ES2134388T3 - Combinaciones de antigenos del virus de la hepatitis c (hcv) para su uso en inmunoensayos para anticuerpos anti-hcv. - Google Patents
Combinaciones de antigenos del virus de la hepatitis c (hcv) para su uso en inmunoensayos para anticuerpos anti-hcv.Info
- Publication number
- ES2134388T3 ES2134388T3 ES95114016T ES95114016T ES2134388T3 ES 2134388 T3 ES2134388 T3 ES 2134388T3 ES 95114016 T ES95114016 T ES 95114016T ES 95114016 T ES95114016 T ES 95114016T ES 2134388 T3 ES2134388 T3 ES 2134388T3
- Authority
- ES
- Spain
- Prior art keywords
- hcv
- combinations
- immuno
- hepatitis
- assays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pinball Game Machines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Thermistors And Varistors (AREA)
Abstract
SE PRESENTAN COMBINACIONES DE ANTIGENOS HCV QUE TIENEN UNA GAMA MAS AMPLIA DE REACTIVIDAD INMUNOLOGICA QUE CUALQUIER ANTIGENO HCV SIMPLE. LAS COMBINACIONES CONSTAN DE UN ANTIGENO DEL DOMINANTE C DE LA POLIPROTEINA DEL HCV, Y UN ANTIGENO ADICIONAL DEL HCV DEL DOMINANTE S, OPCIONALMENTE CON UN ANTIGENO ADICIONAL PARA CUALQUIERA DE LOS DOMINANTES NS3, NS4 O NS5, Y TIENEN LA FORMA DE UNA PROTEINA DE FUSION, UNA MEZCLA FISICA SIMPLE, O DE LOS ANTIGENOS INDIVIDUALES COMUNMENTE UNIDOS A UNA MATRIZ SOLIDA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50435290A | 1990-04-04 | 1990-04-04 | |
| US504352 | 1990-04-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2134388T3 true ES2134388T3 (es) | 1999-10-01 |
| ES2134388T5 ES2134388T5 (es) | 2008-12-01 |
Family
ID=24005897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95114016T Expired - Lifetime ES2134388T5 (es) | 1990-04-04 | 1991-04-03 | Combinaciones de antigenos del virus de la hepatitis c (hcv) para su uso en inmunoensayos para anticuerpos anti-hcv. |
| ES91302910T Expired - Lifetime ES2088465T3 (es) | 1990-04-04 | 1991-04-03 | Combinaciones de antigenos del virus c de la hepatitis (hcv) para uso en inmunoensayos para anticuerpos anti-hcv. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91302910T Expired - Lifetime ES2088465T3 (es) | 1990-04-04 | 1991-04-03 | Combinaciones de antigenos del virus c de la hepatitis (hcv) para uso en inmunoensayos para anticuerpos anti-hcv. |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP0693687B2 (es) |
| JP (1) | JP2733138B2 (es) |
| KR (1) | KR100206150B1 (es) |
| AT (2) | ATE182684T1 (es) |
| BG (1) | BG61291B1 (es) |
| BR (1) | BR9106309A (es) |
| CY (1) | CY1881A (es) |
| DE (2) | DE69131488T2 (es) |
| DK (2) | DK0693687T4 (es) |
| ES (2) | ES2134388T5 (es) |
| FI (1) | FI106317B (es) |
| GB (1) | GB2257784B (es) |
| GR (2) | GR3020964T3 (es) |
| HU (1) | HU217025B (es) |
| IE (1) | IE911105A1 (es) |
| IL (2) | IL170719A (es) |
| LT (1) | LT3808B (es) |
| LV (2) | LV10344A (es) |
| MY (1) | MY107499A (es) |
| NO (1) | NO310241B1 (es) |
| PL (1) | PL172133B1 (es) |
| RO (1) | RO109916B1 (es) |
| RU (1) | RU2130969C1 (es) |
| UA (1) | UA41266C2 (es) |
| WO (1) | WO1991015771A1 (es) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR1001261B (el) | 1989-12-18 | 1993-06-30 | Wellcome Found | Ιϊκός παράγων. |
| US7166287B1 (en) | 1989-12-18 | 2007-01-23 | Glaxo Wellcome Inc. | Viral agent |
| KR940000755B1 (ko) * | 1990-02-16 | 1994-01-29 | 유나이티드 바이오메디칼 인코오포레이티드 | Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드 |
