IL116122A - Intermediates for heterocyclic-cyclic amine derivatives - Google Patents

Intermediates for heterocyclic-cyclic amine derivatives

Info

Publication number
IL116122A
IL116122A IL11612292A IL11612292A IL116122A IL 116122 A IL116122 A IL 116122A IL 11612292 A IL11612292 A IL 11612292A IL 11612292 A IL11612292 A IL 11612292A IL 116122 A IL116122 A IL 116122A
Authority
IL
Israel
Prior art keywords
mmol
formula
phenyl
alkyl
ethyl
Prior art date
Application number
IL11612292A
Other languages
English (en)
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of IL116122A publication Critical patent/IL116122A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
IL11612292A 1991-03-28 1992-03-22 Intermediates for heterocyclic-cyclic amine derivatives IL116122A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67691891A 1991-03-28 1991-03-28
IL101327A IL101327A (en) 1991-03-28 1992-03-22 Heterocyclic-cyclic amine derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
IL116122A true IL116122A (en) 1998-10-30

Family

ID=24716559

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11612292A IL116122A (en) 1991-03-28 1992-03-22 Intermediates for heterocyclic-cyclic amine derivatives
IL11612295A IL116122A0 (en) 1991-03-28 1992-03-22 Intermediates to heterocyclic-cyclic amine derivatives
IL101327A IL101327A (en) 1991-03-28 1992-03-22 Heterocyclic-cyclic amine derivatives and pharmaceutical compositions containing them

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL11612295A IL116122A0 (en) 1991-03-28 1992-03-22 Intermediates to heterocyclic-cyclic amine derivatives
IL101327A IL101327A (en) 1991-03-28 1992-03-22 Heterocyclic-cyclic amine derivatives and pharmaceutical compositions containing them

Country Status (29)

Country Link
EP (1) EP0646115B1 (de)
JP (3) JP2659107B2 (de)
KR (1) KR0179054B1 (de)
CN (1) CN1044242C (de)
AT (1) ATE231505T1 (de)
AU (2) AU658194B2 (de)
BR (1) BR9205811A (de)
CA (2) CA2107105C (de)
CZ (1) CZ289756B6 (de)
DE (1) DE69232907T2 (de)
DK (1) DK0646115T3 (de)
EG (1) EG20281A (de)
ES (1) ES2188584T3 (de)
FI (1) FI934223L (de)
HU (1) HU225047B1 (de)
IE (1) IE920980A1 (de)
IL (3) IL116122A (de)
MX (1) MX9201419A (de)
MY (1) MY108885A (de)
NO (1) NO304071B1 (de)
NZ (3) NZ242151A (de)
PL (3) PL171914B1 (de)
PT (1) PT100300B (de)
RU (1) RU2119920C1 (de)
SG (1) SG49055A1 (de)
UA (1) UA45944C2 (de)
WO (1) WO1992017475A1 (de)
YU (1) YU31392A (de)
ZA (1) ZA922239B (de)

