ES8601686A1 - Un procedimiento para preparar una composicion solida de liberacion rapida a base de un compuesto de dihidropiridina a. - Google Patents

Un procedimiento para preparar una composicion solida de liberacion rapida a base de un compuesto de dihidropiridina a.

Info

Publication number
ES8601686A1
ES8601686A1 ES535019A ES535019A ES8601686A1 ES 8601686 A1 ES8601686 A1 ES 8601686A1 ES 535019 A ES535019 A ES 535019A ES 535019 A ES535019 A ES 535019A ES 8601686 A1 ES8601686 A1 ES 8601686A1
Authority
ES
Spain
Prior art keywords
dihydropyridine
compound
preparing
solid preparation
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535019A
Other languages
English (en)
Other versions
ES535019A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8601686A1 publication Critical patent/ES8601686A1/es
Publication of ES535019A0 publication Critical patent/ES535019A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPOSICIONES SOLIDAS DE LIBERACION RAPIDA A BASE DE COMPUESTOS DE DIHIDROPIRIDINA A. COMPRENDE LA REACCION DEL COMPUESTO DE DIHIDROPIRIDINA A CON HIDROXIPROPILMETILCELULOSA. LA REACCION SE LLEVA A CABO POR DISOLUCION DEL COMPUESTO DE DIHIDROPIRIDINA A EN UN DISOLVENTE ORGANICO INERTE; ADICION DE UN POLIMERO SOLUBLE EN AGUA, TAL COMO LA HIDROXIPROPILMETILCELULOSA, A LA DISOLUCION ORGANICA RESULTANTE PARA PREPARAR UNA SUSPENSION HOMOGENEA; Y A CONTINUACION EVAPORAR EL DISOLVENTE ORGANICO DE LA SUSPENSION DE ACUERDO CON METODOS CONVENCIONALES. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES VASCULARES CORONARIAS, COMO INSUFICIENCIA CARDIACA, ANGINA DE PECHO, INFARTO DE MIOCARDIO O HIPERTENSION.
ES535019A 1983-08-11 1984-08-09 Un procedimiento para preparar una composicion solida de liberacion rapida a base de un compuesto de dihidropiridina a. Granted ES535019A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58147871A JPS6038322A (ja) 1983-08-11 1983-08-11 ジヒドロピリジンａ物質含有易溶性固形製剤

Publications (2)

Publication Number Publication Date
ES8601686A1 true ES8601686A1 (es) 1985-11-01
ES535019A0 ES535019A0 (es) 1985-11-01

Family

ID=15440116

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535019A Granted ES535019A0 (es) 1983-08-11 1984-08-09 Un procedimiento para preparar una composicion solida de liberacion rapida a base de un compuesto de dihidropiridina a.

Country Status (24)

