JP2019502660A - ピラゾールａｃｃ阻害剤およびその使用 - Google Patents

ピラゾールａｃｃ阻害剤およびその使用 Download PDF

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Publication number: JP2019502660A
Authority: JP; Japan
Prior art keywords: grams; compound; membered; sulfur; composition
Prior art date: 2015-11-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2018525693A

Other languages

English (en)

Japanese (ja)

Other versions

JP2019502660A5 (2

Inventor

ショミールゴーシュ，

ジェレミーロバートグリーンウッド，

ジェラルディンシー．ハリマン，

デモラデイ，シルヴァーナマルセルレイト

Original Assignee

ギリアドアポロ，エルエルシー

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-11-25

Filing date

2016-11-22

Publication date

2019-01-31

2016-11-22 Application filed by ギリアドアポロ，エルエルシー, ギリアドアポロ，エルエルシー filed Critical ギリアドアポロ，エルエルシー

2019-01-31 Publication of JP2019502660A publication Critical patent/JP2019502660A/ja

2020-01-30 Publication of JP2019502660A5 publication Critical patent/JP2019502660A5/ja

Status Pending legal-status Critical Current

Links

0 C*N1CCOCC1 Chemical compound C*N1CCOCC1 0.000 description 17
NQRYJNQNLNOLGT-UHFFFAOYSA-N C1CCNCC1 Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
JBLADNFGVOKFSU-UHFFFAOYSA-N CC(C(NC1CCCCC1)=O)=C Chemical compound CC(C(NC1CCCCC1)=O)=C JBLADNFGVOKFSU-UHFFFAOYSA-N 0.000 description 1
QTHYVUKYHIFLMT-UHFFFAOYSA-O CC(C)(C(N)=O)N(C(c1c(N2CC(c3cc(F)ccc3OC)OC(CC3)CCC3O)[s]c([NH2+]C=CC=N)c1C)=O)C2=O Chemical compound CC(C)(C(N)=O)N(C(c1c(N2CC(c3cc(F)ccc3OC)OC(CC3)CCC3O)[s]c([NH2+]C=CC=N)c1C)=O)C2=O QTHYVUKYHIFLMT-UHFFFAOYSA-O 0.000 description 1
AVTSFOLQOFZSPI-QFIPXVFZSA-N CC(C)(C(N)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC(CC3)CCC3=O)[s]c(-[n]3nccc3)c1C)=O)C2=O Chemical compound CC(C)(C(N)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC(CC3)CCC3=O)[s]c(-[n]3nccc3)c1C)=O)C2=O AVTSFOLQOFZSPI-QFIPXVFZSA-N 0.000 description 1
AVKCYWCXZVHYCM-NRFANRHFSA-N CC(C)(C(N)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC3CCOCC3)[s]c(-[n]3nccc3)c1C)=O)C2=O Chemical compound CC(C)(C(N)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC3CCOCC3)[s]c(-[n]3nccc3)c1C)=O)C2=O AVKCYWCXZVHYCM-NRFANRHFSA-N 0.000 description 1
JLTGSGCGCJOYQN-QFIPXVFZSA-N CC(C)(C(O)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC(CC3)CCC3=O)[s]c(-[n]3nccc3)c1C)=O)C2=O Chemical compound CC(C)(C(O)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC(CC3)CCC3=O)[s]c(-[n]3nccc3)c1C)=O)C2=O JLTGSGCGCJOYQN-QFIPXVFZSA-N 0.000 description 1
VPESKKLPHBQAKC-NRFANRHFSA-N CC(C)(C(O)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC3CCOCC3)[s]c(-[n]3nccc3)c1C)=O)C2=O Chemical compound CC(C)(C(O)=O)N(C(c1c(N2C[C@@H](c(cc(cc3)F)c3OC)OC3CCOCC3)[s]c(-[n]3nccc3)c1C)=O)C2=O VPESKKLPHBQAKC-NRFANRHFSA-N 0.000 description 1
MEGAKIOVGGTJFY-UHFFFAOYSA-N CC(C)C(N(C)C(C)C)=O Chemical compound CC(C)C(N(C)C(C)C)=O MEGAKIOVGGTJFY-UHFFFAOYSA-N 0.000 description 1
BNDQAJZZCHWVGR-UHFFFAOYSA-N CC(C)C(N(C1)CC1O)=O Chemical compound CC(C)C(N(C1)CC1O)=O BNDQAJZZCHWVGR-UHFFFAOYSA-N 0.000 description 1
LHPSFBBWOPMGAT-UHFFFAOYSA-N CC(C)C(N1CC=CC1)=O Chemical compound CC(C)C(N1CC=CC1)=O LHPSFBBWOPMGAT-UHFFFAOYSA-N 0.000 description 1
GSBBRQAUAKEVIN-UHFFFAOYSA-N CC(C)C(N1CCOCC1)=O Chemical compound CC(C)C(N1CCOCC1)=O GSBBRQAUAKEVIN-UHFFFAOYSA-N 0.000 description 1
