HRP980406A2 - Thermodynamically stable modification of 1-(4-carbazolyloxy-3-/2-(2-methoxyphenoxy)ethylamino/-2-propanole, process for its preparation and pharmaceutical compositions containing it - Google Patents

Thermodynamically stable modification of 1-(4-carbazolyloxy-3-/2-(2-methoxyphenoxy)ethylamino/-2-propanole, process for its preparation and pharmaceutical compositions containing it

Info

Publication number
HRP980406A2
HRP980406A2 HR97112491.2A HRP980406A HRP980406A2 HR P980406 A2 HRP980406 A2 HR P980406A2 HR P980406 A HRP980406 A HR P980406A HR P980406 A2 HRP980406 A2 HR P980406A2
Authority
HR
Croatia
Prior art keywords
carbazolyloxy
methoxyphenoxy
ethylamino
modification
preparation
Prior art date
Application number
HR97112491.2A
Other languages
English (en)
Croatian (hr)
Inventor
Peter Beyer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of HRP980406A2 publication Critical patent/HRP980406A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
HR97112491.2A 1997-07-22 1998-07-22 Thermodynamically stable modification of 1-(4-carbazolyloxy-3-/2-(2-methoxyphenoxy)ethylamino/-2-propanole, process for its preparation and pharmaceutical compositions containing it HRP980406A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97112491A EP0893440A1 (fr) 1997-07-22 1997-07-22 Une modification thermodynamique stabilisée de 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy)ethylamino]- 2-propanole, un procédé pour sa préparation et une composition pharmaceutique qui la contient

Publications (1)

Publication Number Publication Date
HRP980406A2 true HRP980406A2 (en) 1999-04-30

Family

ID=8227094

Family Applications (1)

Application Number Title Priority Date Filing Date
HR97112491.2A HRP980406A2 (en) 1997-07-22 1998-07-22 Thermodynamically stable modification of 1-(4-carbazolyloxy-3-/2-(2-methoxyphenoxy)ethylamino/-2-propanole, process for its preparation and pharmaceutical compositions containing it

Country Status (31)

Country Link
EP (2) EP0893440A1 (fr)
JP (1) JP2001510824A (fr)
KR (1) KR100336229B1 (fr)
CN (1) CN1125047C (fr)
AR (1) AR015133A1 (fr)
AT (1) ATE236123T1 (fr)
AU (1) AU740453B2 (fr)
BR (1) BR9810776A (fr)
CA (1) CA2296637C (fr)
CZ (1) CZ296947B6 (fr)
DE (1) DE69812964T2 (fr)
DK (1) DK1000027T3 (fr)
ES (1) ES2195366T3 (fr)
HR (1) HRP980406A2 (fr)
HU (1) HUP0003198A3 (fr)
IL (1) IL133677A (fr)
MA (1) MA26523A1 (fr)
MY (1) MY117734A (fr)
NO (1) NO313588B1 (fr)
NZ (1) NZ502136A (fr)
PE (1) PE96999A1 (fr)
PL (1) PL191602B1 (fr)
PT (1) PT1000027E (fr)
RU (1) RU2202542C2 (fr)
SI (1) SI1000027T1 (fr)
TR (1) TR200000148T2 (fr)
TW (1) TW505631B (fr)
UY (1) UY25108A1 (fr)
WO (1) WO1999005105A1 (fr)
YU (1) YU2200A (fr)
ZA (1) ZA986475B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074356A1 (fr) * 2000-04-03 2001-10-11 F. Hoffmann-La Roche Ag Solutions concentrees de carvedilol
CA2413702A1 (fr) 2000-06-28 2002-01-03 Teva Pharmaceuticals Industries Ltd. Carvedilol
EP1655285A1 (fr) * 2000-06-28 2006-05-10 Teva Pharmaceutical Industries Ltd. Procédé de préparation d'une forme crystalline de carvedilol (forme II)
WO2003005970A2 (fr) * 2001-07-13 2003-01-23 Smithkline Beecham Corporation Polymorphe de carvedilol
US20050019399A1 (en) 2001-09-21 2005-01-27 Gina Fischer Controlled release solid dispersions
PL370412A1 (en) * 2001-09-28 2005-05-30 F.Hoffmann-La Roche Ag Pseudopolymorphic forms of carvedilol
US6710184B2 (en) * 2002-01-15 2004-03-23 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
JP2006500320A (ja) * 2002-04-30 2006-01-05 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド カルベジロール一クエン酸塩一水和物
CA2492084A1 (fr) * 2002-06-27 2004-01-08 Sb Pharmco Puerto Rico Inc. Hydobromure de carvedilol
BR0312102A (pt) 2002-06-27 2007-05-29 Sb Pharmco Inc sais de fosfato de carvedilol e/ou seus solvatos, composições correspondentes, e/ou métodos de tratamento
WO2004041252A1 (fr) * 2002-11-08 2004-05-21 Egalet A/S Compositions de carvedilol a liberation commandee
US8877241B2 (en) 2003-03-26 2014-11-04 Egalet Ltd. Morphine controlled release system
WO2004094378A1 (fr) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Procede de fabrication de carvedilol, forme-ii
SI21616A (sl) * 2003-09-02 2005-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalne oblike karvedilola
JP2007512372A (ja) * 2003-11-25 2007-05-17 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド カルベジロール塩、対応する組成物、送達および／または治療方法
CA2589699A1 (fr) * 2004-12-09 2006-06-15 Zach System S.P.A. Procede de preparation de carvedilol et de ses enantiomeres
EP1781611A1 (fr) * 2005-06-09 2007-05-09 Teva Pharmaceutical Industries Ltd. Formes cristallines du carvedilol et leurs procedes de preparation
WO2008002683A2 (fr) 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Carvédilol phosphate
RU2366653C2 (ru) * 2006-07-03 2009-09-10 Ооо "Нанокриохимия" Способ получения рентгеноаморфной модификации карведилола
US20080249317A1 (en) * 2007-04-04 2008-10-09 Apotex Inc. Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
US8821928B2 (en) 2007-06-04 2014-09-02 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
AU2010265213B2 (en) 2009-06-24 2012-08-23 Egalet Ltd. Controlled release formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

