ES2536002T3 - Marcadores para células pre-cancerígenas y cancerígenas y el método para interferir con la proliferación celular en ellas - Google Patents
Marcadores para células pre-cancerígenas y cancerígenas y el método para interferir con la proliferación celular en ellas Download PDFInfo
- Publication number
- ES2536002T3 ES2536002T3 ES10171926.8T ES10171926T ES2536002T3 ES 2536002 T3 ES2536002 T3 ES 2536002T3 ES 10171926 T ES10171926 T ES 10171926T ES 2536002 T3 ES2536002 T3 ES 2536002T3
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- cancer
- markers
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- cell proliferation
- oligonucleotides
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/708—Specific hybridization probes for papilloma
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Una molécula de ARN quimérico mitocondrial aislada que comprende ARN ribosómico mitocondrial 16S sentido covalentemente ligado en su extremo 5' al extremo 3' de un polinucleótido con una secuencia de repetición invertida, en la que la molécula de ARN quimérica comprende una secuencia de nucleótidos seleccionada del grupo que consiste en SEC ID Nº: 1, SEC ID Nº: 2 y SEC ID Nº: 3.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47210603P | 2003-05-21 | 2003-05-21 | |
| US472106P | 2003-05-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2536002T3 true ES2536002T3 (es) | 2015-05-19 |
Family
ID=33551438
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10171933.4T Expired - Lifetime ES2618210T3 (es) | 2003-05-21 | 2004-05-21 | Marcadores para células precancerosas y cancerosas y el método para interferir con la proliferación celular de estas |
| ES04752867T Expired - Lifetime ES2365511T3 (es) | 2003-05-21 | 2004-05-21 | Marcadores para células precancerosas y cancerosas y método para interferir con la proliferación celular. |
| ES10171926.8T Expired - Lifetime ES2536002T3 (es) | 2003-05-21 | 2004-05-21 | Marcadores para células pre-cancerígenas y cancerígenas y el método para interferir con la proliferación celular en ellas |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10171933.4T Expired - Lifetime ES2618210T3 (es) | 2003-05-21 | 2004-05-21 | Marcadores para células precancerosas y cancerosas y el método para interferir con la proliferación celular de estas |
| ES04752867T Expired - Lifetime ES2365511T3 (es) | 2003-05-21 | 2004-05-21 | Marcadores para células precancerosas y cancerosas y método para interferir con la proliferación celular. |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US8318686B2 (es) |
| EP (3) | EP2270159B1 (es) |
| JP (3) | JP5201834B2 (es) |
| AT (1) | ATE506437T1 (es) |
| BR (1) | BRPI0410789B8 (es) |
| CA (1) | CA2526639C (es) |
| DE (1) | DE602004032329D1 (es) |
| DK (3) | DK2270159T3 (es) |
| ES (3) | ES2618210T3 (es) |
| HU (1) | HUE032575T2 (es) |
| MX (1) | MXPA05012620A (es) |
| PL (3) | PL1625142T3 (es) |
| WO (1) | WO2005001030A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1625142T3 (pl) | 2003-05-21 | 2011-11-30 | Andes Biotechnologies Global Inc | Markery komórek przedrakowych i rakowych oraz sposób zaburzania proliferacji tych komórek |
| WO2006062389A2 (en) * | 2004-10-29 | 2006-06-15 | Primagen Holding B.V. | Methods using mitochondrial nucleic acid for determining a health status of an individual |
| CN102589945B (zh) * | 2012-02-16 | 2013-10-23 | 中国人民解放军第三军医大学第二附属医院 | 骨髓涂片存放盒 |
