ES2190692B1 - Formulacion farmaceutica de amoxicilina y clavulanato de potasio. - Google Patents

Formulacion farmaceutica de amoxicilina y clavulanato de potasio.

Info

Publication number
ES2190692B1
ES2190692B1 ES200000935A ES200000935A ES2190692B1 ES 2190692 B1 ES2190692 B1 ES 2190692B1 ES 200000935 A ES200000935 A ES 200000935A ES 200000935 A ES200000935 A ES 200000935A ES 2190692 B1 ES2190692 B1 ES 2190692B1
Authority
ES
Spain
Prior art keywords
potassium clavulanate
amoxicillin
pharmaceutical formulation
formulation
amoxycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn - After Issue
Application number
ES200000935A
Other languages
English (en)
Other versions
ES2190692A1 (es
Inventor
Kevin Storm
Creighton Conley
John Roush
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Pharmaceuticals Pte Ltd
Original Assignee
Beecham Pharmaceuticals Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27383840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2190692(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beecham Pharmaceuticals Pte Ltd filed Critical Beecham Pharmaceuticals Pte Ltd
Publication of ES2190692A1 publication Critical patent/ES2190692A1/es
Application granted granted Critical
Publication of ES2190692B1 publication Critical patent/ES2190692B1/es
Anticipated expiration legal-status Critical
Withdrawn - After Issue legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Formulación farmacéutica de amoxicilina y clavulanato de potasio.
La formulación es de liberación modificada y sus ingredientes activos, la amoxicilina y el clavulanato de potasio, están presentes en una relación de 12:1 a 20:1, formulándose todo el clavulanato de potasio y una primera parte de la amoxicilina con excipientes farmacéuticamente aceptables que permiten la liberación inmediata del clavulanato de potasio y la primera parte de la amoxicilina para formar una fase de liberación inmediata, y formulándose una segunda parte de la amoxicilina con excipientes farmacéuticamente aceptables que permiten la liberación lenta de esta segunda parte para formar una fase de liberación lenta. La formulación se presenta preferiblemente como un comprimido de dos capas y es aplicable al tratamiento de infecciones bacterianas.
ES200000935A 1999-04-13 2000-04-11 Formulacion farmaceutica de amoxicilina y clavulanato de potasio. Withdrawn - After Issue ES2190692B1 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12907499P 1999-04-13 1999-04-13
US60/129074 1999-04-13
US15072799P 1999-08-25 1999-08-25
US60/150727 1999-08-25
US15981399P 1999-10-15 1999-10-15
US60/159813 1999-10-15

Publications (2)

Publication Number Publication Date
ES2190692A1 ES2190692A1 (es) 2003-08-01
ES2190692B1 true ES2190692B1 (es) 2004-11-16

Family

ID=27383840

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200000935A Withdrawn - After Issue ES2190692B1 (es) 1999-04-13 2000-04-11 Formulacion farmaceutica de amoxicilina y clavulanato de potasio.
ES00303033T Expired - Lifetime ES2202004T3 (es) 1999-04-13 2000-04-11 Novedoso procedimiento de tratamiento usando un fuerte regimen de dosificacion de amoxicilina y clavulanato potasico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00303033T Expired - Lifetime ES2202004T3 (es) 1999-04-13 2000-04-11 Novedoso procedimiento de tratamiento usando un fuerte regimen de dosificacion de amoxicilina y clavulanato potasico.

Country Status (44)

