ES2073735T3 - Nuevos analogos de la cadena b del factor de crecimiento derivado de plaquetas y metodo para su produccion homogenea. - Google Patents
Nuevos analogos de la cadena b del factor de crecimiento derivado de plaquetas y metodo para su produccion homogenea.Info
- Publication number
- ES2073735T3 ES2073735T3 ES91902366T ES91902366T ES2073735T3 ES 2073735 T3 ES2073735 T3 ES 2073735T3 ES 91902366 T ES91902366 T ES 91902366T ES 91902366 T ES91902366 T ES 91902366T ES 2073735 T3 ES2073735 T3 ES 2073735T3
- Authority
- ES
- Spain
- Prior art keywords
- present
- growth factor
- production
- new analogs
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000003102 growth factor Substances 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
SE PRESENTAN NUEVOS ANALOGOS PLATELED-DERIVADOS DEL FACTOR DEL CRECIMIENTO (PDFG), CONFORME A LA PRESENTE INVENCION. ASIMISMO SE PRESENTA UN METODO PARA LA PRODUCCION DE CANTIDADES HOMOGENEAS DE ESTOS NOVISIMOS ANALOGOS. LOS NUEVOS ANALOGOS DE LA PRESENTE INVENCION, CUANDO ESTAN REPLEGADOS, CONTIENEN SUBSTANCIALMENTE LA MISMA ACTIVIDAD BIOLOGICA QUE EN ESTADO NATURAL PDGF B SUB 109. EL METODO DE LA PRESENTE INVENCION EMPLEA EL USO DE UN CORDON DE BLOQUEO EN EL GENE C-SIS, U OTRA SECUENCIA CODIFICADA POR UNA PROTEINA PRECURSORA DE PDGF B SUB 109 O ANALOGOS EN UNA POSICION QUE CORRESPONDE CASI A UN AMINOACIDO 111, A CASI UN AMINOACIDO 160. EL METODO DE LA PRESENTE INVENCION, DA POR RESULTADO LA PRODUCCION DE CANTIDADES HOMOGENEAS RELATIVAMENTE AMPLIAS DE RECOMBINANTES PDGF B DESDE CELULAS PATRONES DE ELEVADA EXPRESION, COMO EL "COLI E".
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/454,794 US5149792A (en) | 1989-12-19 | 1989-12-19 | Platelet-derived growth factor B chain analogs |
| US07/624,451 US5272064A (en) | 1989-12-19 | 1990-12-13 | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2073735T3 true ES2073735T3 (es) | 1995-08-16 |
Family
ID=27037609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91902366T Expired - Lifetime ES2073735T3 (es) | 1989-12-19 | 1990-12-17 | Nuevos analogos de la cadena b del factor de crecimiento derivado de plaquetas y metodo para su produccion homogenea. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5272064A (es) |
| EP (1) | EP0458959B1 (es) |
| JP (1) | JPH04504064A (es) |
| AT (1) | ATE123949T1 (es) |
| AU (1) | AU646014B2 (es) |
| CA (1) | CA2032675A1 (es) |
| DE (1) | DE69020335T2 (es) |
| DK (1) | DK0458959T3 (es) |
| ES (1) | ES2073735T3 (es) |
| FI (1) | FI913892A0 (es) |
| GR (1) | GR3017317T3 (es) |
| IE (1) | IE904608A1 (es) |
| IL (1) | IL96723A0 (es) |
| NO (1) | NO913232D0 (es) |
| NZ (1) | NZ236549A (es) |
| PT (1) | PT96272A (es) |
| WO (1) | WO1991008761A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2130748A1 (en) * | 1992-02-26 | 1993-09-02 | Michael E. Stern | Use of platelet derived growth factor in ophthalmic wound healing |
| ZA932179B (en) * | 1992-03-30 | 1994-09-26 | Schering Corp | Monomeric platelet-derived growth factor and prevention of stenosis or restenosis |
