IL115819A - 2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them - Google Patents

2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them

Info

Publication number: IL115819A
Authority: IL; Israel
Prior art keywords: hydrogen; formula; methyl; compound; compounds
Prior art date: 1994-11-02

Application number

IL11581995A

Other languages

English (en)

Other versions

IL115819A0 (en

Inventor

Jose Ignacio Andresgil

Francisco Javi Fernandezgadea

Pilar Gillopetegui

Theo Frans Meert

Victor Karel Sipido

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-02

Filing date

1995-10-31

Publication date

1998-10-30

1995-10-31 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1996-01-19 Publication of IL115819A0 publication Critical patent/IL115819A0/xx

1998-10-30 Publication of IL115819A publication Critical patent/IL115819A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL11581995A 1994-11-02 1995-10-31 2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them IL115819A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94203178		1994-11-02
US08/457,968 US5552399A (en)	1994-11-02	1995-05-31	Substituted tetracyclic azepine derivatives

Publications (2)

Publication Number	Publication Date
IL115819A0 IL115819A0 (en)	1996-01-19
IL115819A true IL115819A (en)	1998-10-30

Family

ID=8217337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11581995A IL115819A (en)	1994-11-02	1995-10-31	2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them

Country Status (30)

Country	Link
US (1)	US5552399A (de)
EP (1)	EP0789701B1 (de)
JP (1)	JP3818541B2 (de)
KR (1)	KR100392060B1 (de)
CN (1)	CN1085667C (de)
AR (1)	AR002238A1 (de)
AT (1)	ATE199087T1 (de)
AU (1)	AU704285B2 (de)
BR (1)	BR9509552A (de)
CA (1)	CA2203661A1 (de)
CZ (1)	CZ286945B6 (de)
DE (1)	DE69520070T2 (de)
DK (1)	DK0789701T3 (de)
ES (1)	ES2155898T3 (de)
FI (1)	FI113050B (de)
GR (1)	GR3035680T3 (de)
HR (1)	HRP950537A2 (de)
HU (1)	HUT77408A (de)
IL (1)	IL115819A (de)
MY (1)	MY113325A (de)
NO (1)	NO308035B1 (de)
NZ (1)	NZ295656A (de)
PL (1)	PL183686B1 (de)
PT (1)	PT789701E (de)
RU (1)	RU2163240C2 (de)
SI (1)	SI0789701T1 (de)
TR (1)	TR199501356A2 (de)
TW (1)	TW349950B (de)
WO (1)	WO1996014320A1 (de)
ZA (1)	ZA959215B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL186541B1 (pl) *	1996-04-12	2004-01-30	Janssen Pharmaceutica Nv	Nowy związek, pochodna izoksazolidyny, kompozycjafarmaceutyczna, zastosowanie pochodnej izoksazolidyny i sposób wytwarzania pochodnej izoksazolidyny
UA52778C2 (uk) *	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) *	2003-11-21	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
US20110086086A1 (en) *	2005-07-26	2011-04-14	Pfizer Inc	Transdermal system for varenicline
CA3069699A1 (en) *	2017-07-13	2019-01-17	Tonix Pharmaceuticals Holding Corp.	Analogs of cyclobenzaprine and amitryptilene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT338799B (de) *	1974-03-02	1977-09-12	Boehringer Sohn Ingelheim	Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
NL7414038A (nl) *	1974-10-28	1976-05-03	Akzo Nv	Nieuwe tetracyclische pyrrolidino derivaten.
DE2647114A1 (de) *	1975-10-21	1977-05-05	Hans Fickler	Vorrichtung zur erzeugung einer laengsbewegung
JPS5572177A (en) *	1978-11-27	1980-05-30	Shionogi & Co Ltd	4,1-benzoxazepine or 4,1-benzothiazepine
PT95522B (pt) *	1989-10-05	1997-08-29	Sankyo Co	Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists

1995
- 1995-05-31 US US08/457,968 patent/US5552399A/en not_active Expired - Fee Related
- 1995-10-20 TW TW084111063A patent/TW349950B/zh active
- 1995-10-25 PL PL95319939A patent/PL183686B1/pl not_active IP Right Cessation
- 1995-10-25 CA CA002203661A patent/CA2203661A1/en not_active Abandoned
- 1995-10-25 DK DK95937006T patent/DK0789701T3/da active
- 1995-10-25 CN CN95195969A patent/CN1085667C/zh not_active Expired - Fee Related
- 1995-10-25 AU AU39249/95A patent/AU704285B2/en not_active Ceased
- 1995-10-25 RU RU97108691/04A patent/RU2163240C2/ru not_active IP Right Cessation
- 1995-10-25 HU HU9702298A patent/HUT77408A/hu unknown
- 1995-10-25 ES ES95937006T patent/ES2155898T3/es not_active Expired - Lifetime
- 1995-10-25 EP EP95937006A patent/EP0789701B1/de not_active Expired - Lifetime
- 1995-10-25 BR BR9509552A patent/BR9509552A/pt not_active IP Right Cessation
- 1995-10-25 CZ CZ19971323A patent/CZ286945B6/cs not_active IP Right Cessation
- 1995-10-25 NZ NZ295656A patent/NZ295656A/xx unknown
- 1995-10-25 JP JP51500996A patent/JP3818541B2/ja not_active Expired - Fee Related
- 1995-10-25 DE DE69520070T patent/DE69520070T2/de not_active Expired - Fee Related
- 1995-10-25 SI SI9530482T patent/SI0789701T1/xx unknown
- 1995-10-25 WO PCT/EP1995/004196 patent/WO1996014320A1/en not_active Ceased
- 1995-10-25 PT PT95937006T patent/PT789701E/pt unknown
- 1995-10-25 AT AT95937006T patent/ATE199087T1/de not_active IP Right Cessation
- 1995-10-25 KR KR1019970702800A patent/KR100392060B1/ko not_active Expired - Fee Related
- 1995-10-31 HR HR08/457,968A patent/HRP950537A2/hr not_active Application Discontinuation
- 1995-10-31 ZA ZA959215A patent/ZA959215B/xx unknown
- 1995-10-31 IL IL11581995A patent/IL115819A/en not_active IP Right Cessation
- 1995-11-01 AR ARP950100010A patent/AR002238A1/es unknown
- 1995-11-02 MY MYPI95003312A patent/MY113325A/en unknown
- 1995-11-02 TR TR95/01356A patent/TR199501356A2/xx unknown
1997
- 1997-04-30 NO NO972017A patent/NO308035B1/no unknown
- 1997-04-30 FI FI971854A patent/FI113050B/fi not_active IP Right Cessation
2001
- 2001-03-30 GR GR20010400530T patent/GR3035680T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3818541B2 (ja)	2006-09-06
FI971854A0 (fi)	1997-04-30
BR9509552A (pt)	1997-09-16
FI113050B (fi)	2004-02-27
US5552399A (en)	1996-09-03
MX9703255A (es)	1997-07-31
GR3035680T3 (en)	2001-06-29
CZ132397A3 (cs)	1998-01-14
CN1085667C (zh)	2002-05-29
DE69520070D1 (de)	2001-03-15
ZA959215B (en)	1997-04-30
ATE199087T1 (de)	2001-02-15
EP0789701A1 (de)	1997-08-20
IL115819A0 (en)	1996-01-19
WO1996014320A1 (en)	1996-05-17
CZ286945B6 (en)	2000-08-16
PL319939A1 (en)	1997-09-01
AU704285B2 (en)	1999-04-15
NZ295656A (en)	1998-10-28
CA2203661A1 (en)	1996-05-17
AU3924995A (en)	1996-05-31
NO308035B1 (no)	2000-07-10
EP0789701B1 (de)	2001-02-07
NO972017L (no)	1997-04-30
ES2155898T3 (es)	2001-06-01
FI971854A7 (fi)	1997-04-30
TW349950B (en)	1999-01-11
NO972017D0 (no)	1997-04-30
DK0789701T3 (da)	2001-06-18
AR002238A1 (es)	1998-03-11
CN1162313A (zh)	1997-10-15
KR100392060B1 (ko)	2003-11-28
PT789701E (pt)	2001-07-31
JPH10508308A (ja)	1998-08-18
TR199501356A2 (tr)	1996-06-21
SI0789701T1 (en)	2001-08-31
PL183686B1 (pl)	2002-06-28
MY113325A (en)	2002-01-31
DE69520070T2 (de)	2001-09-13
HRP950537A2 (en)	1997-08-31
HUT77408A (hu)	1998-04-28
RU2163240C2 (ru)	2001-02-20

Legal Events

Date	Code	Title
1999-03-12	FF	Patent granted
2002-02-10	KB	Patent renewed
2006-02-05	KB	Patent renewed
2010-11-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US6194405B1 (en)	2001-02-27	Method of using substituted tetracyclic tetrahydrofuran derivatives
AU737334B2 (en)	2001-08-16	Halogen substituted tetracyclic tetrahydrofuran derivatives
EP0789701B1 (de)	2001-02-07	Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität
US5773433A (en)	1998-06-30	Substituted tetracyclic oxazepine and thiazepine derivatives
AU716470B2 (en)	2000-02-24	Isoxazolidine derivatives
CA2232195C (en)	2006-09-19	Isoxazolidine derivatives
HK1015771B (en)	2003-07-25	Substituted tetracyclic tetrahydrofuran derivatives