| US6194140B1 (en) | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| DE69132332T2 (de) * | 1990-04-06 | 2000-11-30 | Genelabs Technologies, Inc. | Hepatitis c-virus-epitope |
| CA2049679C (en) * | 1990-08-24 | 2005-06-21 | Sushil G. Devare | Hepatitis c assay utilizing recombinant antigens |
| SK286106B6 (sk) * | 1990-11-08 | 2008-03-05 | Novartis Vaccines & Diagnostics, Inc. | Spôsob vykonávania imunodiagnostickej skúšky na detekciu protilátky proti vírusu hepatitídy C |
| US6274148B1 (en) * | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
| DK0644202T3 (da) * | 1990-12-14 | 1997-09-15 | Innogenetics Nv | Syntetiske antigener til påvisning af antistoffer imod hepatitis C virus |
| US5910404A (en) | 1990-12-14 | 1999-06-08 | Innogenetics N.V. | Synthetic antigens for the detection of antibodies to hepatitis C virus |
| US6007982A (en) * | 1990-12-14 | 1999-12-28 | Innogenetics N.V. | Synthetic antigens for the detection of antibodies to hepatitis C virus |
| DE4041304A1 (de) * | 1990-12-21 | 1992-06-25 | Mikrogen Molekularbiol Entw | Von strukturproteinen des hepatitis c-virus abgeleitete polypeptide, testkits, die diese polypeptide enthalten und impfstoffe gegen infektionen von hepatitis c-viren |
| US5574132A (en) * | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
| EP0573624A4 (en) * | 1991-11-07 | 1997-09-17 | Baxter Diagnostics Inc | Epitope mapping ot the c33c region of hcv |
| EP0610436B9 (en) * | 1991-11-21 | 2003-03-26 | Common Services Agency | Hepatitis-c virus testing |
| DK0625204T3 (da) * | 1992-02-04 | 2002-07-15 | Chiron Corp | Terapeutiske midler mod hepatitis |
| GB9203803D0 (en) * | 1992-02-21 | 1992-04-08 | Wellcome Found | A recombinant polypeptide |
| UA39944C2 (uk) * | 1992-07-07 | 2001-07-16 | Чірон Корпорейшн | Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі |
| EP0593291A3 (en) * | 1992-10-16 | 1995-03-15 | Evernew Biotech Inc | Non-structural protein of the hepatitis C virus, as well as diagnostic procedure and test kit. |
| US6153378A (en) * | 1992-10-16 | 2000-11-28 | Bionova Corporation | Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus |
| JP2778886B2 (ja) * | 1992-10-16 | 1998-07-23 | エバーニュー バイオテック インコーポレイティド | C型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット |
| WO1994013164A1 (en) | 1992-12-10 | 1994-06-23 | Nike International Ltd. | Bonding of rubber to plastic in footwear |
| KR100312534B1 (ko) | 1993-04-28 | 2002-05-13 | 성재갑 | 씨(c)형간염및비(b)형간염동시측정면역블롯검정키트및면역블롯검정법 |
| DK0698216T4 (da) * | 1993-05-10 | 2009-06-15 | Novartis Vaccines & Diagnostic | Fremgangsmåder til typebestemmelse af hepatitis-C-virus og anvendte reagenser heri |
| DE4428705A1 (de) | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus |
| JPH0862219A (ja) * | 1994-08-19 | 1996-03-08 | Dainabotsuto Kk | 還元型抗原に対する抗体アッセイ試薬及びそれを使用した測定方法 |
| JP3665371B2 (ja) * | 1994-08-31 | 2005-06-29 | 株式会社先端生命科学研究所 | C型肝炎ウイルス感染又はグループ判定のためのエピトープキメラ抗原ペプチド、その製法、及びそれを使用する感染又はグループ判定法 |
| CA2172305A1 (en) * | 1995-03-30 | 1996-10-01 | Muneo Aoyama | Multiple antigenic peptide comprising at least two hepatitis c virus-associated peptides |
| AU5924396A (en) * | 1995-05-22 | 1996-12-11 | Bionova Corporation | Compositions and methods for the diagnosis of, and vaccinati on against, hepatitis c virus (hcv) |
