ES8407018A1 - Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol. - Google Patents
Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol.Info
- Publication number
- ES8407018A1 ES8407018A1 ES522440A ES522440A ES8407018A1 ES 8407018 A1 ES8407018 A1 ES 8407018A1 ES 522440 A ES522440 A ES 522440A ES 522440 A ES522440 A ES 522440A ES 8407018 A1 ES8407018 A1 ES 8407018A1
- Authority
- ES
- Spain
- Prior art keywords
- synthesis
- octylaminopropanol
- isopropylthiophenyl
- ester
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- BFCDFTHTSVTWOG-UHFFFAOYSA-N 2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol Chemical compound CCCCCCCCNC(C)C(O)C1=CC=C(SC(C)C)C=C1 BFCDFTHTSVTWOG-UHFFFAOYSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical compound CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- NWEKXBVHVALDOL-UHFFFAOYSA-N butylazanium;hydroxide Chemical compound [OH-].CCCC[NH3+] NWEKXBVHVALDOL-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
PROCEDIMIENTO PARA LA SINTESIS DE 1-(4-ISOPROPILTIOFENIL) -2-N.OCTILAMINOPROPANOL.CONSISTE EN SOMETER 1-(4-TIOFENILO)-2-N.OCTALAMINOPROPANOL A UN PROCESO DE ALQUILACION, HACIENDO REACCIONAR ESTE CON UN AGENTE ALQUILIZANTE IC3H7X, PARA OBTENER COMPUESTOS DE FORMULA (I), DONDE X REPRESENTA UN GRUPO ELIMINABLE, CON PROPENO EN MEDIO ACIDO. LA REACCION SE REALIZA EN PRESENCIA DE AGUA O DE UN DISOLVENTE ORGANICO INERTE TAL COMO CLOROFORMO O DICLOROMETANO; UNA BASE ORGANICA TAL COMO HIDROXIDO SODICO O POTASICO; UN CATALIZADOR DE TRANSFERENCIA DE FASE TAL COMO HIDROXIDO DE TETRA-N.BUTILAMONIO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU83039A LU83039A1 (fr) | 1980-12-24 | 1980-12-24 | Procedes de synthese du 1-(4 isopropylthiophenyl)-2-n octylaminopropanol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES522440A0 ES522440A0 (es) | 1984-08-16 |
| ES8407018A1 true ES8407018A1 (es) | 1984-08-16 |
Family
ID=19729552
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508313A Expired ES8308844A1 (es) | 1980-12-24 | 1981-12-23 | "procedimiento para la sintesis de 1-(4-isopropiltiofenil)-2-n.-octilaminopropanol". |
| ES522442A Granted ES522442A0 (es) | 1980-12-24 | 1983-05-16 | Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol. |
| ES522441A Expired ES8407019A1 (es) | 1980-12-24 | 1983-05-16 | Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol. |
| ES522440A Expired ES8407018A1 (es) | 1980-12-24 | 1983-05-16 | Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol. |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508313A Expired ES8308844A1 (es) | 1980-12-24 | 1981-12-23 | "procedimiento para la sintesis de 1-(4-isopropiltiofenil)-2-n.-octilaminopropanol". |
| ES522442A Granted ES522442A0 (es) | 1980-12-24 | 1983-05-16 | Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol. |
| ES522441A Expired ES8407019A1 (es) | 1980-12-24 | 1983-05-16 | Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol. |
Country Status (11)
| Country | Link |
|---|---|
| JP (4) | JPS5912665B2 (es) |
| KR (1) | KR860000340B1 (es) |
