ES2193475T3 - Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea. - Google Patents

Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea.

Info

Publication number
ES2193475T3
ES2193475T3 ES98204337T ES98204337T ES2193475T3 ES 2193475 T3 ES2193475 T3 ES 2193475T3 ES 98204337 T ES98204337 T ES 98204337T ES 98204337 T ES98204337 T ES 98204337T ES 2193475 T3 ES2193475 T3 ES 2193475T3
Authority
ES
Spain
Prior art keywords
steroid sulfatase
compound
inhibitors
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98204337T
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of ES2193475T3 publication Critical patent/ES2193475T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SUMINISTRA UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO MEZCLADO CON UN DILUYENTE O UN PORTADOR FARMACOLOGICAMENTE ACEPTABLE, EN DONDE EL COMPUESTO TIENE LA FORMULA (I) EN LA QUE CADA R 1 Y R 2 SE SELECCIONAN I NDEPENDIENTEMENTE ENTRE H, ALQUILO, ALQUENILO, CICLOALQUILO Y ARILO; Y EN DONDE EL COMPUESTO ES UN INHIBIDOR DE UNA ENZIMA QUE TIENE ACTIVIDAD DE SULFATASA ESTEROIDE (E.C.3.3.6.2) EN DONDE SI EL GRUPO DE SULFAMATO EN EL COMPUESTO FUERA REEMPLAZADO CON UN GRUPO DE SULFATO PARA FORMAR UN COMPUESTO DE SULFATO E INCUBADO CON UNA ENZIMA DE SULFATASA ESTEROIDE (E.C.3.1.6.2) A UN PH DE 7,4 Y A 37° C PODRIA SUMINISTRAR UN VALOR K M INFERIOR A 50 MI M; Y EN DONDE AL MENOS UNA DE R 1 Y R SUB ,2 ES H.
ES98204337T 1991-08-29 1992-08-28 Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea. Expired - Lifetime ES2193475T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
ES2193475T3 true ES2193475T3 (es) 2003-11-01

Family

ID=10700604

Family Applications (4)

Application Number Title Priority Date Filing Date
ES98204337T Expired - Lifetime ES2193475T3 (es) 1991-08-29 1992-08-28 Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea.
ES99203449T Expired - Lifetime ES2204059T3 (es) 1991-08-29 1992-08-28 Utilizacion de un compuesto de esterol que comprende un grupo ester del acido sulfamico para la preparacion de medicamentos para el control de la produccion de estrogenos.
ES92918285T Expired - Lifetime ES2148178T3 (es) 1991-08-29 1992-08-28 Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa.
ES98204340T Expired - Lifetime ES2196483T3 (es) 1991-08-29 1992-08-28 Inhibidores de la sulfatasa esteroidea.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES99203449T Expired - Lifetime ES2204059T3 (es) 1991-08-29 1992-08-28 Utilizacion de un compuesto de esterol que comprende un grupo ester del acido sulfamico para la preparacion de medicamentos para el control de la produccion de estrogenos.
ES92918285T Expired - Lifetime ES2148178T3 (es) 1991-08-29 1992-08-28 Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa.
ES98204340T Expired - Lifetime ES2196483T3 (es) 1991-08-29 1992-08-28 Inhibidores de la sulfatasa esteroidea.

Country Status (25)

Country Link
US (3) US5616574A (es)
EP (6) EP0928609B1 (es)
JP (6) JP3219408B2 (es)
KR (4) KR100258396B1 (es)
AT (5) ATE237333T1 (es)
AU (2) AU689043B2 (es)
BR (1) BR9206434A (es)
CA (4) CA2305758A1 (es)
CY (4) CY2253B1 (es)
CZ (1) CZ295939B6 (es)
DE (5) DE69233149T2 (es)
DK (4) DK0928609T3 (es)
ES (4) ES2193475T3 (es)
FI (5) FI940903A7 (es)
GB (1) GB9118478D0 (es)
GE (6) GEP20022802B (es)
GR (1) GR3034579T3 (es)
HU (1) HUT66097A (es)
LV (1) LV12618B (es)
NO (6) NO307301B1 (es)
RU (4) RU2001125673A (es)
SG (7) SG73391A1 (es)
SK (4) SK282189B6 (es)
UA (4) UA41875C2 (es)
WO (1) WO1993005064A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
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US6903084B2 (en) 1991-08-28 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
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US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
EP0758230B1 (en) * 1994-04-05 2003-06-11 Celltech Therapeutics Limited Use of steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
JP2000506161A (ja) * 1996-03-05 2000-05-23 インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン スルファメート基を有する化合物
AU713341B2 (en) * 1996-09-12 1999-12-02 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-d-homo-1,3,5,(10)-estratriene derivatives
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) * 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
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US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
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GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
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ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
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US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (en) * 1999-03-10 2000-09-14 Nippon Organon K. K. Novel estradiol derivatives
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Also Published As

