PL3380480T3 - Pirazolowe inhibitory acc i ich zastosowania - Google Patents

Pirazolowe inhibitory acc i ich zastosowania

Info

Publication number
PL3380480T3
PL3380480T3 PL16810189.7T PL16810189T PL3380480T3 PL 3380480 T3 PL3380480 T3 PL 3380480T3 PL 16810189 T PL16810189 T PL 16810189T PL 3380480 T3 PL3380480 T3 PL 3380480T3
Authority
PL
Poland
Prior art keywords
pyrazole
acc inhibitors
acc
inhibitors
pyrazole acc
Prior art date
Application number
PL16810189.7T
Other languages
English (en)
Inventor
Shomir Ghosh
Jeremy Robert Greenwood
Geraldine C. Harriman
Silvana Marcel LEIT DE MORADEI
Original Assignee
Gilead Apollo, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Apollo, Llc filed Critical Gilead Apollo, Llc
Publication of PL3380480T3 publication Critical patent/PL3380480T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PL16810189.7T 2015-11-25 2016-11-22 Pirazolowe inhibitory acc i ich zastosowania PL3380480T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562259973P 2015-11-25 2015-11-25
PCT/US2016/063386 WO2017091600A1 (en) 2015-11-25 2016-11-22 Pyrazole acc inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
PL3380480T3 true PL3380480T3 (pl) 2023-05-08

Family

ID=57543206

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16810189.7T PL3380480T3 (pl) 2015-11-25 2016-11-22 Pirazolowe inhibitory acc i ich zastosowania

Country Status (18)

Country Link
US (2) US20170166582A1 (pl)
EP (1) EP3380480B1 (pl)
JP (1) JP2019502660A (pl)
KR (1) KR20180082556A (pl)
CN (1) CN108349995B (pl)
AR (1) AR106798A1 (pl)
AU (1) AU2016361412A1 (pl)
BR (1) BR112018010113B1 (pl)
CA (1) CA3004796C (pl)
CL (1) CL2018001356A1 (pl)
CO (1) CO2018005368A2 (pl)
EA (1) EA201890913A1 (pl)
ES (1) ES2939833T3 (pl)
MX (1) MX2018006286A (pl)
PL (1) PL3380480T3 (pl)
PT (1) PT3380480T (pl)
SI (1) SI3380480T1 (pl)
WO (1) WO2017091600A1 (pl)

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MX2016009974A (es) 2014-01-31 2016-10-31 Dana Farber Cancer Inst Inc Derivados de diaminopirimidina bencensulfona y sus usos.
US11306105B2 (en) 2015-09-11 2022-04-19 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
JP2018526424A (ja) 2015-09-11 2018-09-13 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド アセトアミドチエノトリアゾロジアゼピンおよびこれらの使用
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
CR20180336A (es) 2015-11-25 2018-08-06 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos
EP3380478B1 (en) 2015-11-25 2020-12-23 Gilead Apollo, LLC Ester acc inhibitors and uses thereof
CA3005900C (en) 2015-11-25 2023-10-31 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
JP2019503338A (ja) 2015-11-25 2019-02-07 ギリアド アポロ， エルエルシー ２，４−ジオキソ−１，４−ジヒドロチエノ［２，３−ｄ］ピリミジンの誘導体を含む殺真菌組成物
MX2018006286A (es) 2015-11-25 2018-09-07 Gilead Apollo Llc Inhibidores de acc pirazolicos y usos de los mismos.
CN108699078A (zh) * 2016-03-02 2018-10-23 吉利德阿波罗公司 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法
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AU2018227575A1 (en) * 2017-03-03 2019-09-19 Gilead Apollo, Llc Processes for the preparation of fungicidal compounds
WO2018171698A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物及其制备方法和用途
EP4424364B1 (en) 2017-03-28 2026-01-21 Gilead Sciences, Inc. Combinations for use in the treatment of cirrhosis and liver fibrosis
WO2018228369A1 (zh) * 2017-06-15 2018-12-20 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
EP3655409B1 (en) * 2017-07-17 2023-12-27 Nanjing Ruijie Pharmatech Co., Ltd. Novel compounds and their uses as acc inhibitors
CN110950884B (zh) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
WO2020092239A1 (en) 2018-10-29 2020-05-07 Gilead Apollo, Llc Processes for the preparation of fungicidal compounds
CN111484504B (zh) * 2019-01-25 2024-05-10 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
JP7374233B2 (ja) 2019-07-02 2023-11-06 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
CN110746439B (zh) * 2019-10-18 2020-10-30 南京瑞捷医药科技有限公司 一种噻吩并嘧啶二酮化合物的制备方法
CN111039880B (zh) * 2019-12-10 2022-06-21 河南大学 咪康唑及其衍生物作为tgr5激动剂的应用
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN113968871A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 苯基取代类acc抑制剂的晶型
US20220192956A1 (en) * 2020-12-18 2022-06-23 The Procter & Gamble Company Superior efficacy of azoxystrobin and other strobilurins

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CN108349995B (zh) 2021-08-03
BR112018010113A2 (pt) 2018-11-21
CA3004796A1 (en) 2017-06-01
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SI3380480T1 (sl) 2023-04-28
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KR20180082556A (ko) 2018-07-18
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