IL132127A - Indazole amide compounds, a process for their preparation, intermediates thereof and pharmaceutical compositions comprising them - Google Patents

Indazole amide compounds, a process for their preparation, intermediates thereof and pharmaceutical compositions comprising them

Info

Publication number: IL132127A
Authority: IL; Israel
Prior art keywords: intermediates; preparation; pharmaceutical compositions; amide compounds; indazole amide
Prior art date: 1997-04-15

Application number

IL13212798A

Other languages

English (en)

Other versions

IL132127A0 (en

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-15

Filing date

1998-04-02

Publication date

2005-06-19

1998-04-02 Application filed by Acraf filed Critical Acraf

2001-03-19 Publication of IL132127A0 publication Critical patent/IL132127A0/xx

2005-06-19 Publication of IL132127A publication Critical patent/IL132127A/xx

Links

DITBWPUMEUDVLU-UHFFFAOYSA-N 1h-indazole-3-carboxamide Chemical class C1=CC=C2C(C(=O)N)=NNC2=C1 DITBWPUMEUDVLU-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Compositions Of Macromolecular Compounds (AREA)
Paints Or Removers (AREA)

IL13212798A 1997-04-15 1998-04-02 Indazole amide compounds, a process for their preparation, intermediates thereof and pharmaceutical compositions comprising them IL132127A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97MI000867A IT1291569B1 (it)	1997-04-15	1997-04-15	Indazolammidi come agenti serotoninergici
PCT/EP1998/002129 WO1998046589A2 (en)	1997-04-15	1998-04-02	Indazole amide compounds as serotoninergic agents

Publications (2)

Publication Number	Publication Date
IL132127A0 IL132127A0 (en)	2001-03-19
IL132127A true IL132127A (en)	2005-06-19

Family

ID=11376888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13212798A IL132127A (en)	1997-04-15	1998-04-02	Indazole amide compounds, a process for their preparation, intermediates thereof and pharmaceutical compositions comprising them

Country Status (26)

Country	Link
US (1)	US6197769B1 (cs)
EP (1)	EP0975623B1 (cs)
JP (2)	JP4578581B2 (cs)
KR (1)	KR100563867B1 (cs)
CN (1)	CN1318416C (cs)
AR (1)	AR012426A1 (cs)
AT (1)	ATE219490T1 (cs)
AU (1)	AU740360B2 (cs)
BG (1)	BG64006B1 (cs)
CA (1)	CA2286870C (cs)
CZ (1)	CZ295190B6 (cs)
DE (1)	DE69806141T2 (cs)
DK (1)	DK0975623T3 (cs)
EA (1)	EA002352B1 (cs)
ES (1)	ES2178205T3 (cs)
GE (1)	GEP20022654B (cs)
HU (1)	HU227973B1 (cs)
IL (1)	IL132127A (cs)
IT (1)	IT1291569B1 (cs)
PL (1)	PL193308B1 (cs)
PT (1)	PT975623E (cs)
SK (1)	SK284731B6 (cs)
TR (1)	TR199902546T2 (cs)
UA (1)	UA58550C2 (cs)
WO (1)	WO1998046589A2 (cs)
ZA (1)	ZA982926B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1291569B1 (it) *	1997-04-15	1999-01-11	Angelini Ricerche Spa	Indazolammidi come agenti serotoninergici
MXPA03007621A (es)	2001-02-23	2003-12-04	Merck & Co Inc	Antagonistas nr2b de n-metil-d-aspartato no arilheterociclicos n-sustituidos.
EP1390034A4 (en) *	2001-04-03	2005-07-13	Merck & Co Inc	N-SUBSTITUTED NONARYL HETEROCYCLO AMIDYL-NMDA / NR2B ANTAGONISTS
ITMI20030287A1 (it)	2003-02-18	2004-08-19	Acraf	Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it)	2003-05-15	2004-11-16	Acraf	Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco ativo nel dolore neuropatico
TW200533348A (en) *	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) *	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en)	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
DE602005016446D1 (de) *	2004-11-05	2009-10-15	Theravance Inc	5-HT4-Rezeptoragonistenverbindungen
DE602005014566D1 (de) *	2004-11-05	2009-07-02	Theravance Inc	Chinolinon-carboxamid-verbindungen
ATE469897T1 (de) *	2004-12-22	2010-06-15	Theravance Inc	Indazolcarbonsäureamidverbindungen
US20060183901A1 (en) *	2005-02-17	2006-08-17	Theravance, Inc.	Crystalline form of an indazole-carboxamide compound
BRPI0608392A2 (pt) *	2005-03-02	2009-12-29	Theravance Inc	compostos de quinolinona como agonistas do receptor 5-ht4
ITMI20062230A1 (it) *	2006-11-22	2008-05-23	Acraf	Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) *	2007-11-12	2012-10-25	Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А.	Медикамент, який є активним при невропатичному болі
US8377968B2 (en) *	2008-06-02	2013-02-19	Zalicus Pharmaceuticals, Ltd.	N-piperidinyl acetamide derivatives as calcium channel blockers
CA2833507A1 (en) *	2011-06-07	2012-12-13	Dainippon Sumitomo Pharma Co., Ltd.	Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof
WO2013124169A1 (en) *	2012-02-21	2013-08-29	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Use of 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
EA024939B1 (ru) *	2012-02-21	2016-11-30	Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.	1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета
WO2014134306A1 (en)	2013-03-01	2014-09-04	Zalicus Pharmaceuticals, Ltd.	Heterocyclic inhibitors of the sodium channel
WO2021007487A1 (en)	2019-07-11	2021-01-14	Praxis Precision Medicines, Inc.	Formulations of t-type calcium channel modulators and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9103862D0 (en) *	1991-02-25	1991-04-10	Glaxo Group Ltd	Chemical compounds
NZ243993A (en) *	1991-08-20	1994-10-26	Smithkline Beecham Plc	Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
IL117438A (en) *	1995-03-16	2001-12-23	Lilly Co Eli	Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
WO1996038420A1 (en) *	1995-05-31	1996-12-05	Nisshin Flour Milling Co., Ltd.	Indazole derivatives having monocyclic amino group
IT1291569B1 (it) *	1997-04-15	1999-01-11	Angelini Ricerche Spa	Indazolammidi come agenti serotoninergici

