ES2257772T3 - Preparacion de nateglinida en comprimidos. - Google Patents

Preparacion de nateglinida en comprimidos.

Info

Publication number: ES2257772T3
Authority: ES; Spain
Prior art keywords: tablets; weight; composition; compound; hydroxypropyl cellulose
Prior art date: 1996-11-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES97912459T

Other languages

English (en)

Spanish (es)

Inventor

Akira Res. Lab. Ajinomoto Co. Inc. Yabuki

Masato Res. Lab. Ajinomoto Co Inc. Kaida

Takahiko Res. Lab. Ajinomoto Co Inc Ando

Nobutaka Res. Lab. Ajinomoto Co Inc Ninomiya

Masanao Res. Lab. Ajinomoto Co Inc Ozaki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ajinomoto Co Inc

Original Assignee

Ajinomoto Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-15

Filing date

1997-11-14

Publication date

2006-08-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18100283&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2257772(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-11-14 Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc

2006-08-01 Application granted granted Critical

2006-08-01 Publication of ES2257772T3 publication Critical patent/ES2257772T3/es

2017-11-14 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000002360 preparation method Methods 0.000 title description 2
OELFLUMRDSZNSF-OFLPRAFFSA-N (2R)-2-[[oxo-(4-propan-2-ylcyclohexyl)methyl]amino]-3-phenylpropanoic acid Chemical compound C1CC(C(C)C)CCC1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-OFLPRAFFSA-N 0.000 title 1
OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 claims abstract description 8
239000000203 mixture Substances 0.000 claims description 38
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 34
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 32
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 32
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 15
239000008101 lactose Substances 0.000 claims description 15
-1 hydroxypropyl group Chemical group 0.000 claims description 12
229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 9
239000000945 filler Substances 0.000 claims description 5
210000004369 blood Anatomy 0.000 abstract description 17
239000008280 blood Substances 0.000 abstract description 17
239000007916 tablet composition Substances 0.000 abstract description 16
235000012054 meals Nutrition 0.000 abstract description 15
239000001768 carboxy methyl cellulose Substances 0.000 abstract description 4
210000002784 stomach Anatomy 0.000 abstract description 4
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract description 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 abstract description 2
239000011575 calcium Substances 0.000 abstract description 2
229910052791 calcium Inorganic materials 0.000 abstract description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 abstract description 2
239000008112 carboxymethyl-cellulose Substances 0.000 abstract description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract description 2
150000001875 compounds Chemical class 0.000 description 33
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
235000013305 food Nutrition 0.000 description 14
239000008213 purified water Substances 0.000 description 14
238000010521 absorption reaction Methods 0.000 description 13
239000008187 granular material Substances 0.000 description 12
230000000052 comparative effect Effects 0.000 description 11
229920002472 Starch Polymers 0.000 description 10
239000002775 capsule Substances 0.000 description 10
235000019359 magnesium stearate Nutrition 0.000 description 10
239000000843 powder Substances 0.000 description 10
239000008107 starch Substances 0.000 description 10
235000019698 starch Nutrition 0.000 description 10
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 9
229920002678 cellulose Polymers 0.000 description 9
239000001913 cellulose Substances 0.000 description 9
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 9
229920003114 HPC-L Polymers 0.000 description 8
239000011248 coating agent Substances 0.000 description 8
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 8
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 8
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 8
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 8
239000000454 talc Substances 0.000 description 8
229910052623 talc Inorganic materials 0.000 description 8
235000012222 talc Nutrition 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
238000000576 coating method Methods 0.000 description 7
239000007788 liquid Substances 0.000 description 7
229940093429 polyethylene glycol 6000 Drugs 0.000 description 7
239000007884 disintegrant Substances 0.000 description 5
230000000694 effects Effects 0.000 description 5
239000004615 ingredient Substances 0.000 description 5
238000000034 method Methods 0.000 description 5
238000005507 spraying Methods 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
241000282472 Canis lupus familiaris Species 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000011230 binding agent Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000008120 corn starch Substances 0.000 description 3
229940099112 cornstarch Drugs 0.000 description 3
210000002381 plasma Anatomy 0.000 description 3
238000010008 shearing Methods 0.000 description 3
239000011734 sodium Substances 0.000 description 3
239000007921 spray Substances 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
239000001856 Ethyl cellulose Substances 0.000 description 2
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
239000000654 additive Substances 0.000 description 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
235000019700 dicalcium phosphate Nutrition 0.000 description 2
239000000975 dye Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
235000019325 ethyl cellulose Nutrition 0.000 description 2
229920001249 ethyl cellulose Polymers 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
239000002245 particle Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
YRQKWRUZZCBSIG-UHFFFAOYSA-N 4-propan-2-ylcyclohexane-1-carboxylic acid Chemical compound CC(C)C1CCC(C(O)=O)CC1 YRQKWRUZZCBSIG-UHFFFAOYSA-N 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
229920002785 Croscarmellose sodium Polymers 0.000 description 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 description 1
229930182832 D-phenylalanine Natural products 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
229960000250 adipic acid Drugs 0.000 description 1
239000001361 adipic acid Substances 0.000 description 1
235000011037 adipic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
229940125904 compound 1 Drugs 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
229960001681 croscarmellose sodium Drugs 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000002542 deteriorative effect Effects 0.000 description 1
JAUGGEIKQIHSMF-UHFFFAOYSA-N dialuminum;dimagnesium;dioxido(oxo)silane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O JAUGGEIKQIHSMF-UHFFFAOYSA-N 0.000 description 1
239000003814 drug Substances 0.000 description 1
LUJQXGBDWAGQHS-UHFFFAOYSA-N ethenyl acetate;phthalic acid Chemical compound CC(=O)OC=C.OC(=O)C1=CC=CC=C1C(O)=O LUJQXGBDWAGQHS-UHFFFAOYSA-N 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
239000001341 hydroxy propyl starch Substances 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
235000013828 hydroxypropyl starch Nutrition 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000012046 mixed solvent Substances 0.000 description 1
229960000698 nateglinide Drugs 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
150000003214 pyranose derivatives Chemical group 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
150000003445 sucroses Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000010936 titanium Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

