ES8601966A1 - Un procedimiento para la preparacion de compuestos de 1,4,4-triazolona. - Google Patents

Un procedimiento para la preparacion de compuestos de 1,4,4-triazolona.

Info

Publication number
ES8601966A1
ES8601966A1 ES536286A ES536286A ES8601966A1 ES 8601966 A1 ES8601966 A1 ES 8601966A1 ES 536286 A ES536286 A ES 536286A ES 536286 A ES536286 A ES 536286A ES 8601966 A1 ES8601966 A1 ES 8601966A1
Authority
ES
Spain
Prior art keywords
antidepressant
triazolone compounds
compounds
triazolone
phenoxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536286A
Other languages
English (en)
Other versions
ES536286A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24145128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8601966(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8601966A1 publication Critical patent/ES8601966A1/es
Publication of ES536286A0 publication Critical patent/ES536286A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE 1,4,4-TRIAZOLONA. CONSISTE EN: A) HACER REACCIONAR HIDRAZINA CON UN ESTER DE ACIDO LACTICO DE FORMULA (III) CON UN COMPUESTO DE FORMULA (IV) PARA FORMAR UN COMPUESTO DE FORMULA (V); C) CALENTAR A REFLUJO ESTE COMPUESTO DE FORMULA (V) PARA OBTENER UN COMPUESTO DE FORMULA (VI); Y D) ALQUILAR EL COMPUESTO OBTENIDO EN (C) CON 1-(3-CLOROPROPIL)-4-(3-CLOROFENILPIPERAZINA, Y DESPUES ESCINDIR EL GRUPO PROTECTOR P CON UN ACIDO DILUIDO PARA FORMAR EL COMPUESTO DE 1,4,4-TRIAZOLONA DE FORMULA (I), DONDE R ES H, ALQUILO INFERIOR C 1 A 4 Y OTROS; N ES 2-4; Y ES HALOGENO O TRIFLUORMETILO; Y Z ES H. SE UTILIZAN EN FARMACOLOGIA COMO ANTIDEPRESIVOS.
ES536286A 1983-09-30 1984-09-27 Un procedimiento para la preparacion de compuestos de 1,4,4-triazolona. Granted ES536286A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/538,027 US4613600A (en) 1983-09-30 1983-09-30 Antidepressant 1,2,4-triazolone compounds

Publications (2)

Publication Number Publication Date
ES8601966A1 true ES8601966A1 (es) 1985-11-16
ES536286A0 ES536286A0 (es) 1985-11-16

Family

ID=24145128

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536286A Granted ES536286A0 (es) 1983-09-30 1984-09-27 Un procedimiento para la preparacion de compuestos de 1,4,4-triazolona.

Country Status (25)

Country Link
US (1) US4613600A (es)
JP (1) JPS60100560A (es)
KR (1) KR880002624B1 (es)
AT (1) AT387963B (es)
AU (1) AU561460B2 (es)
BE (1) BE900714A (es)
CA (1) CA1237723A (es)
CH (1) CH661924A5 (es)
CY (1) CY1541A (es)
DE (1) DE3435745C2 (es)
DK (1) DK169546B1 (es)
ES (1) ES536286A0 (es)
FI (1) FI83310C (es)
FR (1) FR2552759B1 (es)
GB (1) GB2147297B (es)
GR (1) GR80475B (es)
HK (1) HK37391A (es)
IE (1) IE58084B1 (es)
IT (1) IT1178522B (es)
LU (1) LU85561A1 (es)
MY (1) MY102123A (es)
NL (1) NL8402946A (es)
SE (1) SE465928B (es)
YU (1) YU45667B (es)
ZA (1) ZA847589B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
YU44721B (en) * 1983-11-30 1990-12-31 Bristol Myers Co Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5504086A (en) * 1989-10-17 1996-04-02 Ellinwood, Jr.; Everett H. Intraoral dosing method of administering trifluorobenzodiazepines, propoxyphene, and nefazodone
US5256664A (en) * 1992-04-28 1993-10-26 Bristol-Myers Squibb Company Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
US6403593B1 (en) 1995-07-14 2002-06-11 Abbott Laboratories Triazole compounds and the use thereof
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
EP1171133B1 (en) * 1999-04-09 2006-06-21 Sepracor Inc. R-hydroxynefazodone
US6586437B2 (en) 1999-04-09 2003-07-01 Sepracor Inc. (S)-hydroxynefazodone antipsychotic therapy
JP2002541192A (ja) 1999-04-09 2002-12-03 セプラコール， インク． Ｓ−ヒドロキシネファゾドン
US6469008B2 (en) 1999-04-09 2002-10-22 Sepracor Inc. (R)-hydroxynefazodone antipsychotic therapy
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2567249A1 (en) * 2004-04-19 2006-10-05 Jds Pharmaceuticals, Llc Lithium combinations, and uses related thereto
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
WO2009111031A2 (en) * 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
EP2753179A4 (en) * 2011-09-09 2015-03-04 Univ Leland Stanford Junior TOPICAL ITRACONAZOLE FORMULATIONS AND THEIR USE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
IT1052119B (it) * 1972-10-16 1981-06-20 Sigma Tau Ind Farmaceuti Derivati del triazolinone e procedimento per la loro preparazione
US4338317A (en) * 1981-03-16 1982-07-06 Mead Johnson & Company Phenoxyethyl-1,2,4,-triazol-3-one antidepressants

Also Published As

Publication number Publication date
ATA310884A (de) 1988-09-15
MY102123A (en) 1992-03-31
NL8402946A (nl) 1985-04-16
BE900714A (fr) 1985-03-28
SE8404869L (sv) 1985-03-31
FI843779L (fi) 1985-03-31
FR2552759A1 (fr) 1985-04-05
ES536286A0 (es) 1985-11-16
YU172184A (en) 1986-10-31
JPS60100560A (ja) 1985-06-04
AU561460B2 (en) 1987-05-07
LU85561A1 (fr) 1985-06-04
GB2147297B (en) 1987-04-15
FI843779A0 (fi) 1984-09-26
IE842476L (en) 1985-03-30
DK468284A (da) 1985-03-31
SE465928B (sv) 1991-11-18
DE3435745C2 (de) 1994-11-03
CY1541A (en) 1991-03-22
GR80475B (en) 1985-01-31
AT387963B (de) 1989-04-10
FI83310C (fi) 1991-06-25
IE58084B1 (en) 1993-06-30
FR2552759B1 (fr) 1988-10-07
CA1237723A (en) 1988-06-07
JPH0542435B2 (es) 1993-06-28
YU45667B (sh) 1992-07-20
HK37391A (en) 1991-05-24
AU3364884A (en) 1985-04-04
ZA847589B (en) 1985-05-29
KR880002624B1 (ko) 1988-12-07
IT1178522B (it) 1987-09-09
GB8424535D0 (en) 1984-11-07
IT8422922A0 (it) 1984-09-28
DE3435745A1 (de) 1985-04-11
CH661924A5 (de) 1987-08-31
DK169546B1 (da) 1994-11-28
DK468284D0 (da) 1984-09-28
GB2147297A (en) 1985-05-09
FI83310B (fi) 1991-03-15
SE8404869D0 (sv) 1984-09-28
KR850002270A (ko) 1985-05-10
US4613600A (en) 1986-09-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050709