| ES2557741T3 (es) | 2002-03-27 | 2016-01-28 | Immunex Corporation | Procedimientos para incrementar la producción de polipéptidos |
| AU2004209668A1 (en) * | 2003-02-04 | 2004-08-19 | Flanders Interuniversity Institute For Biotechnology | VEGF-B and PDGF modulation of stem cells |
| BR112012000865A2 (pt) | 2009-07-17 | 2019-09-24 | T Tabor Aaron | "composição e método para a modificação genética cosmética de células substancialmente intactas" |
| WO2012019160A1 (en) | 2010-08-05 | 2012-02-09 | Amgen Inc. | Dipeptides to enhance yield and viability from cell cultures |
| LT2699293T (lt) | 2011-04-20 | 2019-04-25 | Amgen Inc. | Automatinio purškimo prietaisas |
| US9133493B2 (en) | 2011-04-21 | 2015-09-15 | Amgen Inc. | Method for culturing mammalian cells to improve recombinant protein production |
| SI2726600T1 (sl) | 2011-07-01 | 2017-07-31 | Amgen Inc. | Sesalska celična kultura |
| WO2013033600A1 (en) | 2011-09-02 | 2013-03-07 | Amgen Inc. | Pharmaceutical product and method of analysing light exposure of a pharmaceutical product |
| AR089231A1 (es) | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
| US20150353542A1 (en) | 2013-01-14 | 2015-12-10 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
| PL3395423T3 (pl) | 2013-03-14 | 2024-03-18 | Amgen Inc. | Usuwanie wypłukanych ligandów do oczyszczania na zasadzie powinowactwa |
| TWI771890B (zh) | 2013-03-14 | 2022-07-21 | 美商安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
| US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
| TWI592183B (zh) | 2013-03-15 | 2017-07-21 | 安美基公司 | 本體輪廓可調適之自動注射器裝置 |
| US10492990B2 (en) | 2013-03-15 | 2019-12-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
| US9481901B2 (en) | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
| SI3063287T1 (sl) | 2013-10-31 | 2025-06-30 | Amgen, Inc. | Uporaba monenzina za regulacijo glikozilacije rekombinantnih proteinov |
| MX376230B (es) | 2014-01-13 | 2025-03-07 | Amgen Inc | Regulación del metábolismo de ornitina para manipular el contenido de glicoformas ricas en manosa de proteínas recombinantes. |
| CN106170554B (zh) | 2014-01-29 | 2021-08-17 | 美国安进公司 | 过表达n-糖基化途径调节基因以调节重组蛋白的糖基化 |
| US10106829B2 (en) | 2014-01-29 | 2018-10-23 | Amgen Inc. | Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins |
| KR102391259B1 (ko) | 2014-06-04 | 2022-04-26 | 암젠 인크 | 포유류 세포 배양물을 회수하는 방법 |
| ES2962593T3 (es) | 2014-11-19 | 2024-03-20 | Amgen Inc | Cuantificación de resto glucano en glucoproteínas recombinantes |
| CA2969225C (en) | 2014-12-01 | 2023-08-22 | Amgen Inc. | Process for manipulating the level of glycan content of a glycoprotein |
| JP7747438B2 (ja) | 2017-11-16 | 2025-10-01 | アムジエン・インコーポレーテツド | 失速及び終点検出を有するオートインジェクタ |
| IL307155B2 (en) | 2018-05-01 | 2025-11-01 | Amgen Inc | Antibodies with modulated glycan profiles |
| TWI777364B (zh) | 2020-01-15 | 2022-09-11 | 大陸商上海藥明生物技術有限公司 | 連續收穫由培養的細胞生產的生物物質的設備和方法 |
| WO2023079058A1 (en) | 2021-11-05 | 2023-05-11 | Yokogawa Insilico Biotechnology Gmbh | Cell culture with reduced production of lactate |
