ES2193475T3 - Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea. - Google Patents

Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea.

Info

Publication number
ES2193475T3
ES2193475T3 ES98204337T ES98204337T ES2193475T3 ES 2193475 T3 ES2193475 T3 ES 2193475T3 ES 98204337 T ES98204337 T ES 98204337T ES 98204337 T ES98204337 T ES 98204337T ES 2193475 T3 ES2193475 T3 ES 2193475T3
Authority
ES
Spain
Prior art keywords
steroid sulfatase
compound
inhibitors
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98204337T
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of ES2193475T3 publication Critical patent/ES2193475T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SUMINISTRA UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO MEZCLADO CON UN DILUYENTE O UN PORTADOR FARMACOLOGICAMENTE ACEPTABLE, EN DONDE EL COMPUESTO TIENE LA FORMULA (I) EN LA QUE CADA R 1 Y R 2 SE SELECCIONAN I NDEPENDIENTEMENTE ENTRE H, ALQUILO, ALQUENILO, CICLOALQUILO Y ARILO; Y EN DONDE EL COMPUESTO ES UN INHIBIDOR DE UNA ENZIMA QUE TIENE ACTIVIDAD DE SULFATASA ESTEROIDE (E.C.3.3.6.2) EN DONDE SI EL GRUPO DE SULFAMATO EN EL COMPUESTO FUERA REEMPLAZADO CON UN GRUPO DE SULFATO PARA FORMAR UN COMPUESTO DE SULFATO E INCUBADO CON UNA ENZIMA DE SULFATASA ESTEROIDE (E.C.3.1.6.2) A UN PH DE 7,4 Y A 37° C PODRIA SUMINISTRAR UN VALOR K M INFERIOR A 50 MI M; Y EN DONDE AL MENOS UNA DE R 1 Y R SUB ,2 ES H.
ES98204337T 1991-08-29 1992-08-28 Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea. Expired - Lifetime ES2193475T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
ES2193475T3 true ES2193475T3 (es) 2003-11-01

Family

ID=10700604

Family Applications (4)

Application Number Title Priority Date Filing Date
ES98204340T Expired - Lifetime ES2196483T3 (es) 1991-08-29 1992-08-28 Inhibidores de la sulfatasa esteroidea.
ES98204337T Expired - Lifetime ES2193475T3 (es) 1991-08-29 1992-08-28 Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea.
ES99203449T Expired - Lifetime ES2204059T3 (es) 1991-08-29 1992-08-28 Utilizacion de un compuesto de esterol que comprende un grupo ester del acido sulfamico para la preparacion de medicamentos para el control de la produccion de estrogenos.
ES92918285T Expired - Lifetime ES2148178T3 (es) 1991-08-29 1992-08-28 Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES98204340T Expired - Lifetime ES2196483T3 (es) 1991-08-29 1992-08-28 Inhibidores de la sulfatasa esteroidea.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES99203449T Expired - Lifetime ES2204059T3 (es) 1991-08-29 1992-08-28 Utilizacion de un compuesto de esterol que comprende un grupo ester del acido sulfamico para la preparacion de medicamentos para el control de la produccion de estrogenos.
ES92918285T Expired - Lifetime ES2148178T3 (es) 1991-08-29 1992-08-28 Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa.

Country Status (25)

Country Link
US (3) US5616574A (es)
EP (6) EP1099706B1 (es)
JP (6) JP3219408B2 (es)
KR (4) KR100258396B1 (es)
AT (5) ATE194843T1 (es)
AU (2) AU689043B2 (es)
BR (1) BR9206434A (es)
CA (4) CA2305767A1 (es)
CY (4) CY2253B1 (es)
CZ (1) CZ295939B6 (es)
DE (5) DE69233149T2 (es)
DK (4) DK0921130T3 (es)
ES (4) ES2196483T3 (es)
FI (5) FI940903A7 (es)
GB (1) GB9118478D0 (es)
GE (6) GEP20022766B (es)
GR (1) GR3034579T3 (es)
HU (1) HUT66097A (es)
LV (1) LV12618B (es)
NO (6) NO307301B1 (es)
RU (4) RU2210574C2 (es)
SG (7) SG103374A1 (es)
SK (4) SK282187B6 (es)
UA (4) UA41875C2 (es)
WO (1) WO1993005064A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
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US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
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US6903084B2 (en) 1991-08-28 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
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GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
WO1995026717A1 (en) * 1994-04-05 1995-10-12 Celltech Therapeutics Limited Use of estrone derivatives as steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4447715C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
ATE286038T1 (de) * 1996-03-05 2005-01-15 Sterix Ltd Verbindungen mit sulfonsäure-amidgruppe
AU713341B2 (en) * 1996-09-12 1999-12-02 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-d-homo-1,3,5,(10)-estratriene derivatives
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
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GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
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AU4093799A (en) 1998-05-22 1999-12-13 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
AU765386B2 (en) * 1998-06-10 2003-09-18 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-(o)-sulphamate for inhibition of estrone sulphatase
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (en) * 1999-03-10 2000-09-14 Nippon Organon K. K. Novel estradiol derivatives
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
JP5042411B2 (ja) * 1999-04-30 2012-10-03 ステリックス リミテッド 抗腫瘍剤としてのエストロン誘導体の使用
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DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE60328233D1 (de) * 2003-05-16 2009-08-13 Theramex Sulfamatbenzothiophenderivate als steroidsulfataseinhibitoren
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US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
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GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
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EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN110974840A (zh) * 2019-12-27 2020-04-10 天津市肿瘤医院 一种类固醇硫酸酯酶抑制剂及其药物用途

