IL83137A - LI-6 polypeptide from lack of glycosylation, a drug containing it, a DNA sequence encoding its expression in bacteria, a vector containing this sequence and bacteria transformed by it - Google Patents

LI-6 polypeptide from lack of glycosylation, a drug containing it, a DNA sequence encoding its expression in bacteria, a vector containing this sequence and bacteria transformed by it

Info

Publication number: IL83137A
Authority: IL; Israel
Prior art keywords: polypeptide; sequence; pharmaceutical composition; expression; dna sequence
Prior art date: 1986-07-08

Application number

IL8313787A

Other languages

English (en)

Hebrew (he)

Original Assignee

Genetics Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-08

Filing date

1987-07-09

Publication date

1995-05-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL83137(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-07-09 Application filed by Genetics Inst filed Critical Genetics Inst

1995-05-26 Publication of IL83137A publication Critical patent/IL83137A/en

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
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Zoology (AREA)
Immunology (AREA)
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General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
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Biophysics (AREA)
Genetics & Genomics (AREA)
Diabetes (AREA)
Hematology (AREA)
Microbiology (AREA)
Mycology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Materials For Medical Uses (AREA)

IL8313787A 1986-07-08 1987-07-09 LI-6 polypeptide from lack of glycosylation, a drug containing it, a DNA sequence encoding its expression in bacteria, a vector containing this sequence and bacteria transformed by it IL83137A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US88320786A	1986-07-08	1986-07-08
US88590586A	1986-07-15	1986-07-15
US4795787A	1987-05-08	1987-05-08

Publications (1)

Publication Number	Publication Date
IL83137A true IL83137A (en)	1995-05-26

Family

ID=27367237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8313787A IL83137A (en)	1986-07-08	1987-07-09	LI-6 polypeptide from lack of glycosylation, a drug containing it, a DNA sequence encoding its expression in bacteria, a vector containing this sequence and bacteria transformed by it

Country Status (18)

