IL64256A - 2,4-diamino-5-(substituted methyl)-pyrimidines,their preparation and pharmaceutical compositions containing them - Google Patents

2,4-diamino-5-(substituted methyl)-pyrimidines,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL64256A
Authority: IL; Israel
Prior art keywords: pyrimidines; diamino; preparation; pharmaceutical compositions; compositions containing
Prior art date: 1980-11-11

Application number

IL64256A

Other languages

English (en)

Other versions

IL64256A0 (en

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-11-11

Filing date

1981-11-10

Publication date

1988-01-31

1981-11-10 Application filed by Wellcome Found filed Critical Wellcome Found

1981-11-10 Priority to IL7563481A priority Critical patent/IL75634A/xx

1981-11-10 Priority to IL7563581A priority patent/IL75635A/xx

1982-02-28 Publication of IL64256A0 publication Critical patent/IL64256A0/xx

1985-06-26 Priority to IL75634A priority patent/IL75634A0/xx

1985-06-26 Priority to IL75635A priority patent/IL75635A0/xx

1988-01-31 Publication of IL64256A publication Critical patent/IL64256A/xx

Links

125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IL64256A 1980-11-11 1981-11-10 2,4-diamino-5-(substituted methyl)-pyrimidines,their preparation and pharmaceutical compositions containing them IL64256A (en)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
IL7563481A IL75634A (en)	1980-11-11	1981-11-10	2,3-disubstituted propanenitrile and cyanopropanoic acid ester derivatives
IL7563581A IL75635A (en)	1980-11-11	1981-11-10	5-(substituted methyl)-halopyrimidines
IL75634A IL75634A0 (en)	1980-11-11	1985-06-26	Substituted acrylonitrile and cyanopropenoate derivatives
IL75635A IL75635A0 (en)	1980-11-11	1985-06-26	Substituted pyrimidine derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8036135		1980-11-11

Publications (2)

Publication Number	Publication Date
IL64256A0 IL64256A0 (en)	1982-02-28
IL64256A true IL64256A (en)	1988-01-31

Family

ID=10517217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL64256A IL64256A (en)	1980-11-11	1981-11-10	2,4-diamino-5-(substituted methyl)-pyrimidines,their preparation and pharmaceutical compositions containing them

Country Status (35)

