ES2063268T3 - Aminas aromaticas y heteroaromaticas para el tratamiento de depresiones, trastornos de insuficiencia cerebral o demencia. - Google Patents

Aminas aromaticas y heteroaromaticas para el tratamiento de depresiones, trastornos de insuficiencia cerebral o demencia.

Info

Publication number
ES2063268T3
ES2063268T3 ES90306020T ES90306020T ES2063268T3 ES 2063268 T3 ES2063268 T3 ES 2063268T3 ES 90306020 T ES90306020 T ES 90306020T ES 90306020 T ES90306020 T ES 90306020T ES 2063268 T3 ES2063268 T3 ES 2063268T3
Authority
ES
Spain
Prior art keywords
lower alkyl
carbon atoms
optionally substituted
dementia
depressions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90306020T
Other languages
English (en)
Inventor
John Frederick White
Michael Christopher Wa Minchin
Christine Ennis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898912784A external-priority patent/GB8912784D0/en
Priority claimed from GB898927087A external-priority patent/GB8927087D0/en
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Application granted granted Critical
Publication of ES2063268T3 publication Critical patent/ES2063268T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Furan Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

LA INVENCION CONCIERNE A COMPUESTOS QUE TIENEN LA FORMULA: O A UNA SAL DE ELLOS, EN DONDE E REPRESENTA HIDROGENO, ALQUILO INFERIOR O UN GRUPO AR1-A1-; AR Y AR1 SON LOS MISMOS O DIFERENTES GRUPOS ARILO (INCLUYENDO LOS HETEROARILOS), LOS CUALES ESTAN OPCIONALMENTE SUSTITUIDOS, P.EJ. POR UNO O MAS SUSTITUYENTES COMUNMENTE USADOS EN QUIMICA FARMACEUTICA; A Y A1 SON LOS MISMOS O DIFERENTES GRUPOS ALQUILENO, QUE TIENEN UNO O DOS ATOMOS DE CARBONO, ENLAZANDO AR Y AR1 A N Y SIENDO OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR Y/O ARILO OPCIONALMENTE SUSTITUIDO, B ES UN GRUPO ALQUILENO DE 3 O 4 ATOMOS DE CARBONO, EL CUAL PUEDE ESTAR SUSTITUIDO POR ALQUILO INFERIOR; D1 REPRESENTA HALOGENO, CH3, CR1R2NH2, SO3H O SO2NR6R7 DONDE R1 Y R2 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR Y R6 Y R7 SON CADA UNO HIDROGENO, ALQUILO INFERIOR O ARALQUILO DE 7 A 12 ATOMOS DE CARBONO O R6 Y R7 JUNTO CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDOS REPRESENTAN UN ANILLO DE 5 O 6 MIEMBROS; TALES COMPUESTOS SE USAN, PARA TRATAR DEPRESIONES O INSUFICIENCIA CEREBRAL O DEMENCIAS EN ANIMALES.
ES90306020T 1989-06-02 1990-06-01 Aminas aromaticas y heteroaromaticas para el tratamiento de depresiones, trastornos de insuficiencia cerebral o demencia. Expired - Lifetime ES2063268T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898912784A GB8912784D0 (en) 1989-06-02 1989-06-02 Amines
GB898927087A GB8927087D0 (en) 1989-11-30 1989-11-30 Amines

Publications (1)

Publication Number Publication Date
ES2063268T3 true ES2063268T3 (es) 1995-01-01

Family

ID=26295435

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90306020T Expired - Lifetime ES2063268T3 (es) 1989-06-02 1990-06-01 Aminas aromaticas y heteroaromaticas para el tratamiento de depresiones, trastornos de insuficiencia cerebral o demencia.

