FR2374331A1 - Procede de blocage selectif de certains groupes amino dans un compose polyamino-organique, compose polyamino-organique ayant certains groupes amino selectivement bloques obtenu par ce procede et intermediaires de synthese necessaires a la mise en oeuvre de ce procede - Google Patents

Procede de blocage selectif de certains groupes amino dans un compose polyamino-organique, compose polyamino-organique ayant certains groupes amino selectivement bloques obtenu par ce procede et intermediaires de synthese necessaires a la mise en oeuvre de ce procede

Info

Publication number
FR2374331A1
FR2374331A1 FR7718225A FR7718225A FR2374331A1 FR 2374331 A1 FR2374331 A1 FR 2374331A1 FR 7718225 A FR7718225 A FR 7718225A FR 7718225 A FR7718225 A FR 7718225A FR 2374331 A1 FR2374331 A1 FR 2374331A1
Authority
FR
France
Prior art keywords
polyamino
amino groups
organic compound
procedure
certain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7718225A
Other languages
English (en)
Other versions
FR2374331B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of FR2374331A1 publication Critical patent/FR2374331A1/fr
Application granted granted Critical
Publication of FR2374331B1 publication Critical patent/FR2374331B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un procédé de blocage sélectif de groupes amino ainsi que de nouveaux dérivés aminocyclitolaminoglycosides sélectivement bloqués. Le blocage sélectif de quelques groupes amino dans un composé polyamino-organique ayant au moins une paire de groupes hydroxyle et amino voisins disponibles est effectué premièrement en préparant in situ des complexes de sel de métal de transition des paires de groupes amino et hydroxyle voisins disponibles dans le compose polyamino-organique, suivi par l'introduction des groupes de blocage sur les groupes amino non complexés et, finalement, l'enlevement des cations du métal de transition à partir du complexe du composé polyamino-organique N-bloqué sélectivement pour obtenir un Composé polyamino-organique ayant des groupes amino sélectivement bloqués. La présente invention est particulièrement utile notamment dans la préparation de dérives d'antibiotiques difficiles à obtenir jusqu'à présent avec un bon rendement
FR7718225A 1976-06-17 1977-06-14 Procede de blocage selectif de certains groupes amino dans un compose polyamino-organique, compose polyamino-organique ayant certains groupes amino selectivement bloques obtenu par ce procede et intermediaires de synthese necessaires a la mise en oeuvre de ce procede Granted FR2374331A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/697,297 US4136254A (en) 1976-06-17 1976-06-17 Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby

Publications (2)

Publication Number Publication Date
FR2374331A1 true FR2374331A1 (fr) 1978-07-13
FR2374331B1 FR2374331B1 (fr) 1981-07-31

Family

ID=24800569

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7718225A Granted FR2374331A1 (fr) 1976-06-17 1977-06-14 Procede de blocage selectif de certains groupes amino dans un compose polyamino-organique, compose polyamino-organique ayant certains groupes amino selectivement bloques obtenu par ce procede et intermediaires de synthese necessaires a la mise en oeuvre de ce procede
FR7809709A Granted FR2395277A1 (fr) 1976-06-17 1978-03-31 Nouveaux 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols selectivement bloques, application de ces nouveaux composes a la preparation de derives 1-n-substitues de 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols, et derives 1-n-substitues ainsi obtenus

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7809709A Granted FR2395277A1 (fr) 1976-06-17 1978-03-31 Nouveaux 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols selectivement bloques, application de ces nouveaux composes a la preparation de derives 1-n-substitues de 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols, et derives 1-n-substitues ainsi obtenus

Country Status (18)