Country Link
US (1) US4654206A (es)
EP (1) EP0137198B1 (es)
JP (1) JPS6038322A (es)
KR (1) KR910003559B1 (es)
AT (1) AT382779B (es)
AU (1) AU564506B2 (es)
BE (1) BE900348A (es)
CA (1) CA1228815A (es)
CH (1) CH660967A5 (es)
DE (1) DE3484259D1 (es)
DK (1) DK164020C (es)
ES (1) ES535019A0 (es)
FI (1) FI83839C (es)
FR (1) FR2550444B1 (es)
GB (1) GB2145332B (es)
GR (1) GR80004B (es)
HK (1) HK6688A (es)
IE (1) IE57757B1 (es)
IL (1) IL72565A (es)
IT (1) IT1183062B (es)
MY (1) MY100042A (es)
PH (1) PH21551A (es)
SG (1) SG73087G (es)
ZA (1) ZA845844B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
GB8608080D0 (en) * 1986-04-02 1986-05-08 Fujisawa Pharmaceutical Co Solid dispersion composition
ES2061623T3 (es) * 1987-03-02 1994-12-16 Brocades Pharma Bv Procedimiento para la obtencion de una composicion farmaceutica y un granulado farmaceutico.
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
NO883326L (no) * 1987-08-11 1989-02-13 Bayer Ag Dhp-retard-tilberedning.
ES2043766T3 (es) * 1987-11-11 1994-01-01 Pharmascience Lab Una nueva composicion farmaceutica que comprende exifona y un polimero soluble en agua.
JPH02206A (ja) * 1987-11-11 1990-01-05 Fujisawa Pharmaceut Co Ltd エキシホンと水溶性高分子化合物とを含有することを特徴とする新規製剤
FR2640137A1 (fr) * 1988-12-08 1990-06-15 Texinfine Sa Systemes transporteurs de principes actifs lipophiles et leur procede d'obtention
JPH0347124A (ja) * 1989-04-20 1991-02-28 Fujisawa Pharmaceut Co Ltd 経口吸収用製剤
JPH05501563A (ja) * 1989-11-18 1993-03-25 シエーリング・アグロケミカルズ・リミテツド プロペン酸誘導体の製造
JP3110794B2 (ja) * 1991-06-05 2000-11-20 ユーシービージャパン株式会社 １，４−ジヒドロピリジン誘導体を含有する製剤
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
DE69301742T2 (de) * 1992-02-17 1996-08-14 Siegfried Ag Pharma Darreichungsformen mit verlaengerter Wirkstoffreigabe
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
DE4316537A1 (de) * 1993-05-18 1994-11-24 Basf Ag Zubereitungen in Form fester Lösungen
US5871776A (en) * 1995-01-31 1999-02-16 Mehta; Atul M. Controlled-release nifedipine
DE19511131A1 (de) * 1995-03-27 1996-10-02 Basf Ag Mechanisch stabile feste Wirkstoffzubereitungsformen
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
HN1998000115A (es) * 1997-08-21 1999-06-02 Warner Lambert Co Formas de dosificación farmacéuticas sólidas
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
JP2003146878A (ja) * 2002-11-22 2003-05-21 Sawai Pharmaceutical Co Ltd ニルバジピン含有易溶性固形製剤およびその製造法
WO2004110354A2 (en) * 2003-05-15 2004-12-23 Roskamp Research, Llc Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis
TWI346114B (en) * 2003-09-29 2011-08-01 Method for stabilization of diarylvinylene compounds
CN100563658C (zh) * 2003-11-14 2009-12-02 味之素株式会社 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂
CN101883564B (zh) * 2007-10-05 2013-10-16 阿尔茨海默病学会美国公司 使用(-)-尼伐地平对映体减少淀粉状蛋白沉积、淀粉状蛋白神经毒性和小神经胶质增生的方法
US20100093810A1 (en) * 2007-10-05 2010-04-15 Alzheimer's Institute Of America, Inc. Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis
EP2814466B1 (en) * 2012-02-15 2018-12-26 Takeda Pharmaceutical Company Limited Tablet comprising 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamide or a salt thereof
KR20190050784A (ko) * 2016-09-07 2019-05-13 사니오나 에이/에스 테소펜신 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852421A (en) * 1970-03-23 1974-12-03 Shinetsu Chemical Co Excipient and shaped medicaments prepared therewith
GB1593261A (en) * 1976-07-23 1981-07-15 Inveresk Res Int Controlled release suppository
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS5668619A (en) * 1980-10-09 1981-06-09 Yamanouchi Pharmaceut Co Ltd Nifedipine-containing solid composition
JPS5877811A (ja) * 1981-11-04 1983-05-11 Kanebo Ltd 安定な易吸収性ニフエジピン製剤の製法
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
JPS58109412A (ja) * 1981-12-23 1983-06-29 Toa Eiyou Kagaku Kogyo Kk ニフエジピン固形製剤
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen

Also Published As

Publication number Publication date
DE3484259D1 (de) 1991-04-18
JPS6038322A (ja) 1985-02-27
GB8419815D0 (en) 1984-09-05
ATA251584A (de) 1986-09-15
GR80004B (en) 1984-11-30
AU564506B2 (en) 1987-08-13
FI843083A0 (fi) 1984-08-06
DK164020B (da) 1992-05-04
FR2550444A1 (fr) 1985-02-15
EP0137198A3 (en) 1986-10-01
FR2550444B1 (fr) 1988-09-16
AU3130684A (en) 1985-02-14
MY100042A (en) 1989-06-29
KR850001691A (ko) 1985-04-01
IL72565A (en) 1988-01-31
DK388884A (da) 1985-02-12
EP0137198A2 (en) 1985-04-17
US4654206A (en) 1987-03-31
PH21551A (en) 1987-12-11
GB2145332A (en) 1985-03-27
SG73087G (en) 1988-03-04
ES535019A0 (es) 1985-11-01
JPH0412245B2 (es) 1992-03-04
ZA845844B (en) 1985-05-29
IE841974L (en) 1985-02-11
AT382779B (de) 1987-04-10
KR910003559B1 (ko) 1991-06-05
IE57757B1 (en) 1993-03-24
IL72565A0 (en) 1984-11-30
FI83839C (fi) 1991-09-10
GB2145332B (en) 1987-03-25
CA1228815A (en) 1987-11-03
HK6688A (en) 1988-01-29
DK388884D0 (da) 1984-08-10
FI843083L (fi) 1985-02-12
BE900348A (fr) 1985-02-11
CH660967A5 (de) 1987-06-30
EP0137198B1 (en) 1991-03-13
IT8422294A0 (it) 1984-08-09
IT1183062B (it) 1987-10-05
DK164020C (da) 1992-09-28
FI83839B (fi) 1991-05-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050705