HRP940967B1 - Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl) 1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate - Google Patents

Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl) 1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate

Info

Publication number: HRP940967B1
Authority: HR; Croatia
Prior art keywords: methoxyethyl; dihydro; chloro; isopropyl; piridine
Prior art date: 1993-12-10

Application number

HRP4424677.3A

Other languages

English (en)

Inventor

Teunis Schuurman

Original Assignee

Teunis Schuurman

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-12-01

Publication date

1999-12-31

1993-12-10 Priority claimed from DE4342194A external-priority patent/DE4342194A1/de

1994-07-13 Priority claimed from DE19944424677 external-priority patent/DE4424677A1/de

1994-12-01 Application filed by Teunis Schuurman filed Critical Teunis Schuurman

1997-08-31 Publication of HRP940967A2 publication Critical patent/HRP940967A2/hr

1999-12-31 Publication of HRP940967B1 publication Critical patent/HRP940967B1/xx

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
-1 compound rac-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyanophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarb oxylate Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001537 neural effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal Substances (AREA)

HRP4424677.3A 1993-12-10 1994-12-01 Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl) 1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate HRP940967B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4342194A DE4342194A1 (de)	1993-12-10	1993-12-10	Halogen-phenyl-substituierte 1,4-Dihydropyridine
DE19944424677 DE4424677A1 (de)	1994-07-13	1994-07-13	Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat

Publications (2)

Publication Number	Publication Date
HRP940967A2 HRP940967A2 (en)	1997-08-31
HRP940967B1 true HRP940967B1 (en)	1999-12-31

Family

ID=25931956

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP4424677.3A HRP940967B1 (en)	1993-12-10	1994-12-01	Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl) 1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate

Country Status (35)

Country	Link
US (1)	US5665740A (fr)
EP (1)	EP0657430B1 (fr)
JP (1)	JP3751041B2 (fr)
KR (1)	KR100332325B1 (fr)
CN (2)	CN1056606C (fr)
AT (1)	ATE180774T1 (fr)
AU (1)	AU686976B2 (fr)
BG (1)	BG62487B1 (fr)
CA (1)	CA2137525C (fr)
CO (1)	CO4290426A1 (fr)
CU (1)	CU22713A3 (fr)
CZ (1)	CZ286065B6 (fr)
DE (1)	DE59408350D1 (fr)
DK (1)	DK0657430T3 (fr)
DZ (1)	DZ1831A1 (fr)
EE (1)	EE03192B1 (fr)
ES (1)	ES2132308T3 (fr)
FI (1)	FI105681B (fr)
GR (1)	GR3030436T3 (fr)
HR (1)	HRP940967B1 (fr)
HU (1)	HU215593B (fr)
IL (1)	IL111922A (fr)
LV (1)	LV11321B (fr)
MA (1)	MA23392A1 (fr)
MY (1)	MY111976A (fr)
NO (1)	NO302362B1 (fr)
NZ (1)	NZ270087A (fr)
PL (1)	PL179973B1 (fr)
RO (1)	RO115800B1 (fr)
SA (1)	SA95160078B1 (fr)
SK (1)	SK282399B6 (fr)
SV (1)	SV1994000072A (fr)
TN (1)	TNSN94127A1 (fr)
TW (1)	TW412529B (fr)
YU (1)	YU48920B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005051389A1 (fr) *	2003-11-21	2005-06-09	Memory Pharmaceuticals Corporation	Utilisation de (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dymethyl-pyridine-3,5-dicarboxylate pour traiter des troubles de la memoire
WO2008058234A2 (fr) *	2006-11-08	2008-05-15	Memory Pharmaceuticals Corporation	Formulations pharmaceutiques pour des composés de 1,4-dihydropyridine ayant une solubilité améliorée
WO2019104041A1 (fr) *	2017-11-21	2019-05-31	Michael Ohlmeyer	Dihydropyridines destinées au traitement d'une déficience cognitive ou d'une lésion cérébrale traumatique

