ES2190692A1 - Formulacion farmaceutica de amoxicilina y clavulanato de potasio. - Google Patents
Formulacion farmaceutica de amoxicilina y clavulanato de potasio.Info
- Publication number
- ES2190692A1 ES2190692A1 ES200000935A ES200000935A ES2190692A1 ES 2190692 A1 ES2190692 A1 ES 2190692A1 ES 200000935 A ES200000935 A ES 200000935A ES 200000935 A ES200000935 A ES 200000935A ES 2190692 A1 ES2190692 A1 ES 2190692A1
- Authority
- ES
- Spain
- Prior art keywords
- potassium clavulanate
- amoxicillin
- pharmaceutical formulation
- release
- amoxycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ABVRVIZBZKUTMK-JSYANWSFSA-M potassium clavulanate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 ABVRVIZBZKUTMK-JSYANWSFSA-M 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 5
- 229960003022 amoxicillin Drugs 0.000 abstract 5
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 5
- 238000009472 formulation Methods 0.000 abstract 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
Formulación farmacéutica de amoxicilina y clavulanato de potasio. La formulación es de liberación modificada y sus ingredientes activos, la amoxicilina y el clavulanato de potasio, están presentes en una relación de 12:1 a 20:1, formulándose todo el clavulanato de potasio y una primera parte de la amoxicilina con excipientes farmacéuticamente aceptables que permiten la liberación inmediata del clavulanato de potasio y la primera parte de la amoxicilina para formar una fase de liberación inmediata, y formulándose una segunda parte de la amoxicilina con excipientes farmacéuticamente aceptables que permiten la liberación lenta de esta segunda parte para formar una fase de liberación lenta. La formulación se presenta preferiblemente como un comprimido de dos capas y es aplicable al tratamiento de infecciones bacterianas.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12907499P | 1999-04-13 | 1999-04-13 | |
| US60/129074 | 1999-04-13 | ||
| US15072799P | 1999-08-25 | 1999-08-25 | |
| US60/150727 | 1999-08-25 | ||
| US15981399P | 1999-10-15 | 1999-10-15 | |
| US60/159813 | 1999-10-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2190692A1 true ES2190692A1 (es) | 2003-08-01 |
| ES2190692B1 ES2190692B1 (es) | 2004-11-16 |
Family
ID=27383840
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200000935A Withdrawn - After Issue ES2190692B1 (es) | 1999-04-13 | 2000-04-11 | Formulacion farmaceutica de amoxicilina y clavulanato de potasio. |
| ES00303033T Expired - Lifetime ES2202004T3 (es) | 1999-04-13 | 2000-04-11 | Novedoso procedimiento de tratamiento usando un fuerte regimen de dosificacion de amoxicilina y clavulanato potasico. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00303033T Expired - Lifetime ES2202004T3 (es) | 1999-04-13 | 2000-04-11 | Novedoso procedimiento de tratamiento usando un fuerte regimen de dosificacion de amoxicilina y clavulanato potasico. |
Country Status (44)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9407386D0 (en) | 1994-04-14 | 1994-06-08 | Smithkline Beecham Plc | Pharmaceutical formulation |
| GB9408117D0 (en) * | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
| TR199800415T1 (en) | 1995-09-07 | 1998-05-21 | Smithkline Beecham Corporation | Farmas�tik form�lasyon. |
| SE9802973D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
| US6878386B1 (en) | 1999-04-13 | 2005-04-12 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate |
| US6294199B1 (en) | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
