FI940733A0 - Polymeerisitoutuneet paklitakselijohdannaiset - Google Patents

Polymeerisitoutuneet paklitakselijohdannaiset

Info

Publication number: FI940733A0
Authority: FI; Finland
Prior art keywords: phe; gly; leu; ala; beta
Prior art date: 1992-06-19

Application number

FI940733A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI940733A7 (fi

Inventor

Nicola Mongelli

Francesco Angelucci

Enrico Pesenti

Antonino Suarato

Giovanni Biasoli

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-19

Filing date

1994-02-16

Publication date

1994-02-16

1994-02-16 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1994-02-16 Publication of FI940733A7 publication Critical patent/FI940733A7/fi

1994-02-16 Publication of FI940733A0 publication Critical patent/FI940733A0/fi

Links

229920000642 polymer Polymers 0.000 title abstract 2
150000004579 taxol derivatives Chemical class 0.000 title 1
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 4
KFKWRHQBZQICHA-STQMWFEESA-N Leu-Phe Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 KFKWRHQBZQICHA-STQMWFEESA-N 0.000 abstract 2
NHCKESBLOMHIIE-IRXDYDNUSA-N Phe-Gly-Phe Chemical compound C([C@H](N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 NHCKESBLOMHIIE-IRXDYDNUSA-N 0.000 abstract 2
IWZRODDWOSIXPZ-IRXDYDNUSA-N Phe-Phe-Gly Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(O)=O)C1=CC=CC=C1 IWZRODDWOSIXPZ-IRXDYDNUSA-N 0.000 abstract 2
AXIOGMQCDYVTNY-ACRUOGEOSA-N Phe-Phe-Leu Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 AXIOGMQCDYVTNY-ACRUOGEOSA-N 0.000 abstract 2
108010084525 phenylalanyl-phenylalanyl-glycine Proteins 0.000 abstract 2
-1 t-butoxy group Chemical group 0.000 abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
HSQGMTRYSIHDAC-BQBZGAKWSA-N Leu-Ala Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(O)=O HSQGMTRYSIHDAC-BQBZGAKWSA-N 0.000 abstract 1
LESXFEZIFXFIQR-LURJTMIESA-N Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)NCC(O)=O LESXFEZIFXFIQR-LURJTMIESA-N 0.000 abstract 1
YOKVEHGYYQEQOP-QWRGUYRKSA-N Leu-Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O YOKVEHGYYQEQOP-QWRGUYRKSA-N 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
MIDZLCFIAINOQN-WPRPVWTQSA-N Phe-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=CC=C1 MIDZLCFIAINOQN-WPRPVWTQSA-N 0.000 abstract 1
GLUBLISJVJFHQS-VIFPVBQESA-N Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](N)CC1=CC=CC=C1 GLUBLISJVJFHQS-VIFPVBQESA-N 0.000 abstract 1
SMFGCTXUBWEPKM-KBPBESRZSA-N Phe-Leu-Gly Chemical compound OC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CC=CC=C1 SMFGCTXUBWEPKM-KBPBESRZSA-N 0.000 abstract 1
QTDBZORPVYTRJU-KKXDTOCCSA-N Phe-Tyr-Ala Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(O)=O QTDBZORPVYTRJU-KKXDTOCCSA-N 0.000 abstract 1
HSRXSKHRSXRCFC-WDSKDSINSA-N Val-Ala Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](C)C(O)=O HSRXSKHRSXRCFC-WDSKDSINSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
108010050848 glycylleucine Proteins 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
108010071185 leucyl-alanine Proteins 0.000 abstract 1
108010044056 leucyl-phenylalanine Proteins 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
108010024607 phenylalanylalanine Proteins 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Epoxy Compounds (AREA)
Peptides Or Proteins (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Analysing Materials By The Use Of Radiation (AREA)

FI940733A 1992-06-19 1994-02-16 Polymeerisitoutuneet paklitakselijohdannaiset FI940733A0 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213077A GB9213077D0 (en)	1992-06-19	1992-06-19	Polymerbound taxol derivatives
PCT/EP1993/001433 WO1994000156A1 (en)	1992-06-19	1993-06-07	Polymer-bound paclitaxel derivatives

Publications (2)

Publication Number	Publication Date
FI940733A7 FI940733A7 (fi)	1994-02-16
FI940733A0 true FI940733A0 (fi)	1994-02-16

