FI960177L - Moninaisia hoidollisia ominaisuuksia omaavat trisubstituoidut imidatsolit - Google Patents

Moninaisia hoidollisia ominaisuuksia omaavat trisubstituoidut imidatsolit Download PDF

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Publication number: FI960177L
Authority: FI; Finland
Prior art keywords: therapeutic properties; diverse therapeutic; trisubstituted imidazoles; trisubstituted; imidazoles
Prior art date: 1993-07-16

Application number

FI960177A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI960177A7 (fi

FI960177A0 (fi

Inventor

Jerry Leroy Adams

Peter William Sheldrake

Timothy Francis Gallagher

Ravi Shanker Garigipati

Paul Elliot Bender

Jeffrey Charles Boehm

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

1994-07-15

Publication date

1996-01-15

1994-07-15 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1996-01-15 Publication of FI960177A7 publication Critical patent/FI960177A7/fi

1996-01-15 Publication of FI960177A0 publication Critical patent/FI960177A0/fi

1996-01-15 Publication of FI960177L publication Critical patent/FI960177L/fi

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)
Virology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)

FI960177A 1993-07-16 1994-07-15 Moninaisia hoidollisia ominaisuuksia omaavat trisubstituoidut imidatsolit FI960177L (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9273393A	1993-07-16	1993-07-16
PCT/US1994/007969 WO1995002591A1 (fr)	1993-07-16	1994-07-15	Imidazoles a tri-substitution et proprietes therapeutiques multiples

Publications (3)

Publication Number	Publication Date
FI960177A7 FI960177A7 (fi)	1996-01-15
FI960177A0 FI960177A0 (fi)	1996-01-15
FI960177L true FI960177L (fi)	1996-01-15

Family

ID=22234840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI960177A FI960177L (fi)	1993-07-16	1994-07-15	Moninaisia hoidollisia ominaisuuksia omaavat trisubstituoidut imidatsolit

Country Status (31)

