IN2014CN02574A - - Google Patents

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Publication number
IN2014CN02574A
IN2014CN02574A IN2574CHN2014A IN2014CN02574A IN 2014CN02574 A IN2014CN02574 A IN 2014CN02574A IN 2574CHN2014 A IN2574CHN2014 A IN 2574CHN2014A IN 2014CN02574 A IN2014CN02574 A IN 2014CN02574A
Authority
IN
India
Prior art keywords
methods
libraries
ligation
nucleotides
chemical
Prior art date
Application number
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English (en)
Inventor
Anthony D Keefe
Richard W Wagner
Alexander Litovchick
Matthew Clark
John W Cuozzo
Ying Zhang
Paolo A Centrella
Christopher D Hupp
Original Assignee
Chem Inc X
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47832597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014CN02574(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chem Inc X filed Critical Chem Inc X
Publication of IN2014CN02574A publication Critical patent/IN2014CN02574A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Structural Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IN2574CHN2014 2011-09-07 2012-09-07 IN2014CN02574A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161531820P 2011-09-07 2011-09-07
US201161536929P 2011-09-20 2011-09-20
PCT/US2012/054228 WO2013036810A1 (fr) 2011-09-07 2012-09-07 Procédés de marquage de banques codées par de l'adn

Publications (1)

Publication Number Publication Date
IN2014CN02574A true IN2014CN02574A (fr) 2015-06-26

Family

ID=47832597

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2574CHN2014 IN2014CN02574A (fr) 2011-09-07 2012-09-07

Country Status (17)

Country Link
US (2) US10865409B2 (fr)
EP (3) EP2748357B1 (fr)
JP (3) JP6674738B2 (fr)
KR (2) KR102124613B1 (fr)
CN (1) CN103998658B (fr)
AP (1) AP2014007483A0 (fr)
AU (3) AU2012304387B2 (fr)
BR (1) BR112014005205A2 (fr)
CA (2) CA3077662A1 (fr)
DK (2) DK2748357T3 (fr)
EA (1) EA032438B1 (fr)
ES (2) ES2675111T3 (fr)
IL (2) IL231191B (fr)
IN (1) IN2014CN02574A (fr)
MX (2) MX360438B (fr)
SG (2) SG11201400374TA (fr)
WO (1) WO2013036810A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
KR102231531B1 (ko) 2009-02-13 2021-03-23 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
RU2565550C2 (ru) 2010-09-24 2015-10-20 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров
ES2675111T3 (es) 2011-09-07 2018-07-06 X-Chem, Inc. Métodos para etiquetar bibliotecas con codificación de ADN
CN104685115A (zh) * 2012-07-13 2015-06-03 X-化学有限公司 具有聚合酶不可读的编码性寡核苷酸连接的dna编码文库
CA2913127A1 (fr) * 2012-12-10 2014-06-19 Fred Hutchinson Cancer Research Center Procedes de criblage
WO2014100069A1 (fr) * 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Amidation orthogonale post-synthèse plus chimie click de cycloaddition azoture-alcyne catalysée par un métal sur arnsi
CN103882532B (zh) * 2012-12-20 2015-10-21 成都先导药物开发有限公司 一种先导化合物的合成及筛选方法与试剂盒
GB201322692D0 (en) * 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
GB201404552D0 (en) * 2014-03-14 2014-04-30 Philochem Ag Purification of dna-conjugate products
US10900065B2 (en) 2014-11-14 2021-01-26 University Of Washington Methods and kits for labeling cellular molecules
MA41298A (fr) * 2014-12-30 2017-11-07 X Chem Inc Procédés de marquage de banques codées par de l'adn
CN104894651B (zh) * 2015-06-29 2017-04-12 天津诺禾医学检验所有限公司 微量起始dna的高通量测序文库构建方法及其所构建的高通量测序文库
US11186836B2 (en) * 2016-06-16 2021-11-30 Haystack Sciences Corporation Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
CN107130300A (zh) * 2016-10-08 2017-09-05 深圳劲宇生物科技有限公司 一种dna编码分子库的合成方法及dna模板
WO2018107093A1 (fr) * 2016-12-09 2018-06-14 University Of Southern California Cartographie à l'échelle du génome de proximités adn-adn dans le noyau