Family

ID=10717411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI940733A FI940733A0 (fi)	1992-06-19	1994-02-16	Polymeerisitoutuneet paklitakselijohdannaiset

Country Status (25)

Country	Link
US (4)	US5362831A (cs)
EP (1)	EP0600062B1 (cs)
JP (1)	JP3693340B2 (cs)
KR (1)	KR100281606B1 (cs)
CN (1)	CN1041281C (cs)
AT (1)	ATE205725T1 (cs)
AU (2)	AU659750B2 (cs)
CA (1)	CA2112482A1 (cs)
CZ (1)	CZ62094A3 (cs)
DE (1)	DE69330776T2 (cs)
ES (1)	ES2164663T3 (cs)
FI (1)	FI940733A0 (cs)
GB (1)	GB9213077D0 (cs)
HU (2)	HUT67914A (cs)
IL (1)	IL106023A (cs)
MX (1)	MX9303598A (cs)
MY (1)	MY109213A (cs)
NZ (1)	NZ253116A (cs)
PL (1)	PL173898B1 (cs)
RU (1)	RU2130462C1 (cs)
SG (1)	SG49248A1 (cs)
TW (1)	TW266201B (cs)
UA (1)	UA39926C2 (cs)
WO (1)	WO1994000156A1 (cs)
ZA (1)	ZA934388B (cs)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69118826T2 (de) *	1990-11-27	1996-11-14	Fuji Photo Film Co Ltd	Propenamidderivate, deren Polymere, Copolymere und deren Verwendung
GB9213077D0 (en) *	1992-06-19	1992-08-05	Erba Carlo Spa	Polymerbound taxol derivatives
US5614549A (en) *	1992-08-21	1997-03-25	Enzon, Inc.	High molecular weight polymer-based prodrugs
US5886026A (en) *	1993-07-19	1999-03-23	Angiotech Pharmaceuticals Inc.	Anti-angiogenic compositions and methods of use
US20030203976A1 (en)	1993-07-19	2003-10-30	William L. Hunter	Anti-angiogenic compositions and methods of use
AU2007254682B2 (en) *	1993-07-19	2011-06-02	Angiotech Pharmaceuticals, Inc.	Anti-angiogenic compositions and methods of use
CA2472404A1 (en)	1993-07-19	1995-02-02	Angiotech Pharmaceuticals, Inc.	Combination of stent and anti-angiogenic factor
GB9320781D0 (en) *	1993-10-08	1993-12-01	Erba Carlo Spa	Polymer-bound camptothecin derivatives
US5840900A (en) *	1993-10-20	1998-11-24	Enzon, Inc.	High molecular weight polymer-based prodrugs
US5880131A (en) *	1993-10-20	1999-03-09	Enzon, Inc.	High molecular weight polymer-based prodrugs
AU8052194A (en) *	1993-10-20	1995-05-08	Enzon, Inc.	2'- and/or 7- substituted taxoids
US5580898A (en) *	1994-05-24	1996-12-03	The Trustees Of The University Of Pennsylvania	Method of stabilizing microtubules
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
US5626862A (en)	1994-08-02	1997-05-06	Massachusetts Institute Of Technology	Controlled local delivery of chemotherapeutic agents for treating solid tumors
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
US5801191A (en) *	1995-06-01	1998-09-01	Biophysica Foundation	Taxoids
AU716005B2 (en)	1995-06-07	2000-02-17	Cook Medical Technologies Llc	Implantable medical device
US5807888A (en) *	1995-12-13	1998-09-15	Xechem International, Inc.	Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5840748A (en) *	1995-10-02	1998-11-24	Xechem International, Inc.	Dihalocephalomannine and methods of use therefor
US6177456B1 (en)	1995-10-02	2001-01-23	Xechem International, Inc.	Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5854278A (en) *	1995-12-13	1998-12-29	Xechem International, Inc.	Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5654448A (en) *	1995-10-02	1997-08-05	Xechem International, Inc.	Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
CN1304058C (zh)	1996-03-12	2007-03-14	Pg－Txl有限公司	水溶性紫杉醇产品
US6441025B2 (en) *	1996-03-12	2002-08-27	Pg-Txl Company, L.P.	Water soluble paclitaxel derivatives
WO1997038727A1 (en)	1996-04-15	1997-10-23	Asahi Kasei Kogyo Kabushiki Kaisha	Medicament composite
US5795909A (en)	1996-05-22	1998-08-18	Neuromedica, Inc.	DHA-pharmaceutical agent conjugates of taxanes
US5919815A (en) *	1996-05-22	1999-07-06	Neuromedica, Inc.	Taxane compounds and compositions
ES2151277T3 (es) *	1996-05-22	2000-12-16	Protarga Inc	Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US6576636B2 (en)	1996-05-22	2003-06-10	Protarga, Inc.	Method of treating a liver disorder with fatty acid-antiviral agent conjugates