| JP2016519083A (ja) * | 2013-03-14 | 2016-06-30 | アンデス バイオテクノロジーズ ソシエダード アノニマAndes Biotechnologies S.A. | 多発性骨髄腫を検出および処置するための方法 |
| HUE042738T2 (hu) * | 2013-03-14 | 2019-07-29 | Andes Biotechnologies Global Inc | Antiszensz oligonukleotidok rákos õssejtek kezelésére |
| WO2015066485A2 (en) * | 2013-10-31 | 2015-05-07 | The Children's Hospital Of Philadelphia | Mitochondrial disease genetic diagnostics |
| EP3116513A4 (en) * | 2014-03-14 | 2017-10-25 | Andes Biotechnologies S.A. | Pharmaceutical compositions comprising rna and use for treating cancer |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US6537973B1 (en) | 1992-03-16 | 2003-03-25 | Isis Pharmaceuticals, Inc. | Oligonucleotide inhibition of protein kinase C |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5646262A (en) * | 1994-07-28 | 1997-07-08 | Georgetown University | Antisense oligonucleotides against hepatitis B viral replication |
| US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
| US6316210B1 (en) | 1995-12-20 | 2001-11-13 | Subsidiary No. 3, Inc. | Genetic suppressor elements against human immunodeficiency virus |
| US6426412B1 (en) | 1995-12-20 | 2002-07-30 | Subsidiary No. 3, Inc. | Nucleic acids encoding human immunodeficiency virus type 1 genetic suppressor elements |
| US5998203A (en) * | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| US6720413B1 (en) | 1997-03-04 | 2004-04-13 | Musc Foundation For Research Development | Methods and compositions for diagnosis and treatment of cancer |
| WO1998053319A2 (en) | 1997-05-21 | 1998-11-26 | The Johns Hopkins University | Gene expression profiles in normal and cancer cells |
| US6071743A (en) | 1997-06-02 | 2000-06-06 | Subsidiary No. 3, Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| US6537972B1 (en) | 1997-06-02 | 2003-03-25 | Subsidiary No. 3., Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| US6764822B1 (en) * | 1997-09-19 | 2004-07-20 | Sequenom, Inc. | DNA typing by mass spectrometry with polymorphic DNA repeat markers |
| JP3251219B2 (ja) | 1997-10-13 | 2002-01-28 | 雅嗣 田中 | ヒトミトコンドリアdnaを用いた遺伝子検出方法 |
| US6417169B1 (en) | 1998-04-23 | 2002-07-09 | Genesense Technologies Inc. | Insulin-like growth factor II antisense oligonucleotide sequences and methods of using same to inhibit cell growth |
| US7105639B2 (en) * | 1998-05-15 | 2006-09-12 | Genentech, Inc. | Anti-PRO 4405 antibodies |
| WO1999065928A2 (en) | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues |
| US6280946B2 (en) | 1998-08-07 | 2001-08-28 | Boston Probes, Inc. | PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and eucarya |
| WO2000026363A1 (en) * | 1998-11-04 | 2000-05-11 | Genset | GENOMIC AND COMPLETE cDNA SEQUENCES OF HUMAN ADIPOCYTE-SPECIFIC APM1 AND BIALLELIC MARKERS THEREOF |
| US6576759B2 (en) | 1999-02-10 | 2003-06-10 | Pangene Corporation | Antisense inhibition of RAD51 |
| JP2003521879A (ja) | 1999-04-20 | 2003-07-22 | マイトコー | アルツハイマー病とともに分離するミトコンドリア遺伝子における一塩基多型 |
| WO2001016323A2 (en) * | 1999-09-01 | 2001-03-08 | Subsidiary N0.3, Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| US6573050B1 (en) | 1999-10-29 | 2003-06-03 | Sunnybrook & Women's College Health Sciences Centre | Treatment, diagnosis and evaluation of anti-cancer therapy resistance in melanoma |
| WO2001076532A2 (en) | 2000-04-11 | 2001-10-18 | Cogent Neuroscience, Inc. | Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death |
| US6673917B1 (en) | 2000-09-28 | 2004-01-06 | University Of Ottawa | Antisense IAP nucleic acids and uses thereof |