Country	Link
US (4)	US4438267A (cs)
EP (1)	EP0051879B1 (cs)
JP (1)	JPS57114581A (cs)
KR (1)	KR880001736B1 (cs)
AR (1)	AR245447A1 (cs)
AU (1)	AU549449B2 (cs)
CA (1)	CA1186310A (cs)
CS (1)	CS273153B2 (cs)
CY (1)	CY1419A (cs)
DD (1)	DD201896A5 (cs)
DE (1)	DE3173752D1 (cs)
DK (1)	DK172884B1 (cs)
EG (1)	EG16107A (cs)
ES (5)	ES8307759A1 (cs)
FI (1)	FI76333C (cs)
GB (1)	GB2087881B (cs)
GR (1)	GR81317B (cs)
HK (1)	HK23388A (cs)
HU (1)	HU188762B (cs)
IE (1)	IE52128B1 (cs)
IL (1)	IL64256A (cs)
IT (1)	IT1210589B (cs)
MC (1)	MC1418A1 (cs)
MY (1)	MY8600678A (cs)
NO (2)	NO160137C (cs)
NZ (1)	NZ198932A (cs)
PH (2)	PH22654A (cs)
PL (4)	PL139523B1 (cs)
PT (1)	PT73960B (cs)
RU (1)	RU1819264C (cs)
SG (1)	SG62686G (cs)
SU (4)	SU1424732A3 (cs)
YU (5)	YU42444B (cs)
ZA (1)	ZA817780B (cs)
ZM (1)	ZM9481A1 (cs)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use
US4590271A (en) *	1982-05-01	1986-05-20	Burroughs Wellcome Co.	2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
ZA833067B (en) *	1982-05-01	1984-12-24	Wellcome Found	Antibacterial compounds
DK190983A (da) *	1982-05-01	1983-11-02	Wellcome Found	2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
US4587341A (en) *	1982-05-07	1986-05-06	Burroughs Wellcome Co.	2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) *	1983-04-14	1988-11-01	Hans Maag	Pyrimidine derivatives
GB8603962D0 (en) *	1986-02-18	1986-03-26	Wellcome Found	Chemical compositions
GB8603964D0 (en) *	1986-02-18	1986-03-26	Cooper Animal Health Ltd	Compositions
LU86703A1 (fr) *	1986-12-08	1988-07-14	Oreal	Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
GB8903978D0 (en) *	1989-02-22	1989-04-05	Coopers Animal Health	Chemical compositions
GB9000241D0 (en) *	1990-01-05	1990-03-07	Coopers Animal Health	Pharmaceutical use
RU95113597A (ru) *	1992-12-02	1997-06-10	ФМК Корпорейшн (US)	Инсектицидная композиция, способы борьбы с насекомыми
KR100224135B1 (ko) *	1993-01-28	1999-10-15	다께다 구니오	퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
US5707996A (en) *	1995-11-06	1998-01-13	Macleod Pharmaceuticals, Inc.	Pharmaceutical solution and methods for preparation thereof
EP1149834A1 (en) *	1995-12-04	2001-10-31	F. Hoffmann-La Roche Ag	Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
RU2141322C1 (ru) *	1997-08-12	1999-11-20	Голощапов Николай Михайлович	Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения
GB0016877D0 (en) *	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
WO2002010156A1 (en) *	2000-07-29	2002-02-07	Arpida Ag	Benzofuran derivatives and their use as antibacterial agents
US7678805B2 (en)	2001-06-29	2010-03-16	Ab Science	Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
JP2005500041A (ja) *	2001-06-29	2005-01-06	アブサイエンス	強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
WO2003002108A2 (en) *	2001-06-29	2003-01-09	Ab Science	Use of tyrosine kinase inhibitors for treating inflammatory diseases
CA2452371A1 (en) *	2001-06-29	2003-01-09	Ab Science	Use of tyrosine kinase inhibitors for treating allergic diseases
CA2461182A1 (en) *	2001-09-20	2003-05-01	Ab Science	Use of tyrosine kinase inhibitors for promoting hair growth
JP2005507916A (ja) *	2001-09-20	2005-03-24	アブサイエンス	細菌感染症を治療するための、強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用方法
US20040242601A1 (en) *	2001-09-20	2004-12-02	Alain Moussy	Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
CA2531757A1 (en)	2003-07-11	2005-01-20	Arpida Ag	Benzofuran derivatives and their use in the treatment of microbial infections
CN101115746A (zh) *	2005-02-18	2008-01-30	阿皮德公开股份有限公司	用于制备苯并呋喃的新方法
CA2619898C (en) *	2005-09-01	2014-03-18	F. Hoffmann-La Roche Ag	Diaminopyrimidines as p2x3 and p2x2/3 modulators
US20100029689A1 (en) *	2008-07-02	2010-02-04	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors
CA2778931A1 (en) *	2009-06-12	2010-12-16	Marianne Allard	Guanine riboswitch binding compounds and their use as antibiotics
CN102649786B (zh) *	2011-02-28	2014-08-27	郑州福源动物药业有限公司	一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
CN103755684B (zh) *	2014-02-10	2015-09-09	青岛蔚蓝生物股份有限公司	一种巴喹普林的制备方法
US20220332714A1 (en) *	2019-06-06	2022-10-20	Beijing Tide Pharmaceutical Co., Ltd.	P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition containing same, and use thereof
CN110818694B (zh) *	2019-11-18	2023-04-21	上海医药工业研究院有限公司	艾拉普林中间体及其应用
WO2022217295A1 (en) *	2021-04-09	2022-10-13	The Trustees Of The University Of Pennsylvania	Control of protein expression with tmp-protac compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3049544A (en) *		1962-08-14		Method for the preparation of
DE1303727B (de)	1959-09-03	1976-02-05	Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London	Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) *	1969-03-06	1976-05-11	Burroughs Wellcome Co.	Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) *	1971-12-01	1973-05-30	Hoffmann La Roche	Nouvelles benzylpyrimidines
GB1468374A (en)	1974-03-06	1977-03-23	Wellcome Found	Process for preparing a pyrimidine derivative
US4039543A (en)	1974-12-24	1977-08-02	Hoffmann-La Roche Inc.	Benzylpyrimidines
GB1582245A (en) *	1976-06-09	1981-01-07	Wellcome Found	Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) *	1977-07-06	1979-01-18	Basf Ag	Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) *	1979-11-30	1981-03-24	Merck & Co., Inc.	Inhibitor of dihydrofolate reductase
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use