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963188A1 (de) *	1969-12-17	1971-06-24	Bayer Ag	Neue Cyanphenyl-1,4-dihydropyridinderivate
US3932646A (en) *	1971-04-10	1976-01-13	Farbenfabriken Bayer Ag	Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
DE2117572C3 (de) *	1971-04-10	1980-03-20	Bayer Ag, 5090 Leverkusen	Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2508181A1 (de) *	1975-02-26	1976-09-09	Bayer Ag	1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2815578C2 (de) *	1978-04-11	1986-01-16	Bayer Ag, 5090 Leverkusen	Neue pharmazeutische Verwendung von Nimodipin
DE2935451A1 (de) *	1979-09-01	1981-03-19	Bayer Ag, 5090 Leverkusen	Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3208628A1 (de) *	1982-03-10	1983-09-22	Bayer Ag, 5090 Leverkusen	Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3239273A1 (de) *	1982-10-23	1984-04-26	Bayer Ag, 5090 Leverkusen	Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5137889A (en) *	1983-12-02	1992-08-11	Otsuka Pharmaceutical Co., Ltd.	Dihydropyridine derivatives and process for preparing the same
DE3718398A1 (de) *	1987-06-02	1988-12-22	Troponwerke Gmbh & Co Kg	Neue kombinationspraeparate mit antidepressiver wirkung
US5114946A (en) *	1987-06-12	1992-05-19	American Cyanamid Company	Transdermal delivery of pharmaceuticals
DE3806277A1 (de) *	1988-02-27	1989-09-07	Troponwerke Gmbh & Co Kg	Verwendung von 1,4-dihydropyridin-derivaten
DE4011695A1 (de) *	1990-04-11	1991-10-17	Bayer Ag	Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
FR2671349B1 (fr) *	1991-01-09	1993-04-23	Lafon Labor	Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
DE4125271A1 (de) *	1991-07-31	1993-02-11	Bayer Ag	Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester

1994
- 1994-11-22 EE EE9400393A patent/EE03192B1/xx not_active IP Right Cessation
- 1994-11-28 EP EP94118671A patent/EP0657430B1/fr not_active Expired - Lifetime
- 1994-11-28 DE DE59408350T patent/DE59408350D1/de not_active Expired - Lifetime
- 1994-11-28 AT AT94118671T patent/ATE180774T1/de active
- 1994-11-28 DK DK94118671T patent/DK0657430T3/da active
- 1994-11-28 ES ES94118671T patent/ES2132308T3/es not_active Expired - Lifetime
- 1994-12-01 HR HRP4424677.3A patent/HRP940967B1/xx not_active IP Right Cessation
- 1994-12-02 CO CO94055078A patent/CO4290426A1/es unknown
- 1994-12-02 CU CU13794A patent/CU22713A3/es unknown
- 1994-12-02 US US08/348,436 patent/US5665740A/en not_active Expired - Lifetime
- 1994-12-06 JP JP32981994A patent/JP3751041B2/ja not_active Expired - Fee Related
- 1994-12-06 RO RO94-01950A patent/RO115800B1/ro unknown
- 1994-12-07 TN TNTNSN94127A patent/TNSN94127A1/fr unknown
- 1994-12-07 PL PL94306157A patent/PL179973B1/pl not_active IP Right Cessation
- 1994-12-07 DZ DZ940128A patent/DZ1831A1/fr active
- 1994-12-07 IL IL11192294A patent/IL111922A/xx not_active IP Right Cessation
- 1994-12-07 SK SK1516-94A patent/SK282399B6/sk not_active IP Right Cessation
- 1994-12-07 CA CA002137525A patent/CA2137525C/fr not_active Expired - Fee Related
- 1994-12-07 NZ NZ270087A patent/NZ270087A/en not_active IP Right Cessation
- 1994-12-08 BG BG99249A patent/BG62487B1/bg unknown
- 1994-12-08 FI FI945777A patent/FI105681B/fi not_active IP Right Cessation
- 1994-12-08 SV SV1994000072A patent/SV1994000072A/es not_active Application Discontinuation
- 1994-12-08 CZ CZ19943093A patent/CZ286065B6/cs not_active IP Right Cessation
- 1994-12-08 AU AU80306/94A patent/AU686976B2/en not_active Ceased
- 1994-12-08 YU YU71794A patent/YU48920B/sh unknown
- 1994-12-09 HU HU9403551A patent/HU215593B/hu not_active IP Right Cessation
- 1994-12-09 LV LVP-94-242A patent/LV11321B/lv unknown
- 1994-12-09 MY MYPI94003289A patent/MY111976A/en unknown
- 1994-12-09 MA MA23720A patent/MA23392A1/fr unknown
- 1994-12-09 NO NO944787A patent/NO302362B1/no not_active IP Right Cessation
- 1994-12-09 KR KR1019940033434A patent/KR100332325B1/ko not_active Expired - Fee Related
- 1994-12-09 CN CN94112892A patent/CN1056606C/zh not_active Expired - Fee Related
1995
- 1995-02-14 TW TW084101294A patent/TW412529B/zh not_active IP Right Cessation
- 1995-06-28 SA SA95160078A patent/SA95160078B1/ar unknown
1999
- 1999-06-09 GR GR990401523T patent/GR3030436T3/el unknown
- 1999-06-30 CN CN99108967A patent/CN1124258C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL111922A (en)	1999-05-09
AU8030694A (en)	1995-06-15
HRP940967A2 (en)	1997-08-31
JP3751041B2 (ja)	2006-03-01
BG99249A (en)	1995-09-29
YU71794A (sh)	1996-10-18
MY111976A (en)	2001-03-31
NO944787L (no)	1995-06-12
EE03192B1 (et)	1999-06-15
KR100332325B1 (ko)	2002-09-04
BG62487B1 (bg)	1999-12-30
FI945777A0 (fi)	1994-12-08
CN1056606C (zh)	2000-09-20
YU48920B (sh)	2002-11-15
LV11321A (lv)	1996-06-20
NO302362B1 (no)	1998-02-23
CA2137525C (fr)	2005-07-12
SA95160078B1 (ar)	2006-09-25
GR3030436T3 (en)	1999-09-30
CU22713A3 (es)	1996-07-05
EP0657430A1 (fr)	1995-06-14
CO4290426A1 (es)	1996-04-17
LV11321B (en)	1996-12-20
IL111922A0 (en)	1995-03-15
CN1124258C (zh)	2003-10-15
DZ1831A1 (fr)	2002-02-17
NZ270087A (en)	1996-08-27
HUT70937A (en)	1995-11-28
FI945777A7 (fi)	1995-06-11
NO944787D0 (no)	1994-12-09
PL179973B1 (pl)	2000-11-30
CZ309394A3 (en)	1995-11-15
US5665740A (en)	1997-09-09
ES2132308T3 (es)	1999-08-16
DE59408350D1 (de)	1999-07-08
DK0657430T3 (da)	1999-11-15
FI105681B (fi)	2000-09-29
SK151694A3 (en)	1995-07-11
TW412529B (en)	2000-11-21
TNSN94127A1 (en)	1995-09-21
HU215593B (hu)	1999-01-28
ATE180774T1 (de)	1999-06-15
CA2137525A1 (fr)	1995-06-11
CZ286065B6 (cs)	2000-01-12
SK282399B6 (sk)	2002-01-07
AU686976B2 (en)	1998-02-12
JPH07242632A (ja)	1995-09-19
MA23392A1 (fr)	1995-07-01
RO115800B1 (ro)	2000-06-30
CN1109874A (zh)	1995-10-11
KR950017958A (ko)	1995-07-22
PL306157A1 (en)	1995-06-12
SV1994000072A (es)	1995-08-09
HU9403551D0 (en)	1995-02-28
CN1244525A (zh)	2000-02-16
EP0657430B1 (fr)	1999-06-02

