NL301253I2 - mavacamten of een farmaceutisch aanvaardbaar zout daarvan - Google Patents

mavacamten of een farmaceutisch aanvaardbaar zout daarvan

Info

Publication number: NL301253I2
Authority: NL; Netherlands
Prior art keywords: mavacamten; pharmaceutically acceptable; acceptable salt; salt; pharmaceutically
Prior art date: 2013-06-21

Application number

NL301253C

Other languages

English (en)

Other versions

NL301253I1 (nl

Original Assignee

Myokardia Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-06-21

Filing date

2023-12-12

Publication date

2024-01-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51177189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL301253(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2023-12-12 Application filed by Myokardia Inc filed Critical Myokardia Inc

2023-12-13 Publication of NL301253I1 publication Critical patent/NL301253I1/nl

2024-01-10 Publication of NL301253I2 publication Critical patent/NL301253I2/nl

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NL301253C 2013-06-21 2023-12-12 mavacamten of een farmaceutisch aanvaardbaar zout daarvan NL301253I2 (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201361838088P	2013-06-21	2013-06-21
US201461939655P	2014-02-13	2014-02-13
US201461981366P	2014-04-18	2014-04-18
PCT/US2014/043192 WO2014205223A1 (en)	2013-06-21	2014-06-19	Pyrimidinedione compounds against cardiac conditions

Publications (2)

Publication Number	Publication Date
NL301253I1 NL301253I1 (nl)	2023-12-13
NL301253I2 true NL301253I2 (nl)	2024-01-10

Family

ID=51177189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL301253C NL301253I2 (nl)	2013-06-21	2023-12-12	mavacamten of een farmaceutisch aanvaardbaar zout daarvan

Country Status (39)

Country	Link
US (9)	US9181200B2 (nl)
EP (3)	EP3702352A1 (nl)
JP (5)	JP6603213B2 (nl)
KR (5)	KR20220020410A (nl)
CN (2)	CN105473576B (nl)
AU (5)	AU2014281408B2 (nl)
BR (1)	BR112015031864B1 (nl)
CA (1)	CA2915967C (nl)
CL (1)	CL2015003689A1 (nl)
CR (1)	CR20160032A (nl)
CY (2)	CY1122964T1 (nl)
DK (1)	DK3010910T3 (nl)
DO (1)	DOP2015000300A (nl)
EA (2)	EA201891009A1 (nl)
ES (1)	ES2773250T3 (nl)
FI (1)	FIC20230036I1 (nl)
FR (1)	FR23C1047I2 (nl)
GT (1)	GT201500348A (nl)
HR (1)	HRP20200379T1 (nl)
HU (2)	HUE047566T2 (nl)
IL (7)	IL317628A (nl)
LT (2)	LT3010910T (nl)
LU (1)	LUC00324I2 (nl)
MX (3)	MX2021005326A (nl)
MY (1)	MY190860A (nl)
NL (1)	NL301253I2 (nl)
NO (1)	NO2023043I1 (nl)
PE (1)	PE20160208A1 (nl)
PH (2)	PH12021552715A1 (nl)
PL (1)	PL3010910T3 (nl)
PT (1)	PT3010910T (nl)
RS (1)	RS59906B1 (nl)
SG (2)	SG10201803459TA (nl)
SI (1)	SI3010910T1 (nl)
SM (1)	SMT202000071T1 (nl)
TN (1)	TN2015000553A1 (nl)
UA (1)	UA117929C2 (nl)
WO (1)	WO2014205223A1 (nl)
ZA (1)	ZA201508959B (nl)