1981
- 1981-11-09 US US06/319,644 patent/US4438267A/en not_active Expired - Lifetime
- 1981-11-10 DK DK198104966A patent/DK172884B1/da active Protection Beyond IP Right Term
- 1981-11-10 SU SU813358051A patent/SU1424732A3/ru active
- 1981-11-10 YU YU2663/81A patent/YU42444B/xx unknown
- 1981-11-10 NO NO813804A patent/NO160137C/no not_active IP Right Cessation
- 1981-11-10 DD DD81234745A patent/DD201896A5/de not_active IP Right Cessation
- 1981-11-10 CA CA000389807A patent/CA1186310A/en not_active Expired
- 1981-11-10 PL PL1981233754A patent/PL139523B1/pl unknown
- 1981-11-10 IT IT8149676A patent/IT1210589B/it active
- 1981-11-10 PT PT73960A patent/PT73960B/pt unknown
- 1981-11-10 AU AU77334/81A patent/AU549449B2/en not_active Expired
- 1981-11-10 ES ES506969A patent/ES8307759A1/es not_active Expired
- 1981-11-10 MC MC811560A patent/MC1418A1/fr unknown
- 1981-11-10 JP JP56180271A patent/JPS57114581A/ja active Granted
- 1981-11-10 IL IL64256A patent/IL64256A/xx not_active IP Right Cessation
- 1981-11-10 CS CS825781A patent/CS273153B2/cs unknown
- 1981-11-10 KR KR1019810004348A patent/KR880001736B1/ko not_active Expired
- 1981-11-10 FI FI813546A patent/FI76333C/fi not_active IP Right Cessation
- 1981-11-10 EG EG653/81A patent/EG16107A/xx active
- 1981-11-10 PL PL1981239278A patent/PL139827B1/pl unknown
- 1981-11-10 GB GB8133833A patent/GB2087881B/en not_active Expired
- 1981-11-10 NZ NZ198932A patent/NZ198932A/en unknown
- 1981-11-10 IE IE2631/81A patent/IE52128B1/en not_active IP Right Cessation
- 1981-11-10 GR GR66482A patent/GR81317B/el unknown
- 1981-11-10 HU HU813359A patent/HU188762B/hu unknown
- 1981-11-10 ZA ZA817780A patent/ZA817780B/xx unknown
- 1981-11-10 PL PL1981239279A patent/PL139427B1/pl unknown
- 1981-11-10 PL PL1981239280A patent/PL139828B1/pl unknown
- 1981-11-11 EP EP81109631A patent/EP0051879B1/en not_active Expired
- 1981-11-11 DE DE8181109631T patent/DE3173752D1/de not_active Expired
- 1981-11-11 ZM ZM94/81A patent/ZM9481A1/xx unknown
- 1981-11-11 CY CY141981A patent/CY1419A/xx unknown
1983
- 1983-01-27 SU SU833543245A patent/SU1318148A3/ru active
- 1983-01-31 SU SU833547444A patent/SU1306473A3/ru active
- 1983-04-02 ES ES521202A patent/ES8405378A1/es not_active Expired
- 1983-04-02 ES ES521204A patent/ES8405380A1/es not_active Expired
- 1983-04-02 ES ES521203A patent/ES521203A0/es active Granted
- 1983-04-02 ES ES521201A patent/ES8405377A1/es not_active Expired
- 1983-09-07 PH PH29502A patent/PH22654A/en unknown
- 1983-09-07 PH PH29503A patent/PH25053A/en unknown
- 1983-10-03 YU YU01981/83A patent/YU198183A/xx unknown
- 1983-10-03 YU YU1983/83A patent/YU43551B/xx unknown
- 1983-10-03 YU YU01982/83A patent/YU198283A/xx unknown
- 1983-10-31 US US06/546,850 patent/US4587342A/en not_active Expired - Lifetime
- 1983-12-30 US US06/567,248 patent/US4603136A/en not_active Expired - Lifetime
1986
- 1986-02-02 RU SU863552053A patent/RU1819264C/ru active
- 1986-03-12 US US06/839,463 patent/US4761475A/en not_active Expired - Lifetime
- 1986-07-17 SG SG626/86A patent/SG62686G/en unknown
- 1986-12-30 MY MY678/86A patent/MY8600678A/xx unknown
1987
- 1987-01-14 SU SU874028793A patent/SU1535379A3/ru active
1988
- 1988-03-30 HK HK233/88A patent/HK23388A/en not_active IP Right Cessation
- 1988-06-17 AR AR88311165A patent/AR245447A1/es active
- 1988-07-26 YU YU144288A patent/YU46697B/sh unknown
1994
- 1994-12-29 NO NO1994029C patent/NO1994029I1/no unknown