DE69734060T2 (de)	1996-05-24	2006-06-29	Angiotech Pharmaceuticals, Inc., Vancouver	Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
EP0961793A4 (en) *	1997-02-11	2000-09-06	Council Of The Queensland	POLYMERS CONTAINING PEPTIDES
WO1998047496A2 (en) *	1997-04-18	1998-10-29	Access Pharmaceuticals, Inc.	Polymer-platinum compounds
US5965118A (en) *	1997-04-18	1999-10-12	Access Pharmaceuticals, Inc.	Polymer-platinum compounds
US8853260B2 (en)	1997-06-27	2014-10-07	Abraxis Bioscience, Llc	Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6501188B1 (en) *	1997-07-03	2002-12-31	Micron Technology, Inc.	Method for improving a stepper signal in a planarized surface over alignment topography
GB9721069D0 (en)	1997-10-03	1997-12-03	Pharmacia & Upjohn Spa	Polymeric derivatives of camptothecin
GB9721070D0 (en)	1997-10-03	1997-12-03	Pharmacia & Upjohn Spa	Bioactive derivatives of camptothecin
WO1999030727A1 (en)	1997-12-17	1999-06-24	Enzon, Inc.	Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US7208010B2 (en)	2000-10-16	2007-04-24	Conor Medsystems, Inc.	Expandable medical device for delivery of beneficial agent
US7208011B2 (en)	2001-08-20	2007-04-24	Conor Medsystems, Inc.	Implantable medical device with drug filled holes
US20040254635A1 (en)	1998-03-30	2004-12-16	Shanley John F.	Expandable medical device for delivery of beneficial agent
US6241762B1 (en)	1998-03-30	2001-06-05	Conor Medsystems, Inc.	Expandable medical device with ductile hinges
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
US6153655A (en) *	1998-04-17	2000-11-28	Enzon, Inc.	Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6293967B1 (en)	1998-10-29	2001-09-25	Conor Medsystems, Inc.	Expandable medical device with ductile hinges
US7018654B2 (en)	1999-03-05	2006-03-28	New River Pharmaceuticals Inc.	Pharmaceutical composition containing an active agent in an amino acid copolymer structure
US7235583B1 (en)	1999-03-09	2007-06-26	Luitpold Pharmaceuticals, Inc.,	Fatty acid-anticancer conjugates and uses thereof
US7060708B2 (en) *	1999-03-10	2006-06-13	New River Pharmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
US6716452B1 (en) *	2000-08-22	2004-04-06	New River Pharmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
US20010041189A1 (en) *	1999-04-13	2001-11-15	Jingya Xu	Poly(dipeptide) as a drug carrier
US6290673B1 (en)	1999-05-20	2001-09-18	Conor Medsystems, Inc.	Expandable medical device delivery system and method
US7229961B2 (en)	1999-08-24	2007-06-12	Cellgate, Inc.	Compositions and methods for enhancing drug delivery across and into ocular tissues
US6669951B2 (en) *	1999-08-24	2003-12-30	Cellgate, Inc.	Compositions and methods for enhancing drug delivery across and into epithelial tissues
US6593292B1 (en)	1999-08-24	2003-07-15	Cellgate, Inc.	Compositions and methods for enhancing drug delivery across and into epithelial tissues
US6730293B1 (en)	1999-08-24	2004-05-04	Cellgate, Inc.	Compositions and methods for treating inflammatory diseases of the skin
CN1111166C (zh) *	1999-09-10	2003-06-11	云南汉德生物技术有限公司	水溶性三尖杉磷碱聚氨基酸酯或其盐,含它们的药物组合物及其医药用途
US20030054977A1 (en) *	1999-10-12	2003-03-20	Cell Therapeutics, Inc.	Manufacture of polyglutamate-therapeutic agent conjugates
AU1820400A (en) *	1999-11-17	2001-05-30	School Of Pharmacy, University Of London, The	Conjugates of hpma copolymer and ellipticin
US6452024B1 (en)	2000-02-22	2002-09-17	Chaichem Pharmaceuticals International	Process for extraction and purification of paclitaxel from natural sources
US20020077290A1 (en) *	2000-03-17	2002-06-20	Rama Bhatt	Polyglutamic acid-camptothecin conjugates and methods of preparation
US20020099013A1 (en) *	2000-11-14	2002-07-25	Thomas Piccariello	Active agent delivery systems and methods for protecting and administering active agents
US7163918B2 (en)	2000-08-22	2007-01-16	New River Pharmaceuticals Inc.	Iodothyronine compositions
DE60133053T2 (de)	2000-10-16	2009-02-26	Conor Medsystems, Inc., Menlo Park	Ausdehnbare medizinische Vorrichtung zur Abgabe eines nützlichen Agens