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US5750542A (en) 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
EP0602242A4 (en) * 1991-08-22 1994-06-29 Yoshitomi Pharmaceutical Benzisoxazole compound and use thereof.
EP0535496A1 (de) * 1991-09-25 1993-04-07 Hoechst-Roussel Pharmaceuticals Incorporated (1-Indanon-2-yl)Methylpiperidine, Zwischenprodukte und Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
JP3462501B2 (ja) * 1992-11-23 2003-11-05 アベンティス・ファーマスーティカルズ・インコーポレイテツド 置換された３−（アミノアルキルアミノ）−１，２−ベンゾイソキサゾールおよび関連化合物
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
PT788500E (pt) * 1994-10-26 2004-05-31 Pfizer Processos e intermediarios para a preparacao de 5,7-dihidro-3-¬2-{1-benziloioeridin-4-il}etil|-6h-pirrolo-¬4,5-f|-1,2-benzisoxazol-6-ona
US5912246A (en) * 1995-02-15 1999-06-15 Pharmacia & Upjohn Company Imidazo 1,2-a!pyridines for the treatment of CNS and cardiac diseases
KR19980703192A (ko) * 1995-03-22 1998-10-15 우에하라아끼라 티아졸 유도체
ES2157442T3 (es) * 1995-06-06 2001-08-16 Aventis Pharma Inc Derivados de benzoisoxazol y de indazol, utilizados como agentes neurolepticos.
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US5916902A (en) * 1995-09-13 1999-06-29 Pfizer Inc. Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
AU7319096A (en) * 1995-11-02 1997-05-22 Merck Sharp & Dohme Limited Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation and their use as selective agonists of 5-ht1-like receptors
FR2751412B3 (fr) * 1996-07-17 1998-09-25 Valbiofrance Methodes de diagnostic in vitro de maladies neurodegeneratives et trousses pour la mise en oeuvre de ces methodes
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
EP0976404A3 (de) * 1998-07-30 2001-06-27 Pfizer Products Inc. Pharmazeutische Zubereitung zur Vorbeugung und Behandlung von kognitiven Störungen bei Säugetieren
HUP0104493A3 (en) 1998-09-30 2002-12-28 Takeda Pharmaceutical Drugs for improving vesical excretory strength
EP1050303A3 (de) * 1999-04-27 2003-01-15 Pfizer Products Inc. Methoden und Zusammenstellungen zur Behandlung von altersgebundenen Verhaltensstörungen von Haustieren
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AU767726B2 (en) * 1999-04-30 2003-11-20 Pfizer Products Inc. Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
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WO2001098271A1 (en) 2000-06-21 2001-12-27 Eisai Co., Ltd. 4-substituted piperidine compound
US7538104B2 (en) * 2001-10-17 2009-05-26 Ciba Specialty Chemicals Corporation Photoactivable nitrogen bases
US7226915B2 (en) * 2003-05-15 2007-06-05 Hoffmann-La Roche Inc. Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
PL1697378T3 (pl) * 2003-12-22 2008-04-30 Memory Pharm Corp Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania
EP1609783A1 (de) * 2004-06-17 2005-12-28 Neuropharma S.A.U. Marine verbindungen mit kalzium-kanal-blockierende eigenschaften zur behandlung der alzheimer-krankheit
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
JP2008545008A (ja) * 2005-06-30 2008-12-11 プロシディオン・リミテッド Ｇｐｃｒアゴニスト
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WO2007126041A1 (ja) 2006-04-28 2007-11-08 Eisai R & D Management Co., Ltd. ベンゾイソオキサゾール化合物
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JP5411927B2 (ja) 2008-05-06 2014-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１アンタゴニストとしてのピラゾール化合物
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JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしての複素環化合物
EP2533645B1 (de) 2010-02-09 2016-07-27 The Johns Hopkins University Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
US8546442B2 (en) 2010-12-23 2013-10-01 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as CCR1 receptor antagonists
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
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Also Published As

Publication number Publication date
NO933445L (no) 1993-09-27
NZ242151A (en) 1994-10-26
WO1992017475A1 (en) 1992-10-15
DE69232907T2 (de) 2003-05-15
PL170567B1 (pl) 1997-01-31
AU658194B2 (en) 1995-04-06
HU9302733D0 (en) 1993-12-28
ATE231505T1 (de) 2003-02-15
JP3051076B2 (ja) 2000-06-12
EG20281A (en) 1998-07-30
YU31392A (sh) 1994-12-28
HUT68357A (en) 1995-06-28
MX9201419A (es) 1992-10-01
ZA922239B (en) 1993-09-27
FI934223A0 (fi) 1993-09-27
MY108885A (en) 1996-11-30
JPH06500794A (ja) 1994-01-27
CA2107105A1 (en) 1992-09-29
NO304071B1 (no) 1998-10-19
NZ248946A (en) 1995-04-27
IE920980A1 (en) 1992-10-07
KR0179054B1 (en) 1999-03-20
PT100300B (pt) 1999-09-30
CA2195129A1 (en) 1992-09-29
JP2659107B2 (ja) 1997-09-30
FI934223A7 (fi) 1993-09-27
IL116122A0 (en) 1996-01-31
CZ289756B6 (cs) 2002-04-17
JP2000154185A (ja) 2000-06-06
AU2178895A (en) 1995-09-07
PL171914B1 (pl) 1997-06-30
EP0646115B1 (de) 2003-01-22
BR9205811A (pt) 1994-06-28
NO933445D0 (no) 1993-09-27
CN1044242C (zh) 1999-07-21
UA45944C2 (uk) 2002-05-15
IL101327A0 (en) 1992-11-15
SG49055A1 (en) 1998-05-18
HU225047B1 (en) 2006-05-29
DK0646115T3 (da) 2003-04-22
NZ250987A (en) 1997-06-24
JPH10158264A (ja) 1998-06-16
PT100300A (pt) 1993-08-31
RU2119920C1 (ru) 1998-10-10
IL101327A (en) 1998-06-15
CA2107105C (en) 2003-10-07
CZ395892A3 (en) 1994-04-13
EP0646115A1 (de) 1995-04-05
AU1878292A (en) 1992-11-02
DE69232907D1 (de) 2003-02-27
FI934223L (fi) 1993-09-27
AU674477B2 (en) 1996-12-19
CN1065267A (zh) 1992-10-14
ES2188584T3 (es) 2003-07-01
PL171915B1 (pl) 1997-06-30
CA2195129C (en) 2002-09-10

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