IL131128A - Nimesulide gel formulations for topical use and processes for their preparation - Google Patents

Nimesulide gel formulations for topical use and processes for their preparation

Info

Publication number: IL131128A
Authority: IL; Israel
Prior art keywords: preparation; processes; topical use; gel formulations; nimesulide
Prior art date: 1997-02-25

Application number

IL13112898A

Other languages

English (en)

Other versions

IL131128A0 (en

Original Assignee

Helsinn Healthcare Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-25

Filing date

1998-02-20

Publication date

2003-11-23

1998-02-20 Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa

2001-01-28 Publication of IL131128A0 publication Critical patent/IL131128A0/xx

2003-11-23 Publication of IL131128A publication Critical patent/IL131128A/xx

Links

238000009472 formulation Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 title abstract 2
229960000965 nimesulide Drugs 0.000 title abstract 2
230000000699 topical effect Effects 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
229920002125 Sokalan® Polymers 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 abstract 1
229940075557 diethylene glycol monoethyl ether Drugs 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000012049 topical pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Orthopedics, Nursing, And Contraception (AREA)

IL13112898A 1997-02-25 1998-02-20 Nimesulide gel formulations for topical use and processes for their preparation IL131128A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97MI000408A IT1289973B1 (it)	1997-02-25	1997-02-25	Sistemi gelificati di nimesulide per uso topico
PCT/EP1998/000990 WO1998037879A1 (en)	1997-02-25	1998-02-20	Nimesulide gel systems for topical use

Publications (2)

Publication Number	Publication Date
IL131128A0 IL131128A0 (en)	2001-01-28
IL131128A true IL131128A (en)	2003-11-23

Family

ID=11376173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13112898A IL131128A (en)	1997-02-25	1998-02-20	Nimesulide gel formulations for topical use and processes for their preparation

Country Status (32)

