FR14C0041I2 - Derive polycyclique de la carbamoylpyridone a activite inhibitrice sur l'integrase du vih - Google Patents

Derive polycyclique de la carbamoylpyridone a activite inhibitrice sur l'integrase du vih

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Publication number
FR14C0041I2
FR14C0041I2 FR14C0041C FR14C0041C FR14C0041I2 FR 14C0041 I2 FR14C0041 I2 FR 14C0041I2 FR 14C0041 C FR14C0041 C FR 14C0041C FR 14C0041 C FR14C0041 C FR 14C0041C FR 14C0041 I2 FR14C0041 I2 FR 14C0041I2
Authority
FR
France
Prior art keywords
carbamoylpyridone
inhibitory activity
hiv integrase
polycyclic derivative
polycyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR14C0041C
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
ViiV Healthcare Co
Original Assignee
Shionogi and Co Ltd
ViiV Healthcare Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37215098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR14C0041(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi and Co Ltd, ViiV Healthcare Co filed Critical Shionogi and Co Ltd
Publication of FR14C0041I1 publication Critical patent/FR14C0041I1/fr
Application granted granted Critical
Publication of FR14C0041I2 publication Critical patent/FR14C0041I2/fr
Active legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR14C0041C 2005-04-28 2014-05-19 Derive polycyclique de la carbamoylpyridone a activite inhibitrice sur l'integrase du vih Active FR14C0041I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005131161 2005-04-28
JP2005312076 2005-10-27
PCT/US2006/016604 WO2006116764A1 (fr) 2005-04-28 2006-04-28 Derive polycyclique de la carbamoylpyridone a activite inhibitrice sur l'integrase du vih

Publications (2)

Publication Number Publication Date
FR14C0041I1 FR14C0041I1 (fr) 2014-06-27
FR14C0041I2 true FR14C0041I2 (fr) 2015-11-13

Family

ID=37215098

Family Applications (2)

Application Number Title Priority Date Filing Date
FR14C0041C Active FR14C0041I2 (fr) 2005-04-28 2014-05-19 Derive polycyclique de la carbamoylpyridone a activite inhibitrice sur l'integrase du vih
FR21C1023C Active FR21C1023I2 (fr) 2005-04-28 2021-06-11 Derives de carbamoylpyridone polycyclique dotes d'une activite inhibitrice de l'integrase du vih

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR21C1023C Active FR21C1023I2 (fr) 2005-04-28 2021-06-11 Derives de carbamoylpyridone polycyclique dotes d'une activite inhibitrice de l'integrase du vih

Country Status (30)

Country Link
US (22) US8129385B2 (fr)
EP (9) EP3372281B1 (fr)
JP (2) JP4295353B2 (fr)
KR (4) KR101363875B1 (fr)
AU (1) AU2006239177B8 (fr)
BE (2) BE2014C038I2 (fr)
BR (1) BRPI0610030B8 (fr)
CA (1) CA2606282C (fr)
CY (7) CY1115151T1 (fr)
DK (6) DK1874117T3 (fr)
EA (1) EA014162B1 (fr)
ES (7) ES2667868T5 (fr)
FI (1) FIC20210017I1 (fr)
FR (2) FR14C0041I2 (fr)
HK (2) HK1249742A1 (fr)
HU (6) HUE044978T2 (fr)
IL (4) IL186555A (fr)
LT (5) LT3284520T (fr)
LU (2) LU92446I2 (fr)
MA (1) MA29460B1 (fr)
MX (2) MX302718B (fr)
NL (2) NL300676I2 (fr)
NO (5) NO339525B1 (fr)
NZ (1) NZ562339A (fr)
PL (5) PL3372281T3 (fr)
PT (5) PT3284520T (fr)
SI (6) SI3187225T1 (fr)
TW (1) TWI378931B (fr)
VN (1) VN34404A1 (fr)
WO (1) WO2006116764A1 (fr)

