ES2053555T3 - Procedimiento de ensayo y sistema de diagnostico de un marcador del metabolismo anormal de lipidos. - Google Patents

Procedimiento de ensayo y sistema de diagnostico de un marcador del metabolismo anormal de lipidos.

Info

Publication number
ES2053555T3
ES2053555T3 ES87308392T ES87308392T ES2053555T3 ES 2053555 T3 ES2053555 T3 ES 2053555T3 ES 87308392 T ES87308392 T ES 87308392T ES 87308392 T ES87308392 T ES 87308392T ES 2053555 T3 ES2053555 T3 ES 2053555T3
Authority
ES
Spain
Prior art keywords
marker
test procedure
diagnostic system
lipid metabolism
abnormal lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87308392T
Other languages
English (en)
Inventor
Richard S Smith
Doreen M Hogle
Linda K Curtiss
Joseph L Witztum
Stephen Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Application granted granted Critical
Publication of ES2053555T3 publication Critical patent/ES2053555T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Fats And Perfumes (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBEN METODOS DE DETERMINACION DE LA RELACION DE APOLIPROTEINA B-100 A APOLIPROTEINA A-1 UTILIZANDO TECNICAS ELISA JUNTO CON MOLECULAS PARATOPICAS MONOCLONALES COMO SON SISTEMAS DE DIAGNOSTICO UTILES PARA LLEVAR A CABO AQUELLAS DETERMINACIONES. SE UTILIZAN MOLECULAS PARATOPICAS MONOCLONALES SEGREGADAS POR HIBRIDOMAS QUE TIENEN NUMEROS DE ASCENSION ATCC HB8742, HB8746, HB9200 Y HB9201.
ES87308392T 1986-09-29 1987-09-22 Procedimiento de ensayo y sistema de diagnostico de un marcador del metabolismo anormal de lipidos. Expired - Lifetime ES2053555T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/913,140 US4828986A (en) 1986-09-29 1986-09-29 Assay method and diagnostic system for determining the ratio of APO B-100 to APO A-I in a blood sample

Publications (1)

Publication Number Publication Date
ES2053555T3 true ES2053555T3 (es) 1994-08-01

Family

ID=25432962

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87308392T Expired - Lifetime ES2053555T3 (es) 1986-09-29 1987-09-22 Procedimiento de ensayo y sistema de diagnostico de un marcador del metabolismo anormal de lipidos.

Country Status (17)