US6764507B2 (en)	2000-10-16	2004-07-20	Conor Medsystems, Inc.	Expandable medical device with improved spatial distribution
US8394813B2 (en) *	2000-11-14	2013-03-12	Shire Llc	Active agent delivery systems and methods for protecting and administering active agents
US6566556B2 (en) *	2000-12-19	2003-05-20	Nippon Shokubai Co., Ltd.	Method for production of alkanolamine and apparatus therefor
US6964680B2 (en)	2001-02-05	2005-11-15	Conor Medsystems, Inc.	Expandable medical device with tapered hinge
US20040073294A1 (en)	2002-09-20	2004-04-15	Conor Medsystems, Inc.	Method and apparatus for loading a beneficial agent into an expandable medical device
ATE378342T1 (de) *	2001-02-20	2007-11-15	Enzon Inc	Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate
FI114710B (fi) *	2001-03-12	2004-12-15	Ctt Cancer Targeting Tech Oy	Leukosyytti-integriinien uusia peptidiligandeja
CA2440935A1 (en)	2001-03-13	2002-09-19	Richard Liggins	Micellar drug delivery vehicles and precursors thereto and uses thereof
US20030157170A1 (en) *	2001-03-13	2003-08-21	Richard Liggins	Micellar drug delivery vehicles and precursors thereto and uses thereof
ES2387562T3 (es)	2001-03-23	2012-09-26	Luitpold Pharmaceuticals, Inc.	Conjugados alcohol graso-medicamento
EP1427407A4 (en)	2001-03-23	2005-05-11	Luitpold Pharm Inc	FAT AMIN DRUG CONJUGATES
DE60220519T2 (de) *	2001-04-20	2007-09-27	The University Of British Columbia, Vancouver	Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
US7056338B2 (en)	2003-03-28	2006-06-06	Conor Medsystems, Inc.	Therapeutic agent delivery device with controlled therapeutic agent release rates
US7375082B2 (en) *	2002-02-22	2008-05-20	Shire Llc	Abuse-resistant hydrocodone compounds
US7338939B2 (en) *	2003-09-30	2008-03-04	New River Pharmaceuticals Inc.	Abuse-resistant hydrocodone compounds
US7169752B2 (en)	2003-09-30	2007-01-30	New River Pharmaceuticals Inc.	Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en)	2001-08-22	2006-01-19	Travis Mickle	Pharmaceutical compositions for prevention of overdose or abuse
US20070066537A1 (en) *	2002-02-22	2007-03-22	New River Pharmaceuticals Inc.	Compounds and compositions for prevention of overdose of oxycodone
US7141540B2 (en) *	2001-11-30	2006-11-28	Genta Salus Llc	Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
KR100822498B1 (ko) *	2002-02-22	2008-04-16	샤이어 엘엘씨	규제된 물질의 남용을 방지하기 위한 새로운 서방성 약학화합물
US7659253B2 (en)	2002-02-22	2010-02-09	Shire Llc	Abuse-resistant amphetamine prodrugs
WO2003072735A2 (en) *	2002-02-22	2003-09-04	New River Pharmaceuticals Inc.	Use of peptide-drug conjugation to reduce inter-subject variability of drug serum levels
US7105486B2 (en) *	2002-02-22	2006-09-12	New River Pharmaceuticals Inc.	Abuse-resistant amphetamine compounds
US7700561B2 (en) *	2002-02-22	2010-04-20	Shire Llc	Abuse-resistant amphetamine prodrugs
US20050169883A1 (en) *	2002-05-06	2005-08-04	Prestwich Glenn D.	Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
ATE424187T1 (de) *	2002-07-15	2009-03-15	Alcon Inc	Bioerodierbare folie zur abgabe eines ophthalmischen arzneimittels
AU2003300076C1 (en)	2002-12-30	2010-03-04	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
WO2004060403A2 (en) *	2003-01-06	2004-07-22	Angiochem Inc.	Aprotinin and anglos as carriers across the blood-brain barrier
US6759539B1 (en)	2003-02-27	2004-07-06	Chaichem Pharmaceuticals International	Process for isolation and purification of paclitaxel from natural sources
EP1610823B1 (en)	2003-03-28	2011-09-28	Innovational Holdings, LLC	Implantable medical device with continuous agent concentration gradient
SI1644019T2 (en) *	2003-05-29	2018-04-30	Shire Llc	Abuse resistant amphetamine compounds
US7169179B2 (en)	2003-06-05	2007-01-30	Conor Medsystems, Inc.	Drug delivery device and method for bi-directional drug delivery