Country	Link
EP (5)	EP0708768B1 (fr)
JP (4)	JPH09500137A (fr)
CN (2)	CN1050126C (fr)
AP (1)	AP484A (fr)
AT (2)	ATE236896T1 (fr)
AU (1)	AU694130C (fr)
BR (2)	BR9407079A (fr)
CA (1)	CA2167311A1 (fr)
CZ (1)	CZ11996A3 (fr)
DE (2)	DE69432463T2 (fr)
DK (1)	DK0708768T3 (fr)
DZ (1)	DZ1798A1 (fr)
ES (2)	ES2197167T3 (fr)
FI (1)	FI960177L (fr)
HK (3)	HK1049657A1 (fr)
HU (1)	HUT75313A (fr)
IL (2)	IL110296A (fr)
MA (1)	MA23270A1 (fr)
MY (1)	MY116478A (fr)
NO (4)	NO316881B1 (fr)
NZ (2)	NZ329994A (fr)
PL (4)	PL181705B1 (fr)
PT (1)	PT708768E (fr)
RU (1)	RU2140918C1 (fr)
SG (1)	SG52368A1 (fr)
SI (1)	SI0708768T1 (fr)
SK (1)	SK282342B6 (fr)
TW (1)	TW330934B (fr)
UA (1)	UA63875C2 (fr)
WO (1)	WO1995002591A1 (fr)
ZA (1)	ZA945193B (fr)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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US5916891A (en)	1992-01-13	1999-06-29	Smithkline Beecham Corporation	Pyrimidinyl imidazoles
US5840746A (en) *	1993-06-24	1998-11-24	Merck Frosst Canada, Inc.	Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
US5670527A (en) *	1993-07-16	1997-09-23	Smithkline Beecham Corporation	Pyridyl imidazole compounds and compositions
US5593992A (en) *	1993-07-16	1997-01-14	Smithkline Beecham Corporation	Compounds
US5616601A (en) *	1994-07-28	1997-04-01	Gd Searle & Co	1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US6613789B2 (en)	1994-07-28	2003-09-02	G. D. Searle & Co.	Heterocyclo-substituted imidazoles for the treatment of inflammation
CZ219597A3 (cs) *	1995-01-12	1998-03-18	Smithkline Beecham Corporation	Nové sloučeniny
GB9500580D0 (en) *	1995-01-12	1995-03-01	Merck Sharp & Dohme	Therapeutic agents
JPH11503110A (ja) *	1995-02-17	1999-03-23	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体拮抗剤
US6369068B1 (en)	1995-06-07	2002-04-09	Smithkline Beecham Corporation	Amino substituted pyrimidine containing compounds
IL118544A (en) *	1995-06-07	2001-08-08	Smithkline Beecham Corp	History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
US5739143A (en) *	1995-06-07	1998-04-14	Smithkline Beecham Corporation	Imidazole compounds and compositions
US6083949A (en) *	1995-10-06	2000-07-04	Merck & Co., Inc.	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US5717100A (en) *	1995-10-06	1998-02-10	Merck & Co., Inc.	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
DE19540027A1 (de) *	1995-10-27	1997-04-30	Gruenenthal Gmbh	Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
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US6046208A (en) *	1996-01-11	2000-04-04	Smithkline Beecham Corporation	Substituted imidazole compounds
ZA97175B (en) *	1996-01-11	1997-11-04	Smithkline Beecham Corp	Novel substituted imidazole compounds.
EP0883402A4 (fr) *	1996-01-11	1999-08-11	Smithkline Beecham Corp	Nouveaux imidazoles cycloalkyle-substitues
AP9700912A0 (en)	1996-01-11	1997-01-31	Smithkline Beecham Corp	Novel cycloalkyl substituted imidazoles
PL187516B1 (pl) *	1996-01-11	2004-07-30	Smithkline Beecham Corp	Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki
US6372741B1 (en) *	1996-03-08	2002-04-16	Smithkline Beecham Corporation	Use of CSAID™ compounds as inhibitors of angiogenesis
EP0889888A4 (fr) *	1996-03-25	2003-01-08	Smithkline Beecham Corp	Nouveau traitement des lesions du systeme nerveux central
ES2239357T3 (es) *	1996-06-10	2005-09-16	MERCK & CO., INC.	Imidazoles sustituidos que tienen actividad inhibidora de citoquinas.
WO1998007425A1 (fr)	1996-08-21	1998-02-26	Smithkline Beecham Corporation	Composes d'imidazole, compositions les contenant et leur utilisation
US5945418A (en) *	1996-12-18	1999-08-31	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US6147080A (en) *	1996-12-18	2000-11-14	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US6608060B1 (en)	1996-12-18	2003-08-19	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US5929076A (en) *	1997-01-10	1999-07-27	Smithkline Beecham Corporation	Cycloalkyl substituted imidazoles
US6187799B1 (en)	1997-05-23	2001-02-13	Onyx Pharmaceuticals	Inhibition of raf kinase activity using aryl ureas
AU7966198A (en)	1997-06-13	1998-12-30	Smithkline Beecham Corporation	Novel pyrazole and pyrazoline substituted compounds