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Also Published As

Publication number Publication date
CA2114630A1 (en) 1993-03-18
JP2000355542A (ja) 2000-12-26
CZ44094A3 (en) 1995-01-18
NO20025725L (no) 1994-04-29
FI940903A0 (fi) 1994-02-25
CA2114630C (en) 2003-09-30
JPH07501515A (ja) 1995-02-16
DE69233053T2 (de) 2003-11-20
JP3581802B2 (ja) 2004-10-27
NO995076L (no) 1994-04-29
KR100321018B1 (ko) 2002-03-20
FI20050991L (fi) 2005-10-03
EP0982032A2 (en) 2000-03-01
HUT66097A (en) 1994-09-28
EP0928609A2 (en) 1999-07-14
ATE278704T1 (de) 2004-10-15
KR100321019B1 (ko) 2002-03-20
DE69233431T2 (de) 2006-02-23
UA70957C2 (uk) 2004-11-15
RU2182152C2 (ru) 2002-05-10
NO314287B1 (no) 2003-03-03
RU2210574C2 (ru) 2003-08-20
SG88783A1 (en) 2002-05-21
GEP20022637B (en) 2002-02-25
CA2305758A1 (en) 1993-03-18
ATE237333T1 (de) 2003-05-15
FI20002260A7 (fi) 2000-10-13
AU717116B2 (en) 2000-03-16
GEP20022802B (en) 2002-09-25
HK1025051A1 (en) 2000-11-03
EP1099706A3 (en) 2002-09-04
ATE246706T1 (de) 2003-08-15
ES2148178T3 (es) 2000-10-16
JP3581820B2 (ja) 2004-10-27
SG103820A1 (en) 2004-05-26
NO995076D0 (no) 1999-10-18
EP0641355B1 (en) 2000-07-19
DE69233149T2 (de) 2004-06-24
SK282187B6 (sk) 2001-12-03
FI20050991A7 (fi) 2005-10-03
DE69231280T2 (de) 2000-11-30
EP0982032A3 (en) 2002-03-20
HK1019753A1 (en) 2000-02-25
SK282189B6 (sk) 2001-12-03
JP2003176297A (ja) 2003-06-24
DK0921130T3 (da) 2003-07-21
ES2196483T3 (es) 2003-12-16
FI20002259L (fi) 2000-10-13
JP3219408B2 (ja) 2001-10-15
GEP20022766B (en) 2002-08-26
JP2000355598A (ja) 2000-12-26
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
ATE239753T1 (de) 2003-05-15
AU689043B2 (en) 1998-03-19
FI940903A7 (fi) 1994-04-20
NO940635D0 (no) 1994-02-24
LV12618A (en) 2001-02-20
SG115508A1 (en) 2005-10-28
EP0921130A3 (en) 2001-09-05
NO995075D0 (no) 1999-10-18
SG73391A1 (en) 2006-08-30
NO20025725D0 (no) 2002-11-28
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EP0928609A3 (en) 2001-11-07
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AU668882B2 (en) 1996-05-23
DE69231280D1 (de) 2000-08-24
LV12618B (en) 2001-07-20
US5830886A (en) 1998-11-03
NO20002595D0 (no) 2000-05-19
NO318009B1 (no) 2005-01-17
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FI20002260L (fi) 2000-10-13
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DK0641355T3 (da) 2000-10-09
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NO307301B1 (no) 2000-03-13
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GB9118478D0 (en) 1991-10-16
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RU2001125673A (ru) 2003-06-27
DE69233020T2 (de) 2003-11-06
US6159960A (en) 2000-12-12
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NO940635L (es) 1994-04-29
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UA70956C2 (uk) 2004-11-15
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ATE194843T1 (de) 2000-08-15
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US5616574A (en) 1997-04-01
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NO2595A (no) 1994-04-29
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