Country	Link
US (2)	US20020119997A1 (pl)
EP (1)	EP0971708B1 (pl)
JP (1)	JP2001513093A (pl)
KR (1)	KR100413143B1 (pl)
CN (1)	CN1148174C (pl)
AT (1)	ATE210437T1 (pl)
AU (1)	AU723843B2 (pl)
BG (1)	BG64664B1 (pl)
BR (1)	BR9807729A (pl)
CA (1)	CA2279277A1 (pl)
CU (1)	CU22836A3 (pl)
CZ (1)	CZ293665B6 (pl)
DE (2)	DE971708T1 (pl)
DK (1)	DK0971708T3 (pl)
EE (1)	EE04041B1 (pl)
ES (1)	ES2169506T3 (pl)
GE (1)	GEP20022628B (pl)
HU (1)	HU226122B1 (pl)
ID (1)	ID22668A (pl)
IL (1)	IL131128A (pl)
IS (1)	IS2090B (pl)
IT (1)	IT1289973B1 (pl)
MX (1)	MXPA99007468A (pl)
NO (1)	NO994040L (pl)
PL (1)	PL190603B1 (pl)
PT (1)	PT971708E (pl)
RS (1)	RS49700B (pl)
RU (1)	RU2181285C2 (pl)
SK (1)	SK284809B6 (pl)
TR (1)	TR199902034T2 (pl)
UA (1)	UA50807C2 (pl)
WO (1)	WO1998037879A1 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU718356B2 (en) *	1998-01-12	2000-04-13	Panacea Biotec Limited	A parenteral water-miscible non-intensely coloured injectable composition of non-steroidal anit-inflammatory drugs
GB2340751B (en) *	1998-08-12	2003-11-05	Edko Trading Representation	Pharmaceutical compositions
RU2238086C2 (ru) *	1999-05-31	2004-10-20	Динеш Шантилал Пател	Новая лекарственная форма n-(4-нитро-2-феноксифенил) метансульфонамида, способ ее получения и применения
US7198801B2 (en)	2000-08-03	2007-04-03	Antares Pharma Ipl Ag	Formulations for transdermal or transmucosal application
US8980290B2 (en)	2000-08-03	2015-03-17	Antares Pharma Ipl Ag	Transdermal compositions for anticholinergic agents
AR030312A1 (es)	2000-08-03	2003-08-20	Antares Pharma Ipl Ag	Composicion novedosa para la administracion transdermica y/o transmucosica de compuestos activos, que asegura adecuados niveles terapeuticos
ES2222817B1 (es) *	2003-07-25	2007-03-01	Luis Ucelay Sanz	Gel frio.
NZ546106A (en)	2003-10-10	2008-10-31	Antares Pharma Ipl Ag	Transdermal pharmaceutical formulation for minimizing skin residues
US7425340B2 (en)	2004-05-07	2008-09-16	Antares Pharma Ipl Ag	Permeation enhancing compositions for anticholinergic agents
WO2006125642A1 (en)	2005-05-27	2006-11-30	Antares Pharma Ipl Ag	Methods and apparatus for transdermal or transmucosal application of testosterone
CN101426475A (zh)	2006-04-21	2009-05-06	安塔雷斯制药Ipl股份公司	使用用于经皮或经粘膜应用的制剂治疗热潮红的方法
TR200906775A1 (tr) *	2009-09-02	2011-03-21	Sanovel İlaç San.Ve Ti̇c.A.Ş.	Nimesulid ve kas gevşetici kombinasyonları
CN102068404A (zh) *	2009-11-25	2011-05-25	中国人民武装警察部队医学院	一种尼美舒利温度敏感水凝胶及其制备方法
UA121985C2 (uk) *	2015-01-23	2020-08-25	Др. Редді'З Лабораторіз Лімітед	Нефарбуюча гелева композиція для місцевого застосування, яка містить німесулід
RU2593777C1 (ru) *	2015-04-20	2016-08-10	Общество с ограниченной ответственностью "Трейдсервис"	Гелевая форма нимесулида, обладающая противовоспалительным и анальгетическим действием
CN108158993A (zh) *	2018-01-12	2018-06-15	连云港本草美汇医药科技有限公司	一种祛痘控油微乳凝胶剂及其制备方法与应用
WO2022066803A1 (en)	2020-09-22	2022-03-31	Alphyn Biologics, Llc	Topical croton lechleri compositions and their use in the treatment of a bacterial colonization or primary or secondary bacterial infection of an underlying skin disorder
CA3209718A1 (en) *	2021-02-25	2022-09-01	Gary Michael PEKOE	Composition for treatment of topical dermatological bacterial skin conditions
PL244577B1 (pl)	2021-12-16	2024-02-12	Univ Gdanski	Sole nimesulidu i sposób otrzymywania kryształów soli nimesulidu
PL249273B1 (pl)	2023-03-28	2026-03-16	Uniwersytet Gdański	Sól potasowa nimesulidu oraz sposób otrzymywania kryształów soli potasowych nimesulidu

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1251838B (it) *	1991-09-20	1995-05-26	Lpb Ist Farm	Uso della nimesulide nel trattamento della cataratta
BE1008307A3 (fr) *	1994-06-16	1996-04-02	Europharmaceuticals Sa	Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.
CA2201722A1 (en) *	1994-10-05	1996-04-18	Satoru Miyata	Antiinflammatory agent for external use
WO1997012608A1 (fr) *	1995-10-05	1997-04-10	Helsinn Healthcare S.A.	Agent anti-inflammatoire externe
HUP9601442A3 (en) *	1995-07-25	1999-03-29	Panacea Biotec Ltd	Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them
HUP9601443A3 (en) *	1996-05-29	1999-03-29	Panacea Biotec Ltd	Injectable analgetic pharmaceutical compositions for intramuscular use containing nimesulid, and process for producing them
IT1291278B1 (it) *	1996-07-05	1999-01-07	Errekappa Euroterapici S P A	Preparazione farmaceutica a base di nimesulide per uso topico

