ES2193106T3 - Nuevas chalconas. - Google Patents

Nuevas chalconas.

Info

Publication number
ES2193106T3
ES2193106T3 ES00964042T ES00964042T ES2193106T3 ES 2193106 T3 ES2193106 T3 ES 2193106T3 ES 00964042 T ES00964042 T ES 00964042T ES 00964042 T ES00964042 T ES 00964042T ES 2193106 T3 ES2193106 T3 ES 2193106T3
Authority
ES
Spain
Prior art keywords
chalconas
certain
avonoids
chalcona
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00964042T
Other languages
English (en)
Inventor
Ezio Bombardelli
Piero Valenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2193106T3 publication Critical patent/ES2193106T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

El presente invento se refiere a una nueva clase de compuestos que tienen estructuras que se refieren a determinadas chalconas sintéticas y de origen natural, así como a métodos para la preparación de tales compuestos y a sus utilizaciones farmacéuticas. El compuesto 1, 3-difenil-2-propen-1-ona es conocido con el nombre común de "chalcona". Muchos avonoides de origen natural comparten características estructurales con la chalcona y se les conoce con el término genérico de "chalconas". Asimismo, se ha demostrado que determinados avonoides, incluyendo los que también se clasifican como "chalconas", tienen actividad anti-cáncer y actividad quimiopreventiva en determinados tumores.
ES00964042T 1999-09-03 2000-08-28 Nuevas chalconas. Expired - Lifetime ES2193106T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9920910.8A GB9920910D0 (en) 1999-09-03 1999-09-03 Novel chalcones

Publications (1)

Publication Number Publication Date
ES2193106T3 true ES2193106T3 (es) 2003-11-01

Family

ID=10860346

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00964042T Expired - Lifetime ES2193106T3 (es) 1999-09-03 2000-08-28 Nuevas chalconas.

Country Status (21)

Country Link
US (1) US6620842B2 (es)
EP (1) EP1212315B1 (es)
JP (1) JP2003508527A (es)
KR (1) KR100819576B1 (es)
CN (1) CN1177843C (es)
AT (1) ATE235483T1 (es)
AU (1) AU776226B2 (es)
CA (1) CA2382130A1 (es)
CZ (1) CZ2002787A3 (es)
DE (1) DE60001851T2 (es)
DK (1) DK1212315T3 (es)
ES (1) ES2193106T3 (es)
GB (1) GB9920910D0 (es)
HK (1) HK1043999B (es)
HU (1) HUP0202579A3 (es)
NO (1) NO20021049L (es)
PL (1) PL353064A1 (es)
PT (1) PT1212315E (es)
RU (1) RU2252938C2 (es)
SK (1) SK3112002A3 (es)
WO (1) WO2001017988A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE471931T1 (de) 2002-04-17 2010-07-15 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
US7638554B2 (en) * 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US20030229136A1 (en) * 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
WO2004006865A2 (en) 2002-07-17 2004-01-22 Cytokinetics, Inc. Compounds, compositions, and methods
US6864264B1 (en) 2002-08-20 2005-03-08 Gloria L. Anderson 1-adamantyl chalcones for the treatment of proliferative disorders
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
CN104169267B (zh) * 2012-03-01 2017-03-01 香港理工大学 含炔烃的类黄酮、含叠氮化物的类黄酮和含三唑的类黄酮作为调节剂用于癌症的多药耐药

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2118321C1 (ru) * 1988-12-21 1998-08-27 Дзе Апджон Компани Замещенные бензопираноны и их фармацевтически приемлемые соли и гидраты
US5023341A (en) * 1989-09-19 1991-06-11 Allergan, Inc. Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
WO1991017749A1 (en) * 1990-05-17 1991-11-28 Baylor College Of Medicine Growth inhibitors and methods of treating cancer and cell proliferative diseases
IT1271301B (it) 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono
US5525625A (en) * 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders

Also Published As

Publication number Publication date
RU2252938C2 (ru) 2005-05-27
PT1212315E (pt) 2003-08-29
HK1043999B (en) 2003-08-15
NO20021049D0 (no) 2002-03-01
DK1212315T3 (da) 2003-06-23
PL353064A1 (en) 2003-10-06
AU776226B2 (en) 2004-09-02
CZ2002787A3 (cs) 2002-06-12
CA2382130A1 (en) 2001-03-15
EP1212315B1 (en) 2003-03-26
CN1371372A (zh) 2002-09-25
AU7510900A (en) 2001-04-10
ATE235483T1 (de) 2003-04-15
KR20020031598A (ko) 2002-05-02
GB9920910D0 (en) 1999-11-10
HK1043999A1 (en) 2002-10-04
WO2001017988A1 (en) 2001-03-15
HUP0202579A3 (en) 2003-07-28
EP1212315A1 (en) 2002-06-12
JP2003508527A (ja) 2003-03-04
CN1177843C (zh) 2004-12-01
SK3112002A3 (en) 2003-10-07
HUP0202579A2 (hu) 2002-11-28
US20030055056A1 (en) 2003-03-20
NO20021049L (no) 2002-05-03
DE60001851D1 (de) 2003-04-30
US6620842B2 (en) 2003-09-16
KR100819576B1 (ko) 2008-04-22
DE60001851T2 (de) 2003-12-11

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