FR23C1047I2 - Composés pyrimidinedione contre les maladies cardiaques - Google Patents

Composés pyrimidinedione contre les maladies cardiaques

Info

Publication number: FR23C1047I2
Authority: FR; France
Prior art keywords: heart diseases; compounds against; against heart; pyrimidinedione compounds; pyrimidinedione
Prior art date: 2013-06-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

FR23C1047C

Other languages

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-06-21

Filing date

2023-12-04

Publication date

2024-11-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51177189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR23C1047(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2023-12-04 Application filed filed Critical

2024-01-12 Publication of FR23C1047I1 publication Critical patent/FR23C1047I1/fr

2024-11-15 Application granted granted Critical

2024-11-15 Publication of FR23C1047I2 publication Critical patent/FR23C1047I2/fr

Status Active legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

FR23C1047C 2013-06-21 2023-12-04 Composés pyrimidinedione contre les maladies cardiaques Active FR23C1047I2 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201361838088P	2013-06-21	2013-06-21
US201461939655P	2014-02-13	2014-02-13
US201461981366P	2014-04-18	2014-04-18
PCT/US2014/043192 WO2014205223A1 (fr)	2013-06-21	2014-06-19	Composés de pyrimidine-dione contre les affections cardiaques

Publications (2)

Publication Number	Publication Date
FR23C1047I1 FR23C1047I1 (fr)	2024-01-12
FR23C1047I2 true FR23C1047I2 (fr)	2024-11-15

Family

ID=51177189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR23C1047C Active FR23C1047I2 (fr)	2013-06-21	2023-12-04	Composés pyrimidinedione contre les maladies cardiaques

Country Status (39)