Country Status (12)

Country Link
US (1) US5086073A (es)
EP (1) EP0407032B1 (es)
JP (1) JPH0347155A (es)
KR (1) KR910000133A (es)
AT (1) ATE113833T1 (es)
AU (1) AU641394B2 (es)
CA (1) CA2017966A1 (es)
DE (1) DE69013994T2 (es)
ES (1) ES2063268T3 (es)
GB (1) GB2233558B (es)
HU (1) HUT58270A (es)
PT (1) PT94218A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430044A (en) * 1987-02-06 1995-07-04 Fisons Corporation Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines
GB9320051D0 (en) * 1993-09-29 1993-11-17 Lilly Industries Ltd Pharmaceutical compounds
AU5233699A (en) * 1998-07-31 2000-02-21 Eli Lilly And Company Sulfonamide derivatives
GB0417802D0 (en) * 2004-08-10 2004-09-15 Novartis Ag Organic compounds
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
DK1848430T3 (da) 2004-12-31 2017-11-06 Dr Reddys Laboratories Ltd Nye benzylamin-derivativer som cetp-inhibitors
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
JP6140168B2 (ja) 2011-09-27 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての５−ベンジルアミノメチル−６−アミノピラゾロ［３，４−ｂ］ピリジン誘導体

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB841634A (en) * 1957-04-17 1960-07-20 Ici Ltd Triphenylmethane derivatives and their use in molluscicidal compositions
GB942309A (en) * 1959-02-06 1963-11-20 Wellcome Found Tertiary n-bromobenzyl-n-butylamines and their preparation
DE1116227B (de) * 1959-07-09 1961-11-02 Thomae Gmbh Dr K Verfahren zur Herstellung von tertiaeren Aminen
CH419131A (fr) * 1961-01-31 1966-08-31 Olin Mathieson Procédé de préparation de dihydrodibenzothiazépines
GB1031425A (en) * 1962-03-30 1966-06-02 Chinoin Gyogyszer Es Vegyeszet New aralkylamines and their preparation
DE1227447B (de) * 1962-03-30 1966-10-27 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von Phenylisopropylaminen
GB1343543A (en) * 1970-01-19 1974-01-10 Crompton & Knowles Corp Mono-and dis-azo dyestuffs containing 3-sulpho-propylamino groups
JPS4740907Y1 (es) * 1970-09-19 1972-12-11
US3956078A (en) * 1972-12-14 1976-05-11 M & T Chemicals Inc. Electrodeposition of copper
CS163580B1 (es) * 1973-04-10 1975-09-15
IE40727B1 (en) * 1974-03-09 1979-08-01 Hoechst Ag Aralkylamines
GB1532957A (en) * 1974-11-04 1978-11-22 Glaxo Lab Ltd Bis(aminomethyl)naphthalene derivatives
DE2940509C2 (de) * 1978-10-06 1995-01-26 Nippon Paint Co Ltd Polymerisierbare Aminosäureverbindungen und ihre Verwendung
EP0177078A1 (en) * 1984-09-12 1986-04-09 Duphar International Research B.V Spasmolytically active tertiary amine derivatives and method of preparing the same
US4647591A (en) * 1985-10-07 1987-03-03 Eli Lilly And Company Method for improving memory
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents
US4649161A (en) * 1986-06-16 1987-03-10 Massachusetts Institute Of Technology Method for treating depression with d-fenfluramine
HU207280B (en) * 1986-09-25 1993-03-29 Chinoin Gyogyszer Es Vegyeszet Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them
NL8700842A (es) * 1987-04-10 1988-11-01 Duphar Int Res
JP2581707B2 (ja) * 1987-10-02 1997-02-12 科研製薬株式会社 抗真菌剤組成物
GB8813185D0 (en) * 1988-06-03 1988-07-06 Wyeth John & Brother Ltd New method & amines used therein

Also Published As

Publication number Publication date
EP0407032B1 (en) 1994-11-09
ATE113833T1 (de) 1994-11-15
EP0407032A3 (en) 1992-01-02
KR910000133A (ko) 1991-01-29
GB2233558B (en) 1993-12-15
PT94218A (pt) 1991-02-08
EP0407032A2 (en) 1991-01-09
JPH0347155A (ja) 1991-02-28
AU641394B2 (en) 1993-09-23
US5086073A (en) 1992-02-04
CA2017966A1 (en) 1990-12-02
HUT58270A (en) 1992-02-28
GB2233558A (en) 1991-01-16
GB9012223D0 (en) 1990-07-18
DE69013994D1 (de) 1994-12-15
HU903266D0 (en) 1990-10-28
DE69013994T2 (de) 1995-04-13
AU5608090A (en) 1990-12-06

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