ES2056164T3 - Sustancia ligante de trombina y procedimiento para la preparacion de la misma. - Google Patents

Sustancia ligante de trombina y procedimiento para la preparacion de la misma.

Info

Publication number
ES2056164T3
ES2056164T3 ES89115272T ES89115272T ES2056164T3 ES 2056164 T3 ES2056164 T3 ES 2056164T3 ES 89115272 T ES89115272 T ES 89115272T ES 89115272 T ES89115272 T ES 89115272T ES 2056164 T3 ES2056164 T3 ES 2056164T3
Authority
ES
Spain
Prior art keywords
thrombin
binding
substance
substances
binding substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89115272T
Other languages
English (en)
Inventor
Nobuo Aoki
Shigeru Kimura
Masami Shiratsuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of ES2056164T3 publication Critical patent/ES2056164T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UNAS NUEVAS SUSTANCIAS DE AGLUTIANTE DE TROMBINA (A) Y (B) SON DESCRITAS. DICHAS SUSTANCIAS TIENEN LAS SIGUIENTES CARACTERISTICAS: (A) PESO MOLECULAR: SI SUSTANCIA AGLUTIANTE DE TROMBINA (A) 90.000 - 92.000 BAJO CONDICIONES DE REDUCIDO DE SUSTANCIA AGLUTIANTE DE TROMBINA (B) 98.000 - 105.000 BAJO CONDICIONES DE REDUCIDO, 60.000 - 65.000 BAJO CONDICIONES DE NO REDUCIDO (B) PUNTO ISOELECTRICO SUSTANCIA AGLUTINANTE DE TROMBINA (A): PH 6.0 - 6.8. SUSTANCIA AGLUTINANTE DE TROMBINA (B): PH 5.8 - 6.5; (C) AFINIDAD: FUERTE AFINIDAD A LA TROMBINA; (D) ACTIVIDAD: - CAPAZ DE PROMOVER LA ACTIVACION CATALIZADA DE LA TROMBINA DE LA PROTEINA C Y PROLONGAR EL TIEMPO DE AGLUTINACION; (E) ESTABILIDAD: ESTABLE PARA DESNATURALIZAR AGENTES (DOCECIBULFATO DE SODIO Y UREA). DICHAS SUSTANCIA DE TROMBINA SON UTILES COMO MEDICINAS PARA CURAR TROMBOSIS.
ES89115272T 1988-08-29 1989-08-18 Sustancia ligante de trombina y procedimiento para la preparacion de la misma. Expired - Lifetime ES2056164T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21413988 1988-08-29
JP11647189 1989-05-10
JP1202027A JPH0720997B2 (ja) 1988-08-29 1989-08-03 新規なトロンビン結合性物質及びその製法

Publications (1)

Publication Number Publication Date
ES2056164T3 true ES2056164T3 (es) 1994-10-01

Family

ID=27313158

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89115272T Expired - Lifetime ES2056164T3 (es) 1988-08-29 1989-08-18 Sustancia ligante de trombina y procedimiento para la preparacion de la misma.

Country Status (7)

Country Link
US (1) US5043425A (es)
EP (1) EP0356836B1 (es)
JP (1) JPH0720997B2 (es)
KR (2) KR900003207A (es)
AT (1) ATE105480T1 (es)
DE (1) DE68915226T2 (es)
ES (1) ES2056164T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
JPH03259084A (ja) * 1990-03-06 1991-11-19 Kowa Co トロンビン結合性物質の製造法
JP3180824B2 (ja) * 1991-08-30 2001-06-25 シスメックス株式会社 血液凝固試薬
US5716795A (en) * 1991-10-04 1998-02-10 Matschiner; John T. Thrombomodulin-based coagulometric assay of the protein C system
US20050089543A1 (en) * 2001-02-01 2005-04-28 Weiser Mark J. Animal scent based repellent and attractant compositions
EP1475098B1 (en) * 2002-01-18 2015-08-05 Asahi Kasei Pharma Corporation High-concentration preparation of soluble thrombomodulin
JP5579385B2 (ja) * 2006-10-06 2014-08-27 旭化成ファーマ株式会社 播種性血管内血液凝固症候群の治療及び／又は改善剤
ES2496596T3 (es) 2007-03-23 2014-09-19 Asahi Kasei Pharma Corporation Método para producir trombomodulina soluble de gran pureza
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
SG10201500036WA (en) 2010-04-30 2015-02-27 Asahi Kasei Pharma Corp Highly-purified soluble thrombomodulin and method for producing same
BR112014011488B1 (pt) 2011-11-15 2022-07-05 Asahi Kasei Pharma Corporation Medicamento para tratamento terapêutico e/ou melhora de sépsis
BR112014028852A2 (pt) 2012-05-31 2018-04-24 Asahi Kasei Pharma Corporation agente para o tratamento profilático e/ou terapêutico de dor neuropática periférica causada por agente anticâncer.
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
BR112021007460A2 (pt) 2018-10-22 2021-11-03 Asahi Kasei Pharma Corp Medicamento para tratamento terapêutico e/ou melhora de um paciente com sepse

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
EP0239644A4 (en) * 1985-06-28 1987-10-27 Asahi Chemical Ind NEW PHYSIOLOGICALLY ACTIVE AGENTS WITH A BLOOD COAGULATING REGULATORY EFFECT.
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法
US5047503A (en) * 1986-07-15 1991-09-10 Kowa Company, Ltd. Thrombin-binding substance and process for its preparation
JP2738428B2 (ja) * 1987-01-08 1998-04-08 旭化成工業株式会社 トロンビンによるプロテインｃの活性化を促進する作用を有するペプチド
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof

Also Published As

Publication number Publication date
DE68915226D1 (de) 1994-06-16
EP0356836A2 (en) 1990-03-07
ATE105480T1 (de) 1994-05-15
KR900003207A (ko) 1990-03-26
JPH0720997B2 (ja) 1995-03-08
US5043425A (en) 1991-08-27
EP0356836A3 (en) 1990-03-28
JPH0386900A (ja) 1991-04-11
KR940027658A (ko) 1994-12-10
EP0356836B1 (en) 1994-05-11
DE68915226T2 (de) 1995-01-05

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