| AR (1) | AR229799A1 (es) |
| AT (1) | AT380872B (es) |
| AU (1) | AU548084B2 (es) |
| CH (2) | CH654296A5 (es) |
| ES (4) | ES8308844A1 (es) |
| IL (1) | IL64631A0 (es) |
| IT (1) | IT1140399B (es) |
| LU (1) | LU83039A1 (es) |
| PT (1) | PT74203B (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
| GB1390748A (en) * | 1973-04-09 | 1975-04-16 | Continental Pharma | Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof |
| LU77237A1 (es) * | 1977-05-03 | 1979-01-18 | ||
| IT1082122B (it) * | 1977-07-11 | 1985-05-21 | Medea Res Srl | Processo per la preparazione dell'1-(4-isopropilmercapto-fenil)-2-n.ottilammino-propanolo |
| LU79970A1 (fr) * | 1978-07-13 | 1980-02-14 | Continental Pharma | Procede de preparation de derives de 1-phenyl-1-propanol |
-
1980
- 1980-12-24 LU LU83039A patent/LU83039A1/fr unknown
-
1981
- 1981-12-21 AT AT0549881A patent/AT380872B/de not_active IP Right Cessation
- 1981-12-23 AR AR287941A patent/AR229799A1/es active
- 1981-12-23 CH CH443/85A patent/CH654296A5/fr not_active IP Right Cessation
- 1981-12-23 ES ES508313A patent/ES8308844A1/es not_active Expired
- 1981-12-23 CH CH8259/81A patent/CH653325A5/fr not_active IP Right Cessation
- 1981-12-23 IL IL64631A patent/IL64631A0/xx unknown
- 1981-12-23 PT PT74203A patent/PT74203B/pt unknown
- 1981-12-24 IT IT25853/81A patent/IT1140399B/it active
- 1981-12-24 AU AU79025/81A patent/AU548084B2/en not_active Ceased
- 1981-12-24 KR KR1019810005129A patent/KR860000340B1/ko not_active Expired
- 1981-12-24 JP JP56208270A patent/JPS5912665B2/ja not_active Expired
-
1982
- 1982-12-06 JP JP57212826A patent/JPS5915905B2/ja not_active Expired
- 1982-12-06 JP JP57212827A patent/JPS5915906B2/ja not_active Expired
- 1982-12-06 JP JP57212825A patent/JPS5938224B2/ja not_active Expired
-
1983
- 1983-05-16 ES ES522442A patent/ES522442A0/es active Granted
- 1983-05-16 ES ES522441A patent/ES8407019A1/es not_active Expired
- 1983-05-16 ES ES522440A patent/ES8407018A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES522440A0 (es) | 1984-08-16 |
| JPS58113169A (ja) | 1983-07-05 |
| IT1140399B (it) | 1986-09-24 |
| IT8125853A0 (it) | 1981-12-24 |
| CH654296A5 (en) | 1986-02-14 |
| ES522441A0 (es) | 1984-08-16 |
| AU7902581A (en) | 1982-07-01 |
| JPS58113171A (ja) | 1983-07-05 |
| JPS5915905B2 (ja) | 1984-04-12 |
| ES508313A0 (es) | 1983-10-01 |
| IL64631A0 (en) | 1982-03-31 |
| CH653325A5 (en) | 1985-12-31 |
| PT74203A (fr) | 1982-01-01 |
| ES8407020A1 (es) | 1984-08-16 |
| JPS5912665B2 (ja) | 1984-03-24 |
| KR860000340B1 (ko) | 1986-04-12 |
| ES8308844A1 (es) | 1983-10-01 |
| AT380872B (de) | 1986-07-25 |
| LU83039A1 (fr) | 1982-07-07 |
| JPS5915906B2 (ja) | 1984-04-12 |
| ATA549881A (de) | 1985-12-15 |
| ES522442A0 (es) | 1984-08-16 |
| JPS5938224B2 (ja) | 1984-09-14 |
| PT74203B (fr) | 1983-05-20 |
| ES8407019A1 (es) | 1984-08-16 |
| AR229799A1 (es) | 1983-11-30 |
| JPS57134459A (en) | 1982-08-19 |
| AU548084B2 (en) | 1985-11-21 |
| KR830007541A (ko) | 1983-10-21 |
| JPS58113170A (ja) | 1983-07-05 |
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