US7883720B2 (en)	2003-07-09	2011-02-08	Wisconsin Alumni Research Foundation	Charge-dynamic polymers and delivery of anionic compounds
US7785653B2 (en)	2003-09-22	2010-08-31	Innovational Holdings Llc	Method and apparatus for loading a beneficial agent into an expandable medical device
EA008864B1 (ru) *	2003-09-30	2007-08-31	Нью Ривер Фармасьютикалз Инк.	Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств
TW200530231A (en)	2003-12-22	2005-09-16	Schering Corp	Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
US7846940B2 (en)	2004-03-31	2010-12-07	Cordis Corporation	Solution formulations of sirolimus and its analogs for CAD treatment
US8003122B2 (en)	2004-03-31	2011-08-23	Cordis Corporation	Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7989490B2 (en)	2004-06-02	2011-08-02	Cordis Corporation	Injectable formulations of taxanes for cad treatment
ES2744225T3 (es)	2005-07-15	2020-02-24	Angiochem Inc	Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos
US20070073385A1 (en) *	2005-09-20	2007-03-29	Cook Incorporated	Eluting, implantable medical device
KR101417136B1 (ko)	2005-12-13	2014-08-07	머크 샤프 앤드 돔 코포레이션	Ｅｒｋ 억제제인 폴리사이클릭 인다졸 유도체 및 이를 포함하는 약제학적 조성물
WO2008005284A2 (en)	2006-06-30	2008-01-10	Cook Incorporated	Methods of manufacturing and modifying taxane coatings for implantable medical devices
CN101611007A (zh)	2006-12-20	2009-12-23	先灵公司	新颖的jnk抑制剂
JP2010514839A (ja) *	2007-01-03	2010-05-06	バーナムインスティテュートフォーメディカルリサーチ	クロット結合化合物に関連する方法および組成物
ES2393639T3 (es)	2007-01-21	2012-12-26	Hemoteq Ag	Producto médico para tratar cierres de conductos corporales y prevención de nuevos cierres
US8784866B2 (en) *	2007-03-26	2014-07-22	William Marsh Rice University	Water-soluble carbon nanotube compositions for drug delivery and medicinal applications
US20080241215A1 (en) *	2007-03-28	2008-10-02	Robert Falotico	Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke
US9365634B2 (en) *	2007-05-29	2016-06-14	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
MY148609A (en)	2007-06-05	2013-05-15	Merck Sharp & Dohme	Polycyclic indazole derivatives and their use as erk inhibitors for the treatment of cancer
US9192697B2 (en)	2007-07-03	2015-11-24	Hemoteq Ag	Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
WO2009070380A2 (en) *	2007-10-03	2009-06-04	William Marsh Rice University	Water-soluble carbon nanotube compositions for drug delivery and medical applications
WO2009049100A2 (en) *	2007-10-09	2009-04-16	Wisconsin Alumni Research Foundation	Ultrathin multilayered films for controlled release of anionic reagents
US8420110B2 (en)	2008-03-31	2013-04-16	Cordis Corporation	Drug coated expandable devices
US8409601B2 (en)	2008-03-31	2013-04-02	Cordis Corporation	Rapamycin coated expandable devices
MX355683B (es)	2008-04-18	2018-04-26	Angiochem Inc	Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso.
US8273404B2 (en)	2008-05-19	2012-09-25	Cordis Corporation	Extraction of solvents from drug containing polymer reservoirs
US8642063B2 (en)	2008-08-22	2014-02-04	Cook Medical Technologies Llc	Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US9198968B2 (en)	2008-09-15	2015-12-01	The Spectranetics Corporation	Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
WO2010043049A1 (en)	2008-10-15	2010-04-22	Angiochem Inc.	Etoposide and doxorubicin conjugates for drug delivery
CA2740316A1 (en)	2008-10-15	2010-04-22	Angiochem Inc.	Conjugates of glp-1 agonists and uses thereof
CA2745524C (en)	2008-12-05	2020-06-09	Angiochem Inc.	Conjugates of neurotensin or neurotensin analogs and uses thereof
US8853353B2 (en)	2008-12-17	2014-10-07	Angiochem, Inc.	Membrane type-1 matrix metalloprotein inhibitors and uses thereof
CZ303072B6 (cs) *	2009-02-13	2012-03-21	Zentiva, K.S.	Polymerní konjugáty paclitaxelu a docetaxelu s pH rízeným uvolnováním kancerostatika
MX2011011023A (es)	2009-04-20	2012-01-20	Angiochem Inc	Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2.