ES97912459T 1996-11-15 1997-11-14 Preparacion de nateglinida en comprimidos. Expired - Lifetime ES2257772T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP8-318541		1996-11-15
JP31854196		1996-11-15

Publications (1)

Publication Number	Publication Date
ES2257772T3 true ES2257772T3 (es)	2006-08-01

Family

ID=18100283

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES97912459T Expired - Lifetime ES2257772T3 (es)	1996-11-15	1997-11-14	Preparacion de nateglinida en comprimidos.
ES05014497T Expired - Lifetime ES2364145T3 (es)	1996-11-15	1997-11-14	Composición de nateglinida en comprimidos.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES05014497T Expired - Lifetime ES2364145T3 (es)	1996-11-15	1997-11-14	Composición de nateglinida en comprimidos.

Country Status (14)

Country	Link
US (4)	US6143323A (de)
EP (3)	EP2277517A1 (de)
JP (1)	JP4171091B2 (de)
KR (1)	KR100343062B1 (de)
CN (1)	CN1245158C (de)
AT (2)	ATE322260T1 (de)
AU (1)	AU718350B2 (de)
CA (1)	CA2271865C (de)
DE (2)	DE69735644T2 (de)
DK (1)	DK1586314T3 (de)
ES (2)	ES2257772T3 (de)
PT (2)	PT965339E (de)
TW (1)	TW492878B (de)
WO (1)	WO1998022105A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100343062B1 (ko) *	1996-11-15	2002-07-02	에가시라 구니오	정제 조성물
EP2263660B1 (de)	1998-05-18	2017-09-27	Takeda Pharmaceutical Company Limited	Im Munde zerfallende Tablette
DE69942777D1 (de) *	1998-07-28	2010-10-28	Takeda Pharmaceutical	Leicht zerfallende feste Zubereitung
JP2000119160A (ja) *	1998-10-06	2000-04-25	Kanebo Ltd	皮膚化粧料
CO5200844A1 (es) *	1999-09-17	2002-09-27	Novartis Ag	Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes
US6559188B1 (en)	1999-09-17	2003-05-06	Novartis Ag	Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
US6878749B2 (en)	1999-09-17	2005-04-12	Novartis Ag	Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
ES2248159T3 (es)	1999-12-28	2006-03-16	Ajinomoto Co., Inc.	Preparaciones orales para diabetes.
EP1283054A4 (de) *	2000-03-17	2006-04-12	Ajinomoto Kk	Medikamente zur behandlung von komplikationen des diabetes und neuropathien, und verwendung davon
WO2002032854A1 (en) *	2000-10-18	2002-04-25	Ajinomoto Co.,Inc.	Process for producing nateglinide crystal
ATE373635T1 (de)	2000-10-18	2007-10-15	Ajinomoto Kk	Verfahren zur herstellung von acylphenylalaninen
BR0114846A (pt)	2000-10-24	2004-02-25	Ajinomoto Kk	Método para produzir cristais de tipo b de nateglinida substancialmente livres de cristais de tipo h
PT1334721E (pt) *	2000-10-24	2009-06-01	Ajinomoto Kk	Preparações de fármacos hidrofílicos contendo nateglinida
AU2001295999A1 (en) *	2000-10-24	2002-05-06	Ajinomoto Co., Inc.	Nateglinide-containing preparations
