ES2104914T3 - Formas truncadas del factor de crecimiento de hepatocitos (hgf). - Google Patents

Formas truncadas del factor de crecimiento de hepatocitos (hgf).

Info

Publication number
ES2104914T3
ES2104914T3 ES92909513T ES92909513T ES2104914T3 ES 2104914 T3 ES2104914 T3 ES 2104914T3 ES 92909513 T ES92909513 T ES 92909513T ES 92909513 T ES92909513 T ES 92909513T ES 2104914 T3 ES2104914 T3 ES 2104914T3
Authority
ES
Spain
Prior art keywords
growth factor
hepatocites
hgf
chain
truncated forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92909513T
Other languages
English (en)
Inventor
Paolo Comoglio
Tiziana Crepaldi
Maria Prat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110202A external-priority patent/GB9110202D0/en
Priority claimed from GB919124896A external-priority patent/GB9124896D0/en
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2104914T3 publication Critical patent/ES2104914T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

UNA PROTEINA QUE ES UTIL COMO ANTAGONISTA DEL FACTOR DE CRECIMIENTO DE HEPATOCITO, SE COMPONE DE OS CADENAS ENLAZADAS DE DISULFURO DE 50 KDA Y 75 O 85 KDA RESPECTIVAMENTE, SIENDO LA CADENA DE 50KDA LA CADENA ALFA DE LA QUINANA DE TIROSINA CODIFICADA POR EL PROTOONCOGEN MET Y SIENDO LA CADENA DE 75 O 85 KDA UNA FORMA TRUNCADA TERMINAL C DE LA CADENA BETA DE DICHA QUINASA DE TIROSINA.
ES92909513T 1991-05-10 1992-04-30 Formas truncadas del factor de crecimiento de hepatocitos (hgf). Expired - Lifetime ES2104914T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110202A GB9110202D0 (en) 1991-05-10 1991-05-10 Truncated forms of the hepatocyte growth factor(hgf)receptor
GB919124896A GB9124896D0 (en) 1991-11-22 1991-11-22 Truncated forms of the hepatocyte growth factor(hgf)receptor

Publications (1)

Publication Number Publication Date
ES2104914T3 true ES2104914T3 (es) 1997-10-16

Family

ID=26298888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92909513T Expired - Lifetime ES2104914T3 (es) 1991-05-10 1992-04-30 Formas truncadas del factor de crecimiento de hepatocitos (hgf).

Country Status (18)