Country	Link
US (9)	US9181200B2 (fr)
EP (3)	EP3702352A1 (fr)
JP (5)	JP6603213B2 (fr)
KR (5)	KR20220020410A (fr)
CN (2)	CN105473576B (fr)
AU (5)	AU2014281408B2 (fr)
BR (1)	BR112015031864B1 (fr)
CA (1)	CA2915967C (fr)
CL (1)	CL2015003689A1 (fr)
CR (1)	CR20160032A (fr)
CY (2)	CY1122964T1 (fr)
DK (1)	DK3010910T3 (fr)
DO (1)	DOP2015000300A (fr)
EA (2)	EA201891009A1 (fr)
ES (1)	ES2773250T3 (fr)
FI (1)	FIC20230036I1 (fr)
FR (1)	FR23C1047I2 (fr)
GT (1)	GT201500348A (fr)
HR (1)	HRP20200379T1 (fr)
HU (2)	HUE047566T2 (fr)
IL (7)	IL317628A (fr)
LT (2)	LT3010910T (fr)
LU (1)	LUC00324I2 (fr)
MX (3)	MX2021005326A (fr)
MY (1)	MY190860A (fr)
NL (1)	NL301253I2 (fr)
NO (1)	NO2023043I1 (fr)
PE (1)	PE20160208A1 (fr)
PH (2)	PH12021552715A1 (fr)
PL (1)	PL3010910T3 (fr)
PT (1)	PT3010910T (fr)
RS (1)	RS59906B1 (fr)
SG (2)	SG10201803459TA (fr)
SI (1)	SI3010910T1 (fr)
SM (1)	SMT202000071T1 (fr)
TN (1)	TN2015000553A1 (fr)
UA (1)	UA117929C2 (fr)
WO (1)	WO2014205223A1 (fr)
ZA (1)	ZA201508959B (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2012087842A1 (fr)	2010-12-23	2012-06-28	The Foundry, Llc	Système de réparation et remplacement de valvule mitrale
WO2012177942A2 (fr)	2011-06-21	2012-12-27	Hanson Gifford, Iii	Dispositifs de valvule cardiaque prosthétiques et systèmes et procédés associés
CN103889369B (zh)	2011-10-19	2016-09-14	托尔福公司	用于心脏瓣膜置换术的装置
US11202704B2 (en)	2011-10-19	2021-12-21	Twelve, Inc.	Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
JP6133309B2 (ja)	2011-10-19	2017-05-24	トゥエルヴ，インコーポレイテッド	人工心臓弁デバイス
US9039757B2 (en)	2011-10-19	2015-05-26	Twelve, Inc.	Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9579198B2 (en)	2012-03-01	2017-02-28	Twelve, Inc.	Hydraulic delivery systems for prosthetic heart valve devices and associated methods
WO2014205234A1 (fr) *	2013-06-21	2014-12-24	MyoKardia, Inc.	Composés de pyrimidinedione substitués par cycloalkyle
SMT202000071T1 (it) *	2013-06-21	2020-03-13	Myokardia Inc	Composti di pirimidinadione contro le condizioni cardiache
US9346776B2 (en)	2014-02-13	2016-05-24	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound
US9527835B2 (en)	2014-02-13	2016-12-27	Incyte Corporation	Cyclopropylamines as LSD1 inhibitors
KR102421235B1 (ko)	2014-02-13	2022-07-15	인사이트 코포레이션	Lsd1 저해제로서 사이클로프로필아민
US9428470B2 (en)	2014-02-13	2016-08-30	Takeda Pharmaceutical Company Limited	Heterocyclic compound
NZ723203A (en)	2014-02-13	2020-08-28	Incyte Corp	Cyclopropylamines as lsd1 inhibitors
WO2016007731A1 (fr)	2014-07-10	2016-01-14	Incyte Corporation	Imidazopyridines et imidazopyrazines à utiliser en tant qu'inhibiteurs de lsd1
WO2016007722A1 (fr)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1
UA122688C2 (uk)	2015-04-03	2020-12-28	Інсайт Корпорейшн	Гетероциклічні сполуки як інгібітори lsd1
JP7427363B2 (ja)	2015-08-12	2024-02-05	インサイト・ホールディングス・コーポレイション	Ｌｓｄ１阻害剤の塩
CN106432222A (zh) *	2016-09-19	2017-02-22	丹诺医药(苏州）有限公司	8‑氯‑1‑环丙基‑7‑氟‑9‑甲基‑4‑氧‑4‑氢‑喹嗪‑3‑羧酸酯及其制备方法
CN106946851B (zh) *	2017-03-14	2019-11-12	牡丹江医学院	一种用于预防和治疗肾结石的药物
US10575950B2 (en)	2017-04-18	2020-03-03	Twelve, Inc.	Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10646338B2 (en)	2017-06-02	2020-05-12	Twelve, Inc.	Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
SI3661514T1 (sl) *	2017-08-04	2026-01-30	MyoKardia, Inc.	Mavacamten za uporabo pri zdravljenju hipertrofične kardiomiopatije
CN117964573B (zh)	2018-01-19	2026-04-14	赛特凯恩蒂克公司	作为心肌节抑制剂的二氢苯并呋喃和茚类似物
EP3814342B1 (fr)	2018-06-26	2022-07-27	Cytokinetics, Inc.	Inhibiteurs de sarcomères cardiaques
