ES8601928A1 - Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas) - Google Patents

Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas)

Info

Publication number
ES8601928A1
ES8601928A1 ES537661A ES537661A ES8601928A1 ES 8601928 A1 ES8601928 A1 ES 8601928A1 ES 537661 A ES537661 A ES 537661A ES 537661 A ES537661 A ES 537661A ES 8601928 A1 ES8601928 A1 ES 8601928A1
Authority
ES
Spain
Prior art keywords
thioureas
ureas
propyl
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537661A
Other languages
English (en)
Other versions
ES537661A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Corp
Original Assignee
Boehringer Ingelheim Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Corp filed Critical Boehringer Ingelheim Corp
Publication of ES8601928A1 publication Critical patent/ES8601928A1/es
Publication of ES537661A0 publication Critical patent/ES537661A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO DE PREPARAR FENILALQUIL(PIPERAZINIL U HOMOPIPERAZINIL)PROPIL-(UREAS O TIOUREAS)SUSTITUIDAS.CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UN AGENTE DE FIJACION DE ACIDO COMO TRIETILAMINA O CARBONATO DE METAL ALCALINO, PARA OBTENER UN COMPUESTO DE FORMULA (I) O SUS SALES DE ADICION DE ACIDO FARMACOLOGICAMENTE ACEPTABLE. SIENDO R1, R 2 Y R3, H, ALQUILO INFERIOR, HIDROXILO Y OTROS; R4, H, ALQUILO DE C 1 A 12, CICLOALQUILO DE C 3 A 8 Y OTROS; X, O O S; Y SUSTITUYENTE REACTIVO QUE REACCIONA CON AMINA; M, 0 O 1; N, 1, 2, 3 O 4; Y P, 2, 3 O 4.SE UTILIZAN PARA EL TRATAMIENTO DE TRASTORNOS INMUNOLOGICOS, INFLAMATORIOS Y ALERGICOS.
ES537661A 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas) Granted ES537661A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50483783A 1983-06-16 1983-06-16

Publications (2)

Publication Number Publication Date
ES8601928A1 true ES8601928A1 (es) 1985-11-01
ES537661A0 ES537661A0 (es) 1985-11-01

Family

ID=24007953

Family Applications (3)

Application Number Title Priority Date Filing Date
ES533448A Expired ES8506651A1 (es) 1983-06-16 1984-06-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas y tioureas) sustituidas
ES537661A Granted ES537661A0 (es) 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas)
ES537662A Granted ES537662A0 (es) 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES533448A Expired ES8506651A1 (es) 1983-06-16 1984-06-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas y tioureas) sustituidas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES537662A Granted ES537662A0 (es) 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas

Country Status (25)

Country Link
EP (1) EP0129207B1 (es)
JP (1) JPS6075469A (es)
KR (1) KR890000175B1 (es)
AR (1) AR242377A1 (es)
AT (1) ATE33023T1 (es)
AU (1) AU565041B2 (es)
CA (1) CA1219260A (es)
CS (1) CS244821B2 (es)
DD (1) DD223710A5 (es)
DE (1) DE3469896D1 (es)
DK (1) DK160554C (es)
ES (3) ES8506651A1 (es)
FI (1) FI76327C (es)
GR (1) GR82367B (es)
HU (1) HU192409B (es)
IE (1) IE59034B1 (es)
IL (1) IL72123A (es)
NO (1) NO161618C (es)
NZ (1) NZ208535A (es)
PH (1) PH24059A (es)
PL (2) PL147413B1 (es)
PT (1) PT78729B (es)
SU (2) SU1542415A3 (es)
YU (2) YU104584A (es)
ZA (1) ZA844527B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661481A (en) * 1983-06-16 1987-04-28 Boehringer Ingelheim Pharmaceuticals, Inc Substituted phenylalkylhomopiperazinylpropyl(ureas or thioureas) useful for treatment of immulogical, inflammatory and allergic disorders
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
JP2722250B2 (ja) * 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
JPH0525145A (ja) * 1991-07-15 1993-02-02 Mochida Pharmaceut Co Ltd アレルギー性疾患治療剤
DE4302485A1 (de) * 1993-01-29 1994-08-04 Merck Patent Gmbh Piperazinderivate
JP3719612B2 (ja) * 1993-06-14 2005-11-24 塩野義製薬株式会社 ヘテロ環を含有する尿素誘導体
ITRM20060090A1 (it) * 2006-02-22 2007-08-23 Sigma Tau Ind Farmaceuti Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita
CN101835750B (zh) 2007-08-22 2013-07-17 阿斯利康(瑞典)有限公司 环丙基酰胺衍生物
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
US20110201623A1 (en) 2010-02-18 2011-08-18 Uczynski Michael A Crystalline Form Of A Cyclopropyl Benzamide Derivative
PT3484880T (pt) * 2016-07-13 2020-12-07 Leo Pharma As Moduladores heteroaromáticos do recetor órfão gama relacionado com retinóide

Also Published As

Publication number Publication date
IE841499L (en) 1984-12-16
ZA844527B (en) 1986-02-26
DK160554B (da) 1991-03-25
DD223710A5 (de) 1985-06-19
EP0129207A2 (en) 1984-12-27
PH24059A (en) 1990-03-05
FI842408A0 (fi) 1984-06-14
SU1387877A3 (ru) 1988-04-07
HU192409B (en) 1987-06-29
DK294084D0 (da) 1984-06-15
KR890000175B1 (ko) 1989-03-09
PL252851A1 (en) 1986-07-01
YU150186A (en) 1987-06-30
DE3469896D1 (en) 1988-04-21
FI842408A7 (fi) 1984-12-17
ES533448A0 (es) 1985-08-01
AR242377A1 (es) 1993-03-31
DK294084A (da) 1984-12-17
YU104584A (en) 1986-12-31
JPS6075469A (ja) 1985-04-27
PL248207A1 (en) 1985-08-13
EP0129207A3 (en) 1985-07-31
KR850000422A (ko) 1985-02-27
AU565041B2 (en) 1987-09-03
FI76327B (fi) 1988-06-30
ES8506651A1 (es) 1985-08-01
PL147413B1 (en) 1989-05-31
EP0129207B1 (en) 1988-03-16
CS244821B2 (en) 1986-08-14
NZ208535A (en) 1987-02-20
IL72123A (en) 1987-09-16
ES8600255A1 (es) 1985-09-16
NO842417L (no) 1984-12-17
GR82367B (es) 1984-12-13
NO161618C (no) 1989-09-06
PT78729A (en) 1984-07-01
SU1542415A3 (ru) 1990-02-07
IL72123A0 (en) 1984-10-31
PT78729B (en) 1986-10-21
NO161618B (no) 1989-05-29
ES537661A0 (es) 1985-11-01
IE59034B1 (en) 1993-12-15
PL146314B1 (en) 1989-01-31
JPH0469147B2 (es) 1992-11-05
ATE33023T1 (de) 1988-04-15
ES537662A0 (es) 1985-09-16
DK160554C (da) 1991-09-09
HUT34464A (en) 1985-03-28
CA1219260A (en) 1987-03-17
FI76327C (fi) 1988-10-10
AU2940484A (en) 1984-12-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020506