Country	Link
EP (2)	EP0316319B1 (de)
JP (1)	JP2664698B2 (de)
KR (1)	KR960013601B1 (de)
AT (2)	ATE143811T1 (de)
AU (1)	AU615630B2 (de)
CA (1)	CA1341355C (de)
DE (2)	DE3751406T2 (de)
DK (1)	DK173279B1 (de)
ES (1)	ES2006776A6 (de)
GR (1)	GR871027B (de)
IE (1)	IE67035B1 (de)
IL (1)	IL83137A (de)
MY (1)	MY102865A (de)
NO (1)	NO176665C (de)
PL (1)	PL159182B1 (de)
PT (1)	PT85285B (de)
SK (1)	SK279144B6 (de)
WO (1)	WO1988000206A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5554513A (en) *	1979-11-21	1996-09-10	Yeda Research & Development Co. Ltd.	Production of recombinant human interferon-beta2
US5510472A (en) *	1979-11-21	1996-04-23	Yeda Research And Development Co. Ltd.	Production of recombinant human interferon-beta2
EP0536520B1 (de) *	1985-10-14	1999-03-03	Yeda Research And Development Co. Ltd.	Verwendung von menschlichem Interferon-Beta 2A für die Herstellung von Medikamenten
JP2648860B2 (ja) *	1986-05-08	1997-09-03	イエダリサーチアンドデベロップメントコンパニーリミテッド	ヒトインターフエロン−β２Ａ及びヒトインターフエロン−β２Ｂ、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途
EP0585957A1 (de) *	1986-08-06	1994-03-09	Ajinomoto Co., Inc.	Rekombinanter B-Zell-Differenzierungsfaktor
JP2676336B2 (ja) *	1986-08-06	1997-11-12	忠三岸本	ヒトｂ細胞分化因子の遺伝子
JPS6356291A (ja) *	1986-08-27	1988-03-10	Chuzo Kishimoto	リコンビナントｂｃｄｆ
NZ226799A (en) *	1987-11-06	1991-08-27	Oncogen	Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
CA1341588C (en) *	1988-01-26	2009-01-06	Michel Revel	Human ifn-beta2/i1-6, its purification and use
IL85204A0 (en) *	1988-01-26	1988-07-31	Yeda Res & Dev	Recombinant human interferon beta2,its preparation and pharmaceutical compositions comprising it
HUT52962A (en) *	1988-03-04	1990-09-28	Sandoz Ag	Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
JPH022353A (ja) *	1988-03-10	1990-01-08	Tosoh Corp	ヒトｂ細胞分化因子の製造法
JPH022354A (ja) *	1988-03-31	1990-01-08	Tosoh Corp	ヒトｂ細胞分化因子の製造法
GB2217327B (en) *	1988-04-12	1992-01-29	British Bio Technology	Synthetic interleukin-6 gene
US5646015A (en) *	1988-08-31	1997-07-08	Astra Ab	Excretion of heterologous proteins from E. coli
US5223407A (en) *	1988-08-31	1993-06-29	Allelix Inc.	Excretion of heterologous proteins from e. coli
US5271931A (en) *	1988-09-14	1993-12-21	The Scripps Research Institute	Methods for increasing C1 inhibitor concentrations using interferon-gamma and/or interleukin-6
JPH0372429A (ja) *	1988-10-07	1991-03-27	Chugai Pharmaceut Co Ltd	血小板減少症の治療剤
US5811523A (en)	1988-11-10	1998-09-22	Trinchieri; Giorgio	Antibodies to natural killer stimulatory factor
JP2805224B2 (ja) *	1989-01-13	1998-09-30	味の素株式会社	血小板減少症治療剤
JPH0331215A (ja) *	1989-06-27	1991-02-12	Ajinomoto Co Inc	制癌療法支持剤
DE3939706C1 (de) *	1989-12-01	1991-03-21	Centre Regional De Transfusion Sanguine, Besancon, Fr
JPH04218000A (ja) *	1990-02-13	1992-08-07	Kirin Amgen Inc	修飾ポリペプチド
DE69122764T2 (de) *	1990-08-31	1997-03-20	Teruo Nishida	Arznei gegen hornhautbeschädigungen
US5641868A (en) *	1991-04-18	1997-06-24	Toray Industries, Inc.	Interlekin-6 compositions, and a production process thereof
CA2085744A1 (en) *	1991-04-18	1992-10-19	Shingou Sakurai	Interleukin-6 compositions, and a production process thereof
ZA924674B (en) *	1991-07-02	1993-04-28	Imclone Systems Inc	Cysteine depleted il-6 mutein
US5338833A (en) *	1992-07-23	1994-08-16	The University Of North Carolina At Chapel Hill	Carboxy terminal IL-6 muteins
US5338834A (en) *	1993-01-26	1994-08-16	Allelix Biopharmaceuticals Inc.	Ultrapure human interleukin-6
WO1994028919A1 (fr) *	1993-06-08	1994-12-22	Ajinomoto Co., Inc.	Accelerateur de la proliferation des cellules hematopietiques
US5578301A (en) *	1993-12-14	1996-11-26	Sandoz Ltd.	Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy
US5599536A (en) *	1993-12-13	1997-02-04	Sandoz Ltd.	Method for suppressing the acute phase response in a patient receiving IL-6 therapy
US5641657A (en) *	1994-05-19	1997-06-24	Human Genome Sciences, Inc.	DNA encoding an interleukin-6 splice variant
EP0721780A3 (de) *	1994-12-16	1997-12-17	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	Mittel zur Förderung von Plättchen und/oder Leucozytenherstellung
EP0912742A1 (de) *	1996-07-19	1999-05-06	Dade Behring Marburg GmbH	Virales interleukin 6
SE9702401D0 (sv)	1997-06-19	1997-06-19	Astra Ab	Pharmaceutical use
US7479540B1 (en)	2003-12-22	2009-01-20	Chandan Prasad	Adipomodulin and related molecules and methods
EP1856147A4 (de) *	2005-02-15	2008-07-02	Apollo Life Sciences Ltd	Molekül und chimere moleküle davon
ES2302402B1 (es) *	2005-06-16	2009-05-08	Proyecto De Biomedicina Cima, S.L.	Uso de una citoquina de la familia de interleuquina-6 en la preparacion de una composicion para administracion combinada con interferon-alfa.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL58765A (en) *	1979-11-21	1986-09-30	Yeda Res & Dev	Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4675285A (en) *	1984-09-19	1987-06-23	Genetics Institute, Inc.	Method for identification and isolation of DNA encoding a desired protein
EP0536520B1 (de) *	1985-10-14	1999-03-03	Yeda Research And Development Co. Ltd.	Verwendung von menschlichem Interferon-Beta 2A für die Herstellung von Medikamenten
EP0585957A1 (de) *	1986-08-06	1994-03-09	Ajinomoto Co., Inc.	Rekombinanter B-Zell-Differenzierungsfaktor