WO2020005888A1 (fr)	2018-06-26	2020-01-02	Cytokinetics, Inc.	Inhibiteurs de sarcomères cardiaques
WO2020047198A1 (fr)	2018-08-31	2020-03-05	Incyte Corporation	Sels d'un inhibiteur de lsd1 et leurs procédés de préparation
CN112867539B (zh) *	2018-08-31	2024-08-06	赛特凯恩蒂克公司	心脏肌小节抑制剂
DK3873904T3 (da) *	2018-10-29	2024-08-05	Myokardia Inc	Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser
CN111116492B (zh) *	2019-01-25	2021-07-09	青岛吉澳医药科技有限公司	氘代苯甲氨嘧啶二酮衍生物及其用途
CN110698415B (zh) *	2019-10-21	2023-05-09	上海先行医药开发有限公司	一种肌球蛋白抑制剂及其制备方法和用途
CN114945372A (zh) *	2019-11-10	2022-08-26	迈奥卡迪亚公司	用肌球蛋白调节剂的治疗方法
JP7795063B2 (ja) *	2020-01-28	2026-01-07	アッシア・ケミカル・インダストリーズ・リミテッド	マバカムテンの固体形態及びその調製のための方法
IL300775A (en)	2020-08-28	2023-04-01	Myokardia Inc	Treatment methods with myosin modulator
CN116323598B (zh) *	2020-11-20	2024-11-15	江苏恒瑞医药股份有限公司	三嗪二酮类衍生物、其制备方法及其在医药上的应用
CN116507621B (zh) *	2020-11-24	2025-10-17	江苏恒瑞医药股份有限公司	嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN114539229B (zh) *	2020-11-24	2024-10-22	江苏恒瑞医药股份有限公司	嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CA3206864A1 (fr) *	2021-02-01	2022-08-04	Divya Jyothi Kallem	Procede de preparation de mavacamten et formes a l'etat solide de celui-ci
TWI823274B (zh) *	2021-02-25	2023-11-21	新加坡商所拓生物醫藥有限公司	取代的吡啶-2,4-二酮類衍生物
TW202302594A (zh)	2021-03-04	2023-01-16	美商胞質動力學公司	心臟肌節抑制劑
CN112939876A (zh) *	2021-03-10	2021-06-11	杭州科巢生物科技有限公司	Mavacamten的晶型I及其制备方法
WO2022189599A1 (fr)	2021-03-12	2022-09-15	Sandoz Ag	Formes cristallines de mavacamten pour le traitement de la cmh
CN117460717A (zh) *	2021-03-17	2024-01-26	翰森生物有限责任公司	含氮杂环酮、其制备方法和医药用途
MX2023010673A (es) *	2021-03-17	2023-09-22	Hansoh Bio Llc	Cetonas heterociclicas que contienen nitrogeno, metodos de preparacion y usos medicinales de las mismas.
EP4371978A4 (fr) *	2021-07-13	2025-09-10	Nippon Soda Co	Procédé de production d'un composé uracile
JP7315632B2 (ja) *	2021-09-16	2023-07-26	楽天グループ株式会社	特典付与システム、特典付与方法、及びプログラム
CN116410143A (zh) *	2021-12-29	2023-07-11	杭州奥默医药股份有限公司	一种多取代脲嘧啶衍生物及其制备方法和应用
CN118591527A (zh) *	2022-01-27	2024-09-03	深圳市康哲生物科技有限公司	7-氮杂螺[4,5]癸烷-6,10-二酮类化合物的晶型及其制备方法
CA3248508A1 (fr)	2022-04-13	2023-10-19	Assia Chemical Industries Ltd.	Formes à l'état solide de mavacamten et leur procédé de préparation
WO2023211872A1 (fr)	2022-04-26	2023-11-02	MyoKardia, Inc.	Méthode d'administration d'inhibiteurs de myosine
CA3254710A1 (fr) *	2022-05-20	2025-07-03	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	Formes cristallines d'un dérivé de triazine-dione et leur procédé de préparation
CN117088854A (zh) *	2022-05-20	2023-11-21	江苏恒瑞医药股份有限公司	一种三嗪二酮类衍生物的可药用盐、晶型及制备方法
TW202416997A (zh) *	2022-09-16	2024-05-01	大陸商江蘇豪森藥業集團有限公司	一種含氮雜環酮化合物的晶型及其製備方法
IL319671A (en)	2022-09-26	2025-05-01	Edgewise Therapeutics Inc	4,1-Dihydroquinazolinone compounds and their uses
WO2024182469A1 (fr) *	2023-02-28	2024-09-06	MyoKardia, Inc.	Inhibiteurs de myosine destinés à être utilisés dans le traitement de la cardiomyopathie hypertrophique
JP7858148B1 (ja)	2023-03-27	2026-05-13	エッジワイズセラピューティクス，インコーポレイテッド	キナゾリンジオン化合物およびその使用
EP4688748A1 (fr)	2023-03-27	2026-02-11	Edgewise Therapeutics, Inc.	Composés d'amide de quinolinone et leurs utilisations
WO2024218783A1 (fr) *	2023-04-17	2024-10-24	Dasha Pharmaceuticals Private Limited	Approche de chimie verte pour la synthèse de mavacamten et de son intermédiaire à l'aide d'une nouvelle méthodologie
IT202300016653A1 (it)	2023-08-03	2025-02-03	Olon Spa	Processo per preparare mavacamten e intermedio di processo.