PLOWFYLEVMTQFE-DEOSSOPVSA-N CC(C)CO[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(N2CCCC2)=O)=O)C1=O)c(cccc1)c1OC Chemical compound CC(C)CO[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(N2CCCC2)=O)=O)C1=O)c(cccc1)c1OC PLOWFYLEVMTQFE-DEOSSOPVSA-N 0.000 description 1
LFCKTDZFQYGDPC-FQEVSTJZSA-N CC(C)CO[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(O)=O)=O)C1=O)c1ccccc1OC Chemical compound CC(C)CO[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(O)=O)=O)C1=O)c1ccccc1OC LFCKTDZFQYGDPC-FQEVSTJZSA-N 0.000 description 1
YQOPNAOQGQSUHF-UHFFFAOYSA-N CC(C)N1CCCC1 Chemical compound CC(C)N1CCCC1 YQOPNAOQGQSUHF-UHFFFAOYSA-N 0.000 description 1
KXIXHISTUVHOCY-UHFFFAOYSA-N CC(C)N1CCCCC1 Chemical compound CC(C)N1CCCCC1 KXIXHISTUVHOCY-UHFFFAOYSA-N 0.000 description 1
JSANAIROAXLLHI-QFIPXVFZSA-N CC(C)NC(C(C)(C)N(C(c1c(N2C[C@@H](c3ccccc3OC)OC(C)C)[s]c(-[n]3nccc3)c1C)=O)C2=O)=O Chemical compound CC(C)NC(C(C)(C)N(C(c1c(N2C[C@@H](c3ccccc3OC)OC(C)C)[s]c(-[n]3nccc3)c1C)=O)C2=O)=O JSANAIROAXLLHI-QFIPXVFZSA-N 0.000 description 1
PDUSWJORWQPNRP-UHFFFAOYSA-N CC(C)NC(C)=O Chemical compound CC(C)NC(C)=O PDUSWJORWQPNRP-UHFFFAOYSA-N 0.000 description 1
VUUDPXQNZWANIF-UHFFFAOYSA-O CC(C)OC(CN(c([s]c([NH2+]C=CC=N)c1C)c1C(N1C(C)(C)C(O)=O)=O)C1=O)c(cccc1)c1OC Chemical compound CC(C)OC(CN(c([s]c([NH2+]C=CC=N)c1C)c1C(N1C(C)(C)C(O)=O)=O)C1=O)c(cccc1)c1OC VUUDPXQNZWANIF-UHFFFAOYSA-O 0.000 description 1
JAEHYCWYLQDBPR-DEOSSOPVSA-N CC(C)O[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(N2CCCCC2)=O)=O)C1=O)c(cccc1)c1OC Chemical compound CC(C)O[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(N2CCCCC2)=O)=O)C1=O)c(cccc1)c1OC JAEHYCWYLQDBPR-DEOSSOPVSA-N 0.000 description 1
YXRBIBGCYMATCB-IBGZPJMESA-N CC(C)O[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(O)=O)=O)C1=O)c1ccccc1OC Chemical compound CC(C)O[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)(C)C(O)=O)=O)C1=O)c1ccccc1OC YXRBIBGCYMATCB-IBGZPJMESA-N 0.000 description 1
GFWQFHOVRJVWNN-FUBQLUNQSA-N CC(C)O[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)C(O)=O)=O)C1=O)c1cc(F)ccc1OC Chemical compound CC(C)O[C@@H](CN(c([s]c(-[n]1nccc1)c1C)c1C(N1C(C)C(O)=O)=O)C1=O)c1cc(F)ccc1OC GFWQFHOVRJVWNN-FUBQLUNQSA-N 0.000 description 1
DUUADMGTZDJNRI-UHFFFAOYSA-N CC(NC1CC1)=O Chemical compound CC(NC1CC1)=O DUUADMGTZDJNRI-UHFFFAOYSA-N 0.000 description 1
MXZVICYKUACCII-HNNXBMFYSA-N CCC[C@@H](c1ccccc1OC)OCC(C)C Chemical compound CCC[C@@H](c1ccccc1OC)OCC(C)C MXZVICYKUACCII-HNNXBMFYSA-N 0.000 description 1
PNKPLNMFBZTDTE-LBPRGKRZSA-N CC[C@@H](c1cc(F)ccc1OC)OC(C)C Chemical compound CC[C@@H](c1cc(F)ccc1OC)OC(C)C PNKPLNMFBZTDTE-LBPRGKRZSA-N 0.000 description 1
YDKGHCSHEUTPKT-UHFFFAOYSA-N CCc1cc(F)ccc1OCCO Chemical compound CCc1cc(F)ccc1OCCO YDKGHCSHEUTPKT-UHFFFAOYSA-N 0.000 description 1
JIYYXAYCSNHBJW-UHFFFAOYSA-N CCc1cc(F)ccc1OCCOC Chemical compound CCc1cc(F)ccc1OCCOC JIYYXAYCSNHBJW-UHFFFAOYSA-N 0.000 description 1
AHVYPIQETPWLSZ-UHFFFAOYSA-N CN1CC=CC1 Chemical compound CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 description 1
QXOBYWRKNIDHJG-UHFFFAOYSA-N Cc1cc(F)ccc1OC Chemical compound Cc1cc(F)ccc1OC QXOBYWRKNIDHJG-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Environmental Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