EP3360962A1 (fr) * 2017-02-14 2018-08-15 Technische Universität Dortmund Synthèse de bibliothèques de codage adn par catalyse micellaire
CN110325491B (zh) 2017-03-17 2022-04-19 成都先导药物开发股份有限公司 编码库的合成方法及组合物
US11795580B2 (en) * 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
WO2019006269A1 (fr) * 2017-06-30 2019-01-03 The Regents Of The University Of California Procédés et systèmes d'évaluation de la méthylation de l'adn dans l'adn acellulaire
EP3688156A4 (fr) * 2017-09-25 2021-06-30 Haystack Sciences Corporation Codage multinomial pour chimie combinatoire dirigée par des oligonucléotides
CN108070009B (zh) * 2017-12-12 2021-04-13 上海药明康德新药开发有限公司 一种制备dna编码化合物文库的方法及起始头片段化合物和制得的dna编码化合物
US11667941B2 (en) 2018-01-12 2023-06-06 Camena Bioscience Limited Compositions and methods for template-free geometric enzymatic nucleic acid synthesis
WO2019149198A1 (fr) * 2018-01-31 2019-08-08 成都先导药物开发股份有限公司 Banque de composés codés par adn et procédé de criblage de composés
WO2019157693A1 (fr) * 2018-02-14 2019-08-22 深圳劲宇生物科技有限公司 Banque moléculaire codée par adn et procédé de criblage de composé à application large
WO2019157692A1 (fr) * 2018-02-14 2019-08-22 深圳劲宇生物科技有限公司 Banque moléculaire codée par adn et procédé de criblage de composé sans restriction de cible
JP7348603B2 (ja) 2018-04-02 2023-09-21 エニュメラ・モレキュラー・インコーポレイテッド 核酸分子を計数するための方法、システム、および組成物
CN110658163A (zh) * 2018-06-29 2020-01-07 成都先导药物开发股份有限公司 一种合成dna编码化合物中的反应监测方法
CN109468310B (zh) * 2018-10-25 2020-12-01 深圳劲宇生物科技有限公司 Dna编码碎片分子库的合成方法和连接基团的筛选方法
US12203130B2 (en) 2018-12-20 2025-01-21 Krylov Sergey N Binder selection using capillary electrophoresis
US12590324B2 (en) 2019-01-14 2026-03-31 Camena Bioscience Limited Compositions and methods for template-free geometric enzymatic nucleic acid synthesis
CN120648764A (zh) * 2019-02-18 2025-09-16 味之素株式会社 包含互补部分的修饰寡核苷酸的制造方法
EP3947718A4 (fr) 2019-04-02 2022-12-21 Enumera Molecular, Inc. Procédés, systèmes et compositions de comptage de molécules d'acide nucléique
AU2020253471A1 (en) * 2019-04-05 2021-10-14 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
WO2020227654A1 (fr) * 2019-05-09 2020-11-12 Pacific Biosciences Of California, Inc. Compositions et méthodes pour la synthèse d'adnc
EP4004202A1 (fr) * 2019-07-25 2022-06-01 X-Chem, Inc. Procédés de marquage et de codage de bibliothèques de composés préexistants
EP4423103A4 (fr) * 2021-10-27 2025-12-10 Juan Pablo Maianti Composés à charge utile masquée marqués par affinité à codage d'adn et leur utilisation dans l'assemblage de bibliothèques à petites molécules activées pour une purification à stade tardif et un criblage multiplexé de ligands covalents
WO2024069235A2 (fr) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions contenant des oligonucléotides ayant des applications théranostiques
WO2025042899A2 (fr) * 2023-08-24 2025-02-27 X-Chem, Inc. Procédés d'identification de composés se liant à une molécule cible à l'aide d'une imagerie miroir de la molécule cible
KR102774172B1 (ko) * 2023-10-25 2025-02-28 서울대학교산학협력단 Rna 변형의 모든 주변 서열을 포함하는 광범위한 rna 변형 라이브러리 설계법 및 그 이용
WO2025217391A1 (fr) * 2024-04-12 2025-10-16 Insitro, Inc. Procédés de préparation de banques combinatoires dirigées par oligonucléotides
WO2026090073A1 (fr) * 2024-10-22 2026-04-30 Genentech, Inc. Particules polymères pour criblage de bibliothèque encodée par adn cellulaire fondée sur la proximité et procédés d'utilisation

Family Cites Families (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3788914T2 (de) * 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5670633A (en) * 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
JP2780572B2 (ja) 1991-09-13 1998-07-30 株式会社島津製作所 オリゴヌクレオチドの酵素的合成法及びオリゴヌクレオチドのプライマーとしての使用
