ES2183160T3 - Procedimiento de preparacion de derivados pirrolidinicos. - Google Patents

Procedimiento de preparacion de derivados pirrolidinicos.

Info

Publication number
ES2183160T3
ES2183160T3 ES97917456T ES97917456T ES2183160T3 ES 2183160 T3 ES2183160 T3 ES 2183160T3 ES 97917456 T ES97917456 T ES 97917456T ES 97917456 T ES97917456 T ES 97917456T ES 2183160 T3 ES2183160 T3 ES 2183160T3
Authority
ES
Spain
Prior art keywords
acid
general formula
pirrolidine
derivative
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97917456T
Other languages
English (en)
Inventor
Natsuki Mori
Noritaka Yoshida
Takeshi Furuta
Kazunori Kan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of ES2183160T3 publication Critical patent/ES2183160T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN OBJETO DE LA PRESENTE INVENCION ES EL DE PREPARAR UN PROCESO PARA PRODUCIR UN DERIVADO DE LA PIRROLIDINA DE FORMULA GENERAL (2), O UNA SAL DE LA MISMA, DE MANERA SIMPLE Y ECONOMICA, CON BUENA PRODUCTIVIDAD Y ELEVADOS RENDIMIENTOS. LA PRESENTE INVENCION CONSISTE EN UN PROCESO PARA PRODUCIR UN DERIVADO DE LA PIRROLIDINA DE FORMULA GENERAL (2) O UNA SAL DEL MISMO, QUE COMPRENDE SOMETER UN COMPUESTO DE LA FORMULA GENERAL (1) A HIDROGENOLISIS, UTILIZANDO UN CATALIZADOR DE METAL EN PRESENCIA DE AL MENOS UN ACIDO PROTICO ELEGIDO ENTRE EL GRUPO FORMADO POR EL ACIDO CLORHIDRICO, ACIDO SULFURICO, ACIDO FOSFORICO, ACIDO P TOLUENSULFONICO, ACIDO METANSULFONICO, ACIDO ACETICO, ACIDO N BUTIRICO, ACIDO TRIFLUORACETICO Y ACIDO OXALICO. R REPRESENTA UNA GRUPO 1 - CIANO - 1, 1 - DIFENILMETILO, 1 CARBAMOIL 1, 1 - DIFENILMETILO, N - BUTIRILOXI, METANSULFONILOXI O P - TOLUENSULFONILOXI.
ES97917456T 1996-04-22 1997-04-22 Procedimiento de preparacion de derivados pirrolidinicos. Expired - Lifetime ES2183160T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12636196 1996-04-22
JP01463997A JP4057088B2 (ja) 1996-04-22 1997-01-09 ピロリジン誘導体の製造方法

Publications (1)

Publication Number Publication Date
ES2183160T3 true ES2183160T3 (es) 2003-03-16

Family

ID=26350627

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97917456T Expired - Lifetime ES2183160T3 (es) 1996-04-22 1997-04-22 Procedimiento de preparacion de derivados pirrolidinicos.

Country Status (6)

Country Link
US (1) US6005119A (es)
EP (1) EP0900787B1 (es)
JP (1) JP4057088B2 (es)
DE (1) DE69715402T2 (es)
ES (1) ES2183160T3 (es)
WO (1) WO1997040008A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100395779B1 (ko) * 2001-05-25 2003-08-21 한국화학연구원 임의적으로 베타-위치가 치환된 알파-아릴알킬기의 제거를통해 3급 아미드 화합물로부터 2급 아미드 화합물을제조하는 방법
KR100939347B1 (ko) * 2005-07-20 2010-01-29 (주)카이로드 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법
WO2009122997A1 (ja) 2008-04-02 2009-10-08 株式会社カネカ （ｓ）－３－（１－シアノ－１，１－ジフェニルメチル）－ピロリジンの製造法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208423A (en) * 1978-11-24 1980-06-17 Syntex Inc. Anticholinergic bronchodilators
US4594343A (en) * 1984-10-19 1986-06-10 Shanklin Jr James R 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US4810703A (en) * 1984-10-19 1989-03-07 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
DE3501496A1 (de) * 1985-01-18 1986-07-24 Behringwerke Ag, 3550 Marburg Verfahren zur bestimmung der aktivitaet des komplementsystems des blutes
IL78939A (en) * 1986-01-17 1990-04-29 Robins Co Inc A H Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds
JPS6341453A (ja) * 1986-08-08 1988-02-22 Tokyo Kasei Kogyo Kk ３−（アシルアミノ）ピロリジン又はその塩の製造法
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
JP2995704B2 (ja) * 1989-02-17 1999-12-27 東京化成工業株式会社 光学活性な１ｈ−３−アミノピロリジン化合物の製造法
JPH03176463A (ja) * 1989-12-02 1991-07-31 Kanegafuchi Chem Ind Co Ltd ピロリジノール誘導体およびその製法
JPH0495067A (ja) * 1990-08-09 1992-03-27 Fujisawa Pharmaceut Co Ltd ピロリジン化合物の製造法
JPH0558995A (ja) * 1991-09-04 1993-03-09 Shionogi & Co Ltd ピロリジン誘導体の製造法
FR2687146B1 (fr) * 1992-02-12 1994-04-01 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
JPH107652A (ja) 1998-01-13
US6005119A (en) 1999-12-21
JP4057088B2 (ja) 2008-03-05
DE69715402T2 (de) 2003-08-07
DE69715402D1 (de) 2002-10-17
WO1997040008A1 (en) 1997-10-30
EP0900787A1 (en) 1999-03-10
EP0900787B1 (en) 2002-09-11
EP0900787A4 (en) 1999-08-11

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