1997
- 1997-02-25 IT IT97MI000408A patent/IT1289973B1/it active IP Right Grant
1998
- 1998-02-20 PT PT98910713T patent/PT971708E/pt unknown
- 1998-02-20 DE DE0971708T patent/DE971708T1/de active Pending
- 1998-02-20 US US09/380,044 patent/US20020119997A1/en not_active Abandoned
- 1998-02-20 AT AT98910713T patent/ATE210437T1/de not_active IP Right Cessation
- 1998-02-20 RU RU99120392/14A patent/RU2181285C2/ru not_active IP Right Cessation
- 1998-02-20 TR TR1999/02034T patent/TR199902034T2/xx unknown
- 1998-02-20 KR KR10-1999-7007621A patent/KR100413143B1/ko not_active Expired - Fee Related
- 1998-02-20 MX MXPA99007468A patent/MXPA99007468A/es active IP Right Grant
- 1998-02-20 AU AU64992/98A patent/AU723843B2/en not_active Ceased
- 1998-02-20 CN CNB988027364A patent/CN1148174C/zh not_active Expired - Fee Related
- 1998-02-20 PL PL98335141A patent/PL190603B1/pl not_active IP Right Cessation
- 1998-02-20 ES ES98910713T patent/ES2169506T3/es not_active Expired - Lifetime
- 1998-02-20 UA UA99084652A patent/UA50807C2/uk unknown
- 1998-02-20 WO PCT/EP1998/000990 patent/WO1998037879A1/en not_active Ceased
- 1998-02-20 RS YUP-385/99A patent/RS49700B/sr unknown
- 1998-02-20 EE EEP199900355A patent/EE04041B1/xx not_active IP Right Cessation
- 1998-02-20 DE DE69802913T patent/DE69802913T2/de not_active Expired - Lifetime
- 1998-02-20 GE GEAP19984969A patent/GEP20022628B/en unknown
- 1998-02-20 IL IL13112898A patent/IL131128A/xx not_active IP Right Cessation
- 1998-02-20 BR BR9807729-5A patent/BR9807729A/pt not_active Application Discontinuation
- 1998-02-20 ID IDW990895A patent/ID22668A/id unknown
- 1998-02-20 EP EP98910713A patent/EP0971708B1/en not_active Expired - Lifetime
- 1998-02-20 SK SK1141-99A patent/SK284809B6/sk not_active IP Right Cessation
- 1998-02-20 CA CA002279277A patent/CA2279277A1/en not_active Abandoned
- 1998-02-20 HU HU0001486A patent/HU226122B1/hu not_active IP Right Cessation
- 1998-02-20 CZ CZ19992986A patent/CZ293665B6/cs not_active IP Right Cessation
- 1998-02-20 DK DK98910713T patent/DK0971708T3/da active
- 1998-02-20 JP JP53727798A patent/JP2001513093A/ja not_active Ceased
1999
- 1999-07-30 IS IS5143A patent/IS2090B/is unknown
- 1999-08-10 BG BG103645A patent/BG64664B1/bg unknown
- 1999-08-20 NO NO994040A patent/NO994040L/no not_active Application Discontinuation
- 1999-08-23 CU CU1999117A patent/CU22836A3/es not_active IP Right Cessation
2002
- 2002-09-26 US US10/254,862 patent/US7186755B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SK114199A3 (en)	2000-11-07
EE04041B1 (et)	2003-06-16
PL335141A1 (en)	2000-04-10
HUP0001486A3 (en)	2002-11-28
EP0971708B1 (en)	2001-12-12
EP0971708A1 (en)	2000-01-19
NO994040D0 (no)	1999-08-20
EE9900355A (et)	2000-02-15
JP2001513093A (ja)	2001-08-28
CU22836A3 (es)	2003-01-29
WO1998037879A1 (en)	1998-09-03
NO994040L (no)	1999-10-20
DK0971708T3 (da)	2002-03-25
UA50807C2 (uk)	2002-11-15
RU2181285C2 (ru)	2002-04-20
DE971708T1 (de)	2000-08-17
HU226122B1 (en)	2008-04-28
US7186755B2 (en)	2007-03-06
RS49700B (sr)	2007-12-31
CN1248165A (zh)	2000-03-22
ITMI970408A1 (it)	1998-08-25
MXPA99007468A (es)	2004-05-05
PT971708E (pt)	2002-05-31
BG64664B1 (bg)	2005-11-30
HK1025265A1 (en)	2000-11-10
IL131128A0 (en)	2001-01-28
IS5143A (is)	1999-07-30
DE69802913T2 (de)	2002-07-04
BG103645A (en)	2000-04-28
CZ293665B6 (cs)	2004-06-16
CZ298699A3 (cs)	2000-02-16
HUP0001486A2 (hu)	2000-10-28
IS2090B (is)	2006-03-15
ID22668A (id)	1999-12-02
YU38599A (sh)	2002-06-19
ATE210437T1 (de)	2001-12-15
KR20000075561A (ko)	2000-12-15
PL190603B1 (pl)	2005-12-30
CN1148174C (zh)	2004-05-05
KR100413143B1 (ko)	2003-12-31
TR199902034T2 (xx)	1999-11-22
BR9807729A (pt)	2000-02-15
US20020119997A1 (en)	2002-08-29
DE69802913D1 (de)	2002-01-24
CA2279277A1 (en)	1998-09-03
IT1289973B1 (it)	1998-10-19
ES2169506T3 (es)	2002-07-01
GEP20022628B (en)	2002-02-25
AU6499298A (en)	1998-09-18
US20030036563A1 (en)	2003-02-20
SK284809B6 (sk)	2005-11-03
AU723843B2 (en)	2000-09-07