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
DK0604552T3 (da) 1991-09-18 1997-08-04 Affymax Tech Nv Fremgangsmåde til syntese af forskellige samlinger af oligomerer
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
EP0665897B1 (fr) 1992-10-01 2003-07-09 The Trustees Of Columbia University In The City Of New York Banques chimiques combinatoires complexes codees avec des etiquettes
US6503759B1 (en) 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5807683A (en) 1992-11-19 1998-09-15 Combichem, Inc. Combinatorial libraries and methods for their use
WO1994024143A1 (fr) 1993-04-12 1994-10-27 Northwestern University Procede de formation d'oligonucleotides
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
WO1994028028A1 (fr) 1993-05-27 1994-12-08 Selectide Corporation Banques en phase solide codees a segregation topoligique
JPH09500378A (ja) 1993-07-02 1997-01-14 リンクス セラピューティクス，インコーポレイティド 枝分れされそして複雑に結合された高分子構造体の集中的合成
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
DK96093D0 (da) 1993-08-25 1993-08-25 Symbicom Ab Improvements in molecular modelling and drug design
US5658782A (en) 1993-10-20 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization Amino acid transporters and uses
BR9407947A (pt) 1993-11-02 1996-11-26 Affymax Tech Nv Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv
US6117976A (en) 1993-11-04 2000-09-12 Medical Research Council Manufacture and use of polypeptides tagged using binding molecules
WO1995016788A1 (fr) 1993-12-17 1995-06-22 Cubicciotti Roger S Assemblage dirige par nucleotides de medicaments et systemes bimoleculaires et multimoleculaires
US6936477B2 (en) 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
JPH08268A (ja) 1994-06-16 1996-01-09 Koichi Nishigaki 連結した２本鎖ｄｎａの製造方法
US5525734A (en) 1994-06-22 1996-06-11 Affymax Technologies N.V. Methods for synthesizing diverse collections of pyrrolidine compounds
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
MX9700725A (es) 1994-07-26 1997-05-31 Scripps Research Inst Coleccion combinatoria soluble.
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
WO1996038726A1 (fr) 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Couches doubles de phospholipides immobilisees par covalence sur des surfaces solides
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
DE19646372C1 (de) 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US5780231A (en) 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5962228A (en) 1995-11-17 1999-10-05 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5846839A (en) 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
DE19642751A1 (de) 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
DK0971946T3 (da) 1997-01-21 2006-10-30 Gen Hospital Corp Selektion af proteiner ved anvendelse af RNA-protein-fusioner
US5888737A (en) 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
EP0985142A4 (fr) 1997-05-23 2006-09-13 Lynx Therapeutics Inc Systeme et appareil destines au traitement sequentiel des analytes
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US20020034732A1 (en) 1997-07-30 2002-03-21 Daniel J. Capon Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
CA2302292A1 (fr) 1997-08-29 1999-03-04 Selective Genetics, Inc. Procedes utilisant une presentation de phage pour selectionner des ligands internalisants en vue d'une administration de gene
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
DE19928591A1 (de) * 1998-06-22 1999-12-23 Roxana Havlina Herstellung von Polymeren aus nukleotidischen und/oder nicht-nukleotidischen Bausteinen auf enzymatischem Weg
US6846655B1 (en) 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