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CN117964573B (zh)	2018-01-19	2026-04-14	赛特凯恩蒂克公司	作为心肌节抑制剂的二氢苯并呋喃和茚类似物
EP3814342B1 (en)	2018-06-26	2022-07-27	Cytokinetics, Inc.	Cardiac sarcomere inhibitors
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DK3873904T3 (da) *	2018-10-29	2024-08-05	Myokardia Inc	Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser
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AU2022202298A1 (en)	2022-04-28
NZ715456A (en)	2021-01-29
CA2915967A1 (en)	2014-12-24
BR112015031864A2 (pt)	2017-07-25
KR20230144117A (ko)	2023-10-13
LTC3010910I2 (nl)	2025-08-25
AU2014281408A1 (en)	2016-01-21
EP4744664A2 (en)	2026-05-20
CN105473576B (zh)	2018-10-30
ZA201508959B (en)	2022-09-28
HUS2300042I1 (hu)	2024-01-28
CY2023027I2 (el)	2024-09-20
USRE50050E1 (en)	2024-07-23
JP2024010108A (ja)	2024-01-23
CY1122964T1 (el)	2021-10-29
EA030846B1 (ru)	2018-10-31
IL275837A (en)	2020-08-31
IL317628A (en)	2025-02-01
HRP20200379T1 (hr)	2020-06-12
IL323967A (en)	2025-12-01
US20170281626A1 (en)	2017-10-05
LUC00324I2 (nl)	2026-02-02
IL302299A (en)	2023-06-01
BR112015031864B1 (pt)	2022-02-15
EP3010910B1 (en)	2020-02-05
SMT202000071T1 (it)	2020-03-13
SG10201803459TA (en)	2018-05-30
AU2020204271A1 (en)	2020-07-16
HK1223930A1 (en)	2017-08-11
GT201500348A (es)	2018-12-20
FR23C1047I1 (fr)	2024-01-12
PL3010910T3 (pl)	2020-07-27
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DK3010910T3 (da)	2020-02-17
EA201690066A1 (ru)	2016-05-31
US20140378464A1 (en)	2014-12-25
JP6603213B2 (ja)	2019-11-06
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CN109384729B (zh)	2023-06-30
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KR20260039799A (ko)	2026-03-20
CN105473576A (zh)	2016-04-06
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WO2014205223A1 (en)	2014-12-24
CL2015003689A1 (es)	2016-10-14
TN2015000553A1 (en)	2017-04-06
CR20160032A (es)	2016-04-01
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MY190860A (en)	2022-05-12
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PH12021552715A1 (en)	2022-05-11
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PH12015502794B1 (en)	2022-09-02
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AU2024202464A1 (en)	2024-05-02
KR20210118470A (ko)	2021-09-30
CA2915967C (en)	2021-07-20
HUE047566T2 (hu)	2020-04-28
US9181200B2 (en)	2015-11-10
CN109384729A (zh)	2019-02-26
AU2018264088A1 (en)	2018-12-06
KR20160026997A (ko)	2016-03-09
LTPA2023535I1 (nl)	2023-12-27
UA117929C2 (uk)	2018-10-25
LT3010910T (lt)	2020-03-10
US20180311242A1 (en)	2018-11-01
DOP2015000300A (es)	2016-03-15
JP7376556B2 (ja)	2023-11-08
KR102359158B1 (ko)	2022-02-08
MX382520B (es)	2025-03-13
PH12015502794A1 (en)	2016-03-21
AU2020204271B2 (en)	2022-01-06
FR23C1047I2 (fr)	2024-11-15
IL243222A0 (en)	2016-02-29
US20200297726A1 (en)	2020-09-24
PE20160208A1 (es)	2016-05-04
RS59906B1 (sr)	2020-03-31
EP3702352A1 (en)	2020-09-02
EA201891009A1 (ru)	2018-09-28
US9585883B2 (en)	2017-03-07
NL301253I1 (nl)	2023-12-13
US20160030428A1 (en)	2016-02-04
IL285971A (en)	2021-10-31
ES2773250T3 (es)	2020-07-10
US20240382486A1 (en)	2024-11-21
US20230165860A1 (en)	2023-06-01
FIC20230036I1 (fi)	2023-12-01
EP3010910A1 (en)	2016-04-27
SI3010910T1 (sl)	2020-04-30
IL275837B (en)	2021-09-30
JP2016522263A (ja)	2016-07-28
SG11201510163TA (en)	2016-01-28

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