Also Published As

Publication number	Publication date
PL239278A1 (en)	1983-08-01
YU42444B (en)	1988-08-31
ES521201A0 (es)	1984-06-01
YU198383A (en)	1984-04-30
IE52128B1 (en)	1987-06-24
YU46697B (sh)	1994-04-05
DD201896A5 (de)	1983-08-17
ES506969A0 (es)	1983-07-01
IT1210589B (it)	1989-09-14
DK496681A (da)	1982-05-12
PL233754A1 (en)	1983-08-01
EP0051879A3 (en)	1982-08-04
YU198183A (en)	1984-04-30
IL64256A0 (en)	1982-02-28
PL239280A1 (en)	1983-08-01
US4438267A (en)	1984-03-20
HK23388A (en)	1988-04-08
SU1306473A3 (ru)	1987-04-23
ES521202A0 (es)	1984-06-01
PL239279A1 (en)	1983-08-01
YU198283A (en)	1984-04-30
GB2087881A (en)	1982-06-03
NO813804L (no)	1982-05-12
PL139427B1 (en)	1987-01-31
NO160137C (no)	1989-03-15
CS825781A2 (en)	1990-07-12
RU1819264C (ru)	1993-05-30
GB2087881B (en)	1985-05-15
ES8307759A1 (es)	1983-07-01
HU188762B (en)	1986-05-28
NZ198932A (en)	1985-05-31
MY8600678A (en)	1986-12-31
MC1418A1 (fr)	1982-10-18
YU144288A (en)	1990-04-30
YU266381A (en)	1984-04-30
PL139827B1 (en)	1987-02-28
YU43551B (en)	1989-08-31
DE3173752D1 (en)	1986-03-20
EP0051879A2 (en)	1982-05-19
JPH0474351B2 (cs)	1992-11-26
JPS57114581A (en)	1982-07-16
FI76333C (fi)	1988-10-10
AR245447A1 (es)	1994-01-31
IE812631L (en)	1982-05-11
SU1535379A3 (ru)	1990-01-07
CY1419A (en)	1988-04-22
NO1994029I1 (no)	1994-12-29
PL139523B1 (en)	1987-01-31
SG62686G (en)	1987-03-27
ES521204A0 (es)	1984-06-01
US4587342A (en)	1986-05-06
SU1318148A3 (ru)	1987-06-15
FI813546L (fi)	1982-05-12
IT8149676A0 (it)	1981-11-10
KR830007628A (ko)	1983-11-04
PL139828B1 (en)	1987-02-28
PH22654A (en)	1988-10-28
AU549449B2 (en)	1986-01-30
KR880001736B1 (ko)	1988-09-10
PH25053A (en)	1991-01-28
EP0051879B1 (en)	1986-02-05
EG16107A (en)	1987-10-30
US4761475A (en)	1988-08-02
ES8405377A1 (es)	1984-06-01
ZA817780B (en)	1983-06-29
ES8405379A1 (es)	1984-06-01
SU1424732A3 (ru)	1988-09-15
ES521203A0 (es)	1984-06-01
PT73960A (en)	1981-12-01
FI76333B (fi)	1988-06-30
ES8405378A1 (es)	1984-06-01
AU7733481A (en)	1982-05-20
CA1186310A (en)	1985-04-30
GR81317B (cs)	1984-12-11
US4603136A (en)	1986-07-29
DK172884B1 (da)	1999-09-06
PT73960B (en)	1983-11-23
CS273153B2 (en)	1991-03-12
ES8405380A1 (es)	1984-06-01
ZM9481A1 (en)	1983-11-21
NO160137B (no)	1988-12-05

