IL77612A - Preparation of 2-methoxy-n-(1-azabicyclo(2.2.2)octan-3-yl)aminobenzamides - Google Patents

Preparation of 2-methoxy-n-(1-azabicyclo(2.2.2)octan-3-yl)aminobenzamides

Info

Publication number: IL77612A
Authority: IL; Israel
Prior art keywords: aminobenzamides; octan; azabicyclo; preparation; sup
Prior art date: 1985-02-04

Application number

IL77612A

Other languages

English (en)

Original Assignee

Robins Co Inc A H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-04

Filing date

1986-01-15

Publication date

1989-09-10

1986-01-15 Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H

1989-09-10 Publication of IL77612A publication Critical patent/IL77612A/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
REUAXQZIRFXQML-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-amine Chemical class C1CC2C(N)CN1CC2 REUAXQZIRFXQML-UHFFFAOYSA-N 0.000 abstract 1
ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 1
XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229960004050 aminobenzoic acid Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

IL77612A 1985-02-04 1986-01-15 Preparation of 2-methoxy-n-(1-azabicyclo(2.2.2)octan-3-yl)aminobenzamides IL77612A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/697,943 US4870181A (en)	1985-02-04	1985-02-04	Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides

Publications (1)

Publication Number	Publication Date
IL77612A true IL77612A (en)	1989-09-10

Family

ID=24803230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL77612A IL77612A (en)	1985-02-04	1986-01-15	Preparation of 2-methoxy-n-(1-azabicyclo(2.2.2)octan-3-yl)aminobenzamides

Country Status (21)

Country	Link
US (1)	US4870181A (da)
EP (1)	EP0190915B1 (da)
JP (1)	JPH0676407B2 (da)
KR (1)	KR930005446B1 (da)
AT (1)	ATE81856T1 (da)
AU (1)	AU589592B2 (da)
CA (1)	CA1288776C (da)
DE (1)	DE3687006T2 (da)
DK (1)	DK170098B1 (da)
FI (1)	FI84913C (da)
GR (1)	GR860320B (da)
HU (1)	HU196796B (da)
IE (1)	IE59396B1 (da)
IL (1)	IL77612A (da)
NO (1)	NO163367C (da)
NZ (1)	NZ215016A (da)
PH (1)	PH21990A (da)
PL (1)	PL148515B1 (da)
PT (1)	PT81956B (da)
YU (1)	YU45763B (da)
ZA (1)	ZA86411B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0272052B1 (en) *	1986-12-16	1992-07-08	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	Anxiolytic-N-(1-Azabicyclo[2.2.2]Oct-3-yl) Benzamides and Thobenzamides
FR2610323B1 (fr) *	1987-02-04	1989-06-23	Delalande Sa	Enantiomeres de configuration absolue s de derives amide de l'amino-3 quinuclidine, leur procede de preparation et leur application en therapeutique
GB8718345D0 (en) *	1987-08-03	1987-09-09	Fordonal Sa	N-substituted benzamides
EP0311724A1 (en) *	1987-10-16	1989-04-19	Synthelabo	Anxiolytic-R-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
US4863919A (en) *	1988-02-01	1989-09-05	A. H. Robins Company, Incorporated	Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
US4892205A (en) *	1988-07-15	1990-01-09	Hoover Universal, Inc.	Concentric ribbed preform and bottle made from same
JP2988711B2 (ja)	1989-10-20	1999-12-13	協和醗酵工業株式会社	縮合プリン誘導体
EP1381603A2 (en)	2000-08-18	2004-01-21	PHARMACIA & UPJOHN COMPANY	Quinuclidine-substituedaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
US6486172B2 (en)	2000-08-18	2002-11-26	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
BR0212123A (pt) *	2001-08-24	2004-07-20	Upjohn Co	7-aza[2.2.1]biciclo-heptanos substituìdos com arila para o tratamento de doenças
JP2005522456A (ja)	2002-02-15	2005-07-28	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	Ｃｎｓ関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド
WO2003072578A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3859443A (en) *	1973-11-15	1975-01-07	Merck & Co Inc	Composition and methods of treatment employing acrylanilides as anticoccidial agents
IT1046849B (it) *	1974-06-12	1980-07-31	Snam Progetti	Processo per la preparazione di derivati adeninici macromolecola rizzati e prodotti cosi ottenuti
US4093734A (en) *	1975-11-03	1978-06-06	Boehringer Ingelheim Gmbh	Amino-benzoic acid amides
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS5936675A (ja) *	1982-07-13	1984-02-28	サンド・アクチエンゲゼルシヤフト	二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
US4593034A (en) *	1984-04-06	1986-06-03	A. H. Robins Company, Inc.	2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides

1985
- 1985-02-04 US US06/697,943 patent/US4870181A/en not_active Expired - Fee Related
1986
- 1986-01-15 IL IL77612A patent/IL77612A/xx not_active IP Right Cessation
- 1986-01-20 ZA ZA86411A patent/ZA86411B/xx unknown
- 1986-01-21 AU AU52589/86A patent/AU589592B2/en not_active Ceased
- 1986-01-24 YU YU9586A patent/YU45763B/sh unknown
- 1986-01-31 PH PH33362A patent/PH21990A/en unknown
- 1986-02-03 KR KR1019860000706A patent/KR930005446B1/ko not_active Expired - Fee Related
- 1986-02-03 PT PT81956A patent/PT81956B/pt not_active IP Right Cessation
- 1986-02-03 HU HU86469A patent/HU196796B/hu not_active IP Right Cessation
- 1986-02-03 PL PL1986257773A patent/PL148515B1/pl unknown
- 1986-02-03 CA CA000500991A patent/CA1288776C/en not_active Expired - Lifetime
- 1986-02-03 FI FI860489A patent/FI84913C/fi not_active IP Right Cessation
- 1986-02-03 NZ NZ215016A patent/NZ215016A/xx unknown
- 1986-02-03 NO NO860373A patent/NO163367C/no unknown
- 1986-02-03 GR GR860320A patent/GR860320B/el unknown
- 1986-02-03 DK DK051686A patent/DK170098B1/da active
- 1986-02-03 IE IE28886A patent/IE59396B1/en not_active IP Right Cessation
- 1986-02-04 JP JP61022818A patent/JPH0676407B2/ja not_active Expired - Lifetime
- 1986-02-04 AT AT86300728T patent/ATE81856T1/de not_active IP Right Cessation
- 1986-02-04 EP EP86300728A patent/EP0190915B1/en not_active Expired - Lifetime
- 1986-02-04 DE DE8686300728T patent/DE3687006T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK51686A (da)	1986-08-05
HUT40119A (en)	1986-11-28
NO163367B (no)	1990-02-05
KR930005446B1 (ko)	1993-06-22
FI84913C (fi)	1992-02-10
AU5258986A (en)	1986-08-07
FI860489L (fi)	1986-08-05
PT81956A (en)	1986-03-01
NZ215016A (en)	1989-08-29
JPS61183286A (ja)	1986-08-15
IE860288L (en)	1986-08-04
PL148515B1 (en)	1989-10-31
YU45763B (sh)	1992-07-20
NO163367C (no)	1990-05-16
ATE81856T1 (de)	1992-11-15
IE59396B1 (en)	1994-02-23
KR860006463A (ko)	1986-09-11
AU589592B2 (en)	1989-10-19
CA1288776C (en)	1991-09-10
NO860373L (no)	1986-08-05
DE3687006T2 (de)	1993-04-22
DK51686D0 (da)	1986-02-03
EP0190915A2 (en)	1986-08-13
GR860320B (en)	1986-06-04
DK170098B1 (da)	1995-05-22
US4870181A (en)	1989-09-26
HU196796B (en)	1989-01-30
FI860489A0 (fi)	1986-02-03
YU9586A (en)	1987-12-31
PT81956B (pt)	1988-01-22
PL257773A1 (en)	1987-10-19
DE3687006D1 (de)	1992-12-03
EP0190915B1 (en)	1992-10-28
JPH0676407B2 (ja)	1994-09-28
FI84913B (fi)	1991-10-31
PH21990A (en)	1988-05-02
EP0190915A3 (en)	1988-12-14
ZA86411B (en)	1986-09-24

Legal Events

Date	Code	Title	Description
1996-05-14	KB	Patent renewed
2000-12-06	RH	Patent void

Publication	Publication Date	Title
AU589592B2 (en)	1989-10-19	Process for the preparation of 2-alkoxy-n-(1-azabicyclo (2.2.2)octan-3-yl) amino-benzamides
HU9502174D0 (en)	1995-09-28	Aminoacid derivatives, medicaments containing these compounds and process for preparing the same
CA2166297A1 (en)	1995-01-12	Process for manufacture of 1-deamino-8-d-arginine vasopressin
DE3260543D1 (en)	1984-09-13	Processes for preparation, isolation and purification of dipeptide sweeteners
KR880009975A (ko)	1988-10-06	화합물
DK492989D0 (da)	1989-10-06	Aminopyrrolidinon, farmaceutisk praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling deraf
CS884386A2 (en)	1987-11-12	Zpusob vyroby novych soli aryloxypropanolaminu s kyselinou difenyloctovou
ES8507098A1 (es)	1985-09-16	Procedimiento para la preparacion de l(-)carnitina en forma de cloridrato o en forma de su sal interna.
EP0400695A3 (en)	1991-07-24	A process for the preparation of tauroursodesoxycholic acid dihydrate
HUT49336A (en)	1989-09-28	Process for production of izotiasolones
EP0306592A3 (en)	1989-10-11	Process for concentration of an aqeous solution of amino acid
HUT50753A (en)	1990-03-28	Process for halogenid production of trans-2,2-dimethil-3-/2,2-dihalovinil/-cycloprophane carbonic acid
IL75899A0 (en)	1985-12-31	Process for preparing l-norcarnitine hydrochloride
IE831080L (en)	1983-11-13	Process for the preparation of amitriptylin oxide from the¹amine using h2o2.
SE8305362D0 (sv)	1983-09-30	Novel substituted phenylazacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds
ES2000283A6 (es)	1988-02-01	Procedimiento para preparar nuevas cetoaminas cicloalifaticas