WO2010124098A2 (en) *	2009-04-24	2010-10-28	Boston Scientific Scimed, Inc.	Use of drug polymorphs to achieve controlled drug delivery from a coated medical device
RU2012103240A (ru)	2009-07-02	2013-08-10	Ангиокем Инк.	Мультимерные пептидные конъюгаты и их применение
EP2944332B1 (en)	2009-07-10	2016-08-17	Boston Scientific Scimed, Inc.	Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en)	2009-07-17	2015-08-19	Boston Scientific Scimed, Inc.	Nucleation of drug delivery balloons to provide improved crystal size and density
JP2013506669A (ja)	2009-09-30	2013-02-28	メルク・シャープ・アンド・ドーム・コーポレーション	Ｅｒｋ阻害剤である新規化合物
EP3239139B1 (en)	2010-05-27	2020-10-28	Ningbo Combireg Pharmaceutical Technology Co. Ltd	Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
EP2611476B1 (en)	2010-09-02	2016-08-10	Boston Scientific Scimed, Inc.	Coating process for drug delivery balloons using heat-induced rewrap memory
US20120303115A1 (en)	2011-05-25	2012-11-29	Dadino Ronald C	Expandable devices coated with a rapamycin composition
US20120302954A1 (en)	2011-05-25	2012-11-29	Zhao Jonathon Z	Expandable devices coated with a paclitaxel composition
US8669360B2 (en)	2011-08-05	2014-03-11	Boston Scientific Scimed, Inc.	Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en)	2011-08-25	2013-02-28	Boston Scientific Scimed, Inc.	Medical device with crystalline drug coating
RU2493848C1 (ru) *	2012-06-14	2013-09-27	Геннадий Петрович Власов	Биодеградируемый полимерный носитель для доставки противоопухолевого лекарственного средства (варианты)
US9956385B2 (en)	2012-06-28	2018-05-01	The Spectranetics Corporation	Post-processing of a medical device to control morphology and mechanical properties
AR099812A1 (es)	2014-03-21	2016-08-17	Abbvie Inc	Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr
EP3307326B9 (en)	2015-06-15	2021-02-24	Angiochem Inc.	Methods for the treatment of leptomeningeal carcinomatosis
AU2016326747A1 (en)	2015-09-25	2018-03-01	Zy Therapeutics Inc.	Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
WO2017128173A1 (zh) *	2016-01-28	2017-08-03	北京和理咨询有限公司	紫杉醇或其衍生物的适配子偶合物及其制备方法和应用
AU2017279550A1 (en)	2016-06-08	2019-01-03	Abbvie Inc.	Anti-B7-H3 antibodies and antibody drug conjugates
MX2018015285A (es)	2016-06-08	2019-09-18	Abbvie Inc	Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco.
US20200147235A1 (en)	2016-06-08	2020-05-14	Abbvie Inc.	Anti-cd98 antibodies and antibody drug conjugates
JP2019524651A (ja)	2016-06-08	2019-09-05	アッヴィ・インコーポレイテッド	抗ｃｄ９８抗体及び抗体薬物コンジュゲート
WO2017214322A1 (en)	2016-06-08	2017-12-14	Abbvie Inc.	Anti-b7-h3 antibodies and antibody drug conjugates
KR20200122294A (ko) *	2017-11-17	2020-10-27	쌩뜨레 나티오날 데 라 르세르쉬 생띠끄 (씨. 엔. 알. 에스)	중합체성 전구약물 및 이의 피하 및/또는 근육내 투여
TWI786579B (zh) *	2020-03-26	2022-12-11	南韓商帝拉貝斯特股份有限公司	包含藥物二聚體的奈米粒子及其用途
AR124681A1 (es)	2021-01-20	2023-04-26	Abbvie Inc	Conjugados anticuerpo-fármaco anti-egfr
EP4475895A4 (en) *	2022-02-11	2026-01-28	Fairleigh Dickinson Univ	Locally administered compositions and their methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CS173846B1 (cs) *	1974-04-23	1977-03-31
CS173849B1 (cs) *	1974-04-25	1977-03-31
GB8500209D0 (en) *	1985-01-04	1985-02-13	Ceskoslovenska Akademie Ved	Synthetic polymeric drugs
US4690790A (en) *	1985-07-23	1987-09-01	Stemcor Corporation	Silicon nitride/silicon carbide composition and articles thereof
US4960790A (en) *	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
PT93772A (pt) *	1989-04-17	1991-01-08	Searle & Co	Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
US5278324A (en) *	1990-08-28	1994-01-11	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
US5200534A (en) *	1992-03-13	1993-04-06	University Of Florida	Process for the preparation of taxol and 10-deacetyltaxol
CA2130578A1 (en) *	1992-04-17	1993-10-28	Geewananda P. Gunawardana	Taxol derivatives
GB9213077D0 (en) *	1992-06-19	1992-08-05	Erba Carlo Spa	Polymerbound taxol derivatives