Also Published As

Publication number Publication date
HUP0003198A3 (en) 2002-10-28
KR100336229B1 (ko) 2002-05-09
CN1264366A (zh) 2000-08-23
TR200000148T2 (tr) 2000-07-21
DK1000027T3 (da) 2003-07-21
NO20000301L (no) 2000-01-21
EP0893440A1 (fr) 1999-01-27
NZ502136A (en) 2002-05-31
SI1000027T1 (en) 2003-10-31
DE69812964D1 (de) 2003-05-08
YU2200A (sh) 2002-03-18
ZA986475B (en) 2000-01-21
PL338432A1 (en) 2000-11-06
PT1000027E (pt) 2003-07-31
WO1999005105A1 (fr) 1999-02-04
JP2001510824A (ja) 2001-08-07
MY117734A (en) 2004-07-31
CA2296637A1 (fr) 1999-02-04
IL133677A0 (en) 2001-04-30
AR015133A1 (es) 2001-04-18
CZ2000221A3 (cs) 2000-05-17
DE69812964T2 (de) 2004-03-04
UY25108A1 (es) 2000-12-29
AU740453B2 (en) 2001-11-01
AU8631998A (en) 1999-02-16
HUP0003198A2 (en) 2001-03-28
PE96999A1 (es) 1999-10-12
RU2202542C2 (ru) 2003-04-20
EP1000027A1 (fr) 2000-05-17
NO20000301D0 (no) 2000-01-21
TW505631B (en) 2002-10-11
CN1125047C (zh) 2003-10-22
KR20010022097A (ko) 2001-03-15
CZ296947B6 (cs) 2006-08-16
IL133677A (en) 2004-06-01
EP1000027B1 (fr) 2003-04-02
ATE236123T1 (de) 2003-04-15
CA2296637C (fr) 2005-11-15
ES2195366T3 (es) 2003-12-01
PL191602B1 (pl) 2006-06-30
NO313588B1 (no) 2002-10-28
HK1029339A1 (en) 2001-03-30
MA26523A1 (fr) 2004-12-20
BR9810776A (pt) 2000-09-19

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Legal Events

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A1OB Publication of a patent application
PNAN Change of the applicant name, address/residence

Owner name: ROCHE DIAGNOSTICS GMBH, DE

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ODBI Application refused