WO2025046606A1 (fr)	2023-08-26	2025-03-06	Micro Labs Limited	Granules de mavacamten pour administration orale
WO2025096779A2 (fr)	2023-11-01	2025-05-08	Bristol Myers Squibb Company	Procédés de traitement avec un inhibiteur de myosine à l'aide de niveaux de protéine
CN120172920A (zh) *	2023-12-20	2025-06-20	福石生物科技(合肥)有限公司	一种肌球蛋白抑制剂及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1280877B (de)	1960-11-16	1968-10-24	Robugen Gmbh	Verfahren zur Herstellung von in 1-Stellung substituierten 4-Aminouracilen
JPS61205261A (ja)	1985-03-08	1986-09-11	Sagami Chem Res Center	６―置換―５―フルオロウラシル誘導体
JPH0637479B2 (ja) *	1987-12-28	1994-05-18	三井東圧化学株式会社	新規ピリミジン誘導体、その製造法およびそれを含有する抗不整脈剤
US5008267A (en)	1988-10-29	1991-04-16	Mitsui Toatsu Chemicals, Incorporated	Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
JPH03173885A (ja)	1989-12-01	1991-07-29	Mitsui Toatsu Chem Inc	ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤
FR2659656B1 (fr)	1990-03-15	1994-09-09	Sanofi Sa	Derives de pyrimidinedione-2,4 et medicaments les contenant.
JPH0413669A (ja) *	1990-04-27	1992-01-17	Mitsui Toatsu Chem Inc	新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤
JPH06128238A (ja) *	1992-10-20	1994-05-10	Mitsui Toatsu Chem Inc	新規ピリミジンジオン誘導体
EP0697407B1 (fr)	1994-08-19	1997-06-25	MITSUI TOATSU CHEMICALS, Inc.	Dérivés de pyrimidinedione et compositions antiarrhythmiques les contenant
US5516905A (en)	1994-08-30	1996-05-14	University Of Massachusetts Medical Center	Antibiotic compounds and methods to treat gram-positive bacterial and mycoplasmal infections
EP0967209B1 (fr)	1998-06-26	2003-01-08	Crompton Vinyl Additives GmbH	6-aminouraciles modifiés sur le NH2, comme stabilisateurs pour des polymères halogènes
US7416856B2 (en)	1999-05-18	2008-08-26	Cytokinetics, Inc.	High sensitivity assay for detection of nucleoside diphosphate production
US7202051B1 (en)	1999-05-18	2007-04-10	Cytokinetics, Inc.	Compositions and assays utilizing ADP or phosphate for detecting protein modulators
AU2247701A (en)	1999-10-21	2001-04-30	Merck & Co., Inc.	Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment
US6495337B1 (en)	2000-03-29	2002-12-17	Cytokinetics, Inc.	High throughput sarcomeric assay
US20030114445A1 (en)	2001-06-15	2003-06-19	Chengxin Zhi	N3-substituted 6-anilinopyrimidines and methods to treat-Gram-positive bacterial and mycoplasmal infections
US20030114414A1 (en)	2001-06-15	2003-06-19	Chengxin Zhi	Methods for synthesizing substituted pyrimidines
AU2002344813A1 (en)	2001-06-15	2003-01-02	University Of Massachusetts	Methods for synthesizing substituted pyrimidines
DE10208460A1 (de)	2002-02-27	2003-09-04	Bayer Ag	Uracil-Thioether
JP2006500351A (ja) *	2002-08-13	2006-01-05	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	マトリックスメタロプロテアーゼ−１３阻害剤としてのピリミジン−２，４−ジオン誘導体
EA013427B1 (ru)	2004-03-15	2010-04-30	Такеда Фармасьютикал Компани Лимитед	Ингибиторы дипептидилпептидазы
US20060194821A1 (en)	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
US8642660B2 (en) *	2007-12-21	2014-02-04	The University Of Rochester	Method for altering the lifespan of eukaryotic organisms
GB0908193D0 (en) *	2009-05-13	2009-06-24	Albright Patents	Treatment of disease state
WO2014205234A1 (fr) *	2013-06-21	2014-12-24	MyoKardia, Inc.	Composés de pyrimidinedione substitués par cycloalkyle
SMT202000071T1 (it) *	2013-06-21	2020-03-13	Myokardia Inc	Composti di pirimidinadione contro le condizioni cardiache