Legal Events

Date	Code	Title
2000-07-16	FF	Patent granted
2000-08-31	KB	Patent renewed
2002-02-10	EXP	Patent expired

Publication	Publication Date	Title
IL64256A (en)	1988-01-31	2,4-diamino-5-(substituted methyl)-pyrimidines,their preparation and pharmaceutical compositions containing them
IL63940A0 (en)	1981-12-31	Substituted imino-diacids,their preparation and pharmaceutical compositions containing them
IL66099A0 (en)	1982-09-30	N-aryl-piperazinealkanamides,their preparation and pharmaceutical compositions containing them
IL65814A (en)	1986-02-28	3-phenylalkylaminoalkyl-3-benzazepine and 1,3-benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL65257A0 (en)	1983-12-30	Arylcyclo-butanealkylamine derivatives,their preparation and pharmaceutical compositions containing them
IL64504A (en)	1985-02-28	Aminoalkoxyphenyl substituted quinazolinones and pyridopyrimidinones,their preparation and pharmaceutical compositions containing them
IL65803A (en)	1988-02-29	Cyclobutene-dione derivatives,their preparation and pharmaceutical compositions containing them
IL64665A (en)	1985-03-31	4-amino-6,7-dimethoxy-2-piperazino-quinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL75147A0 (en)	1985-09-29	Pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL60086A0 (en)	1980-07-31	Pyrimidine compounds,their preparation and pharmaceutical compositions containing them
IL65076A (en)	1984-12-31	3,4-dihydro-5h-2,3-benzo-diazepine derivatives,their preparation and pharmaceutical compositions containing them
IL64777A0 (en)	1982-03-31	3-aminopropoxyaryl derivatives,their preparation and pharmaceutical compositions containing them
IL66683A0 (en)	1982-12-31	Benzo-heterocycles,their preparation and pharmaceutical compositions containing them
IL63368A0 (en)	1981-10-30	4,5-diaryl-alpha-polyfluoroalkyl-1h-imidazole-2-methanamines,their preparation and pharmaceutical compositions containing them
IL65327A0 (en)	1982-05-31	Acylquinolinone derivatives,their preparation and pharmaceutical compositions containing them
ZA816844B (en)	1982-09-29	Substituted iminodiacids,their preparation and pharmaceutical compositions containing them
IL57081A0 (en)	1979-07-25	Substituted 1,3-diarly-2-imino-imidazolidines and hexahydropyrimidines their preparation and pharmaceutical compositions containing them
IL66238A0 (en)	1982-11-30	Benzothiazolesulfonamide derivatives,their preparation and pharmaceutical compositions containing them
IL65160A (en)	1986-04-29	Substituted heteroaromatic guanidine derivatives,their preparation and pharmaceutical compositions containing them
IL63773A (en)	1985-02-28	Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide,its preparation and pharmaceutical compositions containing it
IL65422A (en)	1985-04-30	2-piperazino-pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL64563A0 (en)	1982-03-31	3,4-bis-substituted 1,2,5-oxidiazole 2-oxides,their preparation and pharmaceutical compositions containing them
IL64252A (en)	1985-02-28	3,3-dimethyl-indolin-2-ones,their preparation and pharmaceutical compositions containing them
IL69407A0 (en)	1983-11-30	2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
DE3366170D1 (en)	1986-10-23	Pyrimidone compounds, their preparation, and pharmaceutical compositions containing them