| FR2734639B1 (fr) * | 1995-05-26 | 1997-10-03 | Parteurop | Methode de pronostic de l'evolution d'une infection par le virus de l'hepatite c, et necessaire pour sa mise en oeuvre |
| FR2737209B1 (fr) | 1995-07-25 | 1997-09-19 | Bio Merieux | Peptide capable d'etre reconnu par des anticorps reconnaissant l'antigene c33 du virus de l'hepatite c |
| US6127116A (en) | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| JP3715027B2 (ja) | 1996-05-07 | 2005-11-09 | シスメックス株式会社 | C型肝炎ウイルス感染症診断薬 |
| US7049428B1 (en) | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
| US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
| DE69837155T2 (de) * | 1997-09-22 | 2007-06-21 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zum nachweiss von antikörpern in einer probe |
| AU6098900A (en) * | 1999-07-15 | 2001-02-05 | Bayer Corporation | The use of specific antibody titers to predict hepatic failure in people infected with hepatitis c virus |
| AU1236801A (en) | 1999-10-27 | 2001-05-08 | Chiron Corporation | Activation of hcv-specific t cells |
| RU2179726C2 (ru) * | 1999-11-17 | 2002-02-20 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Способ изготовления контрольных панелей сывороток для контроля качества диагностики гепатита в |
| US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
| WO2001038360A2 (en) * | 1999-11-24 | 2001-05-31 | Chiron Corporation | Novel hcv non-structural polypeptide |
| SI1354204T2 (sl) | 2000-06-15 | 2010-09-30 | Novartis Vaccines & Diagnostic | Hcv antigen antitelo kombinacijska analiza |
| US7491808B2 (en) | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
| RU2172489C1 (ru) * | 2000-07-26 | 2001-08-20 | Тверская государственная медицинская академия | Способ диагностики множественной миеломы |
| JP5175417B2 (ja) | 2000-08-17 | 2013-04-03 | トリペップ アクチ ボラゲット | リバビリンを含むワクチンおよびその使用方法 |
| US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| FR2839722A1 (fr) | 2002-05-17 | 2003-11-21 | Bio Merieux | Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c |
| RU2226694C2 (ru) * | 2002-05-30 | 2004-04-10 | Научно-исследовательский институт детских инфекций | Способ дифференциальной диагностики вирусного гепатита с |
| ES2312806T3 (es) | 2002-09-09 | 2009-03-01 | Novartis Vaccines And Diagnostics, Inc. | Ensayo de vhc. |
| WO2005123952A2 (en) | 2004-06-09 | 2005-12-29 | Pathogen Removal And Diagnostic Technologies Inc. | Particles embedded ina porous substrate for removing target analyte from a sample |
| RU2262704C1 (ru) * | 2004-10-06 | 2005-10-20 | Общество с ограниченной ответственностью Научно-производственное объединение "Диагностические системы" | Набор антигенов для определения антител к вирусу гепатита c "дс-hcv-антигены" |
| JP2005274584A (ja) * | 2005-05-25 | 2005-10-06 | Sysmex Corp | C型肝炎ウイルス感染症診断薬の製造方法 |
| JP4005093B2 (ja) * | 2005-05-25 | 2007-11-07 | シスメックス株式会社 | C型肝炎ウイルス感染症診断薬および抗hcv抗体検出方法 |
| CA2618429A1 (en) | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
| RU2327170C2 (ru) * | 2006-02-27 | 2008-06-20 | Закрытое акционерное общество "ДиТест" | Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса |
| MX2008011361A (es) * | 2006-03-09 | 2008-09-15 | Transgene Sa | Proteina de fusion no-estructural del virus de hepatitis c. |
| EP1978365B1 (en) | 2007-03-16 | 2010-08-25 | Sysmex Corporation | Reagent kit and method for measuring HCV antibody |
| US20090214593A1 (en) | 2007-08-16 | 2009-08-27 | Tripep Ab | Immunogen platform |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