Country Link
US (1) US4136254A (fr)
JP (5) JPS52153944A (fr)
AR (1) AR216648A1 (fr)
BE (1) BE855704A (fr)
CA (1) CA1265130A (fr)
CH (1) CH639979A5 (fr)
DE (3) DE2726712A1 (fr)
DK (1) DK165451C (fr)
ES (1) ES459791A1 (fr)
FR (2) FR2374331A1 (fr)
GB (1) GB1575982A (fr)
HK (1) HK484A (fr)
HU (1) HU182050B (fr)
IE (1) IE45734B1 (fr)
IL (1) IL52318A (fr)
MY (1) MY8500081A (fr)
NL (1) NL177014C (fr)
SE (2) SE447481B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
US4226980A (en) * 1978-12-07 1980-10-07 Abbott Laboratories Novel derivatives of fortimicin B and process for preparing same
US4424345A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4424344A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
EP0054514A1 (fr) * 1980-12-16 1982-06-23 Ciba-Geigy Ag Dérivés d'aminopapulacandin à activité antibiotique
JPS6253997A (ja) * 1985-09-03 1987-03-09 Kowa Co 新規なアミノ配糖体及びこれを含有する製剤
JPS6281784A (ja) * 1985-10-04 1987-04-15 Nippon Telegr & Teleph Corp <Ntt> 半導体レ−ザの発光強度監視方法および半導体レ−ザ装置
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
US5442047A (en) * 1991-12-04 1995-08-15 Schering Corporation Process for preparing isepamicin
EP0478707A1 (fr) * 1989-06-21 1992-04-08 Schering Corporation Procede ameliore de preparation d'isepamicine
IT1237490B (it) * 1989-09-22 1993-06-07 Chementecno S R L Monza Milano Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
CN1040177C (zh) * 1993-04-23 1998-10-14 江苏省微生物研究所 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法
KR100467506B1 (ko) * 2002-10-01 2005-01-24 경동제약 주식회사 이세파마이신의 제조방법
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
EA017824B1 (ru) 2007-11-21 2013-03-29 Эйкеоджен, Инк. Антибактериальные аналоги аминогликозида
AU2009299118B2 (en) 2008-10-03 2015-12-17 Glycan Biosciences Llc Anionic conjugates of glycosylated bacterial metabolite
WO2010132765A2 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010132768A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de sisomicine
WO2010132759A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de la dibékacine
WO2010132757A2 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010132760A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de tobramycine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388141A (en) * 1965-10-05 1968-06-11 Thiokol Chemical Corp Di-schiff bases of hydroxyl substituted diamines and beta-diketones, derivatives, and metal chelates thereof
FR2015139A1 (fr) * 1968-08-06 1970-04-24 Sanyo Chemical Cy Ltd
DE2061537A1 (de) * 1969-12-30 1971-07-08 Snam Progetti S.P.A., Mailand (Italien) Verfahren zur Herstellung von Kobalt(III>Komplexen
US3682995A (en) * 1970-05-04 1972-08-08 Minnesota Mining & Mfg Copper chelate
JPS5220991B2 (fr) * 1972-08-23 1977-06-07
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
GB1441202A (en) * 1973-05-15 1976-06-30 Microbial Chem Res Found 1-n-isoserylkanamycins and the production thereof
US3878193A (en) * 1973-06-26 1975-04-15 Schering Corp Process for the preparation of garamine derivatives
US3872080A (en) * 1973-06-26 1975-03-18 Schering Corp Process for the preparation of garamine and intermediates produced thereby
JPS5512039B2 (fr) * 1974-03-22 1980-03-29
JPS573679B2 (fr) * 1974-03-07 1982-01-22
AR207582A1 (es) * 1974-03-19 1976-10-15 Scherico Ltd Procedimiento para preparar derivados de diaminociclitole
JPS5564598A (en) * 1978-11-11 1980-05-15 Microbial Chem Res Found Preparation of aminoglycoside antibiotic having selectively protected amino group

Also Published As

Publication number Publication date
NL177014C (nl) 1985-07-16
DE2726712C2 (fr) 1987-06-19
JPH0132232B2 (fr) 1989-06-29
IL52318A (en) 1981-06-29
DE2759974C2 (fr) 1988-05-26
JPS5549586B2 (fr) 1980-12-12
DE2760317C2 (fr) 1987-11-26
DE2726712A1 (de) 1977-12-22
JPS5822160B2 (ja) 1983-05-06
CA1265130A (fr) 1990-01-30
SE7706872L (sv) 1978-02-06
JPS6121558B2 (fr) 1986-05-27
NL177014B (nl) 1985-02-18
JPS5576895A (en) 1980-06-10
DK165451B (da) 1992-11-30
JPS5569519A (en) 1980-05-26
DK263277A (da) 1977-12-18
JPS6127997A (ja) 1986-02-07
HU182050B (en) 1983-12-28
DK165451C (da) 1993-04-13
FR2395277A1 (fr) 1979-01-19
JPS5569598A (en) 1980-05-26
ES459791A1 (es) 1978-08-16
FR2395277B1 (fr) 1981-11-20
IE45734B1 (en) 1982-11-17
SE8601074D0 (sv) 1986-03-07
NL7706596A (nl) 1977-12-20
IL52318A0 (en) 1977-08-31
BE855704A (fr) 1977-12-15
SE447481B (sv) 1986-11-17
GB1575982A (en) 1980-10-01
HK484A (en) 1984-01-13
IE45734L (en) 1977-12-17
JPS52153944A (en) 1977-12-21
AR216648A1 (es) 1980-01-15
MY8500081A (en) 1985-12-31
US4136254A (en) 1979-01-23
CH639979A5 (de) 1983-12-15
SE469131B (sv) 1993-05-17
JPS6227073B2 (fr) 1987-06-12
FR2374331B1 (fr) 1981-07-31

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