US20080058424A1 (en) *	2002-05-23	2008-03-06	Cephalon, Inc.	Novel pharmaceutical formulations of modafinil
JP2003252749A (ja) *	2002-03-04	2003-09-10	Shin Etsu Chem Co Ltd	外用基剤
US6830759B2 (en)	2002-06-28	2004-12-14	Ajinomoto Co., Inc.	Antidiabetic preparation for oral administration
CN1247194C (zh) *	2002-08-27	2006-03-29	石药集团中奇制药技术（石家庄）有限公司	一种那格列奈包合物
US20040116532A1 (en) *	2002-09-13	2004-06-17	Craig Heacock	Pharmaceutical formulations of modafinil
US20050065183A1 (en) *	2003-07-31	2005-03-24	Indranil Nandi	Fexofenadine composition and process for preparing
WO2005013964A1 (ja) *	2003-08-08	2005-02-17	Ajinomoto Co., Inc.	ナテグリニド含有製剤
WO2005016315A1 (en) *	2003-08-14	2005-02-24	Ranbaxy Laboratories Limited	Pharmaceutical compositions of nateglinide and a high amount of a water-soluble filler
WO2005094812A1 (ja) *	2004-04-01	2005-10-13	Ajinomoto Co., Inc.	ナテグリニド含有製剤
WO2005117840A1 (en) *	2004-05-31	2005-12-15	Ranbaxy Laboratories Limited	Stable pharmaceutical compositions comprising pulverized granules of nateglinide of form b
WO2006013444A1 (en) *	2004-07-28	2006-02-09	Ranbaxy Laboratories Limited	Preparations of stable pharmaceutical compositions of nateglinide and processes for their preparation
JP2008509144A (ja) *	2004-08-04	2008-03-27	アルザ・コーポレーシヨン	上昇するゼロ次放出パターンを示す持続薬剤放出組成物、そのような組成物を製造する方法
KR20070058540A (ko) *	2004-10-01	2007-06-08	니폰 조키 세야쿠 가부시키가이샤	고형 의약제제
US7276198B2 (en) *	2004-12-28	2007-10-02	The Goodyear Tire & Rubber Company	Method and mold for making tire with tie bar
JP4974057B2 (ja) *	2005-01-31	2012-07-11	味の素株式会社	血糖降下剤を含有する、耐糖能異常、境界型糖尿病、インスリン抵抗性及び高インスリン血症の改善ないし治療用医薬組成物
JPWO2008072532A1 (ja) *	2006-12-07	2010-03-25	第一三共株式会社	貯蔵安定性が改善された医薬組成物
WO2008072533A1 (ja) *	2006-12-07	2008-06-19	Daiichi Sankyo Company, Limited	固形製剤の製造方法
WO2008072535A1 (ja) *	2006-12-07	2008-06-19	Daiichi Sankyo Company, Limited	低置換度ヒドロキシプロピルセルロースを含有する医薬組成物
US20100004279A1 (en) *	2006-12-07	2010-01-07	Tomoyuki Watanabe	Solid medicinal preparation containing mannitol or lactose
TWI405574B (zh) *	2007-06-21	2013-08-21	Otsuka Pharma Co Ltd	藥學固體製劑及其製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6354321A (ja) *	1985-03-27	1988-03-08	Ajinomoto Co Inc	血糖降下剤
JP3586471B2 (ja) *	1991-06-25	2004-11-10	三菱ウェルファーマ株式会社	トラセミド含有医薬組成物
DK0526171T3 (da)	1991-07-30	1997-08-25	Ajinomoto Kk	Krystaller af N-(trans-4-isopropylcyclohexylcarbonyl)-Dphenylalanin og fremgangsmåder til fremstilling deraf
EP0614358A1 (de) *	1991-11-26	1994-09-14	Warner-Lambert Company	Verfahren und zusammensetzung für die entwicklung einer gemfibrozil dosierungsform mit kontrollierter freigabe
KR100343062B1 (ko) *	1996-11-15	2002-07-02	에가시라 구니오	정제 조성물