JP2018525693A 2015-11-25 2016-11-22 ピラゾールａｃｃ阻害剤およびその使用 Pending JP2019502660A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201562259973P	2015-11-25	2015-11-25
US62/259,973		2015-11-25
PCT/US2016/063386 WO2017091600A1 (en)	2015-11-25	2016-11-22	Pyrazole acc inhibitors and uses thereof

Publications (2)

Publication Number	Publication Date
JP2019502660A true JP2019502660A (ja)	2019-01-31
JP2019502660A5 JP2019502660A5 (2)	2020-01-30

Family

ID=57543206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2018525693A Pending JP2019502660A (ja)	2015-11-25	2016-11-22	ピラゾールａｃｃ阻害剤およびその使用

Country Status (18)

Country	Link
US (2)	US20170166582A1 (2)
EP (1)	EP3380480B1 (2)
JP (1)	JP2019502660A (2)
KR (1)	KR20180082556A (2)
CN (1)	CN108349995B (2)
AR (1)	AR106798A1 (2)
AU (1)	AU2016361412A1 (2)
BR (1)	BR112018010113B1 (2)
CA (1)	CA3004796C (2)
CL (1)	CL2018001356A1 (2)
CO (1)	CO2018005368A2 (2)
EA (1)	EA201890913A1 (2)
ES (1)	ES2939833T3 (2)
MX (1)	MX2018006286A (2)
PL (1)	PL3380480T3 (2)
PT (1)	PT3380480T (2)
SI (1)	SI3380480T1 (2)
WO (1)	WO2017091600A1 (2)

