ES8407019A1 - Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol. - Google Patents

Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.

Info

Publication number
ES8407019A1
ES8407019A1 ES522441A ES522441A ES8407019A1 ES 8407019 A1 ES8407019 A1 ES 8407019A1 ES 522441 A ES522441 A ES 522441A ES 522441 A ES522441 A ES 522441A ES 8407019 A1 ES8407019 A1 ES 8407019A1
Authority
ES
Spain
Prior art keywords
synthesis
octylaminopropanol
isopropylthiophenyl
ester
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522441A
Other languages
English (en)
Other versions
ES522441A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Continental Pharma Inc
Original Assignee
Continental Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma Inc filed Critical Continental Pharma Inc
Publication of ES522441A0 publication Critical patent/ES522441A0/es
Publication of ES8407019A1 publication Critical patent/ES8407019A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA SINTESIS DE 1-(4-ISOPROPILTIOFENIL) -2-N.OCTILAMINOPROPANOL.CONSISTE EN HACER REACCIONAR 1-(4-ISOPROPIL-TIOFENILO)-2-AMINOPROPANOL CON FORMALDEHIDO Y HEPTANONA-2- PARA OBTENER EL COMPUESTO DE FORMULA (I), Y POSTERIOR REDUCCION DEL PRODUCTO OBTENIDO EN EL AMINOALCOHOL CORRESPONDIENTE. SE REALIZA EN PRESENCIA DE DISOLVENTES ORGANICOS INERTES COMO ALCOHOLES, DISOLVENTES CLORADOS O HIDROCARBUROS ALIFATICOS O AROMATICOS, A UNA TEMPERATURA SUPERIOR A LA TEMPERATURA AMBIENTE, Y EN PRESENCIA DE UN CATALIZADOR ACIDO TAL COMO ACIDO CLORHIDRICO, SULFURICO Y ACETICO.
ES522441A 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol. Expired ES8407019A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU83039A LU83039A1 (fr) 1980-12-24 1980-12-24 Procedes de synthese du 1-(4 isopropylthiophenyl)-2-n octylaminopropanol

Publications (2)

Publication Number Publication Date
ES522441A0 ES522441A0 (es) 1984-08-16
ES8407019A1 true ES8407019A1 (es) 1984-08-16

Family

ID=19729552

Family Applications (4)

Application Number Title Priority Date Filing Date
ES508313A Expired ES8308844A1 (es) 1980-12-24 1981-12-23 "procedimiento para la sintesis de 1-(4-isopropiltiofenil)-2-n.-octilaminopropanol".
ES522442A Granted ES522442A0 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.
ES522441A Expired ES8407019A1 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.
ES522440A Expired ES8407018A1 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES508313A Expired ES8308844A1 (es) 1980-12-24 1981-12-23 "procedimiento para la sintesis de 1-(4-isopropiltiofenil)-2-n.-octilaminopropanol".
ES522442A Granted ES522442A0 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES522440A Expired ES8407018A1 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol.

Country Status (11)

Country Link
JP (4) JPS5912665B2 (es)
KR (1) KR860000340B1 (es)
AR (1) AR229799A1 (es)
AT (1) AT380872B (es)
AU (1) AU548084B2 (es)
CH (2) CH654296A5 (es)
ES (4) ES8308844A1 (es)
IL (1) IL64631A0 (es)
IT (1) IT1140399B (es)
LU (1) LU83039A1 (es)
PT (1) PT74203B (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1321701A (en) * 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
GB1390748A (en) * 1973-04-09 1975-04-16 Continental Pharma Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof
LU77237A1 (es) * 1977-05-03 1979-01-18
IT1082122B (it) * 1977-07-11 1985-05-21 Medea Res Srl Processo per la preparazione dell'1-(4-isopropilmercapto-fenil)-2-n.ottilammino-propanolo
LU79970A1 (fr) * 1978-07-13 1980-02-14 Continental Pharma Procede de preparation de derives de 1-phenyl-1-propanol

Also Published As

Publication number Publication date
ES522440A0 (es) 1984-08-16
JPS58113169A (ja) 1983-07-05
IT1140399B (it) 1986-09-24
IT8125853A0 (it) 1981-12-24
CH654296A5 (en) 1986-02-14
ES522441A0 (es) 1984-08-16
AU7902581A (en) 1982-07-01
JPS58113171A (ja) 1983-07-05
JPS5915905B2 (ja) 1984-04-12
ES508313A0 (es) 1983-10-01
ES8407018A1 (es) 1984-08-16
IL64631A0 (en) 1982-03-31
CH653325A5 (en) 1985-12-31
PT74203A (fr) 1982-01-01
ES8407020A1 (es) 1984-08-16
JPS5912665B2 (ja) 1984-03-24
KR860000340B1 (ko) 1986-04-12
ES8308844A1 (es) 1983-10-01
AT380872B (de) 1986-07-25
LU83039A1 (fr) 1982-07-07
JPS5915906B2 (ja) 1984-04-12
ATA549881A (de) 1985-12-15
ES522442A0 (es) 1984-08-16
JPS5938224B2 (ja) 1984-09-14
PT74203B (fr) 1983-05-20
AR229799A1 (es) 1983-11-30
JPS57134459A (en) 1982-08-19
AU548084B2 (en) 1985-11-21
KR830007541A (ko) 1983-10-21
JPS58113170A (ja) 1983-07-05

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