IL114759A - Benzoxazole derivatives and pharmaceutical compositions containing them - Google Patents

Benzoxazole derivatives and pharmaceutical compositions containing them

Info

Publication number
IL114759A
IL114759A IL11475995A IL11475995A IL114759A IL 114759 A IL114759 A IL 114759A IL 11475995 A IL11475995 A IL 11475995A IL 11475995 A IL11475995 A IL 11475995A IL 114759 A IL114759 A IL 114759A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
benzoxazole derivatives
benzoxazole
derivatives
Prior art date
Application number
IL11475995A
Other languages
English (en)
Other versions
IL114759A0 (en
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415330A external-priority patent/GB9415330D0/en
Priority claimed from GBGB9425599.9A external-priority patent/GB9425599D0/en
Priority claimed from GBGB9509923.0A external-priority patent/GB9509923D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to IL12552595A priority Critical patent/IL125525A/xx
Publication of IL114759A0 publication Critical patent/IL114759A0/xx
Publication of IL114759A publication Critical patent/IL114759A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11475995A 1994-07-29 1995-07-27 Benzoxazole derivatives and pharmaceutical compositions containing them IL114759A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL12552595A IL125525A (en) 1994-07-29 1995-07-27 Hydroxyalkylamine derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9415330A GB9415330D0 (en) 1994-07-29 1994-07-29 Novel compounds
GBGB9425599.9A GB9425599D0 (en) 1994-12-19 1994-12-19 Novel compounds
GBGB9509923.0A GB9509923D0 (en) 1995-05-17 1995-05-17 Novel compounds
PCT/GB1995/001323 WO1996004261A1 (fr) 1994-07-29 1995-06-07 Benzoxoazoles et derives de pryridine destines a etre utilises pour le traitement du diabete tardif

Publications (2)

Publication Number Publication Date
IL114759A0 IL114759A0 (en) 1995-12-31
IL114759A true IL114759A (en) 1999-10-28

Family

ID=27267309

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11475995A IL114759A (en) 1994-07-29 1995-07-27 Benzoxazole derivatives and pharmaceutical compositions containing them
IL12552595A IL125525A (en) 1994-07-29 1995-07-27 Hydroxyalkylamine derivatives
IL12552598A IL125525A0 (en) 1994-07-29 1998-07-27 Hydroxyalkylamine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL12552595A IL125525A (en) 1994-07-29 1995-07-27 Hydroxyalkylamine derivatives
IL12552598A IL125525A0 (en) 1994-07-29 1998-07-27 Hydroxyalkylamine derivatives

Country Status (16)

Country Link
EP (1) EP0772605A1 (fr)
AP (1) AP776A (fr)
BR (1) BR9508468A (fr)
CA (1) CA2196079A1 (fr)
CZ (1) CZ25497A3 (fr)
DZ (1) DZ1916A1 (fr)
FI (1) FI970357L (fr)
HU (1) HUT76637A (fr)
IL (3) IL114759A (fr)
MA (1) MA23632A1 (fr)
MX (1) MX9700763A (fr)
NO (1) NO307827B1 (fr)
OA (1) OA10470A (fr)
PL (1) PL318766A1 (fr)
SK (1) SK12297A3 (fr)
WO (2) WO1996004261A1 (fr)

Families Citing this family (64)

