ES2297727T3 - Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. - Google Patents

Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. Download PDF

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Publication number
ES2297727T3
ES2297727T3 ES05754708T ES05754708T ES2297727T3 ES 2297727 T3 ES2297727 T3 ES 2297727T3 ES 05754708 T ES05754708 T ES 05754708T ES 05754708 T ES05754708 T ES 05754708T ES 2297727 T3 ES2297727 T3 ES 2297727T3
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ES
Spain
Prior art keywords
group
octahidropirrolo
antivirical
pirrol
employment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05754708T
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English (en)
Inventor
Eun Kyung Lee
Chris Richard Melville
David Mark Rotstein
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2297727T3 publication Critical patent/ES2297727T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de la fórmula I, en la que: X1 se elige entre el grupo formado por -C(=O)R3, -S(=O)2R3 y -C(=O)OR3; X2 se elige entre el grupo formado por -C(=O)R4, -S(=O)2R4, bencilo y -CH2(piridin-3-ilo), dicho bencilo está opcionalmente sustituido por halógeno o alquilo C1-3; uno de R1 y R2 es: (i) fenilo opcionalmente sustituido de una a cuatro veces por sustituyentes elegidos con independencia de su aparición entre el grupo formado por halógeno, alquilo C1-6 y alcoxi C1-6; (ii) heteroarilo elegido entre el grupo formado por piridinilo, N-óxido de piridinilo, pirimidinilo y tiazolilo, dicho heteroarilo está opcionalmente sustituido de una a tres veces por sustituyentes elegidos con independencia entre sí entre el grupo formado por halógeno, alquilo C1-6, haloalquilo C1-6 y alcoxi C1-6; y el otro de R1 y R2 es hidrógeno.
ES05754708T 2004-06-09 2005-06-01 Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. Expired - Lifetime ES2297727T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09
US578759P 2004-06-09

Publications (1)

Publication Number Publication Date
ES2297727T3 true ES2297727T3 (es) 2008-05-01

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05754708T Expired - Lifetime ES2297727T3 (es) 2004-06-09 2005-06-01 Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos.

Country Status (21)

Country Link
US (2) US7164019B2 (es)
EP (1) EP1761542B1 (es)
JP (1) JP2008501743A (es)
CN (1) CN101001860A (es)
AR (1) AR049209A1 (es)
AT (1) ATE382623T1 (es)
AU (1) AU2005251891A1 (es)
BR (1) BRPI0511982A (es)
CA (1) CA2569910A1 (es)
DE (1) DE602005004144T2 (es)
DK (1) DK1761542T3 (es)
ES (1) ES2297727T3 (es)
IL (1) IL179534A0 (es)
MX (1) MXPA06014404A (es)
NO (1) NO20070137L (es)
PL (1) PL1761542T3 (es)
PT (1) PT1761542E (es)
RU (1) RU2006146608A (es)
TW (1) TW200701981A (es)
WO (1) WO2005121145A2 (es)
ZA (1) ZA200609837B (es)

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BR112012027640B1 (pt) 2010-04-29 2021-08-03 The University Of Edinburgh Composto, composição farmacêutica, e, métodos de preparar uma composição farmacêutica, de inibir a função da 11beta-hidroxiesteroide desidrogenase do tipo 1
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MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
CR20160418A (es) 2014-03-26 2016-11-07 Hoffmann La Roche Nuevos compuestos biciclicos de 7 eslabones
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
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Also Published As

Publication number Publication date
ATE382623T1 (de) 2008-01-15
JP2008501743A (ja) 2008-01-24
IL179534A0 (en) 2007-05-15
WO2005121145A2 (en) 2005-12-22
US7714018B2 (en) 2010-05-11
NO20070137L (no) 2007-03-06
PL1761542T3 (pl) 2008-06-30
US20060014767A1 (en) 2006-01-19
US20070117859A1 (en) 2007-05-24
ZA200609837B (en) 2008-09-25
MXPA06014404A (es) 2007-02-19
US7164019B2 (en) 2007-01-16
RU2006146608A (ru) 2008-07-20
EP1761542B1 (en) 2008-01-02
TW200701981A (en) 2007-01-16
EP1761542A2 (en) 2007-03-14
WO2005121145A3 (en) 2006-03-02
DK1761542T3 (da) 2008-04-28
CN101001860A (zh) 2007-07-18
DE602005004144D1 (de) 2008-02-14
DE602005004144T2 (de) 2009-01-29
AU2005251891A1 (en) 2005-12-22
AR049209A1 (es) 2006-07-05
CA2569910A1 (en) 2005-12-22
PT1761542E (pt) 2008-03-26
BRPI0511982A (pt) 2008-01-22

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