2014
- 2014-06-18 SM SM20200071T patent/SMT202000071T1/it unknown
- 2014-06-19 AU AU2014281408A patent/AU2014281408B2/en active Active
- 2014-06-19 IL IL317628A patent/IL317628A/en unknown
- 2014-06-19 EP EP20155100.9A patent/EP3702352A1/fr active Pending
- 2014-06-19 IL IL302299A patent/IL302299A/en unknown
- 2014-06-19 CA CA2915967A patent/CA2915967C/fr active Active
- 2014-06-19 WO PCT/US2014/043192 patent/WO2014205223A1/fr not_active Ceased
- 2014-06-19 CN CN201480046057.3A patent/CN105473576B/zh active Active
- 2014-06-19 CN CN201811208548.XA patent/CN109384729B/zh active Active
- 2014-06-19 SG SG10201803459TA patent/SG10201803459TA/en unknown
- 2014-06-19 SI SI201431491T patent/SI3010910T1/sl unknown
- 2014-06-19 KR KR1020227003283A patent/KR20220020410A/ko not_active Ceased
- 2014-06-19 ES ES14738986T patent/ES2773250T3/es active Active
- 2014-06-19 BR BR112015031864-9A patent/BR112015031864B1/pt active IP Right Grant
- 2014-06-19 EP EP14738986.0A patent/EP3010910B1/fr active Active
- 2014-06-19 UA UAA201600450A patent/UA117929C2/uk unknown
- 2014-06-19 EA EA201891009A patent/EA201891009A1/ru unknown
- 2014-06-19 KR KR1020267006486A patent/KR20260039799A/ko active Pending
- 2014-06-19 RS RS20200149A patent/RS59906B1/sr unknown
- 2014-06-19 LT LTEP14738986.0T patent/LT3010910T/lt unknown
- 2014-06-19 PE PE2015002629A patent/PE20160208A1/es unknown
- 2014-06-19 KR KR1020167001045A patent/KR102304121B1/ko active Active
- 2014-06-19 JP JP2016521578A patent/JP6603213B2/ja active Active
- 2014-06-19 PL PL14738986T patent/PL3010910T3/pl unknown
- 2014-06-19 US US14/309,381 patent/US9181200B2/en not_active Ceased
- 2014-06-19 HU HUE14738986A patent/HUE047566T2/hu unknown
- 2014-06-19 MX MX2021005326A patent/MX2021005326A/es unknown
- 2014-06-19 KR KR1020237033462A patent/KR20230144117A/ko not_active Ceased
- 2014-06-19 EA EA201690066A patent/EA030846B1/ru unknown
- 2014-06-19 IL IL310829A patent/IL310829A/en unknown
- 2014-06-19 PT PT147389860T patent/PT3010910T/pt unknown
- 2014-06-19 DK DK14738986.0T patent/DK3010910T3/da active
- 2014-06-19 PH PH1/2021/552715A patent/PH12021552715A1/en unknown
- 2014-06-19 KR KR1020217029573A patent/KR102359158B1/ko active Active
- 2014-06-19 SG SG11201510163TA patent/SG11201510163TA/en unknown
- 2014-06-19 EP EP26153716.1A patent/EP4744664A2/fr active Pending
- 2014-06-19 HR HRP20200379TT patent/HRP20200379T1/hr unknown
- 2014-06-19 MX MX2015017865A patent/MX382520B/es unknown
- 2014-06-19 MY MYPI2015704457A patent/MY190860A/en unknown
- 2014-06-19 TN TN2015000553A patent/TN2015000553A1/en unknown
- 2014-06-19 PH PH1/2015/502794A patent/PH12015502794B1/en unknown
2015
- 2015-10-14 US US14/883,152 patent/US9585883B2/en active Active
- 2015-12-08 ZA ZA2015/08959A patent/ZA201508959B/en unknown
- 2015-12-14 DO DO2015000300A patent/DOP2015000300A/es unknown
- 2015-12-17 GT GT201500348A patent/GT201500348A/es unknown
- 2015-12-17 IL IL243222A patent/IL243222B/en active IP Right Grant
- 2015-12-18 MX MX2022014414A patent/MX2022014414A/es unknown
- 2015-12-21 CL CL2015003689A patent/CL2015003689A1/es unknown
2016
- 2016-01-15 CR CR20160032A patent/CR20160032A/es unknown
2017
- 2017-01-18 US US15/409,369 patent/US20170281626A1/en not_active Abandoned
2018
- 2018-02-15 US US15/897,549 patent/US20180311242A1/en not_active Abandoned
- 2018-11-15 AU AU2018264088A patent/AU2018264088A1/en not_active Abandoned
2019
- 2019-10-09 JP JP2019185576A patent/JP6980734B2/ja active Active
2020
- 2020-04-15 CY CY20201100354T patent/CY1122964T1/el unknown
- 2020-06-05 US US16/893,500 patent/US20200297726A1/en not_active Abandoned
- 2020-06-26 AU AU2020204271A patent/AU2020204271B2/en active Active
- 2020-07-05 IL IL275837A patent/IL275837B/en unknown
2021
- 2021-01-13 US US17/147,821 patent/US20210346379A1/en not_active Abandoned
- 2021-08-30 IL IL285971A patent/IL285971A/en unknown
- 2021-11-17 JP JP2021186772A patent/JP7376556B2/ja active Active
2022
- 2022-03-19 US US17/699,114 patent/USRE50050E1/en active Active
- 2022-04-06 AU AU2022202298A patent/AU2022202298A1/en not_active Abandoned
2023
- 2023-01-27 US US18/160,393 patent/US20230165860A1/en not_active Abandoned
- 2023-10-26 JP JP2023183708A patent/JP2024010108A/ja active Pending
- 2023-11-30 LU LU00324C patent/LUC00324I2/en unknown
- 2023-12-01 FI FIC20230036C patent/FIC20230036I1/fi unknown
- 2023-12-01 NO NO2023043C patent/NO2023043I1/no unknown
- 2023-12-04 FR FR23C1047C patent/FR23C1047I2/fr active Active
- 2023-12-07 LT LTPA2023535C patent/LTC3010910I2/lt unknown
- 2023-12-11 HU HUS2300042C patent/HUS2300042I1/hu unknown
- 2023-12-12 NL NL301253C patent/NL301253I2/nl unknown
- 2023-12-13 CY CY2023027C patent/CY2023027I2/el unknown
2024
- 2024-02-22 US US18/584,115 patent/US20240382486A1/en active Pending
- 2024-04-16 AU AU2024202464A patent/AU2024202464A1/en active Pending
2025
- 2025-07-31 JP JP2025128210A patent/JP2025163126A/ja active Pending
- 2025-10-15 IL IL323967A patent/IL323967A/en unknown

