NO913232L - Nye blodplatederiverte vekstfaktor-b-kjedeanaloger og metode for homogen produksjon av disse. - Google Patents

Nye blodplatederiverte vekstfaktor-b-kjedeanaloger og metode for homogen produksjon av disse.

Info

Publication number
NO913232L
NO913232L NO91913232A NO913232A NO913232L NO 913232 L NO913232 L NO 913232L NO 91913232 A NO91913232 A NO 91913232A NO 913232 A NO913232 A NO 913232A NO 913232 L NO913232 L NO 913232L
Authority
NO
Norway
Prior art keywords
analogs
production
growth factor
derived growth
pdgf
Prior art date
Application number
NO91913232A
Other languages
English (en)
Other versions
NO913232D0 (no
Inventor
Arlen Read Thomason
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/454,794 external-priority patent/US5149792A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of NO913232L publication Critical patent/NO913232L/no
Publication of NO913232D0 publication Critical patent/NO913232D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Nye blodplatederiverte vekst- faktoranaloger. De nye analoger har, når renaturert, i alt vesentlig samme biologiske aktivitet som naturlig fore- kommende PDGF-B109. Fremgangsmåten be- nytter bruk av et stoppkodon i c-sis- genet, eller annen kodende sekvens for et forløperprotein for PDGF-B109, eller analoger av dette, i en posisjon som tilsvarer tilnærmet aminosyre 111 til aminosyre 160. Fremgangsmåten resul- terer i produksjon av relativt store homogene mengder av rekombinant PDGF-B- analoger fra høyekspresjonsvertceller, som f.eks. E. coli. En fremgangsmåte .for produksjon av homogene mengder av disse nye analoger er også beskrevet.
NO913232A 1989-12-19 1991-08-19 Nye blodplatederiverte vekstfaktor-b-kjedeanaloger og metode for homogen produksjon av disse. NO913232D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/454,794 US5149792A (en) 1989-12-19 1989-12-19 Platelet-derived growth factor B chain analogs
US07/624,451 US5272064A (en) 1989-12-19 1990-12-13 DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
PCT/US1990/007451 WO1991008761A1 (en) 1989-12-19 1990-12-17 Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof

Publications (2)

Publication Number Publication Date
NO913232L true NO913232L (no) 1991-08-19
NO913232D0 NO913232D0 (no) 1991-08-19

Family

ID=27037609

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913232A NO913232D0 (no) 1989-12-19 1991-08-19 Nye blodplatederiverte vekstfaktor-b-kjedeanaloger og metode for homogen produksjon av disse.

Country Status (17)