| US7250176B1 (en) | 1999-04-13 | 2007-07-31 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6756057B2 (en) | 2000-10-12 | 2004-06-29 | Beecham Pharmaceuticals (Pte) Limited | Amoxicillin and potassium clavulanate dosage form |
| AU2001292185A1 (en) | 2000-10-12 | 2002-04-22 | Beecham Pharmaceuticals (Pte) Limited | Formulation containing amoxicillin |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20030035839A1 (en) * | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
| CN1610551A (zh) | 2001-07-06 | 2005-04-27 | 恩德制药公司 | 用作止痛剂的6-羟基羟吗啡酮的肠胃外给药 |
| GB0117618D0 (en) * | 2001-07-19 | 2001-09-12 | Phoqus Ltd | Pharmaceutical dosage form |
| US6863901B2 (en) | 2001-11-30 | 2005-03-08 | Collegium Pharmaceutical, Inc. | Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration |
| US6827946B2 (en) | 2001-12-05 | 2004-12-07 | Collegium Pharmaceutical, Inc. | Compositions containing both sedative and non-sedative antihistamines |
| CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| JP2005528383A (ja) * | 2002-04-10 | 2005-09-22 | ミラー,フレッド,エイチ. | 多重相・複数コンパートメントカプセルシステム |
| US20050042289A1 (en) * | 2003-04-29 | 2005-02-24 | Yamanouchi Pharma Technologies, Inc. | Tablets and methods for modified release of hydrophylic and other active agents |
| JP2007502294A (ja) | 2003-08-12 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
| EP1541129A1 (en) * | 2003-12-12 | 2005-06-15 | Cimex AG | Pharmaceutical effervescent formulation comprising amoxycillin and clavulanic acid |
| EP1750717B1 (en) * | 2004-02-11 | 2017-07-19 | Rubicon Research Private Limited | Controlled release pharmaceutical compositions with improved bioavailability |
| WO2005099672A1 (en) * | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | A modified release pharmaceutical formulation comprising amoxicillin and clavulanate |
| EP1880716A1 (en) * | 2006-07-19 | 2008-01-23 | Sandoz AG | Kit of parts comprising an acid labile and an acid resistant pharmaceutically active ingredient |
| WO2008045060A1 (en) * | 2006-10-10 | 2008-04-17 | Penwest Pharmaceuticals Co. | Robust sustained release formulations |
| TR200909787A2 (tr) | 2009-12-25 | 2011-07-21 | Bi̇lgi̇ç Mahmut | Üçüncü kuşak bir sefalosporin ve klavulanik asit içeren farmasötik formülasyonlar. |
| TR201000686A1 (tr) | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | Bakteriyel enfeksiyonların tedavisinde suda çözünebilir sefdinir ve klavulanik asit formülasyonları.@ |
| TR201000688A2 (tr) | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | Aktif madde olarak sefaklor ve klavulanik asit içeren efervesan formülasyonlar. |
| TR201000687A1 (tr) | 2010-01-29 | 2011-08-22 | Bi̇lgi̇ç Mahmut | Aktif madde olarak sefiksim ve klavulanik asit içeren efervesan formülasyonlar |
| WO2016164470A1 (en) | 2015-04-07 | 2016-10-13 | Church & Dwight Co., Inc. | Multicomponent gummy compositions with soft core |
| CN109394718B (zh) * | 2018-11-15 | 2021-04-27 | 石药集团中诺药业(石家庄)有限公司 | 一种阿莫西林分散片及其制备方法 |
| CN110051637A (zh) * | 2019-05-21 | 2019-07-26 | 葵花药业集团北京药物研究院有限公司 | 阿莫西林克拉维酸钾制剂及其制备方法 |
| WO2023208241A1 (zh) * | 2022-04-29 | 2023-11-02 | 越洋医药开发(广州)有限公司 | 一种吡非尼酮持续性释放口服固体制剂 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995020946A1 (en) * | 1994-02-04 | 1995-08-10 | Smithkline Beecham Plc | Bilayered amoxycillin tablets |
| WO1995028148A1 (en) * | 1994-04-14 | 1995-10-26 | Smithkline Beecham Plc | Pharmaceutical formulation |
| WO1996004908A1 (en) * | 1994-08-17 | 1996-02-22 | Smithkline Beecham Plc | Pharmaceutical formulation containing amoxycillin and potassium clavulanate |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008905B1 (en) * | 1978-09-06 | 1983-02-16 | Beecham Group Plc | Pharmaceutical compositions containing two beta-lactam derivatives |