Also Published As

Publication number	Publication date
KR20220020410A (ko)	2022-02-18
AU2022202298A1 (en)	2022-04-28
NZ715456A (en)	2021-01-29
CA2915967A1 (fr)	2014-12-24
BR112015031864A2 (pt)	2017-07-25
KR20230144117A (ko)	2023-10-13
LTC3010910I2 (fr)	2025-08-25
AU2014281408A1 (en)	2016-01-21
EP4744664A2 (fr)	2026-05-20
CN105473576B (zh)	2018-10-30
ZA201508959B (en)	2022-09-28
HUS2300042I1 (hu)	2024-01-28
CY2023027I2 (el)	2024-09-20
USRE50050E1 (en)	2024-07-23
JP2024010108A (ja)	2024-01-23
CY1122964T1 (el)	2021-10-29
EA030846B1 (ru)	2018-10-31
IL275837A (en)	2020-08-31
IL317628A (en)	2025-02-01
HRP20200379T1 (hr)	2020-06-12
IL323967A (en)	2025-12-01
US20170281626A1 (en)	2017-10-05
LUC00324I2 (fr)	2026-02-02
IL302299A (en)	2023-06-01
BR112015031864B1 (pt)	2022-02-15
EP3010910B1 (fr)	2020-02-05
SMT202000071T1 (it)	2020-03-13
SG10201803459TA (en)	2018-05-30
AU2020204271A1 (en)	2020-07-16
HK1223930A1 (en)	2017-08-11
GT201500348A (es)	2018-12-20
FR23C1047I1 (fr)	2024-01-12
PL3010910T3 (pl)	2020-07-27
NO2023043I1 (no)	2023-12-01
DK3010910T3 (da)	2020-02-17
EA201690066A1 (ru)	2016-05-31
US20140378464A1 (en)	2014-12-25
JP6603213B2 (ja)	2019-11-06
AU2014281408B2 (en)	2018-08-16
CY2023027I1 (el)	2024-02-16
CN109384729B (zh)	2023-06-30
MX2022014414A (es)	2022-12-07
US20210346379A1 (en)	2021-11-11
JP2020019809A (ja)	2020-02-06
MX2021005326A (es)	2022-11-17
KR20260039799A (ko)	2026-03-20
CN105473576A (zh)	2016-04-06
MX2015017865A (es)	2016-09-06
WO2014205223A1 (fr)	2014-12-24
CL2015003689A1 (es)	2016-10-14
TN2015000553A1 (en)	2017-04-06
CR20160032A (es)	2016-04-01
IL243222B (en)	2020-07-30
MY190860A (en)	2022-05-12
NL301253I2 (nl)	2024-01-10
JP6980734B2 (ja)	2021-12-15
PT3010910T (pt)	2020-02-21
PH12021552715A1 (en)	2022-05-11
JP2025163126A (ja)	2025-10-28
JP2022036966A (ja)	2022-03-08
IL310829A (en)	2024-04-01
PH12015502794B1 (en)	2022-09-02
KR102304121B1 (ko)	2021-09-24
AU2024202464A1 (en)	2024-05-02
KR20210118470A (ko)	2021-09-30
CA2915967C (fr)	2021-07-20
HUE047566T2 (hu)	2020-04-28
US9181200B2 (en)	2015-11-10
CN109384729A (zh)	2019-02-26
AU2018264088A1 (en)	2018-12-06
KR20160026997A (ko)	2016-03-09
LTPA2023535I1 (fr)	2023-12-27
UA117929C2 (uk)	2018-10-25
LT3010910T (lt)	2020-03-10
US20180311242A1 (en)	2018-11-01
DOP2015000300A (es)	2016-03-15
JP7376556B2 (ja)	2023-11-08
KR102359158B1 (ko)	2022-02-08
MX382520B (es)	2025-03-13
PH12015502794A1 (en)	2016-03-21
AU2020204271B2 (en)	2022-01-06
IL243222A0 (en)	2016-02-29
US20200297726A1 (en)	2020-09-24
PE20160208A1 (es)	2016-05-04
RS59906B1 (sr)	2020-03-31
EP3702352A1 (fr)	2020-09-02
EA201891009A1 (ru)	2018-09-28
US9585883B2 (en)	2017-03-07
NL301253I1 (fr)	2023-12-13
US20160030428A1 (en)	2016-02-04
IL285971A (en)	2021-10-31
ES2773250T3 (es)	2020-07-10
US20240382486A1 (en)	2024-11-21
US20230165860A1 (en)	2023-06-01
FIC20230036I1 (fi)	2023-12-01
EP3010910A1 (fr)	2016-04-27
SI3010910T1 (sl)	2020-04-30
IL275837B (en)	2021-09-30
JP2016522263A (ja)	2016-07-28
SG11201510163TA (en)	2016-01-28