Country Link
US (1) US4828986A (es)
EP (1) EP0262854B1 (es)
JP (1) JP2656774B2 (es)
AT (1) ATE85435T1 (es)
AU (1) AU611096B2 (es)
CA (1) CA1285869C (es)
DE (1) DE3783991T2 (es)
DK (1) DK173724B1 (es)
ES (1) ES2053555T3 (es)
FI (1) FI89214C (es)
GR (1) GR3008027T3 (es)
IE (1) IE60119B1 (es)
IL (1) IL83938A (es)
NO (1) NO173902C (es)
NZ (1) NZ221941A (es)
PT (1) PT85827B (es)
ZA (1) ZA876970B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0257778B1 (en) * 1986-08-06 1995-03-22 Scripps Clinic And Research Foundation Apolipoprotein b-specific monoclonal antibodies produced by two novel hybridomas
DE3734015A1 (de) * 1987-10-08 1989-04-20 Behringwerke Ag Diagnostisches mittel und verfahren zur bestimmung von apolipoprotein b
AU621575B2 (en) * 1987-11-02 1992-03-19 Scripps Clinic And Research Foundation Diagnostic methods and systems for quantifying apo ai
US5759774A (en) * 1988-05-18 1998-06-02 Cobe Laboratories, Inc. Method of detecting circulating antibody types using dried or lyophilized cells
US5183738A (en) * 1988-09-29 1993-02-02 Japan Immuno Research Laboratories Co., Ltd. Kit for the detection of denatured lipoproteins
US5179008A (en) * 1989-02-09 1993-01-12 Wisconsin Alumni Research Foundation Hybridoma and monoclonal antibody to FHAP
US5473039A (en) * 1989-08-18 1995-12-05 The Scripps Research Institute Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs
US5168045A (en) * 1989-08-18 1992-12-01 The Scripps Research Institute Diagnostic systems and methods using polypeptide analogs of apolipoprotein e
AU662885B2 (en) * 1990-06-07 1995-09-21 Scripps Research Institute, The APO AI polypeptides, antibodies, and immunoassays
WO1992009893A1 (en) * 1990-11-29 1992-06-11 Carbaugh John E DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS AND METHODS FOR LIPOPROTEIN(a)
US5844097A (en) * 1990-11-30 1998-12-01 Monoclonetics International, Inc. Methods for the diagnosis of peripheral nerve damage
EP0559795B1 (en) * 1990-11-30 1995-12-27 Monoclonetics International, Inc. Methods for the diagnosis of chronic lower back and cervical pain
US5408038A (en) * 1991-10-09 1995-04-18 The Scripps Research Institute Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides
AU4924193A (en) * 1992-09-24 1994-04-12 Perseptive Biosystems, Inc. Quantitative measurement of ldl
US6107045A (en) * 1994-06-30 2000-08-22 Oklahoma Medical Research Foundation Antibodies to lipoproteins and apolipoproteins and methods of use thereof
US5994061A (en) * 1995-09-29 1999-11-30 Queen's University At Kingston DNA constructs and methods for screening for increased expression of human apo AI gene
US5741647A (en) * 1996-02-16 1998-04-21 Tam; Joseph Wing On Flow through nucleic acid hybridisation uses thereof and a device thereof
US6248539B1 (en) 1997-09-05 2001-06-19 The Scripps Research Institute Porous semiconductor-based optical interferometric sensor
US6309844B1 (en) * 1997-10-15 2001-10-30 Fujirebio Inc. Anti-apo-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring apo-B-48 using the same
AT5044U1 (de) * 2001-05-10 2002-02-25 Medsystems Diagnostics Gmbh Quantitativer einschritt immuntest in lyophilisierter form
JP4179988B2 (ja) * 2001-07-12 2008-11-12 協和メデックス株式会社 変性リポ蛋白質の定量法、変性リポ蛋白質の定量用試薬、循環器疾患の検出方法および循環器疾患の検出試薬
KR101134605B1 (ko) 2003-10-15 2012-04-09 토우다이 티엘오, 리미티드 시료의 전처리방법 및 이를 이용한 면역학적 측정방법
US7781171B2 (en) 2003-10-15 2010-08-24 Daiichi Pure Chemicals Co., Ltd. Mehod of pretreating sample and immunological assay method using the same
US7521248B2 (en) * 2007-04-20 2009-04-21 Atherotech, Inc. Apo B measurement system and method
CN110042146B (zh) 2011-11-11 2023-09-01 雅培快速诊断国际无限公司 血样本的化验方法
CN118047854B (zh) * 2024-02-26 2024-08-02 武汉鹰达生物科技有限公司 一种人载脂蛋白a-i的分离纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2061282B (en) * 1979-10-22 1983-03-30 Symphar Sa Method for the clinical separation of a-and lipoproteins and kit for carrying out this method
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
JPS60193926A (ja) * 1984-03-15 1985-10-02 Tokyo Daigaku 単クローン性抗ヒトアポリポ蛋白質ｂ１００抗体
JPS60253871A (ja) * 1984-05-30 1985-12-14 Nippon Koutai Kenkyusho:Kk 抗アポａ−１抗体
EP0209543A4 (en) * 1984-12-31 1989-07-11 Internat Genetic Engineering I FRAGMENTS OF HUMAN APOLIPOPROTEINS PEPTIDES, TYPE-SPECIFIC ANTIBODIES AND METHODS OF USE.
US4677057A (en) * 1985-03-11 1987-06-30 Scripps Clinic And Research Foundation Diagnostic assay for the presence of apolipoproteins associated with plasma high density lipoproteins

Also Published As

Publication number Publication date
JPS63277968A (ja) 1988-11-15
DE3783991D1 (de) 1993-03-18
EP0262854B1 (en) 1993-02-03
NZ221941A (en) 1989-05-29
IL83938A0 (en) 1988-02-29
FI89214B (fi) 1993-05-14
IL83938A (en) 1991-12-15
DK173724B1 (da) 2001-07-30
NO173902B (no) 1993-11-08
FI874253A0 (fi) 1987-09-28
AU7902887A (en) 1988-03-31
FI89214C (fi) 1993-08-25
DK509287D0 (da) 1987-09-28
US4828986A (en) 1989-05-09
DE3783991T2 (de) 1993-06-09
IE60119B1 (en) 1994-06-01
IE872605L (en) 1988-03-29
NO874056L (no) 1988-03-30
NO874056D0 (no) 1987-09-28
PT85827A (en) 1987-10-01
NO173902C (no) 1994-02-16
DK509287A (da) 1988-03-30
EP0262854A2 (en) 1988-04-06
CA1285869C (en) 1991-07-09
FI874253L (fi) 1988-03-30
ZA876970B (en) 1988-03-21
GR3008027T3 (es) 1993-09-30
ATE85435T1 (de) 1993-02-15
EP0262854A3 (en) 1989-12-06
JP2656774B2 (ja) 1997-09-24
PT85827B (pt) 1990-08-31
AU611096B2 (en) 1991-06-06

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