. Guanine riboswitch binding compounds and their use as antibiotics
CN102649786B (zh) * 2011-02-28 2014-08-27 郑州福源动物药业有限公司 一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
CN103755684B (zh) * 2014-02-10 2015-09-09 青岛蔚蓝生物股份有限公司 一种巴喹普林的制备方法
US12595261B2 (en) 2019-06-06 2026-04-07 Beijing Tide Pharmaceutical Co., Ltd. P2X3 and/or P2X2/3 receptor antagonist, pharmaceutical composition containing same, and use thereof
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
WO2022217295A1 (en) * 2021-04-09 2022-10-13 The Trustees Of The University Of Pennsylvania Control of protein expression with tmp-protac compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1303727B (de) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) * 1969-03-06 1976-05-11 Burroughs Wellcome Co. Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) * 1971-12-01 1973-05-30 Hoffmann La Roche Nouvelles benzylpyrimidines
GB1468374A (en) 1974-03-06 1977-03-23 Wellcome Found Process for preparing a pyrimidine derivative
US4039543A (en) 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
GB1582245A (en) * 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) * 1977-07-06 1979-01-18 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

Also Published As

Publication number Publication date
SU1535379A3 (ru) 1990-01-07
NZ198932A (en) 1985-05-31
YU144288A (en) 1990-04-30
YU198383A (en) 1984-04-30
RU1819264C (ru) 1993-05-30
PL139427B1 (en) 1987-01-31
ZA817780B (en) 1983-06-29
YU42444B (en) 1988-08-31
PL239278A1 (en) 1983-08-01
SU1306473A3 (ru) 1987-04-23
YU46697B (sh) 1994-04-05
US4603136A (en) 1986-07-29
MC1418A1 (fr) 1982-10-18
ES8405378A1 (es) 1984-06-01
FI813546L (fi) 1982-05-12
ES8405377A1 (es) 1984-06-01
GR81317B (cs) 1984-12-11
ES521204A0 (es) 1984-06-01
PH22654A (en) 1988-10-28
IE52128B1 (en) 1987-06-24
PT73960B (en) 1983-11-23
NO160137C (no) 1989-03-15
ES521203A0 (es) 1984-06-01
IE812631L (en) 1982-05-11
AR245447A1 (es) 1994-01-31
CS825781A2 (en) 1990-07-12
US4587342A (en) 1986-05-06
DK496681A (da) 1982-05-12
MY8600678A (en) 1986-12-31
US4761475A (en) 1988-08-02
FI76333C (fi) 1988-10-10
GB2087881B (en) 1985-05-15
SG62686G (en) 1987-03-27
KR880001736B1 (ko) 1988-09-10
NO1994029I1 (no) 1994-12-29
GB2087881A (en) 1982-06-03
NO813804L (no) 1982-05-12
DD201896A5 (de) 1983-08-17
ES521201A0 (es) 1984-06-01
KR830007628A (ko) 1983-11-04
PL233754A1 (en) 1983-08-01
EP0051879B1 (en) 1986-02-05
YU266381A (en) 1984-04-30
AU549449B2 (en) 1986-01-30
PL139828B1 (en) 1987-02-28
SU1318148A3 (ru) 1987-06-15
US4438267A (en) 1984-03-20
PL239280A1 (en) 1983-08-01
DK172884B1 (da) 1999-09-06
PL239279A1 (en) 1983-08-01
PL139523B1 (en) 1987-01-31
IL64256A (en) 1988-01-31
YU198283A (en) 1984-04-30
PT73960A (en) 1981-12-01
YU43551B (en) 1989-08-31
HU188762B (en) 1986-05-28
IT1210589B (it) 1989-09-14
EP0051879A2 (en) 1982-05-19
ES8405380A1 (es) 1984-06-01
ZM9481A1 (en) 1983-11-21
ES506969A0 (es) 1983-07-01
DE3173752D1 (en) 1986-03-20
ES8405379A1 (es) 1984-06-01
FI76333B (fi) 1988-06-30
JPH0474351B2 (cs) 1992-11-26
ES8307759A1 (es) 1983-07-01
SU1424732A3 (ru) 1988-09-15
EP0051879A3 (en) 1982-08-04
ES521202A0 (es) 1984-06-01
NO160137B (no) 1988-12-05
CS273153B2 (en) 1991-03-12
IL64256A0 (en) 1982-02-28
AU7733481A (en) 1982-05-20
CA1186310A (en) 1985-04-30
PH25053A (en) 1991-01-28
HK23388A (en) 1988-04-08
IT8149676A0 (it) 1981-11-10
JPS57114581A (en) 1982-07-16
PL139827B1 (en) 1987-02-28
YU198183A (en) 1984-04-30
CY1419A (en) 1988-04-22

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