Country Link
EP (4) EP1269997A1 (es)
JP (2) JP4880125B2 (es)
KR (1) KR100634937B1 (es)
CN (1) CN100382782C (es)
AP (1) AP1806A (es)
AR (1) AR031068A1 (es)
AT (2) ATE242629T1 (es)
AU (1) AU767177B2 (es)
BE (2) BE1013309A5 (es)
BG (1) BG65006B1 (es)
BR (1) BRPI0009719B8 (es)
CA (1) CA2366304C (es)
CO (1) CO5170471A1 (es)
CZ (1) CZ298801B6 (es)
DE (3) DE60003255T2 (es)
DK (3) DK200000602A (es)
DZ (1) DZ3150A1 (es)
EA (1) EA004310B1 (es)
ES (2) ES2190692B1 (es)
FI (2) FI4823U1 (es)
FR (1) FR2792198A1 (es)
GB (1) GB2351661B (es)
GR (1) GR1003560B (es)
HU (1) HU229097B1 (es)
IE (1) IE20000271A1 (es)
IL (2) IL145580A0 (es)
IT (1) ITMI20000788A1 (es)
MA (1) MA25352A1 (es)
MX (1) MXPA01010377A (es)
MY (1) MY119953A (es)
NL (2) NL1014914C1 (es)
NO (1) NO329694B1 (es)
NZ (1) NZ514575A (es)
OA (1) OA11926A (es)
PE (1) PE20010053A1 (es)
PL (1) PL197448B1 (es)
PT (2) PT1044680E (es)
RO (1) RO120817B1 (es)
SE (1) SE0001330L (es)
SI (2) SI20304A (es)
SK (1) SK285140B6 (es)
TR (1) TR200102963T2 (es)
TW (1) TWI235067B (es)
WO (1) WO2000061116A2 (es)

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GB9407386D0 (en) 1994-04-14 1994-06-08 Smithkline Beecham Plc Pharmaceutical formulation
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
DK0862431T3 (da) 1995-09-07 2002-03-11 Smithkline Beecham Plc Anvendelse af pædiatrisk farmaceutisk formulering omfattende amoxycillin og clavulanat
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US7250176B1 (en) 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
AU2001292185A1 (en) 2000-10-12 2002-04-22 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
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KR20030034171A (ko) 2001-07-06 2003-05-01 엔도 파마슈티걸즈, 인크. 옥시모르폰 제어 방출 제형
GB0117618D0 (en) * 2001-07-19 2001-09-12 Phoqus Ltd Pharmaceutical dosage form
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JP4732696B2 (ja) 2002-04-09 2011-07-27 フラメル・テクノロジー 活性成分の改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
WO2003086267A2 (en) * 2002-04-10 2003-10-23 Miller Fred H Multi-phase, multi-compartment capsular system
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AU2004264356B2 (en) 2003-08-12 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
EP1541129A1 (en) * 2003-12-12 2005-06-15 Cimex AG Pharmaceutical effervescent formulation comprising amoxycillin and clavulanic acid
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EP2079453A1 (en) * 2006-10-10 2009-07-22 Penwest Pharmaceuticals Co. Robust sustained release formulations
TR200909787A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Üçüncü kuşak bir sefalosporin ve klavulanik asit içeren farmasötik formülasyonlar.
TR201000687A1 (tr) 2010-01-29 2011-08-22 Bi̇lgi̇ç Mahmut Aktif madde olarak sefiksim ve klavulanik asit içeren efervesan formülasyonlar
TR201000688A2 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Aktif madde olarak sefaklor ve klavulanik asit içeren efervesan formülasyonlar.
TR201000686A1 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Bakteriyel enfeksiyonların tedavisinde suda çözünebilir sefdinir ve klavulanik asit formülasyonları.@
WO2016164464A1 (en) * 2015-04-07 2016-10-13 Church & Dwight Co., Inc. Multicomponent gummy compositions with hard core
CN109394718B (zh) * 2018-11-15 2021-04-27 石药集团中诺药业（石家庄）有限公司 一种阿莫西林分散片及其制备方法
CN110051637A (zh) * 2019-05-21 2019-07-26 葵花药业集团北京药物研究院有限公司 阿莫西林克拉维酸钾制剂及其制备方法
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Also Published As