Country Link
US (1) US5571509A (es)
EP (2) EP0584125B1 (es)
JP (1) JP3293823B2 (es)
AT (1) ATE155525T1 (es)
AU (1) AU651452B2 (es)
CA (1) CA2102595C (es)
DE (1) DE69220940T2 (es)
DK (1) DK0584125T3 (es)
ES (1) ES2104914T3 (es)
FI (1) FI934934A7 (es)
GR (1) GR3024998T3 (es)
HU (1) HUT67009A (es)
IE (1) IE921485A1 (es)
IL (1) IL101809A0 (es)
MX (1) MX9202129A (es)
MY (1) MY108614A (es)
NZ (1) NZ242645A (es)
WO (1) WO1992020792A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6344321B1 (en) * 1990-06-11 2002-02-05 Gilead Sciences, Inc. Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
KR950703003A (ko) * 1993-06-30 1995-08-23 비토리노 페라리오 미토게네시스 및 모토게네시스의 펩타이드 억제제(peptide inhibitors of mitogenesis and motogenesis)
US5464815A (en) * 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
US5646036A (en) * 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
WO1997009997A1 (en) * 1995-09-12 1997-03-20 Genentech, Inc. Cystic fibrosis therapy
WO1997012629A1 (en) * 1995-10-05 1997-04-10 Genentech, Inc. Improved angiogenesis using hepatocyte growth factor
AU7389496A (en) * 1995-10-05 1997-04-28 Genentech Inc. Methods and compositions for treating vascular stenosis
ATE465257T1 (de) * 1996-07-03 2010-05-15 Genentech Inc Agonisten für den rezeptor des hepatozyten- wachstumsfaktors und deren anwendungen
US5874306A (en) * 1996-12-12 1999-02-23 The Regents Of The University Of California Culturing human pancreatic endocrine cells in medium containing extracellular matrix from human bladder carcinoma cells
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US6031155A (en) * 1997-06-05 2000-02-29 Cameron-Mills; Verena Arabinoxylan degradation
AU2760602A (en) * 2001-03-23 2002-09-26 Agouron Pharmaceuticals, Inc. Catalytic domains of the human hepatocyte growth factor receptor tyrosine kinase, and materials and methods for identification of inhibitors thereof
US20030118585A1 (en) 2001-10-17 2003-06-26 Agy Therapeutics Use of protein biomolecular targets in the treatment and visualization of brain tumors
US7678769B2 (en) * 2001-09-14 2010-03-16 Compugen, Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
US20070082337A1 (en) * 2004-01-27 2007-04-12 Compugen Ltd. Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby
US20040248157A1 (en) * 2001-09-14 2004-12-09 Michal Ayalon-Soffer Novel polynucleotides encoding soluble polypeptides and methods using same
US20100183573A1 (en) * 2001-09-14 2010-07-22 Compugen Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
WO2007036945A2 (en) * 2005-09-30 2007-04-05 Compugen Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
ITMI20031127A1 (it) * 2003-06-05 2004-12-06 Uni Degli Studi Del Piemont E Orientale Am Anticorpi anti-hgf-r e loro uso
WO2005001486A1 (en) * 2003-06-06 2005-01-06 Genentech, Inc. Modulating the interaction between hgf beta chain and c-met
CN1922208A (zh) * 2003-12-11 2007-02-28 健泰科生物技术公司 用于抑制c－met二聚化及活化的方法和组合物
EP1713900A4 (en) * 2004-01-27 2009-06-17 Compugen Ltd METHOD AND SYSTEMS FOR COMMENTING BIOMOLECULAR SEQUENCES
ME01803B (me) 2004-08-05 2010-12-31 Genentech Inc Humanizovani anti-cmet antagonisti
RU2403261C2 (ru) 2005-04-15 2010-11-10 Дженентек, Инк. Варианты бета-цепи hgf
BRPI0709917A2 (pt) 2006-03-30 2011-07-05 Novartis Ag composições e métodos de uso para anticorpos de c-met
AU2009208607B2 (en) * 2008-01-31 2013-08-01 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
IL198545A0 (en) 2008-05-14 2011-07-31 Metheresis Translational Res Sa High affinity binding site of hgfr and methods for identification of antagonists thereof
PA8849001A1 (es) * 2008-11-21 2010-06-28 Lilly Co Eli Anticuerpos de c-met
KR101671378B1 (ko) * 2009-10-30 2016-11-01 삼성전자 주식회사 ｃ-Ｍｅｔ에 특이적으로 결합하는 항체 및 그의 용도
EP2588107A1 (en) 2010-07-01 2013-05-08 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
RU2013155695A (ru) 2011-06-30 2015-08-10 Дженентек, Инк. Препараты антител против с-мет
EP2758430A4 (en) 2011-09-20 2015-06-03 Lilly Co Eli ANTI-C-MET ANTIBODY
EP3122900A1 (en) 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Cancer treatment with c-met antagonists and correlation of the latter with hgf expression

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009974A1 (en) * 1989-12-27 1991-07-11 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Diagnostic probe for detecting human stomach cancer
US5648273A (en) * 1989-12-27 1997-07-15 The United States Of America, As Represented By The Department Of Health And Human Services Hepatic growth factor receptor is the MET proto-oncogene

Also Published As

Publication number Publication date
IL101809A0 (en) 1992-12-30
US5571509A (en) 1996-11-05
AU651452B2 (en) 1994-07-21
FI934934A0 (fi) 1993-11-08
DE69220940D1 (de) 1997-08-21
DK0584125T3 (da) 1997-09-08
EP0584125A1 (en) 1994-03-02
HUT67009A (en) 1995-01-30
MX9202129A (es) 1992-11-01
MY108614A (en) 1996-10-31
JP3293823B2 (ja) 2002-06-17
GR3024998T3 (en) 1998-01-30
EP0584125B1 (en) 1997-07-16
IE921485A1 (en) 1992-11-18
DE69220940T2 (de) 1998-01-15
ATE155525T1 (de) 1997-08-15
NZ242645A (en) 1994-11-25
JPH06508508A (ja) 1994-09-29
FI934934L (fi) 1994-01-05
WO1992020792A1 (en) 1992-11-26
AU1672092A (en) 1992-12-30
HU9303182D0 (en) 1994-03-28
CA2102595C (en) 2003-01-14
CA2102595A1 (en) 1992-11-11
EP0520158A1 (en) 1992-12-30
FI934934A7 (fi) 1994-01-05

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