Publication	Publication Date	Title
FR23C1047I1 (fr)	2024-01-12	Composés pyrimidinedione contre les maladies cardiaques
ME03664B (fr)	2020-10-20	Stimulateurs de sgc
HUE042186T2 (hu)	2019-06-28	Stimuláló eszköz
BR302014000263S1 (pt)	2015-04-07	Configuração aplicada em calçado
PL3004061T3 (pl)	2018-01-31	Związki 3,4-dihydroizochinolin-2(1h)-ylowe
FR3011445B1 (fr)	2016-02-26	Chaussure
EP2885000A4 (fr)	2015-12-23	Composés thérapeutiques activant les cellules souches
PL2808053T3 (pl)	2019-11-29	Biokompatybilna elektroda wszczepialna
GB2529200B (en)	2019-05-01	Improvement to Analysing Physiological Electrograms
FR2996108B1 (fr)	2016-01-01	Applicateur chauffant
GB201318918D0 (en)	2013-12-11	Footwear with interchangable heels
PL2872614T3 (pl)	2020-11-16	Aplikator sanitarny
DE112014001827A5 (de)	2015-12-10	Gleitschuh
GB201308840D0 (en)	2013-07-03	Insole
ES1085029Y (es)	2013-10-11	Organizador calefactor de calzado
UA29903S (uk)	2015-07-27	Взуття
ES1097055Y (es)	2014-03-24	Calzado
ES1093687Y (es)	2014-02-13	Calzado
BR302013000573S1 (pt)	2014-11-04	Configuração aplicada em calçado
ES1084105Y (es)	2013-10-01	"Conjunto de calzado"
TWM475185U (en)	2014-04-01	Disposable slippers sleeve
BR302014000395S1 (pt)	2015-04-07	Configuração aplicada em calçado
FR3008862B3 (fr)	2015-11-20	Structure de chaussure perfectionnee
UA24660S (uk)	2013-04-25	Черевики
BR302012004291S1 (pt)	2014-05-27	Configuração aplicada em bolsa