| IL58461A0 (en) * | 1978-10-27 | 1980-01-31 | Beecham Group Ltd | Intramammary compositions comprising a clavulanic acid salt |
| FR2470599A1 (fr) * | 1979-12-07 | 1981-06-12 | Panoz Donald | Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus |
| GB9007945D0 (en) * | 1990-04-07 | 1990-06-06 | Beecham Group Plc | Pharmaceutical formulation |
| GB9109862D0 (en) * | 1991-05-08 | 1991-07-03 | Beecham Lab Sa | Pharmaceutical formulations |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| EP1034784A3 (en) * | 1993-01-22 | 2001-06-27 | Smithkline Beecham Plc | Pharmaceutical formulations containing clavulanic acid and an antibacterial agent |
| GB9311030D0 (en) * | 1993-05-28 | 1993-07-14 | Smithkline Beecham Corp | Pharmaceutical formulations |
| IL109770A0 (en) * | 1993-05-29 | 1994-11-28 | Smithkline Beecham Corp | Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby |
| GB9408117D0 (en) * | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
| ITMI941169A1 (it) * | 1994-06-06 | 1995-12-06 | Smithkline Beecham Farma | Formulazioni farmaceutiche |
| GB9416599D0 (en) * | 1994-08-17 | 1994-10-12 | Smithkline Beecham Plc | Pharmaceutical formulation |
| TR199800415T1 (en) * | 1995-09-07 | 1998-05-21 | Smithkline Beecham Corporation | Farmas�tik form�lasyon. |
| GB9616536D0 (en) * | 1996-08-06 | 1996-09-25 | Quadrant Holdings Cambridge | Co-amoxiclav dosage form |
| CA2280857A1 (en) * | 1997-02-14 | 1998-08-20 | Smithkline Beecham Laboratoires Pharmaceutiques | Pharmaceutical formulations comprising amoxocyllin and clavulanate |
| EE9900396A (et) * | 1997-03-11 | 2000-04-17 | Almag Al | Meetod ning seade metallide katmiseks |
| SE9700885D0 (sv) * | 1997-03-12 | 1997-03-12 | Astra Ab | New pharmaceutical formulation |
| ID22340A (id) * | 1997-03-25 | 1999-09-30 | Takeda Chemical Industries Ltd | Komposisi farmasi lekat-mukosa saluran pencernaan |
| JP3746901B2 (ja) * | 1997-10-15 | 2006-02-22 | ユニ・チャーム株式会社 | 開閉自在容器 |
| GB9815532D0 (en) * | 1998-07-17 | 1998-09-16 | Lek Pharmaceutical & Cvhemical | Pharmaceutical suspension formulation |
| GB9818927D0 (en) * | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US6225304B1 (en) * | 1999-02-17 | 2001-05-01 | Pharmaceutical Solutions, Inc. | Soluble forms of amoxicillin and treatment of animals |
-
2000
- 2000-04-11 NO NO20001870A patent/NO329694B1/no not_active IP Right Cessation
- 2000-04-11 EP EP00303033A patent/EP1044680B1/en not_active Expired - Lifetime
- 2000-04-11 EP EP02078926A patent/EP1269996A1/en not_active Withdrawn
- 2000-04-11 PT PT00303033T patent/PT1044680E/pt unknown
- 2000-04-11 AT AT00303033T patent/ATE242629T1/de active
- 2000-04-11 AT AT0027900U patent/AT4327U1/de not_active IP Right Cessation
- 2000-04-11 BE BE2000/0255A patent/BE1013309A5/fr not_active IP Right Cessation
- 2000-04-11 FI FI20000164U patent/FI4823U1/fi active
- 2000-04-11 CZ CZ20001311A patent/CZ298801B6/cs not_active IP Right Cessation
- 2000-04-11 CN CNB008086737A patent/CN100382782C/zh not_active Expired - Lifetime
- 2000-04-11 AP APAP/P/2001/002284A patent/AP1806A/en active
- 2000-04-11 DK DK200000602A patent/DK200000602A/da not_active Application Discontinuation
- 2000-04-11 IT IT2000MI000788A patent/ITMI20000788A1/it unknown
- 2000-04-11 IE IE20000271A patent/IE20000271A1/en not_active IP Right Cessation
- 2000-04-11 TW TW089106937A patent/TWI235067B/zh not_active IP Right Cessation
- 2000-04-11 ES ES200000935A patent/ES2190692B1/es not_active Withdrawn - After Issue