Legal Events

Date	Code	Title	Description
1997-08-31	A1OB	Publication of a patent application
1997-10-31	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
1999-12-31	B1PR	Patent granted
2009-06-29	PPPP	Transfer of rights	Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, DE
2010-11-18	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20101118 Year of fee payment: 17
2012-06-02	PBON	Lapse due to non-payment of renewal fee	Effective date: 20111202

Publication	Publication Date	Title
CA2142610A1 (fr)	1994-03-17	Derives d'anabaseine servant au traitement de maladies degeneratives du systeme nerveux
HUT62337A (en)	1993-04-28	New cyclosporins, pharmaceutical compositions comprising such compounds and process for producing same
CA2094702A1 (fr)	1992-05-06	Derives de substitution de tetrahydropyridines et d'hydroxypiperidines, agents therapeutiques pour le systeme nerveux central
EP0187251A3 (fr)	1987-04-29	1,4-Dihydropyridines, procédé et intermédiaires pour leur préparation et leur utilisation comme médicaments
FR2691065B1 (fr)	1994-07-29	Nouvelles compositions oculaires destinees a la prevention et au traitement de certains troubles de la vision.
HUP9900927A3 (en)	2002-02-28	Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
GR3030436T3 (en)	1999-09-30	Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate.
ZA906057B (en)	1992-04-29	4-(n-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents
EP0383171A3 (fr)	1991-07-24	Dérivés de 2,3,23 trihydroxy-urs-12-ène pour le traitement des troubles cognitifs
FI941911A0 (fi)	1994-04-25	Kondensoidut kinolyylidihydropyridiinit, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineissa
CA2078700A1 (fr)	1993-03-24	Imidazolylmethyl-pyridines
ATE116851T1 (de)	1995-01-15	5-aryl-3h-1,2,4-triazol-3-one und ihre verwendung in der behandlung neurodegenerativer beschwerden.
DK0950053T3 (da)	2003-09-29	Hidtil ukendte benzoylalkyl.1,2,3,6-tetrahydropyridinderivater
SG59972A1 (en)	1999-02-22	Medicaments
Blass	1987	Circulatory and degenerative dementias.
EP0432751A3 (en)	1992-02-12	Isomers of 1-azabicyclo(2.2.2)oct-3-yl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-nitropyridine-3-carboxylate
PT80521B (en)	1986-12-16	Process for the preparation of esters of the 1,4-dihydro-2,6-dimethyl-3-(alcoxicarbonyl or alcoxialcoxicarbonyl)-4-(substituted phenyl) pyridin-5-carboxylic acid of stereochemical isomers and pharmaceutically acceptable salts thereof
AU636488C (en)	1993-10-14	Use of a 1-2(-naphthylethyl)-4-(3-trifluoromethylphenyl)-1, 2,3,6-tetrahydropyridine for the treatment of cerebral and n euronal diseases