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GB9600464D0 (en) * 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
KR20000005224A (ko) * 1996-04-04 2000-01-25 가와무라 요시부미 페닐알킬카르복실산 유도체_
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
WO1999018066A1 (fr) 1997-10-02 1999-04-15 Sankyo Company, Limited Derives d'acide amidocarboxylique
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
BR9812770A (pt) 1997-10-27 2000-12-12 Reddy Research Foundation Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos
US6265401B1 (en) * 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
MXPA00004036A (es) * 1997-10-27 2006-05-24 Reddys Lab Ltd Dr Compuestos triciclicos novedosos y su uso en medicina; proceso para su preparacion y composiciones farmaceuticas que los contienen..
US6444816B1 (en) 1997-10-27 2002-09-03 Dr. Reddy's Research Foundation Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
CN1280574A (zh) 1997-10-27 2001-01-17 雷迪研究基金会 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物
WO1999019313A1 (fr) * 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ces derniers et compositions pharmaceutiques les contenant
JP2002507543A (ja) * 1998-05-27 2002-03-12 ドクター・レディーズ・リサーチ・ファウンデーション 二環系化合物、その製造方法およびそれらを含有する薬学的組成物
GEP20033045B (en) 1998-09-17 2003-08-25 Bristol Myers Squibb Co Method for Treating Diabetes
EP1123292A1 (fr) * 1998-10-21 2001-08-16 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
US6353018B1 (en) 1998-10-21 2002-03-05 Novo Nordisk A/S Compounds, their preparation and use
EP1123269A1 (fr) * 1998-10-21 2001-08-16 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
US6365586B1 (en) 1998-10-21 2002-04-02 Novo Nordisk A/S Compounds, their preparation and use
US6248781B1 (en) 1998-10-21 2001-06-19 Novo Nordisk A/S Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
JP2002527502A (ja) * 1998-10-21 2002-08-27 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの調製及び使用
US6214820B1 (en) 1998-10-21 2001-04-10 Novo Nordisk A/S Compounds, their preparation and use
US6468996B1 (en) 1998-10-21 2002-10-22 Novo Nordisk A/S Substituted hetero-polycyclic compounds as PPARα and PPARγ activators
WO2000023451A1 (fr) * 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
JP2002527507A (ja) * 1998-10-21 2002-08-27 ノボ ノルディスク アクティーゼルスカブ 新規化合物類、それらの調製及び使用
US6300339B1 (en) 1998-10-21 2001-10-09 Novo Nordisk A/S Compounds, their preparation and use
JP2002528535A (ja) * 1998-10-29 2002-09-03 ドクター・レディーズ・リサーチ・ファウンデーション 新規抗糖尿病剤製造の改良方法
US6531596B1 (en) 1998-10-29 2003-03-11 Dr. Reddy's Laboratories Ltd. Process for the preparation of new antidiabetic agents
WO2000063189A1 (fr) * 1999-04-16 2000-10-26 Novo Nordisk A/S Formes cristallines de r-guanidines, d'arginine ou de (l)-arginine (2s-2-ethoxy-3-{4-[2-(10h-phenoxazin-10-yl)ethoxy]phenyl}propanoate
EP1171438A1 (fr) 1999-04-20 2002-01-16 Novo Nordisk A/S Composes, preparation et utilisation associees
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
US7414128B2 (en) 1999-04-20 2008-08-19 Dr. Reddy's Laboratories, Limited Crystalline R-guanidines, Arginine or (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H -phenoxazin-10-yl)ethoxy]phenyl}propanoate
US6274608B1 (en) 1999-04-20 2001-08-14 Novo Nordisk A/S Compounds, their preparation and use
US6369055B1 (en) 1999-04-20 2002-04-09 Novo Nordisk A/S Compounds, their preparation and use
EP1171414A1 (fr) * 1999-04-20 2002-01-16 Novo Nordisk A/S Composes, preparation et utilisation de ces derniers
WO2000063190A1 (fr) * 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, leur preparation et utilisation