AU6502599A (en) 1998-10-05 2000-04-26 Lynx Therapeutics, Inc. Enzymatic synthesis of oligonucleotide tags
AU1318400A (en) 1998-10-19 2000-05-08 Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US5942609A (en) 1998-11-12 1999-08-24 The Porkin-Elmer Corporation Ligation assembly and detection of polynucleotides on solid-support
PT1137812E (pt) 1998-12-02 2007-05-31 Adnexus Therapeutics Inc Fusões adn-proteína e suas utilizações
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US7033753B1 (en) 1999-01-15 2006-04-25 University Of Rochester Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms
AU2951599A (en) 1999-04-08 2000-11-14 Pavel Sergeev Synthesis of biologically active compounds in cells
ATE347616T1 (de) 1999-04-30 2006-12-15 Cyclops Genome Sciences Ltd Ribonukleinsäurederivate
US7270969B2 (en) 1999-05-05 2007-09-18 Phylogica Limited Methods of constructing and screening diverse expression libraries
JP4803933B2 (ja) 1999-08-27 2011-10-26 ブリストル−マイヤーズ スクウィブ カンパニー インビトロ翻訳タンパク質の符号化方法および選別方法
WO2001020331A1 (fr) 1999-09-14 2001-03-22 Xenoport, Inc. Substrats et methodes de criblage pour proteines de transport
WO2001025188A1 (fr) 1999-10-04 2001-04-12 University Of Medicine And Dentistry Of New Jersey Noueaux carbamates et urees
US6844324B1 (en) 1999-11-12 2005-01-18 Massachusetts Institute Of Technology Modular peptide mediated intracellular delivery system and uses therefore
WO2001062772A2 (fr) 2000-02-23 2001-08-30 Xenoport, Inc. Synthese combinatoire auto-codee de multiplets de composes
US6936467B2 (en) 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US7998673B2 (en) 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US6479262B1 (en) * 2000-05-16 2002-11-12 Hercules, Incorporated Solid phase enzymatic assembly of polynucleotides
US6994963B1 (en) 2000-07-10 2006-02-07 Ambion, Inc. Methods for recombinatorial nucleic acid synthesis
US20020072887A1 (en) 2000-08-18 2002-06-13 Sandor Szalma Interaction fingerprint annotations from protein structure models
US6627748B1 (en) 2000-09-11 2003-09-30 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
EP2187317B1 (fr) 2000-09-20 2012-12-05 ARKRAY, Inc. Système de support de client demandant une page du manuel selon l'état d'un client
US6706481B2 (en) 2000-10-27 2004-03-16 Research Development Foundation In vitro selection of signaling aptamers
JP2002315577A (ja) 2000-11-14 2002-10-29 Gencom Co 核酸ライブラリーの作製方法
US20030049616A1 (en) 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
US7070928B2 (en) 2001-03-19 2006-07-04 President And Fellows Of Harvard College Evolving new molecular function
CN1539014A (zh) 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
US20060234231A1 (en) 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US20030143561A1 (en) 2001-06-20 2003-07-31 Nuevolution A/S Nucleoside derivatives for library preparation
EP1401850A1 (fr) 2001-06-20 2004-03-31 Nuevolution A/S Derives nucleosidiques pour elaboration de bibliotheque combinatoire
WO2003078445A2 (fr) 2002-03-15 2003-09-25 Nuevolution A/S Element constitutif formant une double liaison c=c lors de la reaction
DK1483585T3 (da) 2002-03-08 2009-06-22 Eidgenoess Tech Hochschule Kodede, selvsamlende kemiske biblioteker (ESACHEL)
DE60324778D1 (de) 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
AU2003218630A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
US20050221318A1 (en) 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
US20050247001A1 (en) 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
EP1520040A2 (fr) 2002-06-20 2005-04-06 Nuevolution A/S Microreseaux presentant des molecules codees