| AU2002214487A1 (en) | 2000-11-10 | 2002-05-21 | Mitotech Ab | Method for inducing apoptiosis |
| CN1322143C (zh) * | 2000-12-04 | 2007-06-20 | 普里马根公司 | 检测线粒体核酸与核基因核酸比率确定药物活性和/或副作用的方法 |
| US6573051B2 (en) * | 2001-03-09 | 2003-06-03 | Molecular Staging, Inc. | Open circle probes with intramolecular stem structures |
| US6544958B2 (en) | 2001-03-26 | 2003-04-08 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government | Therapy of respiratory influenza virus infection using free and liposome-encapsulated ribonucleotides |
| US6905827B2 (en) * | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| EP1432823A4 (en) | 2001-08-30 | 2005-03-02 | Univ Emory | MITOCHONDRIAL BIOLOGICAL EXPRESSION ARRAYS |
| PL1625142T3 (pl) | 2003-05-21 | 2011-11-30 | Andes Biotechnologies Global Inc | Markery komórek przedrakowych i rakowych oraz sposób zaburzania proliferacji tych komórek |
| US7374927B2 (en) * | 2004-05-03 | 2008-05-20 | Affymetrix, Inc. | Methods of analysis of degraded nucleic acid samples |
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2004
- 2004-05-21 PL PL04752867T patent/PL1625142T3/pl unknown
- 2004-05-21 US US10/557,458 patent/US8318686B2/en not_active Expired - Fee Related
- 2004-05-21 PL PL10171926T patent/PL2270159T3/pl unknown
- 2004-05-21 ES ES10171933.4T patent/ES2618210T3/es not_active Expired - Lifetime
- 2004-05-21 MX MXPA05012620A patent/MXPA05012620A/es active IP Right Grant
- 2004-05-21 AT AT04752867T patent/ATE506437T1/de active
- 2004-05-21 HU HUE10171933A patent/HUE032575T2/en unknown
- 2004-05-21 DK DK10171926.8T patent/DK2270159T3/en active
- 2004-05-21 CA CA2526639A patent/CA2526639C/en not_active Expired - Lifetime
- 2004-05-21 EP EP20100171926 patent/EP2270159B1/en not_active Expired - Lifetime
- 2004-05-21 DE DE602004032329T patent/DE602004032329D1/de not_active Expired - Lifetime
- 2004-05-21 EP EP10171933.4A patent/EP2264170B1/en not_active Expired - Lifetime
- 2004-05-21 JP JP2006533267A patent/JP5201834B2/ja not_active Expired - Fee Related
- 2004-05-21 PL PL10171933T patent/PL2264170T3/pl unknown
- 2004-05-21 ES ES04752867T patent/ES2365511T3/es not_active Expired - Lifetime
- 2004-05-21 EP EP04752867A patent/EP1625142B1/en not_active Expired - Lifetime
- 2004-05-21 DK DK10171933.4T patent/DK2264170T3/en active
- 2004-05-21 BR BRPI0410789A patent/BRPI0410789B8/pt not_active IP Right Cessation
- 2004-05-21 WO PCT/US2004/015929 patent/WO2005001030A2/en not_active Ceased
- 2004-05-21 DK DK04752867.4T patent/DK1625142T3/da active
- 2004-05-21 ES ES10171926.8T patent/ES2536002T3/es not_active Expired - Lifetime
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2012
- 2012-09-26 US US13/627,965 patent/US8895719B2/en not_active Expired - Lifetime
- 2012-12-10 JP JP2012269587A patent/JP5775057B2/ja not_active Expired - Fee Related
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2014
- 2014-09-05 US US14/479,143 patent/US9359648B2/en not_active Expired - Fee Related
- 2014-12-03 JP JP2014244747A patent/JP2015096069A/ja active Pending
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2016
- 2016-04-26 US US15/139,255 patent/US9903000B2/en not_active Expired - Fee Related
-
2018
- 2018-01-10 US US15/867,627 patent/US10876166B2/en not_active Expired - Fee Related
-
2020
- 2020-11-24 US US17/103,671 patent/US20210348236A1/en not_active Abandoned
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