ES2530995T3 - Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana - Google Patents

Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana Download PDF

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ES2530995T3
ES2530995T3 ES08834753T ES08834753T ES2530995T3 ES 2530995 T3 ES2530995 T3 ES 2530995T3 ES 08834753 T ES08834753 T ES 08834753T ES 08834753 T ES08834753 T ES 08834753T ES 2530995 T3 ES2530995 T3 ES 2530995T3
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human
placental perfusate
placental
cells
come
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Xiaokui Zhang
Vanessa A Voskinarian-Berse
Lin Kang
Neerav Dilip Padliya
Robert Hariri
Mohammad A Heidaran
Ajai Pal
Andrew Zeitlin
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Clarity Acquisition II LLC
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Anthrogenesis Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/52—Intestine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
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  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

Células nucleadas humanas del perfusato placentario para usar en un método para el tratamiento de un tumor en un individuo, en donde las células nucleadas humanas del perfusato placentario comprenden células asesinas naturales placentarias intermedias CD56+, CD16- y son susceptibles de obtenerse mediante la perfusión de un ser humano placenta que se ha drenado del cordón umbilical y se enjuaga para retirar sangre residual para producir el perfusato placentario que comprende células placentarias nucleadas; y aislamiento de las células placentarias nucleadas de dicho perfusato placentario.
ES08834753T 2007-09-28 2008-09-29 Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana Active ES2530995T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99576307P 2007-09-28 2007-09-28
US9055508P 2008-08-20 2008-08-20
PCT/US2008/011251 WO2009045360A2 (en) 2007-09-28 2008-09-29 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells

Publications (1)

Publication Number Publication Date
ES2530995T3 true ES2530995T3 (es) 2015-03-09

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ES08834753T Active ES2530995T3 (es) 2007-09-28 2008-09-29 Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana
ES13188706T Active ES2719931T3 (es) 2007-09-28 2008-09-29 Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermedias que provienen de placenta humana

Family Applications After (1)

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ES13188706T Active ES2719931T3 (es) 2007-09-28 2008-09-29 Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermedias que provienen de placenta humana

Country Status (22)

Country Link
US (3) US8263065B2 (es)
EP (3) EP2783692B1 (es)
JP (5) JP5795476B2 (es)
KR (10) KR101648589B1 (es)
CN (3) CN101878034B (es)
AU (1) AU2008307633C1 (es)
BR (1) BRPI0817751A2 (es)
CA (2) CA2700617C (es)
DK (2) DK2783692T3 (es)
ES (2) ES2530995T3 (es)
HR (1) HRP20150220T1 (es)
HU (1) HUE024286T2 (es)
IL (2) IL204860A (es)
MX (2) MX2010003291A (es)
NZ (3) NZ584458A (es)
PL (1) PL2203176T3 (es)
PT (1) PT2203176E (es)
RS (1) RS53841B1 (es)
RU (1) RU2536242C2 (es)
SI (1) SI2203176T1 (es)
WO (1) WO2009045360A2 (es)
ZA (1) ZA201002304B (es)

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