EP1543156A4 (fr) 2002-07-18 2005-12-21 Univ Leland Stanford Junior Detection de ligatures chimiques a l'aide de groupes partants d'extinction de fluorescence
WO2004009814A1 (fr) 2002-07-23 2004-01-29 Nuevolution A/S Rearrangement d'adn par permutation de matrices
WO2004013070A2 (fr) 2002-08-01 2004-02-12 Nuevolution A/S Synthese en plusieurs etapes de molecules synthetisees
WO2004016767A2 (fr) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Developpement d'une nouvelle fonction moleculaire
EP1539953A2 (fr) 2002-09-12 2005-06-15 Nuevolution A/S Synthese de molecules a matrice realisee par proximite
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP1597394A2 (fr) 2003-02-21 2005-11-23 Nuevolution A/S Procede permettant d'obtenir des informations structurelles sur une molecule codee
US7915201B2 (en) 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
EP1652123A2 (fr) 2003-07-03 2006-05-03 Biogen Idec MA Inc. Carte peptidique d'interactions structurelles (sift)
WO2005007815A2 (fr) 2003-07-07 2005-01-27 One Cell Systems, Inc. Sondes marquees a structure en epingle a cheveux et leurs procedes d'utilisation
EP1533385A1 (fr) 2003-09-05 2005-05-25 Nuevolution A/S Composés à matrice pour la génération de molécules codées et procédés dirigés utilisant ces derniers
US7365179B2 (en) 2003-09-09 2008-04-29 Compass Genetics, Llc Multiplexed analytical platform
WO2005026387A1 (fr) 2003-09-18 2005-03-24 Nuevolution A/S Procede permettant d'obtenir des informations structurelles concernant une molecule codee et procede permettant de selectionner des composes
WO2005050224A2 (fr) 2003-11-13 2005-06-02 Epitome Biosystems Inc. Agencements de peptides et de petites molecules et leurs utilisations
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
RU2470077C2 (ru) 2003-12-17 2012-12-20 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Биологически активное соединение, содержащее кодирующий олигонуклеотид (варианты), способ его синтеза, библиотека соединений (варианты), способ ее синтеза и способ поиска соединения, связывающегося с биологической мишенью (варианты)
US20050153321A1 (en) 2003-12-30 2005-07-14 Saba James A. Libraries of multiple-ligand-conjugated nucleic acids
AU2005214329A1 (en) 2004-02-12 2005-09-01 Population Genetics Technologies Ltd Genetic analysis by sequence-specific sorting
EP1723255B1 (fr) 2004-02-17 2010-12-29 Nuevolution A/S Methode d'elimination visant a un enrichissement par hybridation de mesappariements
WO2005090566A2 (fr) 2004-03-22 2005-09-29 Nuevolution A/S Codage par ligature utilisant des oligonucléotides à motifs structuraux
US7405287B2 (en) 2004-08-03 2008-07-29 Board Of Regents, The University Of Texas System Method of treating a cancer
US7745614B2 (en) 2004-09-03 2010-06-29 The Board Of Trustees Of The Leland Stanford Junior University Universal linker compositions for the release or transfer of chemical agents from a polynucleotide
US20060099626A1 (en) 2004-10-27 2006-05-11 Harbury Pehr B DNA-templated combinatorial library device and method for use
CA2587010C (fr) 2004-11-08 2017-08-15 Vipergen Aps Sysnthese chimique guidee par acides nucleiques structurels
EP1828381B1 (fr) 2004-11-22 2009-01-07 Peter Birk Rasmussen Synthese mixte et de dedoublement (split-mix), dirigee par matrice, de banques de petites molecules
AU2005316503A1 (en) 2004-12-17 2006-06-22 Dynavax Technologies Corporation Methods and compositions for induction or promotion of immune tolerance
CN101090979A (zh) * 2004-12-22 2007-12-19 埃克斯魁恩公司 用于分析核酸混合物的探针、文库和试剂盒及其构建方法
JP4969459B2 (ja) * 2005-01-21 2012-07-04 プレジデント アンド フェロウズ オブ ハーバード カレッジ 核酸鋳型合成において使用される遊離反応体
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006099604A2 (fr) 2005-03-16 2006-09-21 Compass Genetics, Llc Procedes et compositions pour releves de mesures sur de multiples plate-formes analytiques