| KR20240128067A (ko) | 2021-12-29 | 2024-08-23 | 브리스톨-마이어스 스큅 컴퍼니 | 랜딩 패드 세포주의 생성 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4479896A (en) * | 1981-12-11 | 1984-10-30 | Antoniades Harry N | Method for extraction localization and direct recovery of platelet derived growth factor |
| US4769328A (en) * | 1984-10-12 | 1988-09-06 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in yeast |
| US4801542A (en) * | 1984-10-12 | 1989-01-31 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4766073A (en) * | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| EP0487116B1 (en) * | 1984-10-12 | 1999-12-29 | ZymoGenetics, Inc. | Biologically active PDGF analogs in eucaryotic cells |
| ATE131532T1 (de) * | 1986-08-13 | 1995-12-15 | Zymogenetics Inc | Expression von biologisch-aktiven pdgf-analogen in eukaryotischen zellen |
| DE3834079A1 (de) * | 1988-10-06 | 1990-04-12 | Biotechnolog Forschung Gmbh | Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren |
| IL96682A0 (en) * | 1989-12-15 | 1991-09-16 | Amgen Inc | Production of biologically active platelet-derived growth factor from high expression host cell systems |
-
1990
- 1990-12-13 US US07/624,451 patent/US5272064A/en not_active Expired - Lifetime
- 1990-12-17 DK DK91902366.3T patent/DK0458959T3/da active
- 1990-12-17 FI FI913892A patent/FI913892A0/fi not_active Application Discontinuation
- 1990-12-17 DE DE69020335T patent/DE69020335T2/de not_active Expired - Fee Related
- 1990-12-17 AU AU71534/91A patent/AU646014B2/en not_active Ceased
- 1990-12-17 AT AT91902366T patent/ATE123949T1/de not_active IP Right Cessation
- 1990-12-17 WO PCT/US1990/007451 patent/WO1991008761A1/en not_active Ceased
- 1990-12-17 EP EP91902366A patent/EP0458959B1/en not_active Expired - Lifetime
- 1990-12-17 JP JP3502837A patent/JPH04504064A/ja active Pending
- 1990-12-17 ES ES91902366T patent/ES2073735T3/es not_active Expired - Lifetime
- 1990-12-19 IL IL96723A patent/IL96723A0/xx unknown
- 1990-12-19 IE IE460890A patent/IE904608A1/en unknown
- 1990-12-19 PT PT96272A patent/PT96272A/pt not_active Application Discontinuation
- 1990-12-19 CA CA002032675A patent/CA2032675A1/en not_active Abandoned
- 1990-12-19 NZ NZ236549A patent/NZ236549A/xx unknown
-
1991
- 1991-08-19 NO NO913232A patent/NO913232D0/no unknown
-
1995
- 1995-09-06 GR GR950402446T patent/GR3017317T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991008761A1 (en) | 1991-06-27 |
| NO913232L (no) | 1991-08-19 |
| AU7153491A (en) | 1991-07-18 |
| FI913892A7 (fi) | 1991-08-16 |
| GR3017317T3 (en) | 1995-12-31 |
| DK0458959T3 (da) | 1995-08-14 |
| CA2032675A1 (en) | 1991-06-20 |
| IE904608A1 (en) | 1991-06-19 |
| NO913232D0 (no) | 1991-08-19 |
| EP0458959A1 (en) | 1991-12-04 |
| NZ236549A (en) | 1993-03-26 |
| JPH04504064A (ja) | 1992-07-23 |
| PT96272A (pt) | 1991-09-30 |
| US5272064A (en) | 1993-12-21 |
| DE69020335D1 (de) | 1995-07-27 |
| EP0458959A4 (en) | 1993-06-16 |
| ATE123949T1 (de) | 1995-07-15 |
| FI913892A0 (fi) | 1991-08-16 |
| IL96723A0 (en) | 1991-09-16 |
| AU646014B2 (en) | 1994-02-03 |
| DE69020335T2 (de) | 1995-11-02 |
| EP0458959B1 (en) | 1995-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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