ES2091012T3 - Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas. - Google Patents

Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas.

Info

Publication number
ES2091012T3
ES2091012T3 ES93913149T ES93913149T ES2091012T3 ES 2091012 T3 ES2091012 T3 ES 2091012T3 ES 93913149 T ES93913149 T ES 93913149T ES 93913149 T ES93913149 T ES 93913149T ES 2091012 T3 ES2091012 T3 ES 2091012T3
Authority
ES
Spain
Prior art keywords
cyclodextrin
preparation
nanospheres
systems based
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93913149T
Other languages
English (en)
Inventor
Mohamed Skiba
Denis Wouessidjewe
Antony Coleman
Hatem Fessi
Jean-Philippe Devissaguet
Dominique Duchene
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2091012T3 publication Critical patent/ES2091012T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/14—Layer or component removable to expose adhesive
    • Y10T428/1405—Capsule or particulate matter containing [e.g., sphere, flake, microballoon, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

LA PREPARACION DEL SISTEMA NANOPARTICULADO SE CARACTERIZA, SEGUN EL INVENTO, PORQUE: 1) SE PREPARA UNA FASE LIQUIDA CONSTITUIDA BASICAMENTE DE UNA SOLUCION DE CICLODEXTRINA MODIFICADA POR GRUPOS ACILO EN UN DISOLVENTE O MEZCLA DE DISOLVENTES ORGANICO(S) Y PUDIENDO AÑADIRLE UNA MOLECULA ACTIVA; 2) SE PREPARA UNA SEGUNDA FASE LIQUIDA CONSTITUIDA BASICAMENTE POR AGUA O MEZCLA ACUOSA, PUDIENDO CONTENER UNO O VARIOS AGENTES TENSOACTIVOS Y PUDIENDO AÑADIRLE UNA MOLECULA ACTIVA; 3) SE AÑADE BAJO AGITACION MODERADA UNA DE LAS FASES LIQUIDAS OBTENIDAS POR 1) O 2) EN LA OTRA, DE MODO QUE SE OBTENGA PRACTICAMENTE AL INSTANTE UNA SUSPENSION COLOIDAL DE NANOESFERAS DE CICLODEXTRINA MODIFICADA. EN CASO CONTRARIO, SE ELIMINA TODO O PARTE DEL DISOLVENTE Y DEL AGUA. SE APLICA A VECTORES DE PRODUCTOS QUIMICOS, FARMACEUTICOS, COSMETICOS, ETC.
ES93913149T 1992-06-16 1993-06-16 Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas. Expired - Lifetime ES2091012T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9207287A FR2692168B1 (fr) 1992-06-16 1992-06-16 Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.

Publications (1)

Publication Number Publication Date
ES2091012T3 true ES2091012T3 (es) 1996-10-16

Family

ID=9430801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93913149T Expired - Lifetime ES2091012T3 (es) 1992-06-16 1993-06-16 Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas.

Country Status (8)

Country Link
US (1) US5718905A (es)
EP (1) EP0646003B1 (es)
JP (1) JPH07507784A (es)
AT (1) ATE141161T1 (es)
DE (1) DE69304065T2 (es)
ES (1) ES2091012T3 (es)
FR (1) FR2692168B1 (es)
WO (1) WO1993025195A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070117862A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5576311A (en) * 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
ATE212545T1 (de) * 1995-03-28 2002-02-15 Fidia Advanced Biopolymers Srl Nanosphären mit einem biokompatiblen polysaccharid
FR2742677B1 (fr) 1995-12-21 1998-01-16 Oreal Nanoparticules enrobees d'une phase lamellaire a base de tensioactif silicone et compositions les contenant
US20070092563A1 (en) 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
BRPI9810945B8 (pt) * 1997-06-27 2021-05-25 Abraxis Bioscience Inc formulações de agentes farmacológicos, métodos para sua preparação e métodos para uso das mesmas
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
SG165156A1 (en) * 1997-06-27 2010-10-28 Abraxis Bioscience Llc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
FR2775435B1 (fr) * 1998-02-27 2000-05-26 Bioalliance Pharma Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs
GB9805417D0 (en) * 1998-03-14 1998-05-06 Core Technologies Limited Production of microparticles
US6344218B1 (en) 1998-11-23 2002-02-05 The Procter & Gamble Company Skin deodorizing and santizing compositions
US6177088B1 (en) 1999-01-07 2001-01-23 Fayette Environmental Services, Inc. Surface-functionalized, probe-containing nanospheres
US6653524B2 (en) 1999-12-23 2003-11-25 Kimberly-Clark Worldwide, Inc. Nonwoven materials with time release additives
CN1439023A (zh) * 2000-04-28 2003-08-27 国立爱尔兰都柏林大学 两亲大环衍生物及其类似物
WO2001085218A2 (en) * 2000-05-11 2001-11-15 Eastman Chemical Company Acylated cyclodextrin guest inclusion complexes
FR2808691B1 (fr) * 2000-05-12 2005-06-24 Coletica Cyclodextrines substituees preferentiellement sur leur face primaire par des fonctions acide ou amine
ES2306684T3 (es) * 2001-09-17 2008-11-16 Nanopart-C S.A. Nuevo sistema coloidal dispersable a base de calixareno en forma de nanoparticulas.
US7879820B2 (en) * 2002-04-22 2011-02-01 L'oreal S.A. Use of a cyclodextrin as pearlescent agent and pearlescent compositions
WO2004006959A1 (en) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd Liquid dosage compositions of stable nanoparticulate active agents
WO2005044224A2 (en) * 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
SE0303179D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
JP2007533747A (ja) * 2004-04-20 2007-11-22 ダウ・コーニング・コーポレイション 活性剤を含むシリコーン小胞
WO2006038552A1 (ja) * 2004-10-01 2006-04-13 Eisai R & D Management Co., Ltd. 微粒子含有組成物およびその製造方法
FR2895257A1 (fr) * 2005-12-22 2007-06-29 Oreal Actif pour le traitement du contour des yeux.
FR2898817B1 (fr) * 2006-03-23 2008-08-08 Univ Rouen Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines
EP2077858A4 (en) 2006-12-06 2011-07-20 Medimmune Llc INTERFERON ALPHA-INDUCED PHARMACODYNAMIC MARKERS
FR2910345A1 (fr) 2006-12-20 2008-06-27 Oreal Particules coeur/ecorce a base de composes silicones
EP2076590A4 (en) 2007-05-03 2011-06-01 Medimmune Llc SELF-IMMUNE DISEASE SELF-ANTIBODY MARKERS
ITMI20081056A1 (it) * 2008-06-10 2009-12-11 Sea Marconi Technologies Sas Nanospugne a base di ciclodestrine come supporto per catalizzatori biologici e nella veicolazione e rilascio di enzimi, proteine, vaccini ed anticorpi
CA2763365C (en) 2009-05-29 2016-09-13 Cydex Pharmaceuticals, Inc. Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
ITTO20110884A1 (it) * 2011-10-04 2013-04-05 Univ Degli Studi Torino Membrana per nanocapsula, nanocapsula comprendente la stessa e suo uso
EP2838653A4 (en) * 2012-04-18 2015-11-25 Cerulean Pharma Inc Methods and systems for polymer precipitation and generation of particles
US11406595B2 (en) * 2012-05-21 2022-08-09 University Of Maryland, College Park Highly stable colloid from aqueous solutions of small organic molecules
WO2014015027A1 (en) 2012-07-18 2014-01-23 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
CN116508750B (zh) * 2023-03-31 2024-09-20 南宁师范大学 环糊精酯的应用和方法、含环糊精酯的农药制剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204244L (sv) * 1982-07-09 1984-01-10 Ulf Schroder Kristalliserad kolhydratsmatris for biologiskt aktiva substanser
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules

Also Published As

Publication number Publication date
WO1993025195A1 (fr) 1993-12-23
EP0646003B1 (fr) 1996-08-14
JPH07507784A (ja) 1995-08-31
DE69304065D1 (de) 1996-09-19
EP0646003A1 (fr) 1995-04-05
ATE141161T1 (de) 1996-08-15
US5718905A (en) 1998-02-17
DE69304065T2 (de) 1997-03-20
FR2692168A1 (fr) 1993-12-17
FR2692168B1 (fr) 1995-03-24

Similar Documents

Publication Publication Date Title
ES2091012T3 (es) Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas.
ATE139439T1 (de) Pharmazeutische formulierung und pharmazeutisches verfahren
MX9203504A (es) Complejo agente: lipido activo de alta proporcion.
ES2031151T3 (es) Procedimiento de preparacion de sistemas coloidales dispersables de una substancia, en forma de particulas esfericas de tipo matricial.
ATE26298T1 (de) Fluessige detergenszusammensetzung.
PE87199A1 (es) Un polisacarido modificado hidrofobicamente para productos del cuidado personal
KR870006893A (ko) 고점성 하이드로겔 또는 그 현탁액의 약학적 제제
ES2115945T3 (es) Preparaciones topicas cosmeticas y medicinales.
EP0731712A4 (en) PHYSIOLOGICALLY STABLE COMPOSITIONS OF BUTYRIC ACID, SALTS AND BUTYRIC ACID DERIVATIVES AS ANTINEOPLASTIC AGENTS
KR830002327A (ko) 약학적 제제
IT1201149B (it) Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
ES2193685T3 (es) Preparados cosmeticos o dermatologicos fluidos, de bajo contenido en lipidos.
NL7708741A (nl) Werkwijze ter bereiding van prostaanzuurderiva- ten alsmede farmaceutische preparaten die deze derivaten als actieve component bevatten.
DE69418468D1 (de) Viskoelastische zusammensetzungen aus organischen fluorierten verbindungen
NL7507268A (nl) Werkwijze ter bereiding van 1(alpha),24-dihydroxy-chole- calciferolen, alsmede derivaten en voorlopers daar- van , alsmede farmaceutische preparaten die deze ver- bindingen als actieve componenten bevatten.
AR008355A1 (es) COMPOSICIoN FARMACÉUTICA PARA ADMINISTRACIoN ORAL, USO, CREMA FARMACEUTICA PARA ADMINISTRACIoN TOPICA Y SUSPENSIoN LIQUIDA PARA ADMINISTRACIoN ORAL.
DK0634925T3 (da) Supermættede topiske præparater
GB946086A (en) Parenteral aqueous solutions of fat-soluble vitamins
CU22836A3 (es) Sistema de gel de nimesulida para uso tópico
BR0008713A (pt) Processos para preparar formulações ecomposições farmacêuticas orais com ecb
DE69005398D1 (de) Topisch kosmetisch anzuwendende depolymerisierte Nukleinsäuren enthaltende Arzneizubereitungen.
ES2083291T3 (es) Preparacion y aplicacion de nuevos sistemas coloidales nanovesiculares dispersables a base de ciclodextrina, en forma de nanocapsulas.
PT85053A (de) Peptide mit einfluss auf die diurese und natriurese verfahren zu ihrer herstellung diese enthaltende mittel und ihre verwendung
DE58903964D1 (de) Fluessige orale formulierung.
HRP20020332B1 (hr) Oralne otopine koje sadrže galantamin i sladilo

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 646003

Country of ref document: ES

FG2A Definitive protection

Ref document number: 646003

Country of ref document: ES