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CY1120345T1 (el) 2019-07-10
SI1874117T1 (sl) 2014-01-31
NL301109I2 (nl) 2021-09-15
EA014162B1 (ru) 2010-10-29
HUE044978T2 (hu) 2019-11-28
SI3187225T1 (sl) 2022-04-29
NO340111B1 (no) 2017-03-13
KR101504998B1 (ko) 2015-03-23
EP3284520A1 (fr) 2018-02-21
IL215788A0 (en) 2011-12-29
DK1874117T3 (da) 2013-09-23
EP3372281A1 (fr) 2018-09-12
PL3284520T3 (pl) 2020-01-31
PL1874117T3 (pl) 2014-01-31
KR101363875B1 (ko) 2014-02-21
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KR101848819B1 (ko) 2018-04-16
DK2465580T3 (en) 2014-03-10
US20170209454A1 (en) 2017-07-27
DK3187225T3 (da) 2022-02-28
BRPI0610030A2 (pt) 2011-10-11
FR14C0041I1 (fr) 2014-06-27
US20090318421A1 (en) 2009-12-24
US11267823B2 (en) 2022-03-08
HK1251191A1 (en) 2019-01-25
PL3372281T3 (pl) 2021-12-27
EP3284519A8 (fr) 2018-04-18
KR20080009733A (ko) 2008-01-29
LT3372281T (lt) 2021-12-10
US9273065B2 (en) 2016-03-01
CY2014024I1 (el) 2015-12-09
US8410103B2 (en) 2013-04-02
EP2465580B1 (fr) 2013-12-18
ES2906792T3 (es) 2022-04-20
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NO339525B1 (no) 2016-12-27
NL301109I1 (nl) 2021-09-15
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DK3372281T3 (da) 2021-09-27
SI3045206T1 (en) 2018-07-31
HK1107227A1 (en) 2008-04-03
AU2006239177B2 (en) 2011-10-20
CY1115151T1 (el) 2015-12-09
FR21C1023I1 (fr) 2021-07-23
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KR20130133061A (ko) 2013-12-05
US20170224695A1 (en) 2017-08-10
WO2006116764A1 (fr) 2006-11-02
CA2606282A1 (fr) 2006-11-02
ES2567197T3 (es) 2016-04-20
LU92446I2 (fr) 2015-10-29
NO20075165L (no) 2007-11-22
EA200702080A1 (ru) 2008-04-28
ES2892304T3 (es) 2022-02-03
IL186555A (en) 2016-10-31
US20170267693A1 (en) 2017-09-21
CA2606282C (fr) 2016-04-26
ES2667868T5 (es) 2023-06-01
DK3284520T3 (da) 2019-09-16
US20200339598A1 (en) 2020-10-29
NZ562339A (en) 2011-01-28
AU2006239177A1 (en) 2006-11-02
EP1874117A1 (fr) 2008-01-09
PL3045206T3 (pl) 2018-08-31
EP3187226A1 (fr) 2017-07-05
HK1172282A1 (en) 2013-04-19
HUS2100023I1 (hu) 2021-07-28
US20120115875A1 (en) 2012-05-10
BE2014C038I2 (fr) 2026-01-07
AU2006239177B8 (en) 2012-02-16
PT2465580E (pt) 2014-02-25
ES2667868T3 (es) 2018-05-14
HUE037795T2 (hu) 2018-09-28
IL225206A (en) 2017-11-30
EP3045206B1 (fr) 2018-03-28
US20170224694A1 (en) 2017-08-10
ES2446324T3 (es) 2014-03-07
PL2465580T3 (pl) 2014-05-30
US20160304535A1 (en) 2016-10-20
EP3045206A1 (fr) 2016-07-20
EP2527007B1 (fr) 2016-03-30
US20150232479A1 (en) 2015-08-20
EP3045206B2 (fr) 2023-02-15
US20170029438A1 (en) 2017-02-02

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