EP0994870A4 (fr)	1997-06-19	2002-10-23	Smithkline Beecham	Nouveaux composes imidazole a substitution d'aryloxypymiridine
US6562832B1 (en)	1997-07-02	2003-05-13	Smithkline Beecham Corporation	Substituted imidazole compounds
US6251914B1 (en)	1997-07-02	2001-06-26	Smithkline Beecham Corporation	Cycloalkyl substituted imidazoles
TW517055B (en) *	1997-07-02	2003-01-11	Smithkline Beecham Corp	Novel substituted imidazole compounds
US7301021B2 (en)	1997-07-02	2007-11-27	Smithkline Beecham Corporation	Substituted imidazole compounds
US6489325B1 (en)	1998-07-01	2002-12-03	Smithkline Beecham Corporation	Substituted imidazole compounds
CA2306077A1 (fr)	1997-10-08	1999-04-15	Smithkline Beecham Corporation	Nouveaux composes substitues de cycloalcenyle
EP1021173A1 (fr) *	1997-10-10	2000-07-26	Imperial College Innovations Limited	Emploi de composes de csaid?tm pour le traitement des contractions uterines
JP3337992B2 (ja) *	1997-11-04	2002-10-28	ファイザー製薬株式会社	５−置換ピコリン酸化合物及びその製造方法
AU1924699A (en)	1997-12-19	1999-07-12	Smithkline Beecham Corporation	Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
US7329670B1 (en)	1997-12-22	2008-02-12	Bayer Pharmaceuticals Corporation	Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en)	1997-12-22	2009-04-14	Bayer Pharmaceuticals Corporation	Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
GB9809869D0 (en) *	1998-05-09	1998-07-08	Medical Res Council	Inhibition of protein kinases
JP2002516322A (ja)	1998-05-22	2002-06-04	スミスクライン・ビーチャム・コーポレイション	新規２−アルキル置換イミダゾール化合物
US6858617B2 (en)	1998-05-26	2005-02-22	Smithkline Beecham Corporation	Substituted imidazole compounds
EP1109918B1 (fr)	1998-06-24	2006-10-04	University of Dundee	Proteine kinases activees par des signaux mitogenes et le stress comprenant deux domaines kinase et leurs utilisations
AU4395399A (en) *	1998-07-02	2000-01-24	Sankyo Company Limited	Five-membered heteroaryl compounds
US6207687B1 (en) *	1998-07-31	2001-03-27	Merck & Co., Inc.	Substituted imidazoles having cytokine inhibitory activity
CA2341370A1 (fr)	1998-08-20	2000-03-02	Smithkline Beecham Corporation	Nouveaux composes de triazole substitues
DE69914357T2 (de)	1998-11-04	2004-11-11	Smithkline Beecham Corp.	Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
US6239279B1 (en)	1998-12-16	2001-05-29	Smithkline Beecham Corporation	Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
EP1158985B1 (fr)	1999-01-13	2011-12-28	Bayer HealthCare LLC	DIPHENYLE UREES A SUBSTITUTION OMEGA-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38
US20020065296A1 (en)	1999-01-13	2002-05-30	Bayer Corporation	Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
US8124630B2 (en)	1999-01-13	2012-02-28	Bayer Healthcare Llc	ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (fr)	1999-01-13	2006-03-22	Bayer Pharmaceuticals Corp.	Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf
ME00275B (fr)	1999-01-13	2011-02-10	Bayer Corp	DIPHENYLUREES A SUBSTITUANTS ω-CARBOXYARYLES, INHIBITRICES DE KINASE RAF
US7122666B2 (en)	1999-07-21	2006-10-17	Sankyo Company, Limited	Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
JP2003514900A (ja)	1999-11-23	2003-04-22	スミスクライン・ビーチャム・コーポレイション	ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
EP1233950B1 (fr)	1999-11-23	2005-10-05	Smithkline Beecham Corporation	3,4-dihydro-(1h)quinazolin-2-ones comme inhibiteurs de csbp/p38 kinase
ATE281439T1 (de)	1999-11-23	2004-11-15	Smithkline Beecham Corp	3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
US6759410B1 (en)	1999-11-23	2004-07-06	Smithline Beecham Corporation	3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6627647B1 (en)	2000-03-23	2003-09-30	Boehringer Ingelheim Pharmaceuticals, Inc.	Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents
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US7235576B1 (en)	2001-01-12	2007-06-26	Bayer Pharmaceuticals Corporation	Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
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US7371763B2 (en)	2001-04-20	2008-05-13	Bayer Pharmaceuticals Corporation	Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