Publication number Publication date
PT102450A (pt) 2001-02-01
SE0001330D0 (sv) 2000-04-11
AT4327U1 (de) 2001-06-25
NL1014915A1 (nl) 2000-10-16
MY119953A (en) 2005-08-30
CO5170471A1 (es) 2002-06-27
BR0009719A (pt) 2002-01-08
TR200102963T2 (tr) 2002-02-21
SI20304A (sl) 2001-02-28
FIU20000164U0 (fi) 2000-04-11
BE1012733A6 (fr) 2001-02-06
EP1044680B1 (en) 2003-06-11
WO2000061116A2 (en) 2000-10-19
NO20001870L (no) 2000-10-16
ITMI20000788A1 (it) 2001-10-11
EA200101075A1 (ru) 2002-04-25
DK200000602A (da) 2000-10-14
IL145580A0 (en) 2002-11-10
NO329694B1 (no) 2010-12-06
SE0001330L (sv) 2000-10-14
NZ514575A (en) 2004-05-28
CZ298801B6 (cs) 2008-02-06
HU0001471D0 (en) 2000-06-28
JP4880125B2 (ja) 2012-02-22
EP1270005A2 (en) 2003-01-02
IL145580A (en) 2007-05-15
DE10017883A1 (de) 2000-10-26
HUP0001471A3 (en) 2001-10-29
JP2002541187A (ja) 2002-12-03
PT102450B (pt) 2003-09-30
GB2351661B (en) 2001-10-10
SK5342000A3 (en) 2000-11-07
AR031068A1 (es) 2003-09-10
DK1044680T3 (da) 2003-09-29
RO120817B1 (ro) 2006-08-30
FI20000863A7 (fi) 2000-10-13
KR20020015312A (ko) 2002-02-27
DZ3150A1 (fr) 2000-10-19
CN100382782C (zh) 2008-04-23
WO2000061116A3 (en) 2001-02-01
BG104329A (en) 2001-11-30
HU229097B1 (en) 2013-07-29
CN1382040A (zh) 2002-11-27
EP1269996A1 (en) 2003-01-02
CA2366304A1 (en) 2000-10-19
GB2351661A (en) 2001-01-10
ATE242629T1 (de) 2003-06-15
ES2190692A1 (es) 2003-08-01
EP1270005A3 (en) 2006-05-17
BG65006B1 (bg) 2006-12-29
AU767177B2 (en) 2003-11-06
BRPI0009719B8 (pt) 2021-05-25
PT1044680E (pt) 2003-10-31
NL1014914C1 (nl) 2000-10-16
FI20000863A0 (fi) 2000-04-11
NO20001870D0 (no) 2000-04-11
PL339591A1 (en) 2000-10-23
DE20006626U1 (de) 2000-10-19
MXPA01010377A (es) 2002-10-23
CA2366304C (en) 2004-06-29
PE20010053A1 (es) 2001-03-10
IE20000271A1 (en) 2001-04-04
DE60003255D1 (de) 2003-07-17
AP1806A (en) 2007-12-14
SI1044680T1 (en) 2003-12-31
FR2792198A1 (fr) 2000-10-20
TWI235067B (en) 2005-07-01
AU5702000A (en) 2000-11-14
FI20000863L (fi) 2000-10-13
EA004310B1 (ru) 2004-02-26
NL1014915C2 (nl) 2001-02-12
EP1269997A1 (en) 2003-01-02
OA11926A (en) 2006-04-12
DE60003255T2 (de) 2004-05-06
EP1044680A1 (en) 2000-10-18
KR100634937B1 (ko) 2006-10-17
HK1032741A1 (en) 2001-08-03
DK200000133U3 (da) 2000-07-28
HUP0001471A2 (en) 2001-03-28
GR1003560B (el) 2001-03-16
CZ20001311A3 (cs) 2000-11-15
MA25352A1 (fr) 2001-12-31
ITMI20000788A0 (it) 2000-04-11
AP2001002284A0 (en) 2001-12-31
GB0008923D0 (en) 2000-05-31
BE1013309A5 (fr) 2001-11-06
BR0009719B1 (pt) 2014-09-30
FI4823U1 (fi) 2001-02-16
JP2011256180A (ja) 2011-12-22
ES2202004T3 (es) 2004-04-01
PL197448B1 (pl) 2008-03-31
SK285140B6 (sk) 2006-07-07

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