1987
- 1987-06-26 IE IE172687A patent/IE67035B1/en not_active IP Right Cessation
- 1987-06-30 GR GR871027A patent/GR871027B/el unknown
- 1987-07-03 CA CA000541216A patent/CA1341355C/en not_active Expired - Fee Related
- 1987-07-07 ES ES8701985A patent/ES2006776A6/es not_active Expired
- 1987-07-07 MY MYPI87000953A patent/MY102865A/en unknown
- 1987-07-07 EP EP87904625A patent/EP0316319B1/de not_active Revoked
- 1987-07-07 JP JP62504291A patent/JP2664698B2/ja not_active Expired - Fee Related
- 1987-07-07 KR KR1019880700256A patent/KR960013601B1/ko not_active Expired - Fee Related
- 1987-07-07 SK SK5150-87A patent/SK279144B6/sk unknown
- 1987-07-07 WO PCT/US1987/001611 patent/WO1988000206A1/en not_active Ceased
- 1987-07-07 DE DE3751406T patent/DE3751406T2/de not_active Revoked
- 1987-07-07 PL PL1987266680A patent/PL159182B1/pl unknown
- 1987-07-07 AT AT93110770T patent/ATE143811T1/de not_active IP Right Cessation
- 1987-07-07 AT AT87904625T patent/ATE124959T1/de not_active IP Right Cessation
- 1987-07-07 AU AU76962/87A patent/AU615630B2/en not_active Ceased
- 1987-07-07 DE DE3751922T patent/DE3751922T2/de not_active Expired - Fee Related
- 1987-07-07 EP EP93110770A patent/EP0574955B1/de not_active Expired - Lifetime
- 1987-07-08 PT PT85285A patent/PT85285B/pt active IP Right Revival
- 1987-07-09 IL IL8313787A patent/IL83137A/en not_active IP Right Cessation
1988
- 1988-03-02 NO NO880929A patent/NO176665C/no unknown
- 1988-03-07 DK DK198801217A patent/DK173279B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU7696287A (en)	1988-01-29
DE3751922T2 (de)	1997-04-03
EP0574955B1 (de)	1996-10-09
EP0316319B1 (de)	1995-07-12
ATE124959T1 (de)	1995-07-15
DK121788D0 (da)	1988-03-07
AU615630B2 (en)	1991-10-10
ES2006776A6 (es)	1989-05-16
DE3751406D1 (de)	1995-08-17
SK515087A3 (en)	1998-07-08
WO1988000206A1 (en)	1988-01-14
SK279144B6 (sk)	1998-07-08
EP0316319A1 (de)	1989-05-24
PT85285B (pt)	1990-03-30
NO176665B (no)	1995-01-30
IE871726L (en)	1988-01-08
NO880929D0 (no)	1988-03-02
DE3751922D1 (de)	1996-11-14
JP2664698B2 (ja)	1997-10-15
NO880929L (no)	1988-03-02
KR960013601B1 (ko)	1996-10-09
KR880701736A (ko)	1988-11-04
DE3751406T2 (de)	1995-12-21
ATE143811T1 (de)	1996-10-15
MY102865A (en)	1993-03-31
NO176665C (no)	1995-05-10
DK121788A (da)	1988-03-07
IE67035B1 (en)	1996-02-21
DK173279B1 (da)	2000-06-05
GR871027B (en)	1987-11-02
CA1341355C (en)	2002-04-09
PT85285A (en)	1987-08-01
EP0574955A1 (de)	1993-12-22
EP0316319A4 (de)	1989-08-09
PL159182B1 (pl)	1992-11-30
PL266680A1 (en)	1988-07-07
JPH01503354A (ja)	1989-11-16

Legal Events

Date	Code	Title
1997-11-20	KB	Patent renewed
2001-06-14	RH	Patent void
2001-10-31	KB	Patent renewed
2003-04-10	HC	Change of name of proprietor(s)
2005-09-25	KB	Patent renewed
2007-08-19	EXP	Patent expired

Publication	Publication Date	Title
CA1341355C (en)	2002-04-09	Production and use of il-6
US5573763A (en)	1996-11-12	Family of CSF-l proteins
US4868119A (en)	1989-09-19	Hematopoietic growth factors
US6066317A (en)	2000-05-23	Method of using IL-11 for treating deficiencies in hematopoietic progenitor or stem cells
AU637620B2 (en)	1993-06-03	A human cytokine, interleukin-9
US4879227A (en)	1989-11-07	Production of a recombinant human colony stimulating factor
US6348191B1 (en)	2002-02-19	Production and use of IL-6
US6284237B1 (en)	2001-09-04	Methods of treatment using IL-6
AU644389C (en)	1995-03-23	A mammalian cytokine, IL-11