ES2170053T3 - Manipulacion del numero de copias de genes en bordetella. - Google Patents

Manipulacion del numero de copias de genes en bordetella.

Info

Publication number
ES2170053T3
ES2170053T3 ES92306474T ES92306474T ES2170053T3 ES 2170053 T3 ES2170053 T3 ES 2170053T3 ES 92306474 T ES92306474 T ES 92306474T ES 92306474 T ES92306474 T ES 92306474T ES 2170053 T3 ES2170053 T3 ES 2170053T3
Authority
ES
Spain
Prior art keywords
bordetella
genes
cepa
natural
cocobacilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92306474T
Other languages
English (en)
Inventor
Sheena Loosmore
Gavin Zealey
Reza Yacoob
Michel Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Sanofi Pasteur SA
Original Assignee
Aventis Pasteur Ltd
Aventis Pasteur SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pasteur Ltd, Aventis Pasteur SA filed Critical Aventis Pasteur Ltd
Application granted granted Critical
Publication of ES2170053T3 publication Critical patent/ES2170053T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LOS NIVELES DE EXPRESION DE LAS PROTEINAS A PARTIR DE CEPAS DEL COCOBACILO BORDETELLA, EN PARTICULAR EL BORDETELLA PERTUSSIS, SE ALTERAN POR MODIFICACION GENETICA RESPECTO A UNA CEPA DEL COCOBACILO BORDETELLA, DE ESTE MODO UNO O MAS DE LOS GENES NATURALES, EN PARTICULAR QUE INCLUYEN LOS GENES TOX, FHA, CYA Y PRN, SE SUPRIMEN DEL GENOMA DE LA CEPA NATURAL Y UNO O MAS DE LOS GENES NATURALES O SU MUTACION GENETICA, PARTICULARMENTE UN GEN TOX* DETOXIFICADO GENETICAMENTE O UN GEN HIBRIDO, SE INTRODUCE EN EL GENOMA DE LA CEPA NATURAL PARA PROPORCIONAR, AL MENOS, DOS COPIAS DE UNO O MAS GENES NATURALES O SUS MUTACIONES GENETICAS O GEN HIBRIDO, SOLO O DOBLE. EL GENOTIPO ALTERADO DE LA CEPA DEL COCOBACILO BORDETELLA ES UTIL EN LA PRODUCCION DE VACUNAS DE CELULAS COMPLETAS O COMPUESTOS DEFINIDOS CONTRA EL COCOBACILO BORDETELLA, EN PARTICULAR CONTRA LA TOS FERINA, QUE SE PUEDEN EMPLEAR EN COMBINACION CON OTRAS VACUNAS.
ES92306474T 1991-07-16 1992-07-15 Manipulacion del numero de copias de genes en bordetella. Expired - Lifetime ES2170053T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919115332A GB9115332D0 (en) 1991-07-16 1991-07-16 Manipulation of gene copy number in bordetella

Publications (1)

Publication Number Publication Date
ES2170053T3 true ES2170053T3 (es) 2002-08-01

Family

ID=10698434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92306474T Expired - Lifetime ES2170053T3 (es) 1991-07-16 1992-07-15 Manipulacion del numero de copias de genes en bordetella.

Country Status (10)

Country Link
US (2) US5439810A (es)
EP (2) EP1184459A3 (es)
JP (2) JP2602600B2 (es)
AT (1) ATE209681T1 (es)
CA (1) CA2073288C (es)
DE (1) DE69232231T2 (es)
DK (1) DK0523976T3 (es)
ES (1) ES2170053T3 (es)
GB (1) GB9115332D0 (es)
PT (1) PT523976E (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
US5643753A (en) * 1990-04-18 1997-07-01 Connaught Laboratories Limited Use of autologous promoters to express gene products in bordetella
FR2728170A1 (fr) * 1994-12-15 1996-06-21 Pasteur Institut Vaccin de type acellulaire anti-bordetella
US5932714A (en) * 1995-02-23 1999-08-03 Connaught Laboratories Limited Expression of gene products from genetically manipulated strains of Bordetella
US5998168A (en) * 1995-06-07 1999-12-07 Connaught Laboratories Limited Expression of gene products from genetically manipulated strains of bordetella
EP1766002B1 (en) * 2004-06-21 2015-11-18 Novozymes A/S Stably maintained multiple copies of at least two orf in the same orientation
EP3800244A1 (en) 2006-03-10 2021-04-07 Institut Pasteur de Lille Live attenuated bordetella strains as a single dose vaccine against whooping cough
MX2008013451A (es) * 2006-04-17 2008-10-30 Schering Plough Ltd Organismos clostridium atenuados recombinantes y vacuna.
ES3024937T3 (en) 2009-04-28 2025-06-05 Inst Nat Sante Rech Med Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
CN104024400B (zh) 2011-12-21 2018-02-16 亚洲生物网有限公司 经修饰的百日咳博德特氏菌菌株
EP2722338A1 (en) * 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
EP4541809A3 (en) * 2016-03-29 2025-06-25 Institut Pasteur de Lille Mutant bordetella strains and methods of use
AU2018353409B2 (en) 2017-10-18 2025-07-17 Institut National De La Santé Et De La Recherche Médicale (Inserm) Bordetella strains expressing serotype 3 Fimbriae
EP4247397A4 (en) 2020-11-17 2024-11-06 Iliad Biotechnologies, LLC TREATMENT AND PREVENTION OF NEUROPATHOLOGY ASSOCIATED WITH NEURODEGENERATIVE DISEASES

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
GB8807860D0 (en) * 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
DE69022106T2 (de) * 1989-04-28 1996-02-15 Sclavo Spa Pertussistoxin-Mutanten, dieselbe produzierende Bordetella-Stämme und ihre Verwendung als Vakzin gegen Pertussis.
GB9008746D0 (en) * 1990-04-18 1990-06-13 Connaught Lab The use of autologous promoters to express gene products in bordetella
EP0485701A1 (en) * 1990-09-28 1992-05-20 American Cyanamid Company Insertion of DNA by modified transposons

Also Published As

Publication number Publication date
EP0523976A2 (en) 1993-01-20
EP0523976B1 (en) 2001-11-28
US5439810A (en) 1995-08-08
DE69232231T2 (de) 2002-05-23
PT523976E (pt) 2002-05-31
JPH07184643A (ja) 1995-07-25
JP2602600B2 (ja) 1997-04-23
CA2073288A1 (en) 1993-01-17
EP0523976A3 (en) 1993-11-10
JPH05317039A (ja) 1993-12-03
JP3070031B2 (ja) 2000-07-24
DK0523976T3 (da) 2002-04-02
GB9115332D0 (en) 1991-08-28
EP1184459A2 (en) 2002-03-06
DE69232231D1 (de) 2002-01-10
ATE209681T1 (de) 2001-12-15
CA2073288C (en) 1999-12-07
US5849530A (en) 1998-12-15
EP1184459A3 (en) 2004-05-12

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