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EP3099677A4 (en)	2014-01-31	2017-07-26	Dana-Farber Cancer Institute, Inc.	Diaminopyrimidine benzenesulfone derivatives and uses thereof
US10793571B2 (en)	2014-01-31	2020-10-06	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
EP3347021A4 (en)	2015-09-11	2019-07-24	Dana-Farber Cancer Institute, Inc.	CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF
RU2018112953A (ru)	2015-09-11	2019-10-14	Дана-Фарбер Кэнсер Инститьют, Инк.	Ацетамидтиенотриазолодиазепины и пути их применения
AR106472A1 (es)	2015-10-26	2018-01-17	Gilead Apollo Llc	Inhibidores de acc y usos de los mismos
MX2018006499A (es)	2015-11-25	2018-08-01	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos.
EA201890949A1 (ru)	2015-11-25	2018-12-28	Джилид Аполло, Ллс	СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
BR112018009212B1 (pt)	2015-11-25	2022-06-14	Gilead Apollo, Llc	Método para controlar patógenos fúngicos agrícolas
AU2016361412A1 (en)	2015-11-25	2018-05-24	Gilead Apollo, Llc	Pyrazole ACC inhibitors and uses thereof
PL3380479T3 (pl)	2015-11-25	2023-05-08	Gilead Apollo, Llc	Triazolowe inhibitory acc i ich zastosowania
SG11201807077RA (en) *	2016-03-02	2018-09-27	Gilead Apollo Llc	Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
EP3571205B1 (en)	2017-01-22	2023-08-30	Sunshine Lake Pharma Co., Ltd.	Thienopyrimidine derivative and use thereof in medicine
WO2018161008A1 (en)	2017-03-03	2018-09-07	Gilead Apollo, Llc	Processes for the preparation of fungicidal compounds
CN110431143B (zh) *	2017-03-24	2022-08-12	浙江海正药业股份有限公司	杂芳基并嘧啶酮类衍生物及其制备方法和用途
SI4122464T1 (sl)	2017-03-28	2024-07-31	Gilead Sciences, Inc.	Terapevtske kombinacije za zdravljenje bolezni jeter
CN110709402B (zh) *	2017-06-15	2022-05-10	浙江海正药业股份有限公司	杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
CN111201234A (zh) *	2017-07-17	2020-05-26	南京瑞捷医药科技有限公司	新型化合物及其作为acc抑制剂的用途
CN110950884B (zh) *	2018-09-27	2024-03-26	上海翰森生物医药科技有限公司	含二并环类衍生物抑制剂、其制备方法和应用
WO2020092239A1 (en)	2018-10-29	2020-05-07	Gilead Apollo, Llc	Processes for the preparation of fungicidal compounds
CN111484504B (zh) *	2019-01-25	2024-05-10	南京圣和药业股份有限公司	Acc抑制剂的光学异构体及其应用
EP3995498A4 (en)	2019-07-02	2023-03-01	Sunshine Lake Pharma Co., Ltd.	THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE
AR119594A1 (es)	2019-08-09	2021-12-29	Gilead Sciences Inc	Derivados de tienopirimidina como inhibidores acc y usos de los mismos
CN110746439B (zh) *	2019-10-18	2020-10-30	南京瑞捷医药科技有限公司	一种噻吩并嘧啶二酮化合物的制备方法
CN111039880B (zh) *	2019-12-10	2022-06-21	河南大学	咪康唑及其衍生物作为tgr5激动剂的应用
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CN113968871A (zh) *	2020-07-25	2022-01-25	南京圣和药业股份有限公司	苯基取代类acc抑制剂的晶型
US20220192956A1 (en) *	2020-12-18	2022-06-23	The Procter & Gamble Company	Superior efficacy of azoxystrobin and other strobilurins

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PL3380480T3 (pl)	2023-05-08
CO2018005368A2 (es)	2018-05-31
ES2939833T3 (es)	2023-04-27
US20190375759A1 (en)	2019-12-12
CA3004796C (en)	2023-11-14
WO2017091600A9 (en)	2018-07-19
CL2018001356A1 (es)	2018-08-17
AU2016361412A9 (en)	2018-12-06
PT3380480T (pt)	2023-03-14
BR112018010113A2 (pt)	2018-11-21
CA3004796A1 (en)	2017-06-01
US20170166582A1 (en)	2017-06-15
WO2017091600A1 (en)	2017-06-01
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