1992
- 1992-06-19 GB GB929213077A patent/GB9213077D0/en active Pending
1993
- 1993-05-25 TW TW082104130A patent/TW266201B/zh active
- 1993-06-07 EP EP93912905A patent/EP0600062B1/en not_active Expired - Lifetime
- 1993-06-07 JP JP50198194A patent/JP3693340B2/ja not_active Expired - Fee Related
- 1993-06-07 DE DE69330776T patent/DE69330776T2/de not_active Expired - Fee Related
- 1993-06-07 CZ CZ94620A patent/CZ62094A3/cs unknown
- 1993-06-07 AU AU43233/93A patent/AU659750B2/en not_active Ceased
- 1993-06-07 PL PL93302437A patent/PL173898B1/pl unknown
- 1993-06-07 NZ NZ253116A patent/NZ253116A/en unknown
- 1993-06-07 KR KR1019940700488A patent/KR100281606B1/ko not_active Expired - Fee Related
- 1993-06-07 ES ES93912905T patent/ES2164663T3/es not_active Expired - Lifetime
- 1993-06-07 HU HU9400800A patent/HUT67914A/hu unknown
- 1993-06-07 AT AT93912905T patent/ATE205725T1/de not_active IP Right Cessation
- 1993-06-07 RU RU94016158A patent/RU2130462C1/ru active
- 1993-06-07 SG SG1996008323A patent/SG49248A1/en unknown
- 1993-06-07 CA CA002112482A patent/CA2112482A1/en not_active Abandoned
- 1993-06-07 WO PCT/EP1993/001433 patent/WO1994000156A1/en not_active Ceased
- 1993-06-15 IL IL106023A patent/IL106023A/en not_active IP Right Cessation
- 1993-06-16 US US08/077,065 patent/US5362831A/en not_active Expired - Fee Related
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- 1993-06-17 CN CN93107196A patent/CN1041281C/zh not_active Expired - Fee Related
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- 1993-07-06 UA UA94005444A patent/UA39926C2/uk unknown
1994
- 1994-02-16 FI FI940733A patent/FI940733A0/fi unknown
- 1994-06-22 US US08/263,832 patent/US5473055A/en not_active Expired - Fee Related
1995
- 1995-04-05 AU AU16282/95A patent/AU671247B2/en not_active Ceased
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Publication number	Publication date
CZ62094A3 (en)	1994-07-13
CA2112482A1 (en)	1994-01-06
IL106023A (en)	1998-03-10
DE69330776T2 (de)	2002-07-04
RU2130462C1 (ru)	1999-05-20
JPH06509822A (ja)	1994-11-02
CN1079971A (zh)	1993-12-29
ZA934388B (en)	1994-08-29
HU9400800D0 (en)	1994-06-28
JP3693340B2 (ja)	2005-09-07
FI940733A7 (fi)	1994-02-16
AU671247B2 (en)	1996-08-15
AU659750B2 (en)	1995-05-25
US5569720A (en)	1996-10-29
IL106023A0 (en)	1993-10-20
ES2164663T3 (es)	2002-03-01
SG49248A1 (en)	1998-05-18
AU4323393A (en)	1994-01-24
US5719265A (en)	1998-02-17
UA39926C2 (uk)	2001-07-16
US5362831A (en)	1994-11-08
KR100281606B1 (ko)	2001-02-15
HU211291A9 (en)	1995-11-28
PL302437A1 (en)	1994-07-25
MX9303598A (es)	1994-01-31
GB9213077D0 (en)	1992-08-05
NZ253116A (en)	1996-05-28
AU1628295A (en)	1995-06-22
HUT67914A (en)	1995-05-29
US5473055A (en)	1995-12-05
EP0600062A1 (en)	1994-06-08
PL173898B1 (pl)	1998-05-29
TW266201B (cs)	1995-12-21
MY109213A (en)	1996-12-31
EP0600062B1 (en)	2001-09-19
DE69330776D1 (de)	2001-10-25
WO1994000156A1 (en)	1994-01-06
ATE205725T1 (de)	2001-10-15
CN1041281C (zh)	1998-12-23

