PH21990A - An improved process for the preparation of 2-alkoxy-n-(1-azabicyclo(2.2.2)octan-3-yl) aminobenzamides - Google Patents

An improved process for the preparation of 2-alkoxy-n-(1-azabicyclo(2.2.2)octan-3-yl) aminobenzamides

Info

Publication number: PH21990A
Authority: PH; Philippines
Prior art keywords: aminobenzamides; octan; azabicyclo; alkoxy; preparation
Prior art date: 1985-02-04

Application number

PH33362A

Other languages

English (en)

Inventor

Young Sek Lo

Original Assignee

Robins Co Inc A H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-04

Filing date

1986-01-31

Publication date

1988-05-02

1986-01-31 Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H

1988-05-02 Publication of PH21990A publication Critical patent/PH21990A/en

Links

238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
REUAXQZIRFXQML-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-amine Chemical class C1CC2C(N)CN1CC2 REUAXQZIRFXQML-UHFFFAOYSA-N 0.000 abstract 1
ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 1
XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229960004050 aminobenzoic acid Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PH33362A 1985-02-04 1986-01-31 An improved process for the preparation of 2-alkoxy-n-(1-azabicyclo(2.2.2)octan-3-yl) aminobenzamides PH21990A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/697,943 US4870181A (en)	1985-02-04	1985-02-04	Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides

Publications (1)

Publication Number	Publication Date
PH21990A true PH21990A (en)	1988-05-02

Family

ID=24803230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH33362A PH21990A (en)	1985-02-04	1986-01-31	An improved process for the preparation of 2-alkoxy-n-(1-azabicyclo(2.2.2)octan-3-yl) aminobenzamides

Country Status (21)

Country	Link
US (1)	US4870181A (da)
EP (1)	EP0190915B1 (da)
JP (1)	JPH0676407B2 (da)
KR (1)	KR930005446B1 (da)
AT (1)	ATE81856T1 (da)
AU (1)	AU589592B2 (da)
CA (1)	CA1288776C (da)
DE (1)	DE3687006T2 (da)
DK (1)	DK170098B1 (da)
FI (1)	FI84913C (da)
GR (1)	GR860320B (da)
HU (1)	HU196796B (da)
IE (1)	IE59396B1 (da)
IL (1)	IL77612A (da)
NO (1)	NO163367C (da)
NZ (1)	NZ215016A (da)
PH (1)	PH21990A (da)
PL (1)	PL148515B1 (da)
PT (1)	PT81956B (da)
YU (1)	YU45763B (da)
ZA (1)	ZA86411B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3780276T2 (de) *	1986-12-16	1993-02-25	Robins Co Inc A H	Angstloesende n-(1-azabicyclo(2.2.2)oct-3-yl)benzamide und -thiobenzamide.
FR2610323B1 (fr) *	1987-02-04	1989-06-23	Delalande Sa	Enantiomeres de configuration absolue s de derives amide de l'amino-3 quinuclidine, leur procede de preparation et leur application en therapeutique
GB8718345D0 (en) *	1987-08-03	1987-09-09	Fordonal Sa	N-substituted benzamides
EP0311724A1 (en) *	1987-10-16	1989-04-19	Synthelabo	Anxiolytic-R-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
US4863919A (en) *	1988-02-01	1989-09-05	A. H. Robins Company, Incorporated	Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
US4892205A (en) *	1988-07-15	1990-01-09	Hoover Universal, Inc.	Concentric ribbed preform and bottle made from same
DE69033614T2 (de)	1989-10-20	2001-04-19	Kyowa Hakko Kogyo K.K., Tokio/Tokyo	Kondensierte Purinderivate
US6479510B2 (en)	2000-08-18	2002-11-12	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
WO2002016357A2 (en)	2000-08-18	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
JP2005504059A (ja) *	2001-08-24	2005-02-10	ファルマシアアンドアップジョンカンパニーリミティドライアビリティーカンパニー	疾患を処置するための置換アリール７−アザ［２．２．１］ビシクロヘプタン
EP1480977A2 (en)	2002-02-15	2004-12-01	PHARMACIA & UPJOHN COMPANY	Substituted aryl compounds for treatment of disease
WO2003072578A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3859443A (en) *	1973-11-15	1975-01-07	Merck & Co Inc	Composition and methods of treatment employing acrylanilides as anticoccidial agents
IT1046849B (it) *	1974-06-12	1980-07-31	Snam Progetti	Processo per la preparazione di derivati adeninici macromolecola rizzati e prodotti cosi ottenuti
NL7611713A (nl) *	1975-11-03	1977-05-05	Thomae Gmbh Dr K	Werkwijze voor de bereiding van verbindingen en preparaten met waardevolle farmacologische eigen- schappen.
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS5936675A (ja) *	1982-07-13	1984-02-28	サンド・アクチエンゲゼルシヤフト	二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
US4593034A (en) *	1984-04-06	1986-06-03	A. H. Robins Company, Inc.	2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides

1985
- 1985-02-04 US US06/697,943 patent/US4870181A/en not_active Expired - Fee Related
1986
- 1986-01-15 IL IL77612A patent/IL77612A/xx not_active IP Right Cessation
- 1986-01-20 ZA ZA86411A patent/ZA86411B/xx unknown
- 1986-01-21 AU AU52589/86A patent/AU589592B2/en not_active Ceased
- 1986-01-24 YU YU9586A patent/YU45763B/sh unknown
- 1986-01-31 PH PH33362A patent/PH21990A/en unknown
- 1986-02-03 NO NO860373A patent/NO163367C/no unknown
- 1986-02-03 FI FI860489A patent/FI84913C/fi not_active IP Right Cessation
- 1986-02-03 IE IE28886A patent/IE59396B1/en not_active IP Right Cessation
- 1986-02-03 DK DK051686A patent/DK170098B1/da active
- 1986-02-03 GR GR860320A patent/GR860320B/el unknown
- 1986-02-03 PT PT81956A patent/PT81956B/pt not_active IP Right Cessation
- 1986-02-03 KR KR1019860000706A patent/KR930005446B1/ko not_active Expired - Fee Related
- 1986-02-03 CA CA000500991A patent/CA1288776C/en not_active Expired - Lifetime
- 1986-02-03 NZ NZ215016A patent/NZ215016A/xx unknown
- 1986-02-03 PL PL1986257773A patent/PL148515B1/pl unknown
- 1986-02-03 HU HU86469A patent/HU196796B/hu not_active IP Right Cessation
- 1986-02-04 DE DE8686300728T patent/DE3687006T2/de not_active Expired - Fee Related
- 1986-02-04 EP EP86300728A patent/EP0190915B1/en not_active Expired - Lifetime
- 1986-02-04 AT AT86300728T patent/ATE81856T1/de not_active IP Right Cessation
- 1986-02-04 JP JP61022818A patent/JPH0676407B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NZ215016A (en)	1989-08-29
DE3687006T2 (de)	1993-04-22
HU196796B (en)	1989-01-30
YU9586A (en)	1987-12-31
JPS61183286A (ja)	1986-08-15
AU5258986A (en)	1986-08-07
GR860320B (en)	1986-06-04
DK170098B1 (da)	1995-05-22
NO860373L (no)	1986-08-05
PL257773A1 (en)	1987-10-19
PT81956A (en)	1986-03-01
FI860489L (fi)	1986-08-05
PT81956B (pt)	1988-01-22
JPH0676407B2 (ja)	1994-09-28
IE59396B1 (en)	1994-02-23
YU45763B (sh)	1992-07-20
FI860489A0 (fi)	1986-02-03
DK51686D0 (da)	1986-02-03
CA1288776C (en)	1991-09-10
HUT40119A (en)	1986-11-28
IL77612A (en)	1989-09-10
KR930005446B1 (ko)	1993-06-22
AU589592B2 (en)	1989-10-19
IE860288L (en)	1986-08-04
DK51686A (da)	1986-08-05
KR860006463A (ko)	1986-09-11
NO163367C (no)	1990-05-16
EP0190915A3 (en)	1988-12-14
US4870181A (en)	1989-09-26
NO163367B (no)	1990-02-05
FI84913C (fi)	1992-02-10
EP0190915B1 (en)	1992-10-28
EP0190915A2 (en)	1986-08-13
DE3687006D1 (de)	1992-12-03
FI84913B (fi)	1991-10-31
PL148515B1 (en)	1989-10-31
ATE81856T1 (de)	1992-11-15
ZA86411B (en)	1986-09-24

Publication	Publication Date	Title
PH21990A (en)	1988-05-02	An improved process for the preparation of 2-alkoxy-n-(1-azabicyclo(2.2.2)octan-3-yl) aminobenzamides
TW272968B (da)	1996-03-21
CA2166297A1 (en)	1995-01-12	Process for manufacture of 1-deamino-8-d-arginine vasopressin
HUT42287A (en)	1987-07-28	Fungicides containing as active substance morfolinioalcane carbonic acid amid salts and process for production of the active substance
IE822175L (en)	1983-03-08	Dipeptide amides
KR880009975A (ko)	1988-10-06	화합물
GB8720805D0 (en)	1987-10-14	2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
DK492989D0 (da)	1989-10-06	Aminopyrrolidinon, farmaceutisk praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling deraf
CS884386A2 (en)	1987-11-12	Zpusob vyroby novych soli aryloxypropanolaminu s kyselinou difenyloctovou
MY101747A (en)	1992-01-17	Dihydroorotic acids derivative, processes for preparing the same
ES8507098A1 (es)	1985-09-16	Procedimiento para la preparacion de l(-)carnitina en forma de cloridrato o en forma de su sal interna.
EP0400695A3 (en)	1991-07-24	A process for the preparation of tauroursodesoxycholic acid dihydrate
HU906355D0 (en)	1991-04-29	Process for producing aryl-ureas and pharmaceutical preparatives containing these compounds as active substance
EP0306592A3 (en)	1989-10-11	Process for concentration of an aqeous solution of amino acid
HUT50753A (en)	1990-03-28	Process for halogenid production of trans-2,2-dimethil-3-/2,2-dihalovinil/-cycloprophane carbonic acid
DE3561392D1 (en)	1988-02-18	Process for preparing l-norcarnitine hydrochloride
IE831080L (en)	1983-11-13	Process for the preparation of amitriptylin oxide from the¹amine using h2o2.
SE8305362D0 (sv)	1983-09-30	Novel substituted phenylazacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds
HU9201315D0 (en)	1992-07-28	Process for the production of medical preparations containing 4-/n,n-dibenzyl-amino/-butyric acid or butyric amid as active agent, or their medically useful salts
IE862740L (en)	1987-04-18	Process for anhydrous salts of trifluoroacetic acid.
HU9201483D0 (en)	1992-07-28	Process for the production of 1h-rh-analogues'acid additive salts, and for the production of medical preparations containing them