ES2939833T3 - Inhibidores de ACC de pirazol y usos de los mismos - Google Patents

Inhibidores de ACC de pirazol y usos de los mismos Download PDF

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Publication number: ES2939833T3
Authority: ES; Spain
Prior art keywords: compound; spp; plants; examples; compounds
Prior art date: 2015-11-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES16810189T

Other languages

English (en)

Spanish (es)

Inventor

Shomir Ghosh

Jeremy Robert Greenwood

Geraldine C Harriman

De Moradei Silvana Marcel Leit

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Gilead Apollo LLC

Original Assignee

Gilead Apollo LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-11-25

Filing date

2016-11-22

Publication date

2023-04-27

2016-11-22 Application filed by Gilead Apollo LLC filed Critical Gilead Apollo LLC

2023-04-27 Application granted granted Critical

2023-04-27 Publication of ES2939833T3 publication Critical patent/ES2939833T3/es

Status Active legal-status Critical Current

2036-11-22 Anticipated expiration legal-status Critical

Links

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HSMVPDGQOIQYSR-KGENOOAVSA-N triflumizole Chemical compound C1=CN=CN1C(/COCCC)=N/C1=CC=C(Cl)C=C1C(F)(F)F HSMVPDGQOIQYSR-KGENOOAVSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
ZSDSQXJSNMTJDA-UHFFFAOYSA-N trifluralin Chemical compound CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O ZSDSQXJSNMTJDA-UHFFFAOYSA-N 0.000 description 1
AKTQJCBOGPBERP-UHFFFAOYSA-N triflusulfuron Chemical compound FC(F)(F)COC1=NC(N(C)C)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2C)C(O)=O)=N1 AKTQJCBOGPBERP-UHFFFAOYSA-N 0.000 description 1
125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
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UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical group ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
229910052722 tritium Inorganic materials 0.000 description 1
KVEQCVKVIFQSGC-UHFFFAOYSA-N tritosulfuron Chemical compound FC(F)(F)C1=NC(OC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(F)(F)F)=N1 KVEQCVKVIFQSGC-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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NQPDZGIKBAWPEJ-UHFFFAOYSA-M valerate Chemical compound CCCCC([O-])=O NQPDZGIKBAWPEJ-UHFFFAOYSA-M 0.000 description 1
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229940082509 xanthan gum Drugs 0.000 description 1
229940002552 xenical Drugs 0.000 description 1
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239000011701 zinc Substances 0.000 description 1
DUBNHZYBDBBJHD-UHFFFAOYSA-L ziram Chemical compound [Zn+2].CN(C)C([S-])=S.CN(C)C([S-])=S DUBNHZYBDBBJHD-UHFFFAOYSA-L 0.000 description 1
FJBGIXKIXPUXBY-UHFFFAOYSA-N {2-[3-(4-chlorophenyl)propyl]-2,4,4-trimethyl-1,3-oxazolidin-3-yl}(imidazol-1-yl)methanone Chemical compound C1=CN=CN1C(=O)N1C(C)(C)COC1(C)CCCC1=CC=C(Cl)C=C1 FJBGIXKIXPUXBY-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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RS57157B1 (sr)	2011-11-11	2018-07-31	Gilead Apollo Llc	Acc inhibitori i njihove primene
EP3099677A4 (en)	2014-01-31	2017-07-26	Dana-Farber Cancer Institute, Inc.	Diaminopyrimidine benzenesulfone derivatives and uses thereof
US10793571B2 (en)	2014-01-31	2020-10-06	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
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PL3380479T3 (pl)	2015-11-25	2023-05-08	Gilead Apollo, Llc	Triazolowe inhibitory acc i ich zastosowania
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BR112018009212B1 (pt)	2015-11-25	2022-06-14	Gilead Apollo, Llc	Método para controlar patógenos fúngicos agrícolas
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2016
- 2016-11-22 AU AU2016361412A patent/AU2016361412A1/en not_active Abandoned
- 2016-11-22 CA CA3004796A patent/CA3004796C/en active Active
- 2016-11-22 US US15/358,627 patent/US20170166582A1/en not_active Abandoned
- 2016-11-22 KR KR1020187016696A patent/KR20180082556A/ko not_active Withdrawn
- 2016-11-22 BR BR112018010113-3A patent/BR112018010113B1/pt active IP Right Grant
- 2016-11-22 CN CN201680067509.5A patent/CN108349995B/zh active Active
- 2016-11-22 MX MX2018006286A patent/MX2018006286A/es unknown
- 2016-11-22 SI SI201631675T patent/SI3380480T1/sl unknown
- 2016-11-22 PT PT168101897T patent/PT3380480T/pt unknown
- 2016-11-22 EA EA201890913A patent/EA201890913A1/ru unknown
- 2016-11-22 JP JP2018525693A patent/JP2019502660A/ja active Pending
- 2016-11-22 PL PL16810189.7T patent/PL3380480T3/pl unknown
- 2016-11-22 EP EP16810189.7A patent/EP3380480B1/en active Active
- 2016-11-22 WO PCT/US2016/063386 patent/WO2017091600A1/en not_active Ceased
- 2016-11-22 ES ES16810189T patent/ES2939833T3/es active Active
- 2016-11-23 AR ARP160103590A patent/AR106798A1/es not_active Application Discontinuation
2018
- 2018-05-18 CL CL2018001356A patent/CL2018001356A1/es unknown
- 2018-05-23 CO CONC2018/0005368A patent/CO2018005368A2/es unknown
2019
- 2019-01-03 US US16/239,360 patent/US10941158B2/en active Active

Also Published As

Publication number	Publication date
PL3380480T3 (pl)	2023-05-08
CO2018005368A2 (es)	2018-05-31
US20190375759A1 (en)	2019-12-12
CA3004796C (en)	2023-11-14
WO2017091600A9 (en)	2018-07-19
CL2018001356A1 (es)	2018-08-17
AU2016361412A9 (en)	2018-12-06
PT3380480T (pt)	2023-03-14
BR112018010113A2 (pt)	2018-11-21
CA3004796A1 (en)	2017-06-01
JP2019502660A (ja)	2019-01-31
US20170166582A1 (en)	2017-06-15
WO2017091600A1 (en)	2017-06-01
EA201890913A1 (ru)	2018-11-30
KR20180082556A (ko)	2018-07-18
EP3380480B1 (en)	2022-12-14
MX2018006286A (es)	2018-09-07
US10941158B2 (en)	2021-03-09
CN108349995A (zh)	2018-07-31
CN108349995B (zh)	2021-08-03
AR106798A1 (es)	2018-02-21
BR112018010113B1 (pt)	2022-06-14
SI3380480T1 (sl)	2023-04-28
AU2016361412A1 (en)	2018-05-24
EP3380480A1 (en)	2018-10-03

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WO2010146032A2 (de)	2010-12-23	Fungizide mischungen
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EP2334654A1 (de)	2011-06-22	Triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
EP2328878A1 (de)	2011-06-08	Triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
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EP2334656A1 (de)	2011-06-22	Triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
JP2011518769A (ja)	2011-06-30	殺菌剤として使用するための置換ピラジニルメチルスルホンアミド
WO2009071389A1 (de)	2009-06-11	Fungizide mischungen
WO2010031842A1 (de)	2010-03-25	Imidazol- und triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
CN103491775A (zh)	2014-01-01	3,4-二取代的吡咯-2,5-二酮及其作为杀真菌剂的用途
WO2009071450A1 (de)	2009-06-11	Fungizide mischungen
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