1997
- 1997-11-14 KR KR1019997004308A patent/KR100343062B1/ko not_active Expired - Lifetime
- 1997-11-14 CA CA002271865A patent/CA2271865C/en not_active Expired - Lifetime
- 1997-11-14 AT AT97912459T patent/ATE322260T1/de not_active IP Right Cessation
- 1997-11-14 WO PCT/JP1997/004152 patent/WO1998022105A1/ja not_active Ceased
- 1997-11-14 EP EP10010714A patent/EP2277517A1/de not_active Withdrawn
- 1997-11-14 PT PT97912459T patent/PT965339E/pt unknown
- 1997-11-14 ES ES97912459T patent/ES2257772T3/es not_active Expired - Lifetime
- 1997-11-14 EP EP05014497A patent/EP1586314B1/de not_active Expired - Lifetime
- 1997-11-14 AT AT05014497T patent/ATE503472T1/de active
- 1997-11-14 DK DK05014497.1T patent/DK1586314T3/da active
- 1997-11-14 DE DE69735644T patent/DE69735644T2/de not_active Expired - Lifetime
- 1997-11-14 ES ES05014497T patent/ES2364145T3/es not_active Expired - Lifetime
- 1997-11-14 EP EP97912459A patent/EP0965339B1/de not_active Expired - Lifetime
- 1997-11-14 AU AU49654/97A patent/AU718350B2/en not_active Ceased
- 1997-11-14 DE DE69740161T patent/DE69740161D1/de not_active Expired - Lifetime
- 1997-11-14 TW TW086117009A patent/TW492878B/zh not_active IP Right Cessation
- 1997-11-14 JP JP32974597A patent/JP4171091B2/ja not_active Expired - Lifetime
- 1997-11-14 PT PT05014497T patent/PT1586314E/pt unknown
- 1997-11-14 CN CNB971811407A patent/CN1245158C/zh not_active Expired - Lifetime
1999
- 1999-05-14 US US09/311,060 patent/US6143323A/en not_active Expired - Lifetime
2000
- 2000-09-29 US US09/672,896 patent/US6296872B1/en not_active Expired - Lifetime
2001
- 2001-08-03 US US09/920,830 patent/US6641841B2/en not_active Expired - Lifetime
2003
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Also Published As

Publication number	Publication date
DE69740161D1 (de)	2011-05-12
JP4171091B2 (ja)	2008-10-22
EP2277517A1 (de)	2011-01-26
ATE322260T1 (de)	2006-04-15
ATE503472T1 (de)	2011-04-15
KR100343062B1 (ko)	2002-07-02
US6143323A (en)	2000-11-07
EP0965339B1 (de)	2006-04-05
JPH10194969A (ja)	1998-07-28
EP1586314A1 (de)	2005-10-19
CA2271865A1 (en)	1998-05-28
US6641841B2 (en)	2003-11-04
DE69735644D1 (de)	2006-05-18
WO1998022105A1 (en)	1998-05-28
ES2364145T3 (es)	2011-08-25
DE69735644T2 (de)	2007-05-03
US6296872B1 (en)	2001-10-02
KR20000053312A (ko)	2000-08-25
PT965339E (pt)	2006-06-30
PT1586314E (pt)	2011-07-01
US20030147951A1 (en)	2003-08-07
DK1586314T3 (da)	2011-06-20
EP1586314B1 (de)	2011-03-30
US6844008B2 (en)	2005-01-18
US20020028239A1 (en)	2002-03-07
CN1242704A (zh)	2000-01-26
AU4965497A (en)	1998-06-10
CN1245158C (zh)	2006-03-15
TW492878B (en)	2002-07-01
CA2271865C (en)	2003-10-14
AU718350B2 (en)	2000-04-13
EP0965339A4 (de)	2003-04-23
EP0965339A1 (de)	1999-12-22

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