1997
- 1997-04-15 IT IT97MI000867A patent/IT1291569B1/it active IP Right Grant
1998
- 1998-02-04 UA UA99116211A patent/UA58550C2/uk unknown
- 1998-04-02 ES ES98919257T patent/ES2178205T3/es not_active Expired - Lifetime
- 1998-04-02 EP EP98919257A patent/EP0975623B1/en not_active Expired - Lifetime
- 1998-04-02 AT AT98919257T patent/ATE219490T1/de active
- 1998-04-02 KR KR1019997009198A patent/KR100563867B1/ko not_active Expired - Fee Related
- 1998-04-02 CN CNB988041987A patent/CN1318416C/zh not_active Expired - Fee Related
- 1998-04-02 DK DK98919257T patent/DK0975623T3/da active
- 1998-04-02 TR TR1999/02546T patent/TR199902546T2/xx unknown
- 1998-04-02 PT PT98919257T patent/PT975623E/pt unknown
- 1998-04-02 CZ CZ19993625A patent/CZ295190B6/cs not_active IP Right Cessation
- 1998-04-02 EA EA199900935A patent/EA002352B1/ru not_active IP Right Cessation
- 1998-04-02 AU AU72159/98A patent/AU740360B2/en not_active Ceased
- 1998-04-02 HU HU0002057A patent/HU227973B1/hu not_active IP Right Cessation
- 1998-04-02 GE GEAP19985083A patent/GEP20022654B/en unknown
- 1998-04-02 PL PL336348A patent/PL193308B1/pl unknown
- 1998-04-02 DE DE69806141T patent/DE69806141T2/de not_active Expired - Lifetime
- 1998-04-02 IL IL13212798A patent/IL132127A/xx not_active IP Right Cessation
- 1998-04-02 US US09/403,007 patent/US6197769B1/en not_active Expired - Lifetime
- 1998-04-02 SK SK1423-99A patent/SK284731B6/sk not_active IP Right Cessation
- 1998-04-02 JP JP54347598A patent/JP4578581B2/ja not_active Expired - Fee Related
- 1998-04-02 WO PCT/EP1998/002129 patent/WO1998046589A2/en not_active Ceased
- 1998-04-02 CA CA002286870A patent/CA2286870C/en not_active Expired - Fee Related
- 1998-04-06 ZA ZA982926A patent/ZA982926B/xx unknown
- 1998-04-15 AR ARP980101721A patent/AR012426A1/es active IP Right Grant
1999
- 1999-11-05 BG BG103863A patent/BG64006B1/bg unknown
2010
- 2010-04-26 JP JP2010100701A patent/JP5237324B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP5237324B2 (ja)	2013-07-17
EA199900935A1 (ru)	2000-04-24
HK1027811A1 (en)	2001-01-23
SK284731B6 (sk)	2005-10-06
HUP0002057A2 (hu)	2001-04-28
EP0975623B1 (en)	2002-06-19
WO1998046589A2 (en)	1998-10-22
BG64006B1 (bg)	2003-09-30
KR20010006120A (ko)	2001-01-26
HU227973B1 (hu)	2012-07-30
ITMI970867A1 (it)	1998-10-15
CZ362599A3 (cs)	2000-04-12
DE69806141T2 (de)	2003-01-30
AU740360B2 (en)	2001-11-01
US6197769B1 (en)	2001-03-06
CA2286870C (en)	2007-05-22
DK0975623T3 (da)	2002-10-14
JP2010195813A (ja)	2010-09-09
EA002352B1 (ru)	2002-04-25
KR100563867B1 (ko)	2006-03-24
IT1291569B1 (it)	1999-01-11
PT975623E (pt)	2002-10-31
AU7215998A (en)	1998-11-11
UA58550C2 (uk)	2003-08-15
SK142399A3 (en)	2000-08-14
EP0975623A2 (en)	2000-02-02
ATE219490T1 (de)	2002-07-15
DE69806141D1 (de)	2002-07-25
PL193308B1 (pl)	2007-01-31
CZ295190B6 (cs)	2005-06-15
WO1998046589A3 (en)	1999-01-28
CN1252798A (zh)	2000-05-10
JP4578581B2 (ja)	2010-11-10
IL132127A0 (en)	2001-03-19
JP2001518906A (ja)	2001-10-16
GEP20022654B (en)	2002-03-25
ES2178205T3 (es)	2002-12-16
CN1318416C (zh)	2007-05-30
AR012426A1 (es)	2000-10-18
PL336348A1 (en)	2000-06-19
CA2286870A1 (en)	1998-10-22
ZA982926B (en)	1998-10-09
TR199902546T2 (xx)	2000-05-22
HUP0002057A3 (en)	2002-01-28
BG103863A (en)	2000-07-31

Legal Events

Date	Code	Title
2006-01-15	FF	Patent granted
2006-01-15	KB	Patent renewed
2008-04-13	KB	Patent renewed
2012-03-29	KB	Patent renewed
2016-11-30	MM9K	Patent not in force due to non-payment of renewal fees

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