JP2002543194A (ja) 1999-04-28 2002-12-17 ドクター・レディーズ・ラボラトリーズ・リミテッド 置換二環系ヘテロ環化合物、その製造方法、並びに抗肥満症及び抗高コレステロール血症剤としてのこれらの使用
US6417212B1 (en) 1999-08-27 2002-07-09 Eli Lilly & Company Modulators of peroxisome proliferator activated receptors
ES2449194T3 (es) * 2000-01-19 2014-03-18 Cadila Healthcare Limited Compuestos que tienen actividades hipolipidémica e hipocolesterolémica, procedimiento para su preparación y composiciones farmacéuticas que los contienen
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
CN1396904A (zh) * 2000-01-28 2003-02-12 诺沃挪第克公司 新颖的化合物、它们的制备和用途
US6509374B2 (en) 2000-04-17 2003-01-21 Novo Nordisk A/S Compounds, their preparation and use
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WO2001087860A2 (fr) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Nouveaux benzoxazinones utilises comme modulateurs du recepteur gamma active de la proliferation des peroxysomes, et methode de traitement associee
PT1280784E (pt) * 2000-05-12 2007-09-03 Ortho Mcneil Pharm Inc 4h-benzo [1,4] oxazin-3-onas biologicamente activas.
WO2001087861A2 (fr) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Methodes de traitement mettant en oeuvre des benzoxazinones comme modulateurs du recepteur gamma active par le proliferateur du peroxisome
US6987123B2 (en) * 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
WO2003059378A2 (fr) 2001-12-29 2003-07-24 Novo Nordisk A/S Utilisation combinee d'un compose glp-1 et d'un autre medicament pour traiter la dyslipidemie
US7015345B2 (en) 2002-02-21 2006-03-21 Asahi Kasei Pharma Corporation Propionic acid derivatives
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
US6653334B1 (en) 2002-12-27 2003-11-25 Kowa Co., Ltd. Benzoxazole compound and pharmaceutical composition containing the same
WO2008139879A1 (fr) * 2007-04-26 2008-11-20 Pharmafrontier, Co., Ltd. Inhibiteur du récepteur couplé à protéine g et produit pharmaceutique
KR101633720B1 (ko) 2011-01-31 2016-06-27 카딜라 핼쓰캐어 리미티드 지방이상증의 치료
UA114360C2 (uk) 2013-04-22 2017-05-25 Каділа Хелткере Лімітед Спосіб лікування та/або зменшення інтенсивності неалкогольної жирової хвороби печінки (нжхп)
US20160107989A1 (en) 2013-05-30 2016-04-21 Cadila Healthcare Limited A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
TW201513857A (zh) 2013-07-05 2015-04-16 Cadila Healthcare Ltd 協同性組成物
IN2013MU02470A (fr) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
IN2013MU02905A (fr) 2013-09-06 2015-07-03 Cadila Healthcare Ltd
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
MX382765B (es) 2016-12-09 2025-03-13 Zydus Lifesciences Ltd Tratamiento para la colangitis biliar primaria.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
CZ1095A3 (en) * 1992-07-03 1995-10-18 Smithkline Beecham Plc Heterocyclic compounds, process of their preparation, their use for the preparation of a pharmaceutical preparation and the pharmaceutical composition containing thereof

Also Published As

Publication number Publication date
AP9700918A0 (en) 1997-01-31
BR9508468A (pt) 1997-11-25
IL114759A0 (en) 1995-12-31
WO1996004260A1 (fr) 1996-02-15
CA2196079A1 (fr) 1996-02-15
IL125525A0 (en) 1999-03-12
OA10470A (en) 2002-04-08
NO970373D0 (no) 1997-01-28
HUT76637A (en) 1997-10-28
IL125525A (en) 2000-02-29
EP0772605A1 (fr) 1997-05-14
MX9700763A (es) 1997-05-31
NO970373L (no) 1997-03-18
AP776A (en) 1999-10-28
DZ1916A1 (fr) 2002-02-17
NO307827B1 (no) 2000-06-05
FI970357A7 (fi) 1997-03-26
SK12297A3 (en) 1997-08-06
CZ25497A3 (en) 1997-09-17
MA23632A1 (fr) 1996-04-01
FI970357A0 (fi) 1997-01-28
PL318766A1 (en) 1997-07-07
FI970357L (fi) 1997-03-26
WO1996004261A1 (fr) 1996-02-15

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