Country Link
US (1) US5272064A (no)
EP (1) EP0458959B1 (no)
JP (1) JPH04504064A (no)
AT (1) ATE123949T1 (no)
AU (1) AU646014B2 (no)
CA (1) CA2032675A1 (no)
DE (1) DE69020335T2 (no)
DK (1) DK0458959T3 (no)
ES (1) ES2073735T3 (no)
FI (1) FI913892A0 (no)
GR (1) GR3017317T3 (no)
IE (1) IE904608A1 (no)
IL (1) IL96723A0 (no)
NO (1) NO913232D0 (no)
NZ (1) NZ236549A (no)
PT (1) PT96272A (no)
WO (1) WO1991008761A1 (no)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
EP0639980A1 (en) * 1992-02-26 1995-03-01 Allergan, Inc. Use of platelet derived growth factor in ophthalmic wound healing
WO1993020204A1 (en) * 1992-03-30 1993-10-14 Schering Corporation Monomeric platelet-derived growth factor and prevention of stenosis or restenosis
WO2003083066A2 (en) 2002-03-27 2003-10-09 Immunex Corporation Methods for increasing polypeptide production
EP1594527A2 (en) * 2003-02-04 2005-11-16 Ludwig Institute For Cancer Research Vegf-b and pdgf modulation of stem cells
US9132202B2 (en) 2009-07-17 2015-09-15 Aaron T. Tabor Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
EP2601287B1 (en) 2010-08-05 2015-01-07 Amgen Inc. Dipeptides to enhance yield and viability from cell cultures
CA3021845C (en) 2011-04-20 2022-03-29 Amgen Inc. Autoinjector apparatus
WO2012145682A1 (en) 2011-04-21 2012-10-26 Amgen Inc. A method for culturing mammalian cells to improve recombinant protein production
KR101662412B1 (ko) 2011-07-01 2016-10-04 암젠 인크 포유동물 세포 배양
KR20140058669A (ko) 2011-09-02 2014-05-14 암젠 인크 의약품 및 의약품의 광 노출을 분석하는 방법
AR089231A1 (es) 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
TWI625390B (zh) 2013-03-14 2018-06-01 安美基公司 用於增加重組蛋白質之甘露糖含量之方法
AU2014240596B2 (en) 2013-03-14 2018-09-27 Amgen Inc. Removal of leaked affinity purification ligand
EP2968775B1 (en) 2013-03-15 2019-12-18 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
CN105142695B (zh) 2013-03-15 2020-06-02 安进公司 身体轮廓可调适的自动注射器装置
TWI580451B (zh) 2013-03-15 2017-05-01 安美基公司 用於注射器之匣盒及使用具有自動注射器及匣盒之自動注射器設備之方法
US9481901B2 (en) 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins
ES3030960T3 (en) 2013-10-31 2025-07-02 Amgen Inc Use of monensin to regulate glycosylation of recombinant proteins
MX376230B (es) 2014-01-13 2025-03-07 Amgen Inc Regulación del metábolismo de ornitina para manipular el contenido de glicoformas ricas en manosa de proteínas recombinantes.
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
BR112016017606A2 (pt) 2014-01-29 2017-10-10 Amgen Inc superexpressão de reguladores de via de n-glicosilação para modular a glicosilação de proteínas recombinantes
SG10202113019XA (en) 2014-06-04 2021-12-30 Amgen Inc Methods for harvesting mammalian cell cultures
US11275090B2 (en) 2014-11-19 2022-03-15 Amgen Inc. Quantitation of glycan moiety in recombinant glycoproteins
PL3227454T3 (pl) 2014-12-01 2020-07-27 Amgen Inc. Sposób manipulowania poziomem zawartości glikanów w glikoproteinie
AU2018368338B2 (en) 2017-11-16 2024-07-25 Amgen Inc. Autoinjector with stall and end point detection
IL321253A (en) 2018-05-01 2025-08-01 Amgen Inc Antibodies with a modulated glycan profile
WO2021143699A1 (en) 2020-01-15 2021-07-22 Wuxi Biologics (Shanghai) Co. Ltd. An apparatus and a method for continuously harvesting a biological substance produced by a cultured cell
WO2023079058A1 (en) 2021-11-05 2023-05-11 Yokogawa Insilico Biotechnology Gmbh Cell culture with reduced production of lactate
EP4457342A1 (en) 2021-12-29 2024-11-06 Bristol-Myers Squibb Company Generation of landing pad cell lines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479896A (en) * 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor
US4801542A (en) * 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4769328A (en) * 1984-10-12 1988-09-06 Zymogenetics Inc. Expression of biologically active PDGF analogs in yeast
EP0487116B1 (en) * 1984-10-12 1999-12-29 ZymoGenetics, Inc. Biologically active PDGF analogs in eucaryotic cells
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
EP0259632B1 (en) * 1986-08-13 1995-12-13 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
DE3834079A1 (de) * 1988-10-06 1990-04-12 Biotechnolog Forschung Gmbh Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems

Also Published As

Publication number Publication date
FI913892A7 (fi) 1991-08-16
IE904608A1 (en) 1991-06-19
AU646014B2 (en) 1994-02-03
DE69020335D1 (de) 1995-07-27
EP0458959B1 (en) 1995-06-21
PT96272A (pt) 1991-09-30
ATE123949T1 (de) 1995-07-15
JPH04504064A (ja) 1992-07-23
ES2073735T3 (es) 1995-08-16
IL96723A0 (en) 1991-09-16
FI913892A0 (fi) 1991-08-16
US5272064A (en) 1993-12-21
DE69020335T2 (de) 1995-11-02
CA2032675A1 (en) 1991-06-20
GR3017317T3 (en) 1995-12-31
AU7153491A (en) 1991-07-18
EP0458959A1 (en) 1991-12-04
NO913232D0 (no) 1991-08-19
NZ236549A (en) 1993-03-26
WO1991008761A1 (en) 1991-06-27
DK0458959T3 (da) 1995-08-14
EP0458959A4 (en) 1993-06-16

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