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Date	Code	Title	Description
1997-01-21	GB	Transfer or assigment of application	Owner name: PHARMACIA & UPJOHN S.P.A.

Publication	Publication Date	Title
FI940733A0 (fi)	1994-02-16	Polymeerisitoutuneet paklitakselijohdannaiset
RU95112841A (ru)	1997-06-27	Полимерный конъюгат, способ его получения, производная 20-0-ациламинокамптотецина и способ ее получения, фармацевтическая композиция
RU94016158A (ru)	1995-09-27	Полимерный конъюгат, способ его получения, фармацевтическая композиция
IL118957A0 (en)	1996-10-31	Camptothecin derivatives their preparation and pharmaceutical compositions containing them
EA200000376A1 (ru)	2000-10-30	Полимерные производные камптотецинов
ATE146480T1 (de)	1997-01-15	Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate
KR970042553A (ko)	1997-07-24	캠프토테신 유도체
DE69015244D1 (de)	1995-02-02	Peptidverbindungen, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
US6034058A (en)	2000-03-07	Semi-synthetic alanyl dilemnin analogs
US20070048252A1 (en)	2007-03-01	Conjugates of the hydrophilic polymer and the molecules from boxwood extraction, and pharmaceutical compositions of the conjugates
US5571785A (en)	1996-11-05	Biologically active compounds
ATE89549T1 (de)	1993-06-15	Peptide mit inhibitorischer wirkung auf enzymatische systeme, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
WO1997010262A1 (fr)	1997-03-20	Derives peptidiques
NO940567L (no)	1994-02-18	Polymerbundne paclitaxelderivater
TH9590B (th)	2000-05-31	อนุพันธ์แพคลิทาเซลที่จับกับโพลีเมอร์
TH13694A (th)	1994-01-14	อนุพันธ์แพคลิทาเซลที่จับกับโพลีเมอร์
Newell et al.	1990	Clinical Studies with the p-Carboxyl Dimethyl Phenyl Triazene CB10-277
KR100197443B1 (ko)	1999-06-15	4베타-(아미노메틸카르보닐)-4'-0-데메틸-4-0-에피-포도필로톡신 화합물, 이의 제조 방법 및 이를 포함하는 항암제 조성물
ATE95169T1 (de)	1993-10-15	Peptide mit inhibitorischer wirkung auf enzymatische systeme, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
TH14266B (th)	2003-02-21	อนุพันธ์เพพไทด์ชนิดใหม่