Legal Events

Date	Code	Title
2004-05-12	FF	Patent granted
2004-06-01	KB	Patent renewed
2008-12-29	KB	Patent renewed
2012-10-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL131128A (en)	2003-11-23	Nimesulide gel formulations for topical use and processes for their preparation
ES2175413T5 (es)	2016-05-26	Formulaciones de aerosol
DK0758248T3 (da)	2003-10-27	Formuleringer til faktor IX
ES2159564T3 (es)	2001-10-16	Preparados farmaceuticos para principios activos dificilmente solubles.
WO1999051271A3 (en)	1999-11-18	Compositions comprising glycol derivatives and alcohols
WO2001005355A3 (en)	2003-10-02	Formulations for il-11
TR199801861T2 (xx)	1998-12-21	Farmas�tik olarak yararl� bile�imler.
BR0007589A (pt)	2002-10-15	Inibidores da proliferação de células
ATE251443T1 (de)	2003-10-15	Antimikrobielle kosmetische präparate
CA2352915A1 (en)	2002-01-18	Pharmaceutical compositions containing mupirocin
IL129616A0 (en)	2000-02-29	Novel CIS-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
EP0842663A4 (en)	2003-06-18	OPHTHALMIC PREPARATIONS
ES2188909T3 (es)	2003-07-01	Nuevos derivados de cis-3,4-cromano utiles para la prevencion o tratamiento de sindromes o enfermedades relacionados con el estrogeno. os
ZA979645B (en)	1998-04-28	Heterocyclic compounds, compositions and uses.
BR9813102A (pt)	2000-08-22	Derivados de ácido metilenobisfosfÈnico novos
DE69829849D1 (de)	2005-05-25	Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
SE9803107D0 (sv)	1998-09-14	Novel Compunds
ES2087178T3 (es)	1996-07-16	Disulfato de ws7622a, procedimiento para su preparacion y su uso.
AU4146000A (en)	2000-11-21	Remedies for glomerulosclerosis
IT1255696B (it)	1995-11-10	Composto con attivita' vasodilatatrice procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono
TH22662A (th)	1996-12-27	สารสูตรผสมของ 2-คลอโร-2'-ดีออกซิแอดีโนซินชนิดละลายได้