Publication number Publication date
RU2207134C2 (ru) 2003-06-27
SG115508A1 (en) 2005-10-28
JP2000038341A (ja) 2000-02-08
CZ44094A3 (en) 1995-01-18
FI20002259A7 (fi) 2000-10-13
CA2114630A1 (en) 1993-03-18
AU668882B2 (en) 1996-05-23
ES2204059T3 (es) 2004-04-16
CY2398B1 (en) 2004-09-10
EP1099706B1 (en) 2004-10-06
US5830886A (en) 1998-11-03
HK1020672A1 (en) 2000-05-19
CA2305758A1 (en) 1993-03-18
GEP20022637B (en) 2002-02-25
CA2114630C (en) 2003-09-30
NO940635L (es) 1994-04-29
DE69233053T2 (de) 2003-11-20
ATE246706T1 (de) 2003-08-15
JPH07501515A (ja) 1995-02-16
GEP20022802B (en) 2002-09-25
DK0928609T3 (da) 2003-07-21
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
CY2397B1 (en) 2004-09-10
AU2490592A (en) 1993-04-05
JP2000355542A (ja) 2000-12-26
EP0921130A3 (en) 2001-09-05
EP0982032A3 (en) 2002-03-20
EP0928609A2 (en) 1999-07-14
UA70956C2 (uk) 2004-11-15
DK0982032T3 (da) 2003-11-03
AU1007799A (en) 1999-03-04
DE69231280D1 (de) 2000-08-24
AU5837396A (en) 1996-09-05
BR9206434A (pt) 1994-09-27
AU717116B2 (en) 2000-03-16
KR100321018B1 (ko) 2002-03-20
ATE237333T1 (de) 2003-05-15
NO20044458L (no) 1994-04-29
KR100321019B1 (ko) 2002-03-20
ES2196483T3 (es) 2003-12-16
NO2595A (no) 1994-04-29
JP3219408B2 (ja) 2001-10-15
HU9400583D0 (en) 1994-05-30
CZ295939B6 (cs) 2005-12-14
SG103374A1 (en) 2004-04-29
LV12618B (en) 2001-07-20
FI20050991L (fi) 2005-10-03
SG88783A1 (en) 2002-05-21
JP2000355598A (ja) 2000-12-26
NO940635D0 (no) 1994-02-24
SG103820A1 (en) 2004-05-26
NO308903B1 (no) 2000-11-13
ATE278704T1 (de) 2004-10-15
JP2003176297A (ja) 2003-06-24
SK282189B6 (sk) 2001-12-03
NO995075L (no) 1994-04-29
NO314287B1 (no) 2003-03-03
EP0928609A3 (en) 2001-11-07
EP0921130B1 (en) 2003-05-07
EP1099706A2 (en) 2001-05-16
SK24694A3 (en) 1994-11-09
DK0921130T3 (da) 2003-07-21
GEP20063773B (en) 2006-03-27
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
EP0982032B1 (en) 2003-08-06
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GB9118478D0 (en) 1991-10-16
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US5616574A (en) 1997-04-01
EP1099706A3 (en) 2002-09-04
GR3034579T3 (en) 2001-01-31
SK282188B6 (sk) 2001-12-03
CA2305749A1 (en) 1993-03-18
EP0641355B1 (en) 2000-07-19
DE69231280T2 (de) 2000-11-30
KR100258396B1 (ko) 2000-08-01
LV12618A (en) 2001-02-20
WO1993005064A1 (en) 1993-03-18
FI20002260A7 (fi) 2000-10-13
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NO995076L (no) 1994-04-29
NO995075D0 (no) 1999-10-18
SG106116A1 (en) 2004-09-30
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NO308774B1 (no) 2000-10-30
ATE194843T1 (de) 2000-08-15
RU2001125673A (ru) 2003-06-27
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FI940903A7 (fi) 1994-04-20
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EP0921130A2 (en) 1999-06-09
FI940903A0 (fi) 1994-02-25
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UA41875C2 (uk) 2001-10-15
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RU2210574C2 (ru) 2003-08-20
DE69233149T2 (de) 2004-06-24
RU94019334A (ru) 1996-10-20
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ATE239753T1 (de) 2003-05-15
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JP2002255993A (ja) 2002-09-11
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HK1025051A1 (en) 2000-11-03
DE69233020T2 (de) 2003-11-06
HK1019753A1 (en) 2000-02-25
NO20025725D0 (no) 2002-11-28
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