- 2000-04-11 CO CO00026419A patent/CO5170471A1/es not_active Application Discontinuation
- 2000-04-11 NL NL1014915A patent/NL1014915C2/nl not_active IP Right Cessation
- 2000-04-11 DK DK00303033T patent/DK1044680T3/da active
- 2000-04-11 EA EA200101075A patent/EA004310B1/ru not_active IP Right Cessation
- 2000-04-11 SE SE0001330A patent/SE0001330L/xx not_active Application Discontinuation
- 2000-04-11 OA OA1200100257A patent/OA11926A/en unknown
- 2000-04-11 ES ES00303033T patent/ES2202004T3/es not_active Expired - Lifetime
- 2000-04-11 MX MXPA01010377A patent/MXPA01010377A/es active IP Right Grant
- 2000-04-11 CA CA002366304A patent/CA2366304C/en not_active Expired - Lifetime
- 2000-04-11 SI SI200030183T patent/SI1044680T1/xx unknown
- 2000-04-11 FI FI20000863A patent/FI20000863A7/fi unknown
- 2000-04-11 HU HU0001471A patent/HU229097B1/hu unknown
- 2000-04-11 PT PT102450A patent/PT102450B/pt active IP Right Grant
- 2000-04-11 AR ARP000101657A patent/AR031068A1/es not_active Application Discontinuation
- 2000-04-11 SI SI200000097A patent/SI20304A/sl not_active IP Right Cessation
- 2000-04-11 BR BRPI0009719A patent/BRPI0009719B8/pt not_active IP Right Cessation
- 2000-04-11 NL NL1014914A patent/NL1014914C1/nl not_active IP Right Cessation
- 2000-04-11 MY MYPI20001509A patent/MY119953A/en unknown
- 2000-04-11 GB GB0008923A patent/GB2351661B/en not_active Revoked
- 2000-04-11 RO ROA200000399A patent/RO120817B1/ro unknown
- 2000-04-11 SK SK534-2000A patent/SK285140B6/sk not_active IP Right Cessation
- 2000-04-11 FR FR0004631A patent/FR2792198A1/fr active Pending
- 2000-04-11 DE DE10017883A patent/DE10017883A1/de not_active Withdrawn
- 2000-04-11 EP EP02078928A patent/EP1269997A1/en not_active Withdrawn
- 2000-04-11 DE DE60003255T patent/DE60003255T2/de not_active Expired - Lifetime
- 2000-04-11 EP EP02078927A patent/EP1270005A3/en not_active Withdrawn
- 2000-04-11 DZ DZ003150A patent/DZ3150A1/xx active
- 2000-04-11 BE BE00/0256A patent/BE1012733A6/fr not_active IP Right Cessation
- 2000-04-11 DK DK200000133U patent/DK200000133U3/da not_active IP Right Cessation
- 2000-04-11 DE DE20006626U patent/DE20006626U1/de not_active Expired - Lifetime
- 2000-04-11 JP JP2000610449A patent/JP4880125B2/ja not_active Expired - Lifetime
- 2000-04-11 BG BG104329A patent/BG65006B1/bg unknown
- 2000-04-11 NZ NZ514575A patent/NZ514575A/en not_active IP Right Cessation
- 2000-04-11 IL IL14558000A patent/IL145580A0/xx active IP Right Grant
- 2000-04-11 PL PL339591A patent/PL197448B1/pl unknown
- 2000-04-11 WO PCT/IB2000/000992 patent/WO2000061116A2/en not_active Ceased
- 2000-04-11 PE PE2000000332A patent/PE20010053A1/es not_active Application Discontinuation
- 2000-04-11 GR GR20000100122A patent/GR1003560B/el unknown
- 2000-04-11 KR KR1020017012988A patent/KR100634937B1/ko not_active Expired - Fee Related
- 2000-04-11 AU AU57020/00A patent/AU767177B2/en not_active Expired
- 2000-04-11 TR TR2001/02963T patent/TR200102963T2/xx unknown
-
2001
- 2001-09-24 IL IL145580A patent/IL145580A/en not_active IP Right Cessation
- 2001-10-12 MA MA26356A patent/MA25352A1/fr unknown
-
2011
- 2011-07-22 JP JP2011161132A patent/JP2011256180A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995020946A1 (en) * | 1994-02-04 | 1995-08-10 | Smithkline Beecham Plc | Bilayered amoxycillin tablets |
| WO1995028148A1 (en) * | 1994-04-14 | 1995-10-26 | Smithkline Beecham Plc | Pharmaceutical formulation |
| WO1996004908A1 (en) * | 1994-08-17 | 1996-02-22 | Smithkline Beecham Plc | Pharmaceutical formulation containing amoxycillin and potassium clavulanate |
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