FR2823747B1 (fr) *	2001-04-24	2003-05-23	Oreal	Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
FR2823751B1 (fr) *	2001-04-24	2003-05-23	Oreal	Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
WO2002094267A1 (fr) *	2001-05-24	2002-11-28	Sankyo Company, Limited	Preparation pharmaceutique pour prevenir ou traiter l'arthrite
SI1478358T1 (sl)	2002-02-11	2013-09-30	Bayer Healthcare Llc	Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
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1994
- 1994-07-12 IL IL11029694A patent/IL110296A/xx not_active IP Right Cessation
- 1994-07-13 DZ DZ940081A patent/DZ1798A1/fr active
- 1994-07-13 AP APAP/P/1994/000654A patent/AP484A/en active
- 1994-07-14 MA MA23584A patent/MA23270A1/fr unknown
- 1994-07-14 MY MYPI94001844A patent/MY116478A/en unknown
- 1994-07-15 SK SK47-96A patent/SK282342B6/sk unknown
- 1994-07-15 BR BR9407079A patent/BR9407079A/pt not_active Application Discontinuation
- 1994-07-15 AT AT94923503T patent/ATE236896T1/de not_active IP Right Cessation
- 1994-07-15 CN CN94193161A patent/CN1050126C/zh not_active Expired - Fee Related
- 1994-07-15 PL PL94312614A patent/PL181705B1/pl unknown
- 1994-07-15 HU HU9503855A patent/HUT75313A/hu unknown
- 1994-07-15 RU RU96103386/04A patent/RU2140918C1/ru not_active IP Right Cessation
- 1994-07-15 DE DE69432463T patent/DE69432463T2/de not_active Expired - Fee Related
- 1994-07-15 PT PT94923503T patent/PT708768E/pt unknown
- 1994-07-15 SG SG1996003561A patent/SG52368A1/en unknown
- 1994-07-15 EP EP94923503A patent/EP0708768B1/fr not_active Expired - Lifetime
- 1994-07-15 ES ES94923503T patent/ES2197167T3/es not_active Expired - Lifetime
- 1994-07-15 EP EP02076580A patent/EP1227091A3/fr not_active Withdrawn
- 1994-07-15 CA CA002167311A patent/CA2167311A1/fr not_active Abandoned
- 1994-07-15 FI FI960177A patent/FI960177L/fi unknown
- 1994-07-15 PL PL94332408A patent/PL181721B1/pl unknown
- 1994-07-15 DE DE69434316T patent/DE69434316T2/de not_active Expired - Fee Related
- 1994-07-15 PL PL94332406A patent/PL181694B1/pl unknown
- 1994-07-15 NZ NZ329994A patent/NZ329994A/xx unknown
- 1994-07-15 SI SI9430449T patent/SI0708768T1/xx unknown
- 1994-07-15 JP JP7504744A patent/JPH09500137A/ja active Pending
- 1994-07-15 WO PCT/US1994/007969 patent/WO1995002591A1/fr not_active Ceased
- 1994-07-15 AT AT02079534T patent/ATE291576T1/de not_active IP Right Cessation
- 1994-07-15 ZA ZA945193A patent/ZA945193B/xx unknown
- 1994-07-15 CZ CZ96119A patent/CZ11996A3/cs unknown
- 1994-07-15 PL PL94332405A patent/PL181723B1/pl unknown
- 1994-07-15 AU AU73354/94A patent/AU694130C/en not_active Ceased
- 1994-07-15 NZ NZ269457A patent/NZ269457A/en unknown
- 1994-07-15 EP EP02076582A patent/EP1227092A3/fr not_active Withdrawn
- 1994-07-15 UA UA96010110A patent/UA63875C2/uk unknown
- 1994-07-15 ES ES02079534T patent/ES2237650T3/es not_active Expired - Lifetime
- 1994-07-15 DK DK94923503T patent/DK0708768T3/da active
- 1994-07-15 EP EP02079534A patent/EP1291346B1/fr not_active Expired - Lifetime
- 1994-07-15 EP EP02076581A patent/EP1229035A1/fr not_active Withdrawn
- 1994-10-04 TW TW083109192A patent/TW330934B/zh active
1996
- 1996-01-15 NO NO960173A patent/NO316881B1/no not_active IP Right Cessation
1997
- 1997-05-13 BR BR1100546-7A patent/BR1100546A/pt active IP Right Grant
1998
- 1998-05-04 IL IL12431898A patent/IL124318A0/xx unknown
- 1998-06-17 CN CN98115012A patent/CN1218801A/zh active Pending
- 1998-12-16 HK HK03100345.9A patent/HK1049657A1/en unknown
- 1998-12-16 HK HK03100350.1A patent/HK1049659A1/en unknown
- 1998-12-16 HK HK03100349.5A patent/HK1049658A1/en unknown
2001
- 2001-02-19 NO NO20010839A patent/NO20010839D0/no not_active Application Discontinuation
- 2001-02-19 NO NO20010837A patent/NO20010837D0/no not_active Application Discontinuation
- 2001-02-19 NO NO20010838A patent/NO20010838D0/no not_active Application Discontinuation
2003
- 2003-12-10 JP JP2003412020A patent/JP2004083600A/ja active Pending
- 2003-12-10 JP JP2003412029A patent/JP2004099622A/ja active Pending
- 2003-12-10 JP JP2003412024A patent/JP2004149541A/ja active Pending