NZ564545A (en) 2005-06-09 2011-03-31 Praecis Pharm Inc Methods for synthesis of encoded libraries
US20090035824A1 (en) 2005-06-17 2009-02-05 Liu David R Nucleic acid-templated chemistry in organic solvents
AU2006272626B2 (en) 2005-07-26 2010-12-09 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
WO2007016488A2 (fr) 2005-07-29 2007-02-08 Ensemble Discovery Corporation Analyse de bibliotheques chimiques codees
WO2007041201A2 (fr) 2005-10-03 2007-04-12 Applera Corporation Compositions, procedes et kits pour l'amplification d'acides nucleiques
EP1940755A2 (fr) 2005-10-28 2008-07-09 Praecis Pharmaceuticals Inc. Procedes d'identification de composes etudies, par recours a des bibliotheques codees
LT2336315T (lt) 2005-12-01 2017-11-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei
WO2007087312A2 (fr) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Décompte moléculaire
WO2007124758A1 (fr) 2006-05-03 2007-11-08 Vipergen Aps Procédé de préparation de composés par synthèse dirigée par des acides nucléiques
US8153830B2 (en) 2006-10-26 2012-04-10 Sumitomo Chemical Company, Limited Production method of asymmetric copper complex crystal
CN101219219B (zh) 2007-01-10 2013-02-13 北京普罗吉生物科技发展有限公司 包含血管抑素或其片段的复合物、其制备方法及应用
CN101896623B (zh) 2007-10-22 2013-12-18 Lgc有限公司 寡核苷酸及其应用
WO2009066447A1 (fr) 2007-11-19 2009-05-28 Japan Advanced Institute Of Science And Technology Nucléotide artificiel sensible à la lumière ayant une aptitude de photo-réticulation
WO2009077173A2 (fr) * 2007-12-19 2009-06-25 Philochem Ag Bibliothèques de produits chimiques codés par adn
US20120107840A1 (en) 2008-04-09 2012-05-03 Sru Biosystems, Inc Methods for Label Free Testing of Cells
JP4814904B2 (ja) 2008-04-16 2011-11-16 国立大学法人北陸先端科学技術大学院大学 核酸類の配列選択的な精製方法
CA2723265C (fr) * 2008-05-02 2015-11-24 Epicentre Technologies Corporation Marquage selectif d'arn par ligature en 5'
TW201011006A (en) 2008-06-16 2010-03-16 Nuevolution As IAP binding compounds
WO2010011944A2 (fr) 2008-07-25 2010-01-28 Wagner Richard W Procédés de criblage de protéines
US20120100530A1 (en) 2009-01-30 2012-04-26 Oxford Nanopore Technologies Limited Enzyme mutant
KR102231531B1 (ko) 2009-02-13 2021-03-23 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
US20120004137A1 (en) 2009-02-13 2012-01-05 X-Body, Inc. Identification of nucleic acid delivery vehicles using dna display
EP2610352B1 (fr) 2009-02-16 2014-10-08 Epicentre Technologies Corporation Ligature indépendante de la matrice d'un ADN simple brin
US8728725B2 (en) 2009-07-06 2014-05-20 Trilink Biotechnologies Chemically modified ligase cofactors, donors and acceptors
US8574864B2 (en) * 2009-11-05 2013-11-05 Epicentre Technologies Corporation Methods and kits for 3'-end-tagging of RNA
DE102009058769A1 (de) * 2009-12-16 2011-06-22 MagForce Nanotechnologies AG, 10589 Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung
US20110237535A1 (en) 2010-03-26 2011-09-29 Sru Biosystems, Inc. Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries
CA2832672A1 (fr) 2010-04-16 2011-10-20 Nuevolution A/S Complexes bifonctionnels et procedes de fabrication et d'utilisation de tels complexes
US9880160B2 (en) 2011-03-15 2018-01-30 X-Body, Inc. Antibody screening methods
US8846883B2 (en) 2011-08-16 2014-09-30 University Of Southhampton Oligonucleotide ligation
ES2675111T3 (es) 2011-09-07 2018-07-06 X-Chem, Inc. Métodos para etiquetar bibliotecas con codificación de ADN
CN104685115A (zh) 2012-07-13 2015-06-03 X-化学有限公司 具有聚合酶不可读的编码性寡核苷酸连接的dna编码文库
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries

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