| ES2828713T3 (es) | 2014-10-29 | 2021-05-27 | Abbott Lab | Ensayos de detección de anticuerpos anti-VHC objeto usando péptidos de captura NS3 |
| JP2018124277A (ja) * | 2017-02-02 | 2018-08-09 | 三洋化成工業株式会社 | 粒子含有組成物、免疫測定用試薬、免疫測定方法及び粒子の保存方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US456637A (en) | 1891-07-28 | Fence | ||
| US390599A (en) | 1888-10-02 | Tool for weaver s use | ||
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| CA1341423C (en) † | 1984-10-31 | 2003-03-04 | Paul A. Luciw | Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome |
| US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| JPH02500880A (ja) * | 1987-11-18 | 1990-03-29 | カイロン コーポレイション | Nanbvの診断用薬およびワクチン |
| KR0185373B1 (ko) † | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
| GR1001261B (el) * | 1989-12-18 | 1993-06-30 | Wellcome Found | Ιϊκός παράγων. |
| CA2032907C (en) † | 1989-12-22 | 2002-05-14 | Richard R. Lesniewski | Hepatitis c assay |
-
1991
- 1991-03-29 HU HU9203146A patent/HU217025B/hu unknown
- 1991-03-29 PL PL91296329A patent/PL172133B1/pl unknown
- 1991-03-29 WO PCT/US1991/002225 patent/WO1991015771A1/en not_active Ceased
- 1991-03-29 JP JP3507636A patent/JP2733138B2/ja not_active Expired - Lifetime
- 1991-03-29 BR BR919106309A patent/BR9106309A/pt not_active IP Right Cessation
- 1991-03-29 KR KR1019920702437A patent/KR100206150B1/ko not_active Expired - Lifetime
- 1991-03-29 RO RO92-01275A patent/RO109916B1/ro unknown
- 1991-03-29 UA UA93004190A patent/UA41266C2/uk unknown
- 1991-03-29 RU SU5053084A patent/RU2130969C1/ru active
- 1991-04-01 IL IL170719A patent/IL170719A/en not_active IP Right Cessation
- 1991-04-01 IL IL97741A patent/IL97741A0/xx not_active IP Right Cessation
- 1991-04-02 MY MYPI91000551A patent/MY107499A/en unknown
- 1991-04-03 AT AT95114016T patent/ATE182684T1/de not_active IP Right Cessation
- 1991-04-03 IE IE110591A patent/IE911105A1/en unknown
- 1991-04-03 AT AT91302910T patent/ATE139343T1/de not_active IP Right Cessation
- 1991-04-03 ES ES95114016T patent/ES2134388T5/es not_active Expired - Lifetime
- 1991-04-03 EP EP95114016A patent/EP0693687B2/en not_active Expired - Lifetime
- 1991-04-03 DK DK95114016T patent/DK0693687T4/da active
- 1991-04-03 DE DE69131488T patent/DE69131488T2/de not_active Expired - Lifetime
- 1991-04-03 ES ES91302910T patent/ES2088465T3/es not_active Expired - Lifetime
- 1991-04-03 DK DK91302910.4T patent/DK0450931T3/da active
- 1991-04-03 EP EP91302910A patent/EP0450931B1/en not_active Expired - Lifetime
- 1991-04-03 DE DE69120138T patent/DE69120138T2/de not_active Expired - Lifetime
-
1992
- 1992-09-28 FI FI924349A patent/FI106317B/fi active
- 1992-09-28 GB GB9220480A patent/GB2257784B/en not_active Expired - Lifetime
- 1992-10-01 NO NO19923839A patent/NO310241B1/no not_active IP Right Cessation
- 1992-10-02 BG BG96943A patent/BG61291B1/bg unknown
-
1993
- 1993-05-31 LV LV930038D patent/LV10344A/en unknown
- 1993-05-31 LV LVP-93-438.1A patent/LV10344B/en unknown
- 1993-12-30 LT LTIP1747A patent/LT3808B/lt not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY188196A patent/CY1881A/xx unknown
- 1996-09-05 GR GR960402319T patent/GR3020964T3/el unknown
-
1999
- 1999-09-29 GR GR990402455T patent/GR3031361T3/el unknown
Also Published As
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