Also Published As

Publication number	Publication date
NO20010837D0 (no)	2001-02-19
HU9503855D0 (en)	1996-02-28
JPH09500137A (ja)	1997-01-07
DK0708768T3 (da)	2003-08-04
PL181694B1 (pl)	2001-09-28
DZ1798A1 (fr)	2002-02-17
AU694130B2 (en)	1998-07-16
EP0708768B1 (fr)	2003-04-09
MA23270A1 (fr)	1995-04-01
EP1291346A1 (fr)	2003-03-12
NO960173D0 (no)	1996-01-15
NO10839A (no)	1996-01-15
DE69434316D1 (de)	2005-04-28
FI960177A7 (fi)	1996-01-15
AP484A (en)	1996-04-23
UA63875C2 (en)	2004-02-16
NZ269457A (en)	1998-08-26
MY116478A (en)	2004-02-28
PT708768E (pt)	2003-08-29
ATE291576T1 (de)	2005-04-15
SK4796A3 (en)	1997-01-08
HK1049657A1 (en)	2003-05-23
EP0708768A4 (fr)	1996-08-21
PL181721B1 (en)	2001-09-28
FI960177A0 (fi)	1996-01-15
CZ11996A3 (en)	1996-10-16
TW330934B (en)	1998-05-01
AU7185098A (en)	1998-08-27
HK1049659A1 (en)	2003-05-23
EP1229035A1 (fr)	2002-08-07
JP2004149541A (ja)	2004-05-27
ATE236896T1 (de)	2003-04-15
DE69434316T2 (de)	2006-03-09
EP1227091A3 (fr)	2002-08-07
IL124318A0 (en)	1998-12-06
PL181723B1 (pl)	2001-09-28
AU694130C (en)	2002-12-05
CA2167311A1 (fr)	1995-01-26
DE69432463D1 (de)	2003-05-15
CN1218801A (zh)	1999-06-09
EP1291346B1 (fr)	2005-03-23
RU2140918C1 (ru)	1999-11-10
AU7335494A (en)	1995-02-13
AU705568B2 (en)	1999-05-27
NO20010838D0 (no)	2001-02-19
NZ329994A (en)	1999-07-29
NO316881B1 (no)	2004-06-14
HK1012392A1 (en)	1999-07-30
JP2004083600A (ja)	2004-03-18
ES2197167T3 (es)	2004-01-01
SK282342B6 (sk)	2002-01-07
PL312614A1 (en)	1996-04-29
BR9407079A (pt)	1996-08-27
CN1050126C (zh)	2000-03-08
ZA945193B (en)	1995-04-20
PL181705B1 (pl)	2001-09-28
AP9400654A0 (en)	1994-07-31
SI0708768T1 (en)	2003-10-31
NO20010839D0 (no)	2001-02-19
NO10837A (no)	1996-01-15
WO1995002591A1 (fr)	1995-01-26
DE69432463T2 (de)	2004-02-12
NO10838A (no)	1996-01-15
HUT75313A (en)	1997-05-28
CN1129447A (zh)	1996-08-21
BR1100546A (pt)	2004-08-31
EP1227091A2 (fr)	2002-07-31
NO960173L (no)	1996-01-15
ES2237650T3 (es)	2005-08-01
EP0708768A1 (fr)	1996-05-01
EP1227092A3 (fr)	2002-08-07
EP1227092A2 (fr)	2002-07-31
IL110296A0 (en)	1994-10-21
IL110296A (en)	1999-12-31
HK1049658A1 (en)	2003-05-23
JP2004099622A (ja)	2004-04-02
SG52368A1 (en)	1998-09-28

Publication	Publication Date	Title
FI960177L (fi)	1996-01-15	Moninaisia hoidollisia ominaisuuksia omaavat trisubstituoidut imidatsolit
NO2000012I1 (no)	2000-11-28	Celecoxib
NO20022254D0 (no)	2002-05-10	Injeksjonsspröyte
NO985734L (no)	1998-12-08	Br÷nnpakning
DE69424027D1 (de)	2000-05-25	Katheter
DK0727133T3 (da)	2003-03-17	Headset-grænsefladeenhed
DE69423046D1 (de)	2000-03-23	Schnellzurückziehbarer katheter
DE69403556D1 (de)	1997-07-10	Mikromanipulator
BR9405926A (pt)	1995-12-26	Artigo compósito
FI954537A7 (fi)	1995-10-27	4-aryyli-isoindoli analgeetteja
BR9406092A (pt)	1995-12-12	Cateter
FI942792A7 (fi)	1994-12-15	Lipoksigenaasia inhiboivia imidatsoliyhdisteitä
FI962506L (fi)	1996-06-17	Psoriasiksen hoito
DK120993D0 (da)	1993-10-27	Forbindelsesindretning
KR950013358U (ko)	1995-06-15	안마기
KR950013194U (ko)	1995-06-15	장식대용 회전대
KR950002944U (ko)	1995-02-16	회전구이기
KR940024006U (ko)	1994-11-16	미용용구 세트대
ES1025229Y (es)	1994-06-01	Equilibrador magnetico con efecto terapeutico.
KR940026222U (ko)	1994-12-08	안마기
FI934310A0 (fi)	1993-10-01	Liitosrakenne
KR950006583U (ko)	1995-03-21	질통
KR940005337U (ko)	1994-03-18	복합 노트북
KR940005334U (ko)	1994-03-18	복합 노트북
LT2559B (lt)	1994-02-28	Alkoholoksidazes imobilizacijos budas